Matches in Nanopublications for { ?s <http://purl.org/nanopub/x/asSentence> ?o ?g. }
- assertion asSentence Excessive+C5a+in+sepsis+functions+as+a+critical+inflammatory+mediator+to+enhance+IL-8+production+mainly+through+MAPK+signaling+pathways. assertion.
- assertion asSentence Human+C5aR+antagonist+treatment+reduced+total+hepatic+reperfusion+injury-induced+mortality+in+rats. assertion.
- assertion asSentence In+apoptosis-initiated+cells%2C+the+ligand-dependent+C5aR-mediated+dual+signal+affects+the+fate+of+cells%2C+either+apoptosis+execution+or+survival%2C+through+regulation+of+RGS3+gene+expression+and+subsequent+modulation+of+ERK+signal. assertion.
- assertion asSentence Intestinal+epithelial+cells+express+C5aR+apically+and+directly+respond+to+C5a+through+the+ERK+signaling+pathway. assertion.
- assertion asSentence Cell+cycle+induction+by+C5b-9+in+aortic+endothelial+cells+is+RGC-32+dependent+and+this+is+in+part+through+regulation+of+Akt+and+growth+factor+release. assertion.
- assertion asSentence Cell+cycle+induction+by+C5b-9+in+aortic+endothelial+cells+is+RGC-32+dependent+and+this+is+in+part+through+regulation+of+Akt+and+growth+factor+release. assertion.
- assertion asSentence Complement+C5b-9+induce+a+JNK%2FBid-dependent+and+JNK-independent+necrotic+cell+death. assertion.
- assertion asSentence One+can+predict+that+the+indel+segment+of+C8alpha+assumes+a+conformation+that+allows+for+multiple+points+of+contact+with+C8gamma. assertion.
- assertion asSentence Cell+cycle+induction+by+C5b-9+in+aortic+endothelial+cells+is+RGC-32+dependent+and+this+is+in+part+through+regulation+of+Akt+and+growth+factor+release. assertion.
- assertion asSentence One+can+predict+that+the+indel+segment+of+C8alpha+assumes+a+conformation+that+allows+for+multiple+points+of+contact+with+C8gamma. assertion.
- assertion asSentence C8gamma+binds+an+indel+peptide+of+C8alpha+sequence+and+forms+a+non-covalent+complex. assertion.
- assertion asSentence The+haploinsufficiency+of+C9%2C+a+terminal+complement+complex+component%2C+engenders+reduced+intraocular+secretion+of+VEGF+and+decreased+risk+for+CNV+development. assertion.
- assertion asSentence Caveolin-1+and+dynamin-2+are+essential+for+removal+of+the+complement+C5b-9+complex+via+endocytosis. assertion.
- assertion asSentence Elevated+serum+anti-carbonic+anhydrase+II+antibodies+in+patients+with+ulcerative+colitis. assertion.
- assertion asSentence The+roles+of+the+residues+of+the+hydrophilic+side+of+the+active+site+cavity+in+maintaining+efficient+catalysis+by+carbonic+anhydrase+II. assertion.
- assertion asSentence Influence+of+small+structural+changes+on+affinity+and+mode+of+binding%2C+the+degree+of+flexibility+in+the+design+of+sulfamate-based+inhibitors+of+carbonic+anhydrase+II. assertion.
- assertion asSentence Expression+of+the+hypoxia+marker+carbonic+anhydrase+IX+is+critically+dependent+on+SP1+activity. assertion.
- assertion asSentence MAPK+cascade+is+involved+in+the+regulation+of+CA9+gene+expression+under+both+hypoxia+and+high+cell+density. assertion.
- assertion asSentence High+levels+of+the+hypoxia+regulated+proteins+HIF1alpha+and+CA9+in+HNC+predict+resistance+to+platinum+based+radio-chemotherapy. assertion.
- assertion asSentence A+role+for+CA9+as+an+endogenous+marker+of+tumor+hypoxia+is+currently+not+supported+by+available+clinical+data. assertion.
- assertion asSentence Low+CA-IX+expression+and+absence+of+VHL+mutation+being+associated+with+a+poor+clinicopathological+phenotype+and+diminished+survival. assertion.
- assertion asSentence CAIX+is+overexpressed+in+the+majority+of+vulvar+carcinomas+with+relationships+to+advanced+tumor+stages+and+development+of+lymph+node+metastases. assertion.
- assertion asSentence High+carbonic+anhydrase+IX+is+associated+with+recurrence+in+breast+cancer. assertion.
- assertion asSentence CAIX+is+particularly+well+suited+to+maintain+the+extracellular+pH+at+a+value+that+favors+the+survival+fitness+of+tumor+cells. assertion.
