Matches in Nanopublications for { ?s <http://purl.org/nanopub/x/asSentence> ?o ?g. }
- assertion asSentence Butyrylcholinesterase+K+variant+on+chromosome+3+q+is+associated+with+Type+II+diabetes+in+white+Caucasian+subjects. assertion.
- assertion asSentence Human+butyrylcholinesterase+is+reversibly+inhibited+by+tetraethylammonium+ion. assertion.
- assertion asSentence Levels+are+decreased+in+colonic+adenocarcinomas. assertion.
- assertion asSentence Recombinant+human+butyrylcholinesterase+interacts+with+beta-amyloid+fibrils+and+can+attenuate+their+formation+and+branching. assertion.
- assertion asSentence Differences+between+the+t+peptides+of+Aacetylcholinesterase+and+butyrylcholinesterase+are+conserved+among+all+vertebrates. assertion.
- assertion asSentence A+founder+mutation+in+the+BCKDHA+is+responsible+for+the+high+incidence+of+the+maple+syrup+urine+disease+among+Portuguese+Gypsies. assertion.
- assertion asSentence A+key+tyrosine+residue+in+the+E1b+active+site+functions+as+a+conformational+switch+to+reduce+the+reactivity+of+the+thiamine+diphosphate+cofactor+through+interactions+with+its+thiazolium+ring. assertion.
- assertion asSentence Cyclin+D1+play+important+roles+in+esophageal+carcinogenesis. assertion.
- assertion asSentence Cyclopentenone+causes+cell+cycle+arrest+and+represses+cyclin+D1+promoter+activity+in+MCF-7+breast+cancer+cells. assertion.
- assertion asSentence VHL-mediated+hypoxia+regulation+of+cyclin+D1+in+renal+carcinoma+cells. assertion.
- assertion asSentence Overexpression+of+Icat+induces+G%282%29+arrest+and+cell+death+in+tumor+cell+mutants+for+adenomatous+polyposis+coli%2C+beta-catenin%2C+or+Axin. assertion.
- assertion asSentence Expression+levels+of+CCND1+predict+the+cellular+effects+of+mTOR+inhibitors+in+ovarian+carcinoma. assertion.
- assertion asSentence CCND1+polymorphism+is+associated+with+an+increased+risk+of+endometrial+cancer. assertion.
- assertion asSentence Cyclin+D1+overexpression+alters+the+proliferation+and+differentiation+behavior+of+HaCaT+skin+keratinocytes+in+organotypic+co-cultures. assertion.
- assertion asSentence The+suppression+of+cyclin+D1+levels+during+S+phase+is+regulated+by+cell+cycle+position+rather+than+signaling+activity. assertion.
- assertion asSentence Curcumin+treatment+inhibited+cyclin+D1+mRNA+expression+in+K562+chronic+leukaemia+cells. assertion.
- assertion asSentence Cyclin+D1+expression+is+an+independent+poor+prognostic+factor+in+women+with+early-stage%2C+hormone+receptor-positive+breast+cancer+who+received+adjuvant+tamoxifen-based+therapy. assertion.
- assertion asSentence miR-34a+reduces+both+mRNA+and+protein+levels+of+cyclin+D1+%28CCND1%29+and+cyclin-dependent+kinase+6+%28CDK6%29. assertion.
- assertion asSentence Overexpression+of+cyclin+D1+is+associated+with+cholangiocarcinoma. assertion.
- assertion asSentence The+overexpression+of+cyclin+D1+found+in+colon+cancer+favours+tumour+dedifferentiation+as+one+mechanism+of+tumour+progression. assertion.
- assertion asSentence DACH1+inhibits+breast+cancer+cellular+proliferation+via+cyclin+D1. assertion.
- assertion asSentence Cyclin+D1+overexpression+is+associated+with+longer+survival+in+colon+cancer. assertion.
