Matches in Nanopublications for { ?s <http://purl.org/nanopub/x/asSentence> ?o ?g. }
- assertion asSentence FGF2+signaling+switches+the+outcome+of+BMP4-induced+differentiation+of+human+embryonic+stem+cells+by+maintaining+NANOG+levels+through+the+MEK-ERK+pathway. assertion.
- assertion asSentence An+anti-angiogenic+role+for+BMP4+in+laser-induced+CNV%2C+mediated+by+direct+inhibition+of+MMP-9+and+indirect+inhibition+of+VEGF. assertion.
- assertion asSentence BMP-6+increases+the+levels+of+osteopontin%2C+BMP-2%2C+alkaline+phosphatase+and+core+binding+factor+alpha+1+mRNAs+in+human+periodontal+%28HPL%29+ligament+cells. assertion.
- assertion asSentence A+functional+bone+morphogenetic+protein+6+%28BMP-6%29+signalling+pathway+is+present+in+adult+pre-T-leukemia+lymphoma+cell+line+Jurkat+TAg. assertion.
- assertion asSentence BMP-6+is+an+important+mediator+to+support+healthy+follicle+growth+in+the+human+ovary. assertion.
- assertion asSentence BMP-7+plays+an+important+role+in+the+regulation+of+anti-inflammatory+response+in+the+adult+gut+tissue. assertion.
- assertion asSentence Modulation+of+endogenous+osteogenic+protein-1+%28OP-1%29+by+interleukin-1+in+adult+human+articular+cartilage. assertion.
- assertion asSentence Recombinant+human+BMP-7+plays+a+role+in+the+migration+of+bone-forming+cells. assertion.
- assertion asSentence Immunohistochemistry+of+cirrhotic+human+liver+demonstrated+upregulated+BMP7+protein+expression+in+hepatocytes+as+compared+with+normal+human+liver. assertion.
- assertion asSentence BMP7+gene-modified+bone+marrow+stromal+cells+and+load-bearing+can+promote+bone+regeneration+in+segmental+defects. assertion.
- assertion asSentence BMP-7+expression+is+one+of+the+strong+predictors+of+risk+of+tumour+recurrence+in+gastric+cancer. assertion.
- assertion asSentence High+BMP7+expression+is+associated+with+esophageal+squamous+cell+carcinoma. assertion.
- assertion asSentence The+involvement+of+BMP7+in+several+pathological+conditions%2C+such+as+incomplete+fracture+healing%2C+osteoarthritis%2C+the+development+of+bone+metastases%2C+renal+fibrosis+and+obesity. assertion.
- assertion asSentence Germline+BMPR1A+defect+is+the+disease-causing+mutation+in+50%25+of+the+HMPS+families. assertion.
- assertion asSentence rs1434536+in+the+3%27UTR+of+BMPR1B+gene+affects+the+binding+ability+of+miR-125b+to+BMPR1B+mRNA+and+contributes+to+the+genetic+predisposition+to+localized+prostate+cancer+and+patients+aged%3E70+years. assertion.
- assertion asSentence Loss+of+BMPRII+signaling+in+mouse+smooth+muscle+%28due+to+dominant+negative+human+transgene%29is+sufficient+to+produce+the+pulmonary+hypertensive+phenotype. assertion.
- assertion asSentence Human+granulosa-like+tumor+cell+line+KGN+expressed+BMP+type+I+%28BMPR1A+and+BMPR1B%29+and+type+II+receptors+%28BMPR2%29+and+the+BMP+signaling+molecules+SMADs+%28SMAD1+and+SMAD5%29. assertion.
- assertion asSentence Mutations+of+the+gene+that+code+bone+morphogenic+protein+type+2+receptor+%28BMPR2%29+are+involved+in+the+pathogenesis+of+pulmonary+arterial+hypertension+both+in+it+familial+and+its+idiopathic+forms. assertion.
- assertion asSentence Etk+activation+is+essential+for+transducing+the+EGF-induced+apoptotic+signaling+in+breast+cancer+cells. assertion.
- assertion asSentence In+humans%2C+BNIP3+is+strongly+expressed+in+most+follicular+lymphomas%2C+especially+those+that+are+Bcl-2+negative. assertion.
- assertion asSentence The+methylation+of+BNIP3+and+DAPK+can+predict+lower+response+to+chemotherapy+and+poor+prognosis+in+gastric+cancer. assertion.
- assertion asSentence A+complete+deletion+of+the+polyAla+tract+of+FOXL2+induces+a+significant+intranuclear+aggregation. assertion.
