Matches in Nanopublications for { ?s <http://purl.org/nanopub/x/asSentence> ?o ?g. }
- assertion asSentence The+high+expression+of+activated+ERK+is+not+caused+by+BRAF+gene+mutation+in+nasal+mucosa+malignant+melanomas. assertion.
- assertion asSentence B-Raf+mutations%2C+microsatellite+instability+and+p53+protein+expression+is+not+associated+with+sporadic+basal+cell+carcinomas. assertion.
- assertion asSentence BRAF+mutation+is+associated+with+papillary+thyroid+cancer. assertion.
- assertion asSentence BRAF+mutations+and+llelic+loss+of+susceptibility+loci+are+associated+with+familial+non-medullary+thyroid+cancer. assertion.
- assertion asSentence The+BRAF%2FMEK%2FERK+pathway+is+upregulated+in+progressive+retinal+arterial+macroaneurysm+patients%2C+caused+by+mutation+in+IGFBP7. assertion.
- assertion asSentence BRAF+mutations+are+of+pathogenetic+significance+in+wild+type+gastrointestinal+stromal+tumors. assertion.
- assertion asSentence BRAF+mutations+are+associated+with+hairy+cell+leukemia+and+related+lymphoproliferative+disorders. assertion.
- assertion asSentence The+antibody+response+against+the+catalytic+domain+of+BRAF+is+not+specific+for+rheumatoid+arthritis. assertion.
- assertion asSentence Aberrant+gene+methylation+driven+by+BRAF%28V600E%29+altered+expression+of+the+DNA+methyltransferase+1+and+histone+methyltransferase+EZH2+profoundly. assertion.
- assertion asSentence Mutational+activation+of+both+BRAF+and+PIK3CA+genes+does+contribute+to+hepatocellular+tumorigenesis+at+somatic+level+in+Southern+Italian+population. assertion.
- assertion asSentence BRAF+mutation+is+associated+with+colorectal+serrated+adenocarcinoma. assertion.
- assertion asSentence Reactivation+of+mitogen-activated+protein+kinase+%28MAPK%29+pathway+by+FGF+receptor+3+%28FGFR3%29%2FRas+mediates+resistance+to+vemurafenib+in+human+B-RAF+V600E+mutant+melanoma. assertion.
- assertion asSentence Germline+mutations+in+BRCA2+account+for+breast+neoplasms+predisposition+in+the+majority+of+families. assertion.
- assertion asSentence There+is+no+significant+effect+of+AIB1+genetic+variation+on+breast+cancer+risk+in+BRCA2+mutation+carriers. assertion.
- assertion asSentence Expression+of+BRCA2+and+MAGE-D1+synergistically+suppresses+cell+proliferation+independently+of+the+p53+pathway. assertion.
- assertion asSentence The+frequency+of+hereditary+ovarian+carcinoma+is+attributed+to+BRCA2+gene+mutation. assertion.
- assertion asSentence Human+BRCA2+has+multiple+BRC+repeats%2C+motifs+of+approximately+30+residues%2C+that+associate+in+a+ternary+complex+with+RAD51+on+single-stranded+DNA+and+double-stranded+DNA. assertion.
- assertion asSentence Self-image+and+self-disclosure+concerning+prophylactic+mastectomy+%28PM%29+for+women+with+a+BRCA1%2F2+mutation. assertion.
- assertion asSentence The+site+of+first+distant+metastasis+is+different+between+BRCA1-+and+BRCA2-associated+and+sporadic+breast+cancer+patients. assertion.
- assertion asSentence BRCA2+mutations+are+associated+with+breast+and+ovarian+cancer. assertion.
- assertion asSentence Since+BRCA1%2F2+mutation+carrier+status+is+associated+with+more+aggressive+disease%2C+it+is+a+prognostic+factor+for+PRCA+outcome. assertion.
- assertion asSentence Down-regulation+of+BRCA2+leads+to+radio-sensitization+mainly+through+the+inhibition+of+homologous+recombination+repair+type+double-strand+break+repair. assertion.
- assertion asSentence BRCA2+IVS4-12del5+is+a+deleterious+mutation. assertion.
- assertion asSentence CBP-mediated+post-translational+N-glycosylation+of+BRCA2. assertion.
- assertion asSentence Recruitment+of+fanconi+anemia+and+breast+cancer+proteins+to+DNA+damage+sites+is+differentially+governed+by+replication. assertion.
- assertion asSentence BRCA2+mutation+testing+is+associated+with+ovarian+cancer+prevention. assertion.
- assertion asSentence The+ITGB3+Leu33Pro+polymorphism+does+not+modify+breast+or+ovarian+cancer+risk+in+BRCA2+mutation+carriers. assertion.
