Matches in Nanopublications for { ?s <http://purl.org/nanopub/x/asSentence> ?o ?g. }
- assertion asSentence Substitution+of+a+D-prolyl+residue+for+the+glycyl+within+the+Lys-Gly-Tyr-Tyr+CD40-binding+motif+of+CD40L+leads+to+a+complete+loss+of+cooperativity+in+the+interaction+of+the+mimetic+with+its+cognate+receptor. assertion.
- assertion asSentence Upon+CD40+ligand+stimulation%2C+endogenous+and+exogenous+CD40+receptor+is+rapidly+mobilized+into+lipid+rafts+compared+with+unstimulated+Aortic+Endothelial+Cells. assertion.
- assertion asSentence Reduced+BDNF+secretion+from+PBMCs+and+defective+regulation+effect+of+CD40+stimulation+on+BDNF+levels+in+untreated+relapsing+remitting+multiple+sclerosis+are+reversible+by+therapy+with+IFN-beta1a. assertion.
- assertion asSentence Downregulation+of+CD40+is+associated+with+highly+invasive+and+metastatic+pancreatic+ductal+adenocarcinomas. assertion.
- assertion asSentence TNFRSF5+polymorphism+is+associated+with+non-Hodgkin+lymphoma. assertion.
- assertion asSentence Overexpression+of+CD40+is+associated+with+good+response+to+immunochemotherapy+in+diffuse+large+B-cell+lymphoma. assertion.
- assertion asSentence sCD40L+enhances+agonist-induced+platelet+activation+and+aggregation+through+a+CD40-dependent+tumor+necrosis+factor+receptor-associated+factor-2%2FRac1%2Fp38+mitogen-activated+protein+kinase+signaling+pathway. assertion.
- assertion asSentence CD40%2FCD40L+interaction+induces+E-selectin+dependent+adhesion+of+leukocytes+to+human+endothelial+cells+and+reduces+endothelial+cell+migration+by+inhibiting+the+Akt%2FeNOS+signaling+pathway. assertion.
- assertion asSentence The+two+investigated+single-nucleotide+polymorphisms+%28SNPs%29%2C+rs4810485+and+rs1883832%2C+in+CD40+are+not+associated+with+FUS+in+the+Han+Chinese+population. assertion.
- assertion asSentence A+CD40+single-nucleotide+polymorphism+affects+the+lymphocyte+profiles+in+the+bronchoalveolar+lavage+of+Japanese+patients+with+sarcoidosis. assertion.
- assertion asSentence CD40%2FCD40L+interactions+are+important+for+the+activation+of+macrophages+as+effector+cells+that+mediate+inflammation+and+tissue+damage+in+T+cell-mediated+inflammatory+processes. assertion.
- assertion asSentence Association+of+CD40+ligand+expression+on+HTLV-I-infected+T+cells+and+maturation+of+dendritic+cells. assertion.
- assertion asSentence Burkitt+lymphoma+cell+population+depletion+activates+autonomous+CD154-dependent+survival. assertion.
- assertion asSentence CD40L+can+induce+maturation+of+monocyte-derived+dendritic+cells+and+elicit+sustained+antiviral+cytotoxic+T+lymphocyte+responses%2C+either+alone+or+cooperatively+with+TNF-alpha+or+RANKL. assertion.
- assertion asSentence CD154+regulates+TNF-alpha-dependent+antiprotozoal+activity+in+monocyte-derived+macrophages+when+interferon-gamma+signaling+is+deficient. assertion.
- assertion asSentence Platelet+CD40L+expression+occurs+via+arachidonic+acid-mediated+gp91phox+activation. assertion.
- assertion asSentence Activates+the+Jun+amino-terminal+kinase+pathway+through+transient+phosphorylation+of+Burkitt+lymphoma+cells+in+vitro. assertion.
- assertion asSentence The+whole+blood+gene+expression+quantities+of+costimulatory+molecules+CD154+and+ICOS+reasonably+robustly+differentiated+rejection+patients+from+control+patients. assertion.
- assertion asSentence Soluble+CD40L+level+is+a+predictor+of+vascular+events+in+patients+with+nonvalvular+atrial+fibrillation. assertion.
- assertion asSentence In+heart+failure+patients%2C+platelet+CD40L+is+upregulated+by+TNFalpha+via+a+cyclooxygenase-1-independent%2C+arachidonic+acid-mediated+oxidative+stress+mechanism. assertion.
- assertion asSentence Elevated+circulating+levels+of+soluble+CD-40+ligand+in+haemodialysis+patients+with+symptomatic+coronary+heart+disease. assertion.