- assertion asSentence Blepharophimosis+and+bilateral+Duane+syndrome+associated+with+a+FOXL2+mutation. assertion.
- assertion asSentence FOXL2+mutations+in+Indian+families+with+blepharophimosis-ptosis-epicanthus+inversus+syndrome. assertion.
- assertion asSentence FOXL2+polyAla+expansions+lead+to+protein+mislocalization+and+aggregation+in+a+length-dependent+manner. assertion.
- assertion asSentence Missense+mutations+in+the+DNA-binding+forkhead+domain+of+FOXL2+lead+to+mislocalization%2C+protein+aggregation+and+altered+transactivation. assertion.
- assertion asSentence FOXL2+represses+the+transcription+of+aromatase%2C+cholesterol+side-chain+cleavage+enzyme+P450scc+and+cyclin+D2+in+granulosa+cells. assertion.
- assertion asSentence Mutation+c.704delG+in+FOXL2+led+to+a+truncated+protein+is+associated+with+both+type+I+and+II+of+blepharophimosis-ptosis-epicanthus+inversus+syndrome. assertion.
- assertion asSentence FOXL2+is+a+relatively+sensitive+and+highly+specific+marker+for+sex+cord-stromal+ovarian+tumors. assertion.
- assertion asSentence BRCA1+and+BARD1+are+associated+with+the+RNA+polymerase+II+holoenzyme. assertion.
- assertion asSentence Contribution+of+BRCA1+and+BRCA2+mutations+to+breast+and+ovarian+cancer+in+Pakistan. assertion.
- assertion asSentence BRCA1+germline+mutations+in+Indian+familial+breast+cancer. assertion.
- assertion asSentence Both+TopBP1+and+BRCA1+specifically+regulate+the+G%282%29-M+checkpoint%2C+partially+compensating+each+function. assertion.
- assertion asSentence Recurrent+BRCA1+mutations+have+no+role+in+predisposition+to+prostate+cancer+in+Finland. assertion.
- assertion asSentence A+mutation+in+a+pedigree+of+an+Asian%2FFilipino+family%2C+with+breast+cancer. assertion.
- assertion asSentence BRCA1-BARD1+complexes+act+as+an+adaptor+to+mediate+phosphorylation+of+p53%2C+influencing+G%281%29%2FS+cell+cycle+progression+after+DNA+damage. assertion.
- assertion asSentence Patients+with+bilateral+breast+cancer+having+BRCA1+mutations+are+significantly+younger+than+non-carriers. assertion.
- assertion asSentence BRCA1+participates+in+DNA+decatenation+and+in+the+maintenance+of+genomic+stability. assertion.
- assertion asSentence Self-assembly+has+profound+consequences+for+the+processive+formation+of+polyubiquitin+%28poly-Ub%29+chains+in+ubiquitination+reactions+directed+by+the+breast+and+ovarian+cancer+tumor+susceptibility+protein+BRCA1. assertion.
- assertion asSentence Down+regulation+of+BRCA1+protein+and+loss+of+heterozygosity+correlated+with+the+clinicopathological+parameters+in+the+pathogenesis+of+sporadic+breast+cancer+women+in+Chennai+%28South+India%29. assertion.
- assertion asSentence BRCA1+can+regulate+the+functions+of+its+substrates+through+nonproteasomal+pathways+that+do+not+involve+substrate+degradation. assertion.
- assertion asSentence A+role+for+BRCA1%2F2+mutations+in+colorectal+cancer+risk+in+a+subgroup+of+breast+cancer+and%2For+ovarian+cancer+affected+carriers. assertion.
- assertion asSentence BRCA1+enzymatic+activity+regulates+transcriptional+repression%2C+during+which+the+ubiquitin+moiety+itself+interferes+with+the+assembly+of+basal+transcription+factors+at+the+promoter. assertion.
- assertion asSentence Two+BRCA1+mutations%2C+5382insC+and+G1738R%2C+both+located+in+exon+20%2C+account+for+46%25+of+the+families+found+to+carry+a+mutation+in+Greek+breast%2Fovarian+cancer+families. assertion.
- assertion asSentence Carriers+of+BRCA1+mutations+fare+significantly+worse+than+carriers+of+BRCA2%2C+even+when+their+tumors+are+diagnosed+at+an+apparently+early+stage. assertion.
- assertion asSentence 4843delC%2C+a+deleterious+mutation+of+the+BRCA1+gene%2C+is+due+to+a+founder+effect+originating+in+the+Sicilian+region+of+Italy. assertion.
