Matches in Nanopublications for { ?s <http://purl.org/nanopub/x/asSentence> ?o ?g. }
- assertion asSentence Thrombin+is+able+to+induce+activation+of+caspases+3+and+9+in+human+platelets+and+significantly+increases+the+amount+in+the+cytoskeleton+of+the+active+forms+of+both+caspases+and+the+procaspases+3+and+9. assertion.
- assertion asSentence Expression+level+of+intracellular+activated+caspase-3+in+peripheral+T+cell+subsets+increases+in+patients+with+active+systemic+lupus+erythematosus+%28SLE%29%2C+compared+to+patients+with+inactive+SLE+and+healthy+controls. assertion.
- assertion asSentence PTP-PEST+actively+contributes+to+the+cellular+apoptotic+response+and+reveal+the+importance+of+caspases+as+regulators+of+PTPs+in+apoptosis. assertion.
- assertion asSentence Human+tumor+xenograft+in+nude+mice+is+suppressed+significantly+by+the+treatment+with+a+hTERT%2Fre-Caspase-3+system. assertion.
- assertion asSentence Cystatin+A+suppresses+UVB-induced+apoptosis+of+keratinocytes+by+the+inhibition+of+caspase+3+activation. assertion.
- assertion asSentence NF-kappa-B+inhibition+enhances+CASP3+degradation+of+Akt1+and+apoptosis+in+response+to+campogthecin. assertion.
- assertion asSentence The+activity+of+Caspase-3+increased+significantly+in+MMT-induced+apoptosis+in+PC-3M+cells. assertion.
- assertion asSentence Survivin-DeltaEx3+plays+a+key+role+in+the+inhibition+of+caspase-3+activity. assertion.
- assertion asSentence Quercetin+can+activate+the+expression+of+Caspase-3+and+induce+the+apoptosis+of+nasopharyngeal+carcinoma+HEN1+cells. assertion.
- assertion asSentence shRNA+directed+against+hTERT+inhibits+cell+viability+by+regulating+telomerase+activity+and+PCNA+protein+expression+in+NPC+cells. assertion.
- assertion asSentence Extracellular+adenosine+induces+apoptosis+in+Caco-2+cells+by+activating+caspase-9+and+the+downstream+effector+caspase+caspase-3+in+association+with+mitochondrial+damage+via+A%282a%29+adenosine+receptors. assertion.
- assertion asSentence Caspase+cleavage+of+Atg4D+stimulates+GABARAP-L1+processing+and+triggers+mitochondrial+targeting+and+apoptosis. assertion.
- assertion asSentence vIRF-2+mediates+IRF-3+inactivation+by+a+mechanism+involving+caspase-3. assertion.
- assertion asSentence Beclin-1+is+depleted+in+Alzheimer%27s+disease+brain+following+caspase-3+cleavage. assertion.
- assertion asSentence Cathepsin+L+is+present+in+the+nucleus+and+regulates+the+transcription+of+effector+caspases+3+and+7%2C+in+a+p53+dependent+manner. assertion.
- assertion asSentence Association+of+death+receptor+4%2C+Caspase+3+and+5+gene+polymorphism+with+increased+risk+to+bladder+cancer+in+North+Indians. assertion.
- assertion asSentence Combination+treatment+with+dihydrotanshinone+I+and+irradiation+enhances+apoptotic+effects+in+human+cervical+cancer+by+HPV+E6+down-regulation+and+caspase-3+activation. assertion.
- assertion asSentence A+mutation+in+the+allosteric+site+of+the+caspase+3+dimer+interface+of+Val266+to+histidine+abolishes+activity+of+the+enzyme. assertion.
- assertion asSentence Association+of+death+receptor+4%2C+Caspase+3+and+5+gene+polymorphism+with+increased+risk+to+bladder+cancer+in+North+Indians. assertion.
- assertion asSentence Caspase+7+activation+is+a+prominent+feature+in+periodontitis-associated+tissue+injury. assertion.
- assertion asSentence Single+Nucleotide+Polymorphisms+in+CASP7+is+asspciated+with+lung+cancer. assertion.
- assertion asSentence Sodium+salicylate-triggered+apoptosis+in+HL-60+cells+depends+on+caspase-8+activation. assertion.
- assertion asSentence CASP8+cleavage+product+of+BAP31+at+the+endoplasmic+reticulum+stimulates+Ca%282%2B%29-dependent+mitochondrial+fission%2C+enhancing+the+release+of+cytochrome+C+in+response+to+this+initiator+caspase. assertion.
- assertion asSentence Caspase+8-mediated+cell+death+is+central+to+the+biological+control+of+antigen-independent+expansion+of+recent+thymic+emigrants+from+human+cord+blood. assertion.