- assertion asSentence In+the+absence+of+CD40-CD154+interactions%2C+there+is+a+marked+reduction+in+SHM+and%2C+specifically%2C+mutations+of+AICDA-targeted+G+residues+in+RGYW+motifs+along+with+a+decrease+in+transversions+normally+related+to+UNG2+activity. assertion.
- assertion asSentence The+mutated%2C+cleavage-resistant+form+of+CD40L+is+a+more+potent+inducer+of+apoptosis+than+wild-type+ligand+in+CD40-positive+carcinoma+cell+lines. assertion.
- assertion asSentence Human+X-linked+variable+immunodeficiency+caused+by+a+hypomorphic+mutation+in+XIAP+in+association+with+a+rare+polymorphism+in+CD40LG. assertion.
- assertion asSentence Simvastatin+and+atorvastatin+attenuate+VCAM-1+and+uPAR+expression+on+human+endothelial+cells+and+platelet+surface+expression+of+CD40+ligand. assertion.
- assertion asSentence CD44+directs+membrane-type+1+matrix+metalloproteinase+to+lamellipodia+by+associating+with+its+hemopexin-like+domain. assertion.
- assertion asSentence Engagement+of+CD44+mediates+deactivation+of+human+monocytes+in+the+presence+of+tumor+cells%2C+an+effect+apparently+involved+in+IL-1+receptor+associated+kinase-M+%28IRAK-M%29+up-regulation. assertion.
- assertion asSentence The+concentration+of+the+soluble+form+of+CD44%2C+a+competitive+inhibitor+for+CD44+and+hyaluronic+acid+binding%2C+is+higher+in+the+peritoneal+fluid+of+patients+with+endometriosis+than+in+the+peritoneal+fluid+of+patients+without+endometriosis. assertion.
- assertion asSentence CEA+and+CD44v+cooperate+to+mediate+colon+carcinoma+cell+adhesion+to+E-+and+L-selectin+at+elevated+shear+stresses. assertion.
- assertion asSentence CD44+and+nm23-H1+proteins+play+an+important+coordinated+regulation+role+in+the+carcinogenesis%2C+development+and+metastasis+of+laryngeal+carcinoma. assertion.
- assertion asSentence TIMP1+functions+as+a+differentiating+and+survival+factor+of+GC+B+cells+by+modulating+CD44+and+SHP1+in+the+late+centrocyte%2Fpost-GC+stage%2C+regardless+of+EBV+infection. assertion.
- assertion asSentence E-cadherine+and+CD44+immunoexpression+in+oral+squamous+cell+carcinoma+as+prognosis+factors. assertion.
- assertion asSentence PKC+activation+can+up-regulate+CD44+expression+by+phosphorylation+in+human+erythrocytes. assertion.
- assertion asSentence Adhesion+of+haematopoietic+stem+cells+to+liver+compartments+is+integrin+and+CD44+dependent+and+modulated+by+CXCR3+and+CXCR4. assertion.
- assertion asSentence Expression+of+CD44+in+endometrium+and+fallopian+tubes+from+infertile+women. assertion.
- assertion asSentence Transportin+regulates+nuclear+import+of+CD44. assertion.
- assertion asSentence Both+endothelial+cell+E-+and+P-selectins+are+implicated+in+ischemia%2Freperfusion-induced+stem+cell+recruitment+to+the+infarct+site+where+transgenic+CD44+serves+as+the+ligand+that+engages+P-+and+E-selectin+on+the+cerebral+microvasculature. assertion.
- assertion asSentence CD44+mRNA+of+magnetically+separated+CD45EpCAM%2B+cell+fraction+of+peritoneal+washes+is+a+useful+genetic+marker+for+predicting+high-risk+individuals+among+gastric+cancer+patients+with+stage+II+and+III. assertion.
- assertion asSentence Hyaluronan+homeostasis+is+deranged+in+asthma%2C+with+increased+production+by+fibroblasts+and+decreased+CD44+expression+on+alveolar+macrophages. assertion.
- assertion asSentence Platelet-derived+P-selectin+plays+a+prominant+role+in+hematogenous+metastasis+from+colon+carcinoma+via+CD44v+binding+on+tumor+cells. assertion.
- assertion asSentence C-Met+recruits+ICAM-1+as+a+coreceptor+to+compensate+for+the+loss+of+CD44+in+Cd44+null+mice. assertion.
- assertion asSentence High+CD44+expression+is+associated+with+cholangiocarcinoma. assertion.
- assertion asSentence CD44+and+activated+T+cell+infiltration+play+an+important+role+in+the+development+of+plexiform+lesions+particularly+in+idiopathic+pulmonary+arterial+hypertension. assertion.
- assertion asSentence Interaction+of+CD47+with+thrombospondin-1+contributes+to+the+perpetuation+of+inflammation+in+rheumatoid+synovitis. assertion.