- assertion asSentence High-risk+patients+with+BRCA1-negative+tumors+should+be+screened+first+for+BRCA2+gene. assertion.
- assertion asSentence The+prevalence+of+BRCA1+and+BRCA2+germline+mutations+in+high-risk+breast+cancer+patients+of+Chinese+Han+nationality. assertion.
- assertion asSentence BRCA1+is+not+required+for+the+ubiquitylation+of+human+RNA+polymerase+II. assertion.
- assertion asSentence Support+a+role+for+BRCA1+mRNA+expression+as+a+predictive+marker+of+survival+in+sporadic+epithelial+ovarian+cancer. assertion.
- assertion asSentence There+is+a+highly+significant+reduction+in+life+expectancy+in+BRCA1+compared+with+BRCA2+carriers+in+ovarian+cancer. assertion.
- assertion asSentence Higher+BRCA1+mRNA+expression+is+significantly+correlated+with+advanced+disease+and+ERBB2+overexpression+in+breast+cancers. assertion.
- assertion asSentence In+human+breast+cancer%2C+BRCA1+is+significantly+involved+in+the+pathogenesis+of+centrosome+aberrations. assertion.
- assertion asSentence Nomenclature+for+BRCA1%2F2+DNA+test. assertion.
- assertion asSentence BRCA1+and+BRCA2+mutations+are+associated+with+breast+and+ovarian+cancer. assertion.
- assertion asSentence The+ITGB3+Leu33Pro+polymorphism+does+not+modify+breast+or+ovarian+cancer+risk+in+BRCA1+mutation+carriers. assertion.
- assertion asSentence Presence+of+BRCA1%2F2+genes+mutations+are+associated+with+more+aggressiveness+of+the+breast+cancer+and+absence+of+the+ER%2C+PR%2C+HER-2+receptors. assertion.
- assertion asSentence The+incidence+of+breast+and+ovarian+cancer+in+BRCA2+mutation+carriers+and+of+ovarian+cancer+in+BRCA1+mutation+carriers+is+still+high+after+60+years. assertion.
- assertion asSentence A+high+proportion+of+DNA+variants+of+BRCA1+is+associated+with+aberrant+splicing+in+breast%2Fovarian+cancer+patients. assertion.
- assertion asSentence Interaction+between+BRCA1%2FBRCA2+and+ATM%2FATR+associate+with+breast+cancer+susceptibility. assertion.
- assertion asSentence Early+malignant+transformation+through+FAK+and+STAT1+networking+in+BRCA1+mutant+ovarian+epithelium. assertion.
- assertion asSentence BRCA1+germline+mutation+is+associated+with+breast+and+ovarian+cancer. assertion.
- assertion asSentence Development+of+a+scoring+method+to+screen+for+BRCA1%2F2+mutations. assertion.
- assertion asSentence Targeted+prostate+cancer+screening+in+men+with+mutations+in+BRCA1+and+BRCA2+detects+aggressive+prostate+cancer. assertion.
- assertion asSentence Mutations+in+BRCA1+is+associated+with+breast+cancer. assertion.
- assertion asSentence There+are+no+predominant+recurring+germline+mutations+in+BRCA1+or+BRCA2+genes+among+ethnically+diverse+Jewish+and+non+Jewish+high+risk+families+in+Israel. assertion.
- assertion asSentence BRCA1+and+BRCA2+genetic+test+in+high+risk+patients+and+families. assertion.
- assertion asSentence BRCA1-mutated+and+basal-like+breast+cancers+have+similar+comparative+genomic+hybridization+profiles+and+a+high+incidence+of+protein+truncating+TP53+mutations. assertion.
- assertion asSentence High+BRCA1+is+associated+with+thymic+epithelial+tumors. assertion.
- assertion asSentence Morphological+predictors+of+BRCA1+germline+mutations+in+young+women+with+breast+cancer. assertion.
- assertion asSentence Oral+contraceptive+use+and+paternal+origin+of+mutation+affect+breast+cancer+penetrance+in+Jewish+BRCA1+and+BRCA2+mutation+carriers. assertion.
- assertion asSentence Epigenetic+silencing+of+BRCA1+is+uncommon+and+is+associated+with+the+triple-negative+phenotype+in+women+of+north+India. assertion.
- assertion asSentence BRCA1+controls+a+physiological+arrest+at+the+M+phase+apart+from+its+established+role+in+DNA+damage+response. assertion.