- assertion asSentence Caspase-8+expression+and+proteolysis+in+human+brain+after+severe+intracranial+hypertension. assertion.
- assertion asSentence Lower+gene+expression+of+caspase-8+correlates+with+detectable+blood-brain+barrier+leakage+and+active+inflammation+in+the+brain+as+reflected+by+gadolinium-enhancing+lesions+on+MRI. assertion.
- assertion asSentence Hypermethylation+of+the+pro-apoptotic+CASP8+is+a+differential+feature+of+glioblastoma+multiforme+relapses. assertion.
- assertion asSentence Death+effector+domain+DEDa%2C+a+self-cleaved+product+of+caspase-8%2FMch5%2C+translocates+to+the+nucleus+by+binding+to+ERK1%2F2+and+upregulates+procaspase-8+expression+via+a+p53-dependent+mechanism. assertion.
- assertion asSentence CASP8+variant+is+associated+with+breast+cancer+risk. assertion.
- assertion asSentence Upregulation+of+important+elements+of+apoptosis+at+mRNA+level+of+FLICE+in+acute+lymphoblastic+leukemia+cells+after+CD40+ligation. assertion.
- assertion asSentence Transgenic+FADD%2Fcaspase-8+play+an+essential+role+in+maintaining+S6+kinase+activity+during+T+cell+cycle+progression. assertion.
- assertion asSentence Proteasome+inhibition+can+sensitize+cells+to+apoptosis+elicited+by+tumor+necrosis+factor+ligands+and+retarding+caspase-8+degradation+provides+one+explanation+for+this+activity. assertion.
- assertion asSentence CASP8+variants+D302H+and+-652+6N+ins%2Fdel+do+not+influence+the+risk+of+colorectal+cancer+in+the+United+Kingdom+population. assertion.
- assertion asSentence Caspase+8+is+activated+in+villous+cytotrophoblasts+just+prior+to+fusion+of+these+cells+and+escorts+the+nuclei+from+the+mononucleated+to+the+syncytial+state. assertion.
- assertion asSentence Histone+deacetylase+inhibitors+cooperate+with+IFN-gamma+to+restore+CASP8+expression+and+overcome+TRAIL+resistance+in+cancers+with+silencing+of+CASP8. assertion.
- assertion asSentence TRAIL+induced+apoptosis+in+neuroblastoma+cells+expressing+caspase+8. assertion.
- assertion asSentence In+human+hepatocellular+liver+carcinoma+cells+%28HepG2+cells%29+exposed+to+TNF-alpha+and+cycloheximide%2C+both+NO+and+HTrxn+affect+the+caspase+cascade+at+its+initial+stage+of+activation+of+caspase+8. assertion.
- assertion asSentence A+photosensitizer+conjugated+to+a+small-molecule+PSMA+inhibitor+is+capable+of+selectively+initiating+apoptosis+via+the+caspase-8%2F-3+pathway+in+PMSA%2B+prostate+tumor+cells+upon+low-intensity+light+irradiation. assertion.
- assertion asSentence High+caspase-8+activity+is+associated+with+cervical+malignancy. assertion.
- assertion asSentence The+interleukin-21+signaling+cascade+is+negatively+regulated+by+CASP8. assertion.
- assertion asSentence DJ-1+protects+against+TRAIL-induced+apoptosis+through+the+regulation+of+death-inducing+signaling+complex+%28DISC%29+formation. assertion.
- assertion asSentence Caspase-8-mediated+cleavage+of+IRF-3+helps+to+modulate+dsRNA-dependent+gene+induction. assertion.
- assertion asSentence Cathepsin+D+is+able+to+initiate+the+caspase+cascade+by+direct+activation+of+caspase-8. assertion.
- assertion asSentence Adenovirus+encoding+HIV-1+Vpr+activates+caspase+9+and+induces+apoptotic+cell+death+in+both+p53+positive+and+negative+human+tumor+cell+lines. assertion.
- assertion asSentence Pro-CASP9+moved+from+the+nucleus+to+the+mitochondria+of+U937+cells+during+TPA-induced+differentiation. assertion.
- assertion asSentence Caspase-9+is+activated+in+oxidized+low-density+lipoprotein+%28ox-LDL%29+induces+apoptosis+in+endothelial+cells. assertion.
- assertion asSentence During+intrinsic+apoptosis%2C+caspase-9+can+feed+back+to+mitochondria+to+induce+cytochrome+c+release+and+collapse+of+DeltaPsim. assertion.
- assertion asSentence rhEPO+can+significantly+inhibit+the+activity+of+caspase-3+or+caspase-9+in+endothelial+cell+apoptosis+in+a+dose-dependent+manner. assertion.