- assertion asSentence Ion+channel+gating+is+regulated+by+calcium+and+calmodulin+binding. assertion.
- assertion asSentence CACNA1A+a+frequent+recurrent+mutation+in+hemiplegic+migraine. assertion.
- assertion asSentence The+Spinocerebellar+ataxia+type+6+is+caused+by+a+CAG+repeat+expansion+in+the+CACNA1A+gene+which+encodes+the+alpha1A+subunit+of+the+P%2FQ-type+voltage-gated+calcium+channel. assertion.
- assertion asSentence The+COOH+terminus+of+hCa%28v%291.2b+contains+sites+for+the+SH2+and+SH3+binding+of+Src+kinase. assertion.
- assertion asSentence Introduction+into+Ca%28v%292.1+of+the+homologous+mutation+of+Ca%28v%291.2+causing+the+Timothy+syndrome+questions+the+role+of+V421+in+the+phenotypic+definition+of+P-type+Ca%282%2B%29+channel. assertion.
- assertion asSentence Overexpression+of+the+intracellular+II-III+loop+domains+of+Cav1.2+and+Cav1.3+can+dislodge+the+corresponding+endogenous+channels+from+the+lipid+raft+regions+of+the+membrane+in+rat+insulinoma+%28INS-1%29+cells. assertion.
- assertion asSentence L-type+calcium+channel+blockers+exert+an+antiinflammatory+effect+by+suppressing+expression+of+plasminogen+receptors+on+macrophages. assertion.
- assertion asSentence Ca%28v%291.2+splice+variant+with+exon+9%2A+is+critical+for+regulation+of+cerebral+artery+diameter. assertion.
- assertion asSentence The+rs1006737+variant+of+CACNA1C+does+influence+language+production+on+a+semantic+level+in+conjunction+with+the+underlying+neural+systems. assertion.
- assertion asSentence Variation+in+CACNA1C+is+associated+with+treatment+response+among+hypertensive+patients+with+stable+coronary+artery+disease. assertion.
- assertion asSentence Regulation+of+the+mutually+exclusive+exons+8a+and+8+in+the+CaV1.2+calcium+channel+transcript+by+polypyrimidine+tract-binding+protein. assertion.
- assertion asSentence Enhancement+of+calcium+transport+in+Caco-2+monolayer+through+PKCzeta-dependent+Cav1.3-mediated+transcellular+and+rectifying+paracellular+pathways+by+prolactin. assertion.
- assertion asSentence Ca%28v%292.3+Ca2%2B+channel+interacts+with+the+G1-subunit+of+V-ATPase. assertion.
- assertion asSentence Misregulated+splicing+and+altered+gating+of+Ca%28V%291.1+calcium+channel+is+associated+with+muscle+weakness+in+myotonic+dystrophy. assertion.
- assertion asSentence There+are+significantly+higher+number+of+invading+cells+in+DDR1a+expressing+hepatocellular+carcinoma+cells. assertion.
- assertion asSentence KIBRA+interacts+with+discoidin+domain+receptor+1+to+modulate+collagen-induced+signalling. assertion.
- assertion asSentence MMTR+is+an+intrinsic+negative+cell+cycle+regulator+that+modulates+the+CAK+kinase+activity+via+interaction+with+MAT1. assertion.
- assertion asSentence Collagen+I+induces+discoidin+domain+receptor+%28DDR%29+1+expression+through+DDR2+and+a+JAK2-ERK1%2F2-mediated+mechanism+in+primary+human+lung+fibroblasts. assertion.
- assertion asSentence Timothy+syndrome+is+a+disease+of+excessive+cellular+Ca%282%2B%29+entry+and+life-threatening+arrhythmias+caused+by+a+mutation+in+the+primary+cardiac+L-type+Ca%282%2B%29+channel+%28Ca%28V%291.2%29. assertion.
- assertion asSentence Functional+properties+of+the+CaV1.2+calcium+channel+activated+by+calmodulin+in+the+absence+of+alpha2delta+subunits. assertion.
- assertion asSentence The+cad+gene+is+regulated+by+a+nonclassical+ERalpha%2FSp1-mediated+pathway. assertion.
- assertion asSentence S-nitrosation+of+Ca%282%2B%29-loaded+and+Ca%282%2B%29-free+recombinant+calbindin+D%2828K%29+from+human+brain. assertion.
- assertion asSentence Katacalcin+regulates+human+CD14%2B+PBMC+migration+via+signaling+events+involving+protein+kinase+A-dependent+cAMP+pathways. assertion.
- assertion asSentence Octreotide+augments+the+amount+of+CGRP+in+cultured+thyroid+tumor+cells+and+increases+the+amount+of+CGRP+in+the+culture+media. assertion.
