Matches in Nanopublications for { ?s <http://purl.org/nanopub/x/asSentence> ?o ?g. }
- assertion asSentence Runx2+plus+BMP2+mediated+efficient+conversion+of+fibroblast-like+ligamentum+flavum+cells+into+osteoblast-+like+cells. assertion.
- assertion asSentence Reduced+AML1+activities+predispose+cells+to+the+acquisition+of+the+activating+FLT3+mutation+as+a+secondary+event+leading+to+full+transformation+in+acute+myeloblastic+leukemia+M0. assertion.
- assertion asSentence AML1+mutations+and+deletion+of+genes+on+chromosome+arm+7q+cooperate+in+leukemogenesis+and+predispose+to+leukemic+transformation. assertion.
- assertion asSentence TEL-AML1+ALL+has+significantly+lower+de+novo+purine+synthesis+and+differential+expression+of+genes+involved+in+purine+metabolism. assertion.
- assertion asSentence Present+in+acute+myeloid+leukemia+of+M2+subtype. assertion.
- assertion asSentence RUNX3+regulates+RUNX1+expression+in+human+B+lymphoid+cell+lines. assertion.
- assertion asSentence One+of+the+chromosome+bands+most+often+involved+in+structural+rearrangements+in+B-cell+precursor+acute+lymphoblastic+leukemia. assertion.
- assertion asSentence RUNX1+rearrangements+in+acute+myeloblastic+leukemia+relapsing+after+hematopoietic+stem+cell+transplantation. assertion.
- assertion asSentence It+would+appear+prudent+to+screen+young+patients+with+myelodysplasia%2FAML+for+RUNX1+mutation%2C+before+consideration+of+sibling+hematopoietic+stem+cell+transplantation. assertion.
- assertion asSentence ETV6%2FRUNX1+fusion+lacking+prognostic+effect+in+pediatric+patients+with+acute+lymphoblastic+leukemia. assertion.
- assertion asSentence Downregulation+of+RUNX1+by+RUNX3+is+required+for+EBV-driven+B-cell+proliferation. assertion.
- assertion asSentence CHIP+serves+as+an+E3+ubiquitin+ligase+that+regulates+Runx1+protein+stability+via+an+ubiquitination+and+degradation+mechanism+that+is+independent+of+Hsp70%2F90. assertion.
- assertion asSentence RUNX1+mutation+is+associated+with+acute+myeloid+leukemia+M0. assertion.
- assertion asSentence CD9+expression+can+be+used+to+predict+childhood+TEL%2FAML1-positive+acute+lymphoblastic+leukemia. assertion.
- assertion asSentence RUNX1%2FRUNX1T1+rearrangement+by+cryptic+insertion+of+the+RUNX1+gene+is+associated+with+acute+myeloid+leukemia. assertion.
- assertion asSentence ALOX12+is+a+direct+transcriptional+target+of+RUNX1. assertion.
- assertion asSentence RUNX1+mutation+is+associated+with+myelodysplastic+syndromes. assertion.
- assertion asSentence RUNX1+deficiency+is+associated+with+persistent+corepressor+interaction+with+PU.1. assertion.
- assertion asSentence Amplified+segment+in+the+%27Down+syndrome+critical+region%27+on+HSA21+shared+between+Down+syndrome+and+euploid+AML-M0+excludes+RUNX1%2C+ERG+and+ETS2. assertion.
- assertion asSentence AML1%2FETO+participates+in+a+protein+complex+with+the+RA+receptor+alpha+%28RARalpha%29+at+RA+regulatory+regions+on+RARbeta2. assertion.
- assertion asSentence An+evolutionary+conserved+GATA+binding+site+is+critical+in+transcriptional+regulation+of+the+MTG16+promoter. assertion.
- assertion asSentence Transcriptional+repression+of+RUNX3+is+caused+by+promoter+hypermethylation+of+the+RUNX3+CpG+island+in+colorectal+cancer+cell+lines. assertion.