- assertion asSentence The+CCND1+870A+allele+is+associated+with+nasopharyngeal+carcinoma+in+Han+population. assertion.
- assertion asSentence The+MAPK+kinase-1%2F2+inhibitor%2C+U0126%2C+fully+restored+cAMP+down-regulation+of+CCND1+in+endometrial+stromal+fibroblasts+of+women+with+vs.+without+endometriosis. assertion.
- assertion asSentence Loss+of+cyclin+D1+in+ovarian+cancer+cells+treated+with+SHetA2+is+sufficient+to+induce+G%281%29+cell+cycle+arrest+and+this+strategy+is+not+impeded+by+the+presence+of+cyclin+E2. assertion.
- assertion asSentence Expression+of+cyclin+D1+and+P21WAF1+is+related+to+drug-resistance+of+gastric+cancers. assertion.
- assertion asSentence Cyclin+D1b+participates+into+multiple+myeloma+pathogenesis+via+previously+unrevealed+actions. assertion.
- assertion asSentence Hr+and+VDR+interact+via+multiple+protein-protein+interfaces%2C+catalyzing+histone+demethylation+to+effect+chromatin+remodeling+and+repress+the+transcription+of+VDR+target+genes+that+control+the+hair+cycle. assertion.
- assertion asSentence Abolishing+the+expression+of+cyclin+D1%2C+Cdk4+or+Nek2+in+MCF10A+human+mammary+epithelial+cells+expressing+H-Ras%28G12V%29+abrogated+Ras-induced+centrosome+amplification. assertion.
- assertion asSentence Overexpressions+of+nuclear+cyclin+D1+is+associated+with+non-small+cell+lung+cancer. assertion.
- assertion asSentence Cyclin-D1+overexpression+is+associated+with+leiomyosarcoma. assertion.
- assertion asSentence Cyclin+D1+provides+a+transcriptional+switch+that+allows+the+tumor+suppressor+activity+of+RUNX3+to+be+repressed+in+cancer+cells. assertion.
- assertion asSentence Cyclin+D1+is+a+selective+modifier+of+androgen-dependent+signaling+and+androgen+receptor+function. assertion.
- assertion asSentence Cyclin+D1+positive+diffuse+large+B-cell+lymphoma+is+a+post-germinal+center-type+lymphoma+without+alterations+in+the+CCND1+gene+locus. assertion.
- assertion asSentence ROC1+expression+is+negatively+correlated+with+cyclin+D1+expression%2C+demonstrating+its+importance+in+the+degradation+of+cyclin+D1+in+melanomas. assertion.
- assertion asSentence Aurora-A+overexpressing+cells+fail+to+overcome+the+restriction+point+at+the+G1%2FS+transition+due+to+diminished+RB+phosphorylation+caused+by+reduced+Cyclin+D1+expression. assertion.
- assertion asSentence The+expressions+of+CDK4+and+Cyclin+D1+increased+along+with+progression+of+gallbladder+mucosa+hyperplasia+and+p16+decreased+to+the+lowest+level+in+gallbladder+cancer. assertion.
- assertion asSentence CCND1+amplification+is+associated+with+a+more+aggressive+phenotype+within+histological+grade+2+tumours+and+luminal+A+subtype+tumours. assertion.
- assertion asSentence Binding+of+ErbB3%2880+KDa%29+on+the+promoter+activates+Cyclin+D1+transcription+and+subsequent+protein+expression%2C+leading+to+an+increased+cell+proliferation. assertion.
- assertion asSentence Cyclin+D1+overexpression+is+associated+with+oral+cavity+squamous+cell+carcinoma. assertion.
- assertion asSentence CCND1+is+amplified+and+overexpressed+in+a+substantial+proportion+of+vulvar+carcinomas+and+associated+with+the+occurrence+of+locoregional+lymph+node+metastases%2C+especially+in+human+papillomavirus-negative+tumors. assertion.