- assertion asSentence NT-proBNP+levels+correlate+with+PCT+and+CRP+levels+in+septic+patients. assertion.
- assertion asSentence Elevated+calcitonin+is+associated+with+metastasis+of+prostate+cancer. assertion.
- assertion asSentence Plasma+CGRP+is+useful+for+diagnosis+in+paediatric+migraine. assertion.
- assertion asSentence Serum+levels+of+high-sensitivity+C-reactive+protein+and+procalcitonin+are+biomarkers+for+transplantrelated+complications+such+as+graft-versus-host+disease+or+infection. assertion.
- assertion asSentence Serum+procalcitonin+is+not+habitually+elevated+in+HIV-negative+pulmonary+tuberculosis+patients+and+is+a+useful+biomarker+for+discriminating+between+pulmonary+tuberculosis+and+community-acquired+pneumonia. assertion.
- assertion asSentence A+substantial+decrease+in+serum+procalcitonin+precursor+level+is+predictive+of+survival+in+patients+with+severe+sepsis. assertion.
- assertion asSentence Alternative+splicing+contributes+to+dysfunctionality+of+glioma+neovascularization. assertion.
- assertion asSentence P53+protein+stimulates+CAMII+gene+expression+in+041+cells. assertion.
- assertion asSentence The+thrombospondin-1+%28TSP-1%29+binding+site+in+calreticulin%2C+spanning+residues+19-36%2C+augments+the+expression+of+TSP-1+and+is+a+potent+triggering+factor+for+T+cell+migration. assertion.
- assertion asSentence Calreticulin+controls+the+rate+of+assembly+of+CD1d+molecules+in+the+endoplasmic+reticulum. assertion.
- assertion asSentence Skeletal+muscle+CaMKII+kinase+isoform+expression+and+serum+response+factor+phosphorylation+is+higher+with+endurance-type+exercise+training%2C+adaptations+that+are+restricted+to+active+muscle. assertion.
- assertion asSentence Kv4.3+K+channels+contribute+to+cell+apoptosis+and+necrosis+through+activating+CaMKII. assertion.
- assertion asSentence The+role+of+CaMKII+in+regulating+GLUT4+expression+in+skeletal+muscle. assertion.
- assertion asSentence HDAC4+as+a+specific+downstream+substrate+of+CaMKIIdeltaB+in+cardiac+cells+and+have+broad+applications+for+the+signaling+pathways+leading+to+cardiac+hypertrophy+and+heart+failure. assertion.
- assertion asSentence Single+nucleotide+polymorphism+in+CAMK2D+gene+is+associated+with+epithelial+ovarian+cancer. assertion.
- assertion asSentence In+Turner+yndrome%2C+loss+of+voltage-dependent+inactivation+is+an+upstream+initiating+event+for+arrhythmia+phenotypes+that+are+ultimately+dependent+on+CaMKII+activation. assertion.
- assertion asSentence Human+cathelicidin+%28LL-37%2FhCAP%2F18%29+and+beta-defensin-2+demonstrated+synergistic+antimicrobial+activity+and+efficiently+killed+group+B+Streptococcus%2C+an+important+neonatal+pathogen. assertion.
- assertion asSentence Cathelicidin+LL-37+induces+activation+of+both+the+p38+and+ERK1%2F2+kinases+in+monocytes+and+epithelial+cells. assertion.
- assertion asSentence Significantly+up-regulated+at+the+mRNA+and+protein+level+in+chronic+rhinosinusitis+patients+in+response+to+fungal+allergens. assertion.
- assertion asSentence The+host+defence+peptide+cathelicidin+LL-37%2FhCAP-18+acts+as+growth+factor+for+human+lung+cancer. assertion.
- assertion asSentence LL-37+significantly+improved+re-epithelialization+and+granulation+tissue+formation. assertion.
- assertion asSentence The+epigenetic+control+of+gene+transcription+by+histone+acetylation+is+important+for+1%2C25D3-regulated+cathelicidin+and+CD14+expression. assertion.
- assertion asSentence Sebocytes+express+functional+cathelicidin+antimicrobial+peptides+and+can+act+to+kill+propionibacterium+acnes. assertion.
- assertion asSentence Myeloid+cells+of+patients+with+severe+congenital+neutropenia+are+capable+of+producin+pro-LL37. assertion.
- assertion asSentence High+CAP18+is+associated+with+breast+cancer+metastasis. assertion.
- assertion asSentence Keratinocytes+in+psoriatic+lesional+skin+express+increased+Toll-like+receptor+%28TLR%29+9+that+similarly+localizes+with+elevated+expression+of+the+cathelicidin+antimicrobial+peptide+LL-37. assertion.