- assertion asSentence BRCA2+mutation+is+associated+with+very+young+age+of+onset+of+breast+cancer. assertion.
- assertion asSentence PALB2+can+function+synergistically+with+a+BRCA2+chimera+%28termed+piccolo%2C+or+piBRCA2%29+to+further+promote+strand+invasion. assertion.
- assertion asSentence BRCA2+frame+shift+mutations+are+associated+with+defective+protein+translocation. assertion.
- assertion asSentence There+are+no+predominant+recurring+germline+mutations+in+BRCA1+or+BRCA2+genes+among+ethnically+diverse+Jewish+and+non+Jewish+high+risk+families+in+Israel. assertion.
- assertion asSentence Oral+contraceptive+use+and+paternal+origin+of+mutation+affect+breast+cancer+penetrance+in+Jewish+BRCA1+and+BRCA2+mutation+carriers. assertion.
- assertion asSentence BRCA2+and+PALB2+are+main+regulators+of+G2+checkpoint+maintenance+following+DNA-damage. assertion.
- assertion asSentence TAS106+induces+the+down-regulation+of+BRCA2+and+the+subsequent+abrogation+of+the+homologous+recombination+pathway%2C+leading+to+a+radiosensitizing+effect. assertion.
- assertion asSentence Germline+mutations+in+the+BRCA2+gene+is+associated+with+pancreatic+cancer. assertion.
- assertion asSentence BRCA1+and+BRCA2+mutations+occurred+more+frequently+in+platinum-sensitive+EOC+than+platinum-resistant+disease. assertion.
- assertion asSentence The+roles+of+TTP+and+BRF+proteins+in+regulated+mRNA+decay. assertion.
- assertion asSentence Up-regulation+of+EMMPRIN+by+epidermal+growth+factor+and+transforming+growth+factor-beta%2C+demonstrate+a+role+in+wound+healing. assertion.
- assertion asSentence CD147+downregulation+by+RNAi+technology+decreases+the+invasive+capability+of+prostate+cancer+cells. assertion.
- assertion asSentence EMMPRIN+regulates+migration%2C+MMP+production+by+mouth+cancer+SCC+cells+and+deposition+of+the+TN-C+matrix. assertion.
- assertion asSentence Downregulation+of+CD147+affects+hepatocellular+carcinoma+cell+structure+and+function. assertion.
- assertion asSentence Integrin+alpha6beta1+co-localizes+and+interacts+with+HAb18G%2FCD147+to+mediate+tumor+invasion+and+metastatic+processes. assertion.
- assertion asSentence The+increased+expression+of+CD147+and%2For+MMP-9+correlates+with+a+poor+clinical+outcome+in+patients+with+non-Hodgkin%27s+lymphoma. assertion.
- assertion asSentence The+expression+of+CD147+is+considered+closely+correlated+with+tumor+invasion%2C+metastasis+and+prognosis+in+breast+cancer. assertion.
- assertion asSentence Acute+high+glucose+stimulation+down-regulates+the+expressions+of+MMP-2+and+EMMPRIN+at+RNA+and+protein+levels+in+the+endothelial+cells. assertion.
- assertion asSentence Sp1+is+essential+for+regulating+the+CD147+gene+expression+in+human+lung+cancer. assertion.
- assertion asSentence Sinomenine+reduces+invasion+and+migration+ability+in+fibroblast-like+synoviocytes+cells+co-cultured+with+activated+human+monocytic+THP-1+cells+by+inhibiting+the+expression+of+MMP-2%2C+MMP-9%2C+CD147. assertion.
- assertion asSentence Promoter+hypomethylation+up-regulates+CD147+expression+through+increasing+Sp1+binding+and+associates+with+poor+prognosis+in+human+hepatocellular+carcinoma. assertion.
- assertion asSentence The+SNPs+investigated+in+the+BST1%2C+PARK15+and+PARK9+genes+associated+with+PD+susceptibility+are+not+associated+with+PD+in+the+northern+Han+Chinese+population. assertion.
- assertion asSentence Tetherin+restricts+productive+HIV-1+cell-to-cell+transmission. assertion.
- assertion asSentence Human+and+pigtail+macaque+BST-2+restrict+simian-human+immunodeficiency+virus. assertion.
- assertion asSentence Beta-TrCP+is+not+strictly+required+for+Vpu%27s+ability+to+counteract+the+CD317-imposed+virion+release+block+and+support+the+relevance+of+cell+surface+down-modulation+of+the+restriction+factor+as+a+central+mechanism+of+Vpu+antagonism. assertion.