- assertion asSentence The+differential+pattern+of+global+gene+expression+due+to+stable+expression+of+BRCA1+in+ovarian+cancer+cells. assertion.
- assertion asSentence BRCA1+is+required+for+postreplication+repair+after+UV-induced+DNA+damage. assertion.
- assertion asSentence Germline+mutations+in+the+BRCA1+gene+is+associated+with+pancreatic+cancer. assertion.
- assertion asSentence BRCA1+mutations+are+associated+with+unselected+Nigerian+breast+cancer+patients. assertion.
- assertion asSentence BRCA1+and+BRCA2+mutations+correlate+with+TP53+abnormalities+and+presence+of+immune+cell+infiltrates+in+ovarian+high-grade+serous+carcinoma. assertion.
- assertion asSentence BRCA1+and+BRCA2+mutations+occurred+more+frequently+in+platinum-sensitive+EOC+than+platinum-resistant+disease. assertion.
- assertion asSentence MEK1+interacts+with+B-Raf. assertion.
- assertion asSentence Mutations+in+the+BRAF+protooncogene+%28V599E%29may+be+an+alternative+pathway+of+tumorigenesis+of+familial+colorectal+cancer. assertion.
- assertion asSentence BRAF+mutations+proved+to+be+absent+in+tumors+from+hereditary+nonpolyposis+colorectal+cancer+syndrome+%28HNPCC%29+families+with+germline+mutations+in+the+MMR+genes+MLH1+and+MSH2. assertion.
- assertion asSentence V600E+B-Raf+requires+the+Hsp90+chaperone+for+stability+and+is+degraded+in+response+to+Hsp90+inhibitors. assertion.
- assertion asSentence Merlin+and+MLK3+can+interact+in+situ+and+merlin+can+disrupt+the+interactions+between+B-Raf+and+Raf-1+or+those+between+MLK3+and+either+B-Raf+or+Raf-1. assertion.
- assertion asSentence Braf+mutations+in+thyroid+tumorigenesis. assertion.
- assertion asSentence B-Raf%28V600E%29+signaling+deregulates+the+mitotic+spindle+checkpoint+through+stabilizing+Mps1+levels+in+melanoma+cells. assertion.
- assertion asSentence Akt3+and+mutant+V600E+B-Raf+cooperate+to+promote+early+melanoma+development. assertion.
- assertion asSentence There+is+a+higher+frequency+of+the+BRAF%28V600E%29+mutation+in+papillary+thyroid+carcinomas+than+in+normal+thyroid+tissue. assertion.
- assertion asSentence Targets+of+phosphorylation+by+B-Raf+signaling+are+investigated+in+melanoma. assertion.
- assertion asSentence BRAF+mutations+represent+an+alternative+molecular+pathway+in+the+early+tumorigenesis+of+a+subset+of+KIT%2FPDGFRA+wild-type+GISTs+and+are+per+se+not+associated+with+a+high+risk+of+malignancy. assertion.
- assertion asSentence Mutations+in+BRAF+protein+is+associated+with+Colorectal+Carcinoma. assertion.
- assertion asSentence BRAFV600E+oncogene+induces+transforming+growth+factor+beta+secretion+leading+to+sodium+iodide+symporter+repression+and+increased+malignancy+in+thyroid+cancer. assertion.
- assertion asSentence The+knowledge+of+BRAF+mutation+status+can+facilitate+more+accurate+risk+stratification+and+better+decision+making+at+various+steps+in+the+management+of+papillary+thyroid+cancer. assertion.
- assertion asSentence BRAF+gene+mutation+is+associated+with+colorectal+cancer. assertion.
- assertion asSentence BRAF+activating+mutations+are+a+major+genetic+alteration+in+this+histologic+group+of+pediatric+low-grade+brain+tumors. assertion.
- assertion asSentence Mutated+in+melanoma. assertion.
- assertion asSentence BRAF+mutation+is+rare+in+advanced-stage+low-grade+ovarian+serous+carcinomas. assertion.
- assertion asSentence BRAF%28V600E%29+mutation+is+associated+with+thyroid+nodules. assertion.
- assertion asSentence Braf+mutation+is+associated+with+basal+and+treatment-induced+regulation+of+the+PI3K-AKT+pathway+as+a+critical+regulator+of+AZD6244+sensitivity+in+cutaneous+melanoma. assertion.
- assertion asSentence The+dermoscopical+and+histopathological+patterns+of+nevi+correlate+with+the+frequency+of+BRAF+mutations. assertion.