- assertion asSentence Endoplasmic+reticulum+chaperones+stabilize+nicotinic+receptor+subunits+and+regulate+receptor+assembly. assertion.
- assertion asSentence Calpain1+plays+an+important+role+in+controlling+the+levels+of+autophagy+in+normal+living+cells+by+regulating+the+levels+of+a+key+signaling+molecule%2C+ATG12-ATG5+conjugate. assertion.
- assertion asSentence TGase+2-mu-calpain+system+is+significant+in+the+NF-kappaB+pathway+via+I-kappaBalpha+polymerization+and+subsequent+degradation. assertion.
- assertion asSentence H.+pylori+activates+calpain+via+TLR2+to+disrupt+gastric+epithelial+adherens+junctions+structure. assertion.
- assertion asSentence mCANP+degrades+human+aquaporin+0. assertion.
- assertion asSentence Knockdown+of+calpain+2+expression+using+shRNA+or+chemical+inhibition+of+calpain+activity+reduced+glioblastoma+cell+invasion+by+90%25. assertion.
- assertion asSentence Confocal+immunostaining+demonstrated+colocalization+of+m-calpain+and+the+aggrecan+product+within+the+lower+hypertrophic+chondrocytes+and+in+limited+region+of+the+pericellular+matrix. assertion.
- assertion asSentence Syndecan-2+exerts+its+pro-apoptotic+function+through+modulation+of+the+endothelin-1%2FNFkappaB+signaling+and+through+downregulation+of+calpain-6. assertion.
- assertion asSentence The+calcyphosine+crystal+diffracted+to+2.8+A+and+belonged+to+space+group+P2%281%292%281%292%2C+with+the+unit+cell+parameters+a%3D70.39+A%2C+b%3D132.02+A%2C+c%3D46.20+A. assertion.
- assertion asSentence CAPAZA1+is+over+expressed+in+malignant+melanoma. assertion.
- assertion asSentence The+PYRIN-CARD+protein+ASC+is+an+activating+adaptor+for+caspase-1. assertion.
- assertion asSentence Caspase+1+has+a+role+in+T-cell+protein+tyrosine+phosphatase-induced+apoptosis+in+a+human+tumor+cell+line. assertion.
- assertion asSentence Overexpression+of+Caspase-1+is+a+frequent+event+in+pancreatic+disorders+and+neoplasms. assertion.
- assertion asSentence The+high+degree+of+substrate+specificity+displayed+by+caspase-1+is+maintained+through+rapid+spontaneous+inactivation+of+this+protease. assertion.
- assertion asSentence Bax+plays+an+important+role+in+UV-induced+apoptosis+and+in+caspase-2+activation+in+tumor+cells. assertion.
- assertion asSentence Apoptosis+signaling+triggered+by+ascididemin+is+routed+via+CASP2+and+JNK+to+mitochondria. assertion.
- assertion asSentence Tumor-suppressing+function+of+caspase-2+requires+catalytic+site+Cys-320+and+site+Ser-139+in+mice. assertion.
- assertion asSentence Hypoxia-induced+cleavage+of+caspase-3+and+DFF45%2FICAD+in+human+failed+cardiomyocytes. assertion.
- assertion asSentence IFN-gamma-mediated+caspase-3+activation+and+C.+burnetii+killing+depend+on+the+expression+of+membrane+TNF. assertion.
- assertion asSentence Caspase-3+mediates+a+mitochondrial+amplification+loop+that+is+required+for+the+optimal+release+of+cytochrome+c%2C+mitochondrial+permeability+shift+transition%2C+%26+cell+death+during+apoptosis+induced+by+treatment+with+the+microtubule-damaging+agent+paclitaxel. assertion.
- assertion asSentence Existence+of+a+regulatory+mechanism+of+protein+stability+and+PTEN-protein+interactions+during+apoptosis%2C+executed+by+caspase-3+in+a+PTEN+phosphorylation-regulated+manner. assertion.
- assertion asSentence Caspase-3+is+activated+in+oxidized+low-density+lipoprotein+%28ox-LDL%29+induces+apoptosis+in+endothelial+cells. assertion.
- assertion asSentence Caspase-3+activation+in+human+disease+can+play+a+prominent+role+in+localized+cellular+degenerative+processes+without+causing+nuclear+or+cell+death. assertion.
- assertion asSentence Gossypol+induced+complete+cytochrome+c+release+from+mitochondria+amd+increased+caspases-3+and+-9+activity+in+large+cell+lymphoma+cells. assertion.
- assertion asSentence Caspase+3+plays+a+important+role+in+apoptotic+process+of+mesothelioma+cells. assertion.
- assertion asSentence Caspase+3+activation+is+a+prominent+feature+in+periodontitis-associated+tissue+injury. assertion.