- assertion asSentence Important+target+of+DNA+methylation+in+the+evolution+of+microsatellite+instability+in+gastric+cancer. assertion.
- assertion asSentence RUNX3+expression+suppressed+cell+proliferation+by+inducing+apoptosis+via+the+death-receptor+mitochondria-mediated+pathway+in+human+gastric+carcinoma+MKN-1+cells. assertion.
- assertion asSentence RUNX3+inactivation+by+promoter+hypermethylation+and+protein+mislocalization+constitute+an+early+event+in+breast+cancer+progression. assertion.
- assertion asSentence DNA+copy-number+loss+on+1p36.1+harboring+RUNX3+with+promoter+hypermethylation+and+associated+loss+of+RUNX3+expression+in+liver+fluke-associated+intrahepatic+cholangiocarcinoma. assertion.
- assertion asSentence RUNX3+deregulation+is+associated+with+Helicobacter+pylori-induced+pathogenesis+and+development+of+intestinal+metaplasia. assertion.
- assertion asSentence Abnormal+expression+of+Ezh2%2C+Runx3+and+caspase-3+is+associated+with+the+development+and+progression+of+endometrioid+adenocarcinoma. assertion.
- assertion asSentence It+is+a+tumor+suppressor+protein+and+plays+a+role+as+a+coactivator+of+P53. assertion.
- assertion asSentence RUNX3+plays+a+pivotal+role+in+5-aza-CdR-+and+TSA-induced+cell+proliferation+and+apoptosis+in+K562+and+Reh+cells. assertion.
- assertion asSentence Examine+consequences+of+expression+of+abnormal+chimeric+protein+CBFbeta-MYH11+in+acute+myelomonocytic+leukemia. assertion.
- assertion asSentence CBFbeta+is+essential+for+TEL-AML1%27s+ability+to+promote+self-renewal+of+B+cell+precursors+in+vitro. assertion.
- assertion asSentence Vif+proteins+of+human+and+simian+immunodeficiency+viruses+require+cellular+CBFbeta+to+degrade+APOBEC3G. assertion.
- assertion asSentence The+c-Cbl%2FCD2AP+complex+binds+to+activated+Flt-1+and+plays+a+crucial+role+in+its+endocytosis+and+subsequent+degradation. assertion.
- assertion asSentence H-Ras+interacts+with+Spry2-binding+partners%2C+c-Cbl+and+CIN85%2C+in+a+Spry2-dependent+manner. assertion.
- assertion asSentence The+interplay+between+Nedd4-2-related+E3+ligases+that+regulate+ACK1+levels+and+Cbl+that+modifies+EGF+receptor+impinges+on+cell+receptor+dynamics. assertion.
- assertion asSentence Casitas+B-lineage+lymphoma+protein+c-Cbl+acts+as+a+mediator+in+Src-induced+activation+of+the+PI3K-Akt+signal+transduction+pathway+through+regulating+phosphorylation+of+PI3K. assertion.
- assertion asSentence C-Cbl+promotes+glioma+invasion+through+up-regulation+of+MMP2. assertion.
- assertion asSentence Serine%2Fthreonine+phosphorylation+reduces+the+binding+affinity+between+the+TKB+domain+of+c-Cbl+and+its+target+proteins%2C+EGFR+and+Sprouty2. assertion.
- assertion asSentence Both+binding+and+orientation+is+dictated+by+the+c-MET+phosphorylated+tyrosine+and+an+adjacent+arginine+forming+intra-peptide+hydrogen+bonds+and+aligning+unidirectionally+with+complementary+charges+in+the+phosphotyrosine+binding+pocket+of+c-Cbl. assertion.
- assertion asSentence CBL+mutation+is+asssociated+with+chronic+myelogenous+leukemia. assertion.
- assertion asSentence The+ubiquitination+and+degradation+of+stimulated+FcgammaRIIa+mediated+by+c-Cbl+are+positively+regulated+by+the+adaptor+protein+CIN85+in+a+PKC-dependent+manner+and+these+events+contribute+to+the+termination+of+FcgammaRIIa+signaling. assertion.