- assertion asSentence Inactivating+mutations+in+non-hodgkin+lymphoma. assertion.
- assertion asSentence CASP10+levels+are+increased+following+DNA+damage+in+a+p53-dependent+manner. assertion.
- assertion asSentence Prx6+modulates+TRAIL+signaling+as+a+negative+regulator+of+caspase-8+and+caspase-10+in+death-inducing+signaling+complex+formation+of+TRAIL-resistant+metastatic+cancer+cells. assertion.
- assertion asSentence Caspase-10+isoforms+play+distinct+and+opposing+roles+in+the+initiation+of+death+receptor-mediated+tumour+cell+apoptosis. assertion.
- assertion asSentence The+protein+factor-arrest+11+%28Far11%29+is+essential+for+the+toxicity+of+human+caspase-10+in+yeast+and+participates+in+the+regulation+of+autophagy+and+the+DNA+damage+signaling. assertion.
- assertion asSentence Missense+mutation+in+the+CASQ2+gene+is+associated+with+autosomal-recessive+CPVT%28catecholamine-induced+polymorphic+ventricular+tachycardia%29. assertion.
- assertion asSentence Influence+of+calcium-sensing+receptor+gene+on+urinary+calcium+excretion+in+stone-forming+patients. assertion.
- assertion asSentence CaR+dimerization+through+its+ECD+is+essential+for+the+formation+of+a+functional+tertiary+structure+of+the+CaR. assertion.
- assertion asSentence Aromaatic+amino+acids+have+a+physiological+impact+on+systems+in+which+the+CaR+is+expressed. assertion.
- assertion asSentence Calcification+is+associated+with+loss+of+functional+calcium-sensing+receptor+in+vascular+smooth+muscle+cells. assertion.
- assertion asSentence Mechanisms+of+CaR-induced+cancer+cell+growth+and+survival. assertion.
- assertion asSentence CaSR+polymorphisms+cannot+be+predictors+of+secondary+hyperparathyroidism+in+kidney+transplantation. assertion.
- assertion asSentence Polymorphisms+in+CASR+is+not+associated+with+colorectal+cancer. assertion.
- assertion asSentence Catalase+in+livers+enhances+drug+oxidation+activities+catalyzed+by+P450+in+human+liver+microsomes. assertion.
- assertion asSentence Genetic+polymorphisms+of+CAT+and+PPARy2+do+not+play+a+significant+role+in+the+development+of+SLE+in+a+Korean+population. assertion.
- assertion asSentence Protective+role+of+the+-262T+allele+of+the+CAT+gene+against+the+rapid+development+of+diabetic+nepheropathy. assertion.
- assertion asSentence By+chronically+reducing+catalase+activity+to+approximately+38%25+of+normal%2C+cells+respond+in+a+dramatic+manner%2C+displaying+a+cascade+of+accelerated+aging+reactions. assertion.
- assertion asSentence Hydrogen+peroxide+derived+from+myeloid+cells+overexpressing+catalase+promotes+neovascularization+in+response+to+ischemia+and+is+a+necessary+factor+for+the+development+of+ischemia-induced+inflammation. assertion.
- assertion asSentence Caveolin-1+contributes+to+assembly+of+store-operated+Ca2%2B+influx+channels+by+regulating+plasma+membrane+localization+of+TRPC1. assertion.
- assertion asSentence Cav-1+haploinsufficiency+in+human+breast+epithelial+cells+can+lead+to+partial+transformation. assertion.
- assertion asSentence Caveolin-1+regulates+primary+breast+tumor+growth+and+spontaneous+metastasis+of+breast+cancer. assertion.
- assertion asSentence Caveolin-1+in+human+breast+cancer+cells+enhances+matrix-independent+cell+survival+that+is+mediated+by+upregulation+of+IGF-I+receptor+expression+and+signaling. assertion.
- assertion asSentence Cell-cell+contact+is+required+for+BeWo+trophoblasts+to+exhibit+plasmalemmal+caveolin-1. assertion.
- assertion asSentence Expression+of+caveolin+is+sufficient+to+drive+the+formation+of+caveolae+in+cell+lines+normally+lacking+caveolin%2C+such+as+human+colon+cancer+cells+%28Caco-2%29. assertion.
- assertion asSentence CAV1+phosphorylation+on+Tyr-14+increases+the+induction+of+apoptosis+by+taxanes+in+breast+cancer+cells. assertion.
- assertion asSentence HPV+type+31+%28HPV31%29+entry+and+initiation+of+early+infection+events+require+both+caveolin+1+and+dynamin+2+and+occur+independently+of+clathrin-mediated+endocytosis. assertion.