- assertion asSentence BCL2+antisense+transcripts+decrease+intracellular+Bcl-2+expression+and+sensitize+LNCaP+prostate+cancer+cells+to+apoptosis-inducing+agents. assertion.
- assertion asSentence Bcl-2+expression+is+upregulated+by+VEGF+in+neuroblastoma+cells. assertion.
- assertion asSentence Conformational+change+of+Bcl2+due+to+association+with+peptidyl+prolyl+isomerase+can+contribute+to+irreversible+apoptotic+signaling. assertion.
- assertion asSentence Transgenic+mice+over-expressing+human+Bcl-2+in+myeloid+cells+exhibit+markedly+increased+neutrophil+accumulation+and+reduced+bacteria+counts+in+peritoneum+following+cecal+ligation+and+puncture%2C+consistent+with+an+increased+host+response. assertion.
- assertion asSentence The+immunodetection+of+both+p53+and+bcl-2+proteins+in+squamous+cell+carcinoma+of+the+uterine+cervix+can+be+used+as+an+independent+diagnostic+marker+for+cervical+cancer+associated+with+HPV+infection. assertion.
- assertion asSentence Down+regulation+in+Hep3B+cell+line+in+the+presence+of+Ni%282%2B%29. assertion.
- assertion asSentence Bcl-2+expression+markedly+enhanced+spontaneous+lung+metastasis+from+orthotopically+implanted+primary+tumors. assertion.
- assertion asSentence PCNA+expression+induces+apoptosis+by+up-regulating+cleaved+caspase-3+and+poly+adp+ribose+polymerase+expression+and+down-regulating+Bcl-2+protein+expression+in+leiomyoma+cells. assertion.
- assertion asSentence Oct-2%2C+therefore%2C+acts+as+a+cell+survival+factor+in+t%2814%3B18%29+lymphoma+cells+by+directly+activating+the+antiapoptotic+gene+bcl-2. assertion.
- assertion asSentence Bcl-2+expression+appears+significantly+%28p%3C0.005%29+more+often+in+cases+of+mild+colonic+dysplasia+%2861.1%25%29+compared+to+inflammatory-regenerative+mucosa+%2814.8%25%29. assertion.
- assertion asSentence bcl2+and+ROS1+oncogene+expression+in+meningiomas+are+not+concurrent+and+neither+can+be+ascribed+to+any+histologic+subtype+or+grade+of+tumor. assertion.
- assertion asSentence Bcl-2+expression+acts+as+a+regulator+of+HSV-2+replication. assertion.
- assertion asSentence Antiapoptotic+proteins+Bcl-2+and+Bcl-X%28L%29+bind+and+suppress+NALP1%2C+reducing+caspase-1+activation+and+interleukin-1beta+%28IL-1beta%29+production. assertion.
- assertion asSentence Antiapoptotic+activities+of+BCL2+correlate+with+vascular+maturation+and+transcriptional+modulation+of+endothelial+cells. assertion.
- assertion asSentence The+interaction+of+Bcl-2+with+IP3Rs+contributes+to+the+regulation+of+proapoptotic+Ca2%2B+signals+by+Bcl-2. assertion.
- assertion asSentence There+is+a+strong+correlation+between+Bcl-2+levels+and+resistance+to+Fas-mediated+apoptosis. assertion.
- assertion asSentence Treatment+of+KG-1+cells+with+Resveratrol+increased+apoptosis%2C+downregulated+Bcl2+and+upregulated+Bax. assertion.
- assertion asSentence The+nongenomic+effects+of+estrogen+initiated+from+plasma+membrane+by+E2-BSA+cannot+lead+to+transcriptional+effect+of+Bcl-2+expression. assertion.
- assertion asSentence The+expressions+of+PCNA+and+Bcl-2+proteins+increased+significantly+in+the+lymphocytes+of+patients+with+oral+lichen+planus. assertion.