- assertion asSentence Recurrent+homozygous+CBL-inactivating+mutations+are+associated+with+myeloid+malignancies. assertion.
- assertion asSentence Cbl-b+plays+a+negative+role+in+Crk-L-C3G-mediated+Rap1+and+LFA-1+activation+in+T+cells. assertion.
- assertion asSentence Cbls+suppress+cell+death+in+healthy+neurons+at+least+in+part+by+inhibiting+the+ability+of+mixed+lineage+kinases+to+activate+JNK+signaling. assertion.
- assertion asSentence Interplay+between+transgenic+Cblb-dependent+T+cell+anergy+and+other+mechanisms+prevents+organ-specific+islet-cell+autoimmunity. assertion.
- assertion asSentence CBLB+mutation+is+asssociated+with+chronic+myelogenous+leukemia. assertion.
- assertion asSentence Over+expression+of+TGF-beta+and+CTLA-4+leads+to+T+cell+hyporesponsiveness%2C+a+major+hallmark+of+leprosy%2C+by+increasing+the+expression+of+Cbl-b. assertion.
- assertion asSentence Cbln1+and+Cbln2+are+co-expressed+in+the+endolysosomal+compartment+of+the+thalamic+neurons+responsible+for+the+synaptic+alterations+in+striatum+of+Cbln1-null+mice. assertion.
- assertion asSentence The+common+carbonyl+reductase+3+%28CBR3%29valine244methionine+polymorphism+encodes+for+CBR3+isoforms+with+distinctive+enzymatic+properties%2C+as+revealed+in+DNA+variation+panels+from+10+ethnic+groups. assertion.
- assertion asSentence CBR3+polymorphisms+contribute+to+increased+cardiomyopathy+risk+associated+with+anthracycline+treatment+of+childhood+cancer. assertion.
- assertion asSentence Base+pair+variable+numbeer+tandem+repeaets+does+not+contribute+to+the+etiology+of+mental+reteardation. assertion.
- assertion asSentence Functional+rescue+of+mutant+human+cystathionine+beta-synthase+by+manipulation+of+Hsp26+and+Hsp70+levels+in+Saccharomyces+cerevisiae. assertion.
- assertion asSentence Mutuaion+in+the+cystathionine+beta+synthase+mRNA+is+associated+with+homocystinuria. assertion.
- assertion asSentence Mutations+in+cystathionine-beta-synthase+is+associated+with+homocystinuria. assertion.
- assertion asSentence Gastrin+and+CCK+exert+a+trophic+action+on+some+of+the+biliary+tract+cancers. assertion.
- assertion asSentence Allelic+variants+are+specifically+associated+with+distinctly+different+eating+patterns%2C+namely+extreme+snacking+behavior+or+excessive+portion+size. assertion.
- assertion asSentence Differences+in+summer+and+winter+and+in+diurnal+blood+levels+correlated+with+external+temperature. assertion.
- assertion asSentence There+is+regional+variation+in+CCK+in+the+upper+small+intestine. assertion.
- assertion asSentence Neither+treatment+of+pancreatic+cancer+cells+with+CCK+antibodies+nor+the+down-regulation+of+CCK+mRNA+and+peptide+by+shRNAs+altered+growth+in+vitro+or+in+vivo. assertion.
- assertion asSentence Significant+association+between+polymorphism+at+the+-85+locus+of+the+CCKAR+gene+in+patients+with+hallucination%2C+especially+patients+with+hallucination+in+delirium+tremens. assertion.
- assertion asSentence Finds+significant+differences+in+intelligence+for+Cholecystokinin+A+receptor+gene+promoter+polymorphisms+A-81G+and+G-128T+in+community-living+Japanese. assertion.
- assertion asSentence LPS+can+up-regulate+the+expression+of+CCK-AR+and+CCK-BR+mRNA+in+vascular+endothelial+cells. assertion.