- assertion asSentence Alanine-18+is+important+for+HIV-1+group+M+Vpu+localization+and+tetherin-Vpu+interactions. assertion.
- assertion asSentence Tetherin+is+a+potent+interferon-induced+antiviral+molecule+that+inhibits+the+release+of+diverse+mammalian+virus. assertion.
- assertion asSentence Vesicular+stomatitis+Indiana+virus-activated+IRF7+upregulates+expression+of+the+BST2+gene+independently+of+interferon+signaling. assertion.
- assertion asSentence Plasma+BTD+activity+increases+in+hepatic+glycogen+storage+disease+patients. assertion.
- assertion asSentence BTEB1%2FProgesterone+receptor+cross-talk+to+facilitate+progesterone+dependent+gene+transcription+in+endometrial+epithelial+cells. assertion.
- assertion asSentence KLF2+is+a+transcription+factor+important+in+the+integration+of+multiple+endothelial+functions+associated+with+regions+of+the+arterial+vasculature+that+are+relatively+resistant+to+atherogenesis. assertion.
- assertion asSentence KLF5+protein+degradation+is+blocked+by+an+N-terminal+FLAG+tag+or+a+small+N-terminal+deletion+without+reducing+ubiquitination+and+degradation+mediated+by+WWP1. assertion.
- assertion asSentence KLF5+promotes+breast+cell+survival+partially+through+fibroblast+growth+factor-binding+protein+1-pERK-mediated+dual+specificity+MKP-1+protein+phosphorylation+and+stabilization. assertion.
- assertion asSentence Single+nucleotide+polymorphisms+in+the+KLF5+gene+is+associated+with+hypertension. assertion.
- assertion asSentence Endogenous+Fbw7+suppresses+the+FGF-BP+gene+expression+and+breast+cell+proliferation+through+targeting+KLF5+for+degradation. assertion.
- assertion asSentence The+granulocyte-associated+transcription+factor+Kruppel-like+factor+5+is+silenced+by+hypermethylation+in+acute+myeloid+leukemia. assertion.
- assertion asSentence Btk+is+not+essential+for+early+lipopolysaccharide+signaling+in+human+monocytes. assertion.
- assertion asSentence Plasmacytoid+dendritic+cells+express+a+signalosome+consisting+of+Lyn%2C+Syk%2C+Btk%2C+Slp65+%28Blnk%29+and+PLCgamma2. assertion.
- assertion asSentence Btk+mutation+is+associated+with+myelodysplastic+syndrome+in+X-linked+agammaglobulinemia. assertion.
- assertion asSentence As+part+of+a+common+complex+in+checkpoint-activated+cells%2C+Bub1+monitors+different+spindle+events+compared+to+BubR1+and+integrates+different+signals+into+a+single+signal+that+is+then+relayed+to+the+downstream+cell+cycle+machinery. assertion.
- assertion asSentence The+checkpoint+pathway+can+be+abrogated+by+mutations+in+BUB1+in+the+pancreatic+cancer+cell+line+Hs766T. assertion.
- assertion asSentence Bub1+defines+the+persistent+cohesion+site+along+the+mitotic+chromosome+by+affecting+Shugoshin+localization. assertion.
- assertion asSentence Expression+of+wild-type+Bub1+suppressed+multinuclei+formation+induced+by+HTLV-I+Tax+protein+both+in+A549+and+HeLa+cells. assertion.
- assertion asSentence Bub1%2C+an+anaphase-promoting+complex%2F+cyclosome+%28APC%2FC%29+inhibitor%2C+is+also+an+APC%2FC+substrate. assertion.
- assertion asSentence The+spindle+checkpoint+kinase+Bub1+contributes+to+the+maintenance+of+Sgo1+steady-state+protein+levels+in+an+APC%2FC-independent+mechanism. assertion.
- assertion asSentence Depletion+of+the+outer+kinetochore+protein+hBub1+upon+activation+of+SAC+primarily+triggers+early+cell+death+mediated+by+p53. assertion.
- assertion asSentence BubR1+links+regulation+of+chromosome-spindle+attachment+to+mitotic+checkpoint+signalling. assertion.
- assertion asSentence Plk1+facilitates+chromosome+alignment+during+prometaphase+through+BubR1. assertion.
- assertion asSentence BubR1+expression+is+a+novel%2C+independent+adverse+prognostic+factor+after+pancreatoduodenectomy+of+pancreatobiliary-type+adenocarcinomas. assertion.
- assertion asSentence Bystin+is+necessary+for+efficient+cleavage+of+the+internal+transcribed+spacer+1+at+site+2+and+for+further+processing+of+the+pre-rRNA. assertion.