- assertion asSentence Treatment+with+active+matabolite+of+vitamin+D+%281alpha%2C25-dihydroxyvitamin+D3%29+down-regulates+BCL2+mRNA+expression. assertion.
- assertion asSentence Inhibiting+the+pore-forming+and+anti-Bax+activities+of+Bcl2+in+the+membrane+is+strongly+correlated+with+pro-apoptotic+function+in+cells. assertion.
- assertion asSentence Downmodulation+of+Bcl-2+sensitizes+metastatic+LNCaP-LN3+cells+to+undergo+apoptosis+via+the+intrinsic+pathway. assertion.
- assertion asSentence Interplay+between+Beclin+1+and+Bcl-2+is+required+for+both+autophagy+and+apoptosis+modulation. assertion.
- assertion asSentence A+single+nucleotide+polymorphism+protects+against+azoospermia+by+influencing+the+balance+of+pro-+aand+antiapoptosis+in+spermatogenesis+in+a+Han+Chinese+population. assertion.
- assertion asSentence BCL-2+expression+measured+by+PCR+in+tsticular+cancer+cells+is+as+effective+as+a+monospecific+oligonucleotide+against+BCL-2+expression. assertion.
- assertion asSentence Low+BCL-2+is+associated+with+lymph+node+metastasis+and+chemosensitivity+in+breast+carcinoma. assertion.
- assertion asSentence The+Bcl-2+family+of+proteins+is+crucial+for+airway+epithelial+homeostasis. assertion.
- assertion asSentence Cerebrospinal+fluid+Bcl-2+and+cytochrome+C+levels+are+elevated+in+adults+after+severe+traumatic+brain+injury. assertion.
- assertion asSentence Noxa%2FBcl-2+protein+interactions+contribute+to+bortezomib+resistance+in+human+lymphoid+cells. assertion.
- assertion asSentence Concurrent+IGH%2FBCL2+and+MYC+rearrangements+are+associated+with+non-Hodgkin+lymphoma. assertion.
- assertion asSentence Ethanol-induced+neuronal+apoptosis+follows+both+the+mitochondria-mediated+%28miR-497-+and+BCL2-mediated%29+and+non-mitochondria-mediated+%28miR-302b-+and+CCND2-mediated%29+pathway. assertion.
- assertion asSentence Genotyping+reveals+two+single+nucleotide+polymorphisms+in+the+BCL2+gene+and+a+single+nucleotide+polymorphism+in+the+SERPINA4+gene+associated+with+a+decreased+risk+of+developing+acute+kidney+injury. assertion.
- assertion asSentence Inhibition+of+Mcl-1+and+A1+strongly+induced+cell+death+in+some+melanoma+cell+lines. assertion.
- assertion asSentence Mature+dendritic+cells+are+protected+from+Fas%2FCD95-mediated+apoptosis+by+upregulation+of+Bcl-X%28L%29. assertion.
- assertion asSentence Bcl-xL+directly+binds+to+Apaf-1. assertion.
- assertion asSentence The+BCLX+pre-mRNA+is+splicing+by+extracellular+factors+and+their+distinct+requirements+for+pre-mRNA+elements. assertion.
- assertion asSentence Stable+Bcl-XL+siRNA+transfectants+have+an+increased+spontaneous+apoptosis. assertion.
- assertion asSentence 1-Bromopropane+inhibits+nuclear+factor+kappa+B+activation+to+reduce+Bcl-xL+expression+in+astrocytes. assertion.
- assertion asSentence Bcl-X%28L%29+conferred+complete+resistance+to+apoptosis+induced+by+fas+ligation+in+atherosclerotic+carotid+artery. assertion.
- assertion asSentence Expressed+in+most+dysmorphic+neurons+in+focal+cortical+dysplasia+type+II. assertion.
- assertion asSentence Gambogic+acid+induces+the+apoptosis+of+Raji+cells+through+DIO-1+upregulation%2C+nuclear+translocation%2C+Bcl-xL+downregulation+and+caspase+3+activation. assertion.