- assertion asSentence An+association+is+not+found+between+cholecystokinin+A+receptor+polymorphisms+and+antipsychotic+induced+weight+gain+in+schizophrenia+patients. assertion.
- assertion asSentence The+presence+of+CCK+receptors+in+human+ductal+pancreatic+tumor+samples+is+mainly+due+to+CCK2+expression+in+residual+pancreatic+islets+and+CCK1+in+pancreatic+nerves. assertion.
- assertion asSentence Targeted+CCK2R+expression+in+the+pancreas+of+Elas-CCK2+transgenic+mice+leads+to+the+overexpression+of+beta+1-integrin. assertion.
- assertion asSentence LPS+can+up-regulate+the+expression+of+CCK-AR+and+CCK-BR+mRNA+in+vascular+endothelial+cells. assertion.
- assertion asSentence Frame+shift+mutation+in+KRIT1+gene+is+associated+with+cerebral+and+multiple+spinal+cavernous+malformations. assertion.
- assertion asSentence Cyclin+G1+enhanced+radiation+sensitivity+by+overriding+radiation-induced+G2+arrest+through+transcriptional+upregulation+of+cyclin+B1. assertion.
- assertion asSentence Defective+p53+signaling+in+p53+wild-type+tumors+attenuates+p21waf1+induction+and+cyclin+B+repression+rendering+them+sensitive+to+Chk1+inhibitors+that+abrogate+DNA+damage-induced+S+and+G2+arrest. assertion.
- assertion asSentence Cdc14B-dependent+modulation+of+Cdc25+phosphatase+and+Cdk1%2Fcyclin+B+activity+is+linked+to+correct+chromosome+segregation+and+bipolar+spindle+formation%2C+processes+that+are+required+for+proper+progression+through+mitosis+and+maintenance+of+genomic+stability. assertion.
- assertion asSentence Cyclin+B1+appeared+to+be+involved+in+the+genesis+or+progression+of+breast+cancers. assertion.
- assertion asSentence Cdk1%2Fcyclin+B+plays+a+key+role+in+mitotic+arrest-induced+apoptosis+via+Mcl-1+phosphorylation%2C+promoting+its+degradation+and+subsequently+releasing+Bak+from+sequestration. assertion.
- assertion asSentence FBXL2+targets+cyclin+D2+for+ubiquitination+and+degradation+to+inhibit+leukemic+cell+proliferation. assertion.
- assertion asSentence Alpha+interferon+suppresses+the+cyclin+D3+and+cdc25A+genes%2C+leading+to+a+reversible+G0-like+arrest. assertion.
- assertion asSentence Ectopic+expression+of+cyclin+E+in+estrogen+responsive+cells+abrogates+antiestrogen+mediated+growth+arrest. assertion.
- assertion asSentence HuR+critically+contributes+to+cyclin+E1+overexpression+and+its+growth-promoting+function+in+breast+cancer+cells. assertion.
- assertion asSentence CCNE1+overexpression+is+critical+to+growth+and+survival+of+ovarian+cancer+tumors+with+CCNE1+gene+amplification. assertion.
- assertion asSentence Cyclin+E1+is+repressed+independent+of+effects+on+cyclin+D1+in+a+3D+collagen+environment+and+dependent+on+beta1+integrin+interaction+with+collagen+I%2C+reducing+proliferation+of+invasive+breast+cancer+cells. assertion.
- assertion asSentence High+Cyclin+H+is+associated+with+gastrointestinal+stromal+tumours. assertion.
- assertion asSentence Cyclin+T1+acetylation+triggers+dissociation+of+Hexim1+and+7SK+snRNA+from+cyclin+T1%2FCDK9+and+activates+the+transcriptional+activity+of+P-TEFb. assertion.
- assertion asSentence Binding+to+Cyclin+T1+induces+an+asymmetry+or+sterical+hindrance+in+the+first+coiled+coil+segment+of+dimeric+Hexim1+that+disallows+formation+of+a+2%3A2+complex. assertion.