- assertion asSentence The+knockdown+of+caveolin-1+in+endothelial+cells+decreases+caveolin-2+phosphorylation+at+serine+23+and+upregulation+of+serine+23+phosphorylation+depends+on+caveolin-1-driven+targeting+to+plasma+membrane+lipid+rafts+and+caveolae. assertion.
- assertion asSentence AnxA6+interferes+with+caveolin+transport+through+the+inhibition+of+cPLA%282%29. assertion.
- assertion asSentence Caveolin+mediates+rapid+glucocorticoid+effects+and+couples+glucocorticoid+action+to+the+antiproliferative+program. assertion.
- assertion asSentence Wild-type+APC+regulates+CAV1+expression+in+human+colon+adenocarcinoma+cell+lines+via+FOXO1a+and+C-myc. assertion.
- assertion asSentence Co-expression+of+fatty+acid+synthase+and+caveolin-1+in+pancreatic+ductal+adenocarcinoma. assertion.
- assertion asSentence Caveolin-1+is+the+membrane+protein+that+forms+part+of+the+caveolae.The+main+functions+of+caveolae+are+transcytosis+of+both+large+and+small+molecules+across+cell+membrane. assertion.
- assertion asSentence Increased+caveolin+1+is+associated+with+metastatic+lymph+node+sites+in+non-small-cell+lung+cancer. assertion.
- assertion asSentence Loss+of+stromal+Cav-1+is+predictive+of+elevated+levels+of+epithelial+Cav-1+and+epithelial+Akt-activation+and+is+associated+with+advanced+prostate+cancer. assertion.
- assertion asSentence Upregulation+of+caveolin-1+expression+is+associated+with+nasopharyngeal+carcinoma. assertion.
- assertion asSentence Caveolin+1+expression+inhibits+TrxR1-mediated+cell+transformation. assertion.
- assertion asSentence Positive+expression+of+caveolin-1+in+bladder+transitional+cell+carcinoma+can+be+regarded+as+a+high+risk+factor+of+recurrence. assertion.
- assertion asSentence Single+Nucleotide+Polymorphisms+in+CAV1+is+associated+with+primary+open-angle+glaucoma. assertion.
- assertion asSentence Dynamic+movement+of+cav-1+is+essential+for+physiological+contractile+response+of+colonic+smooth+muscle. assertion.
- assertion asSentence Caveolin-1+overexpression+is+associated+with+hepatocellular+cancer. assertion.
- assertion asSentence Variations+in+the+CAV1+gene+are+associated+with+insulin+resistance+and+hypertension. assertion.
- assertion asSentence Over+expression+of+caveolin-1+in+the+tumour+cell+cytoplasm+predicts+a+poor+prognosis+of+patients+with+clear+cell+RCC. assertion.
- assertion asSentence Insignificant+differences+in+Cav-1+between+the+sera+of+patients+and+controls+%285.69+in+the+cancer+group+vs.+5.42+ng%2Fml+in+the+control+group%29. assertion.
- assertion asSentence Promoter+hypermethylation+and+loss+of+expression+of+the+CAV-1+gene+is+associated+with+breast+cancer. assertion.
- assertion asSentence Caveolin-1+and+dynamin-2+are+essential+for+removal+of+the+complement+C5b-9+complex+via+endocytosis. assertion.
- assertion asSentence Heterologously+and+endogenously+expressed+D1+dopamine+receptors+in+renal+cells+are+associated+with+and+regulated+by+caveolin-2. assertion.
- assertion asSentence Single+Nucleotide+Polymorphisms+in+CAV2+is+associated+with+primary+open-angle+glaucoma. assertion.
- assertion asSentence Adenovirus-mediated+overexpression+of+human+caveolin-3+inhibits+hypertrophic+responses+in+rat+cardiomyocytes. assertion.
- assertion asSentence Caveolin-3+negatively+regulates+Kir6.2%2FSUR2A+channel+function. assertion.
- assertion asSentence An+unexpected+interaction+is+found+between+transgenic+Runx2+and+mouse+parathyroid+hormone-related+protein+%28PTHrP%29+in+controlling+the+rate+of+chondrocyte+proliferation. assertion.
- assertion asSentence TFIIA+gamma+together+with+ATF4+and+Runx2+stimulates+osteocalcin+promoter+activity+and+endogenous+mRNA+expression. assertion.
- assertion asSentence High+glucose+levels+can+evoke+the+calcification+of+human+aortic+smooth+muscle+cells+by+inducing+osteoblastic+trans-differentiation+and+intracellular+calcium+deposition+via+the+BMP-2%2FCbfalpha-1+pathway. assertion.