- assertion asSentence Overexpression+of+translocator+protein+is+associated+with+inflammatory+bowel+disease. assertion.
- assertion asSentence Binds+with+Hepacivirus+core+protein+on+CD8%2B+and+CD4%2B+positive+t-cells+and+inactivates+lck+and+akt. assertion.
- assertion asSentence p32+overexpression+effectively+blocks+mRNA+accumulation+from+the+adenovirus+major+late+transcription+unit+%28MLTU%29+and+stimulates+RNA+polymerase+II+carboxy-terminal+domain+phosphorylation+in+virus-infected+cells. assertion.
- assertion asSentence P.+falciparum-infected+red+blood+cells+use+the+32-kDa+human+protein+gC1qR%2FHABP1%2Fp32+as+a+receptor+to+bind+to+human+brain+microvascular+endothelial+cells. assertion.
- assertion asSentence Mitochondrial+p32%2FC1QBP+is+a+critical+mediator+of+p14ARF-induced+apoptosis. assertion.
- assertion asSentence Dysregulated+shedding+of+C1q-R+molecules+contributes+to+vascular+cryoglobulin-induced+damage+via+the+classic+complement-mediated+pathway+in+chronically+hepatitis+C-infected+patients%2C+with+and+without+mixed+cryoglobulinemia. assertion.
- assertion asSentence Knocking+down+p32+expression+in+human+cancer+cells+strongly+shifts+their+metabolism+from+oxidative+phosphorylation+%28OXPHOS%29+to+glycolysis. assertion.
- assertion asSentence iC1INH+has+an+anti-vascular+permeability+independent+on+the+serpin+function. assertion.
- assertion asSentence The+SNPs+rs3753394+and+rs800292+of+CFH+and+rs11200638+of+HTRA1+are+significantly+associated+with+the+risk+of+PCV+%28polypoidal+choroidal+vasculopathy%29+in+Chinese+patients. assertion.
- assertion asSentence C2%2FCFB+variants+play+a+protective+role+in+the+risk+of+developing+neovascular+AMD+and+PCV+in+the+Japanese. assertion.
- assertion asSentence C3+gene+is+a+priority+candidate+controlling+risk+for+asthma+and+allergic+disease+in+the+Barbados+population+of+African+descent. assertion.
- assertion asSentence The+dominant+types+of+C1q+complexes+that+circulate+in+vivo+are+C1q-C3d+and+C1q-C4d+complexes. assertion.
- assertion asSentence C3+gene+is+associated+with+systemic+lupus+erythematosus+and+decreased+serum+level+of+C3+arre+correlated+with+this+allele. assertion.
- assertion asSentence Diagnosis+of+hereditary+deficiency+of+the+third+complement+component+%28C3%29+with+compound+heterozygous+mutation+of+the+gene. assertion.
- assertion asSentence The+binding+of+complement+C3d+to+ubiquitous+surface+protein+A+%28UspA%29+is+an+efficient+strategy+of+Moraxella+catarrhalis+to+block+complement+activation+and+to+inhibit+C3a-mediated+inflammation. assertion.
- assertion asSentence SNPs+in+the+lysyl+oxidase-like+protein+4+and+complement+component+3+genes+are+associated+with+increased+risk+for+endometriosis+and+endometriosis-associated+infertility+in+a+Puerto+Rican+population. assertion.
- assertion asSentence Genetic+sophistication+of+human+complement+components+C4A+and+C4B+and+RP-C4-CYP21-TNX+%28RCCX%29+modules+in+the+major+histocompatibility+complex. assertion.
- assertion asSentence The+dominant+types+of+C1q+complexes+that+circulate+in+vivo+are+C1q-C3d+and+C1q-C4d+complexes. assertion.
- assertion asSentence Complement+C4a+gene+expression+is+regulated+both+by+obesity+and+by+the+region+between+visceral+and+subcutaneous+adipose+tissue. assertion.
- assertion asSentence C4A+and+C4B+gene-dosage+variations+play+in+infectious+and+autoimmune+diseases. assertion.
- assertion asSentence Genetic+sophistication+of+human+complement+components+C4A+and+C4B+and+RP-C4-CYP21-TNX+%28RCCX%29+modules+in+the+major+histocompatibility+complex. assertion.
- assertion asSentence Omplement+C4d+region+staining+in+peritubular+capillaries+in+kidney+allograft+biopsies+is+a+hallmark+of+antibody-mediated+rejection. assertion.
- assertion asSentence CAPN5+polymorphisms+are+associated+with+a+risk+of+polycystic+ovary+syndrome. assertion.