- assertion asSentence Microsomal+triglyceride+transfer+protein+regulates+endogenous+and+exogenous+antigen+presentation+by+group+1+CD1+molecules. assertion.
- assertion asSentence The+intracellular+trafficking+route+of+CD1a+is+essential+for+efficient+presentation+of+lipid+antigens+that+traffic+through+the+early+endocytic+and+recycling+pathways. assertion.
- assertion asSentence Microsomal+triglyceride+transfer+protein+regulates+endogenous+and+exogenous+antigen+presentation+by+group+1+CD1+molecules. assertion.
- assertion asSentence CD1d-dimer+staining+revealed+human+natural+killer+T+cells+reactivity+toward+Sphingomonas+glycosphingolipids. assertion.
- assertion asSentence Preferential+stimulatory+activities+of+two+alpha-galactosylceramide+C-glycoside+analogues+against+human+vs+mouse+invariant+natural+killer+%28NK%29T+cells+are+due+to+the+differences+between+human+vs+mouse+CD1d+molecules. assertion.
- assertion asSentence Enhancing+immunostimulatory+function+of+human+embryonic+stem+cell-derived+dendritic+cells+by+CD1d+overexpression. assertion.
- assertion asSentence PSTPIP1+acts+downstream+of+CD2%2FCD2AP+to+link+CD2+engagement+to+the+WASp-evoked+actin+polymerization+required+for+synapse+formation+and+T+cell+activation. assertion.
- assertion asSentence Another+role+of+the+CD2-CD58+pathway+that+allows+nonimmune+and+immune+cells+to+interact+directly+with+dendritic+cells+and+initiate+innate+and+adaptive+immune+responses. assertion.
- assertion asSentence CD2-mediated+priming+of+resting+natural+killer+%28NK%29+cells+is+unaffected+by+their+degree+of+functional+maturation. assertion.
- assertion asSentence CD2+expression+does+not+contribute+to+improve+the+diagnosis+of+systemic+mastocytosis+when+compared+with+aberrant+CD25+expression+alone. assertion.
- assertion asSentence Enumeration+of+NK+cells+and+of+T+lymphocytes+expressing+TCR+alpha%2Fbeta+in+human+body+effusions+is+not+helpful+in+attempting+to+distinguish+between+benign+and+malignant+effusions. assertion.
- assertion asSentence When+compared+with+other+human+T+cell+subsets%2C+T+cell+receptor%2FCD3-activated+Vgamma9Vdelta2-expressing+T+cells+display+an+unusually+delayed+and+sustained+intracellular+calcium+mobilization%2C+dramatically+quickened+and+shortened+on+costimulation+by+NKG2D. assertion.
- assertion asSentence Altered+expression+of+the+TCR+signaling+related+genes+CD3+and+FcepsilonRIgamma+in+patients+with+aplastic+anemia. assertion.
- assertion asSentence The+CD3+gamma+gene+promoter+is+lymphoid+specific%2C+initiates+transcription+from+multiple+start+sites+and+contains+two+core+promoters+capable+of+recruiting+the+general+transcription+machinery+through+specificity+protein+binding+motifs. assertion.
- assertion asSentence CD3gamma+and+CD3delta+evolved+from+a+common+precursor+gene+to+optimize+major+histocompatibility+antigen+%28MHC%29-triggered+alphabeta+T+cell+receptor+activation. assertion.
- assertion asSentence T+cells+expressing+decreased+zeta+exhibit+differential+transcription+patterns+in+systemic+lupus+erythematosus. assertion.
- assertion asSentence The+CD3-zeta+chimeric+antigen+receptor+overcomes+TCR+Hypo-responsiveness+of+human+terminal+late-stage+T+cells. assertion.
- assertion asSentence NF-kappaB+activation+upon+interaction+of+HIV-1+envelope+glycoproteins+with+cell+surface+CD4+involves+IkappaB+kinases. assertion.