- assertion asSentence Treatment+with+active+matabolite+of+vitamin+D+%281alpha%2C25-dihydroxyvitamin+D3%29+down-regulates+BCL-XL. assertion.
- assertion asSentence Bcl-x%28L%29+inhibits+and+maintains+Bax+in+the+cytosol+by+constant+retrotranslocation+of+mitochondrial+Bax. assertion.
- assertion asSentence Peptide+%3D+to+BH3+region+of+proapoptotic+protein+BID%2C+bound+in+cleft+of+antiapoptotic+protein+BCL-w.Binding+induced+major+conformational+rearrangements+in+both+peptide+%26+protein+components+%26+led+to+displacement+%26+unfolding+of+BCL-w+C-terminal+alpha-helix. assertion.
- assertion asSentence Bcl-w+is+a+direct+target+of+miR-122+that+functions+as+an+endogenous+apoptosis+regulator+in+these+human+hepatocellular+carcinoma+-derived+cell+lines. assertion.
- assertion asSentence Over-expression+of+miR-133B+increased+apoptosis+in+response+to+gemcitabine+and+reduced+MCL-1+and+BCL2L2+expression. assertion.
- assertion asSentence High-level+expression+of+BCL3+differentiates+t%282%3B5%29%28p23%3Bq35%29-positive+anaplastic+large+cell+lymphoma+from+Hodgkin+disease. assertion.
- assertion asSentence Supported+by+IL-12+signals%2C+Bcl-3+enhances+survival+and+clonal+expansion+of+transgenic+OT-1+CD8+T+cells. assertion.
- assertion asSentence COX-2+inhibitor+can+inhibit+the+expression+of+BCL-3+and+cyclin+D1+in+a+dose-dependent+manner+human+colon+cancer+cell+line+SW480. assertion.
- assertion asSentence Bcl-6+mediates+the+B+cell+phenotype+by+directly+targeting+the+ataxia+telangiectasia-+and+Rad3-related+%28ATR%29+gene+in+centroblasts+and+lymphoma+cells. assertion.
- assertion asSentence Chromosomal+transloacations+or+mutations+that+disrupt+the+IRF4-responsive+region+in+the+BCL6+promoter+block+its+downregulation+by+CD40+signaling+and+is+associated+with+B+cell+lymphoma. assertion.
- assertion asSentence Gene+expression+levels+of+bcl-6%2C+lpp+and+miR-28+are+different+in+various+diffuse+large+B+cell+lymphoma+cell+lines. assertion.
- assertion asSentence Expression+of+BCR%2FABL+and+BCL-2+in+myeloid+progenitors+leads+to+myeloid+leukemias. assertion.
- assertion asSentence Enriched+CD34%2B+cells+from+patients+with+BCR-ABL-positve+chronic+myelocytic+leukemia+in+chronic+phase+or+blast+crisis+do+not+associate+blast+crisis+with+mutation. assertion.
- assertion asSentence Mutation+in+the+kinase+domain+of+Bcr-Abl+is+associated+with+resistance+to+STI571. assertion.
- assertion asSentence Point+mutations+in+the+BCR-ABL+kinase+domain+is+associated+with+imatinib+resistance+in+Philadelphia+chromosome-positive+chronic+myeloid+leukemia. assertion.
- assertion asSentence Bcr-Abl+stability+and+oncogenic+signaling+in+chronic+myeloid+leukemia+%28CML%29+cells+are+under+the+control+of+Jak2. assertion.
- assertion asSentence The+g.1181A%3EG+mutation+generated+an+alternative+splicing+site+in+the+BCS1L+transcript%2C+causing+a+19-nucleotides+deletion+in+its+5%27UTR+region+and+Complex+III+deficiency. assertion.
- assertion asSentence Kinins+modulate+receptor+endocytosis+to+rapidly+decrease+B2R+and+increase+B1R+on+the+cell+surface. assertion.