- assertion asSentence CD47+associates+with+Fas+upon+its+activation+and+augments+Fas-mediated+apoptosis. assertion.
- assertion asSentence CD47+signaling+is+active+within+cells+of+the+neurovascular+interface. assertion.
- assertion asSentence The+level+of+CD58+molecule+%28in+both+serum+and+PBMC+form%29+of+patients+with+hepatitis+B+is+related+to+the+degree+of+liver+damage. assertion.
- assertion asSentence Susceptibility+gene+for+multiple+sclerosis+in+Australians. assertion.
- assertion asSentence CD59+is+trafficked+to+the+cytoplasmic+inclusion+by+a+Golgi+apparatus-independent+pathway+during+a+Chlamydia+cell+infection. assertion.
- assertion asSentence CD63+is+a+cell+surface+binding+partner+for+TIMP-1%2C+regulating+cell+survival+and+polarization+via+TIMP-1+modulation+of+tetraspanin%2Fintegrin+signaling+complex. assertion.
- assertion asSentence C-terminal+modifications+that+retain+LMP1+in+Golgi+compartments+preclude+assembly+within+CD63-enriched+domains+and%2For+exosomal+discharge+leading+to+NF-kappaB+overstimulation. assertion.
- assertion asSentence High+CD68+and+kallikrein+6+expression+is+associated+with+glioma+progression. assertion.
- assertion asSentence Increased+CD69+of+T+lymphocytes%2C+along+with+abnormally+elevated+immunologically+active+molecules+play+an+important+role+in+immune+pathogenesis+of+patients+with+myelodysplastic+syndrome%28MDS%29. assertion.
- assertion asSentence Intron+I+acts+as+an+important+regulatory+element+of+CD69+expression. assertion.
- assertion asSentence Systemic+lupus+erythematosus+T+cells+and+T+cells+treated+with+DNA+methyltransferase+inhibitors+and+ERK+pathway+inhibitors+overexpress+CD70. assertion.
- assertion asSentence CD27-CD70+interactions+in+the+pathogenesis+of+Waldenstrom+macroglobulinemia. assertion.
- assertion asSentence CD70+and+CD11a+facilitate+the+survival+of+T+and+B+lymphocytes+and+indirectly+enhance+the+destruction+of+platelets+in+immune+thrombocytopenia. assertion.
- assertion asSentence H.+pylori+urease+B+binds+to+CD74+on+gastric+epithelial+cells+and+initiates+NF-kappaB+activation+and+interleukin-8+production. assertion.
- assertion asSentence The+B+cell-specific+B29+gene+promoter+is+transactivated+in+B+and+non-B+cells+by+cotransfection+with+the+B+cell-specific+octamer+cofactor+gene%2C+Bob1+%28OCA-B%2FOBF-1%29. assertion.
- assertion asSentence Following+B+cell+receptor+cross-linking%2C+a+significant+amount+of+the+transgenic+Ig+beta+pool+%28together+with+Ig+alpha%29+remains+on+the+B+cell+surface+independent+of+surface+immunoglobulin+internalization. assertion.
- assertion asSentence In+the+plasma+membrane%2C+PrP%28c%29+colocalizes+with+the+tetraspanin+CD81%2C+sharing+the+same+microdomain. assertion.
- assertion asSentence HCV+envelope+glycoprotein+E2+can+bind+to+CD81+receptors+which+are+expressed+on+thyroid+cells+and+induce+a+cascade+of+signaling+pathway+leading+to+IL-8+release. assertion.
- assertion asSentence CD81+up-regulation+can+increase+the+risk+of+hepatitis+C+virus%2C+particularly+in+HIV-infected+subjects. assertion.
- assertion asSentence CD81+is+required+for+the+formation+of+actin+membrane+protrusions+via+RAC1+activation+in+adhesion-dependent+immune+cell+migration. assertion.
- assertion asSentence EGF-TM7+pre-mRNAs+also+undergo+the+rare+trans-splicing%2C+leading+to+the+generation+of+functional+chimeric+receptors. assertion.
- assertion asSentence Secreted+CD151+can+be+a+useful+genetic+marker+for+the+diagnosis+of+metastatic+prostate+cancer. assertion.
- assertion asSentence Curcumin+downregulated+Helicobacter+pylori+induced+cytidine+deaminase+expression+in+gastric+epithelial+cells. assertion.
- assertion asSentence Compared+with+their+parental+cells%2C+the+expressions+of+CDA%2C+RRM1%2C+PTEN+and+ERCC1+increase+in+human+gemcitabine-resistant+non-small+cell+lung+cancer+cell+lines. assertion.
- assertion asSentence Cdc2+provides+a+signal+that+triggers+inactivation+of+S6K1+in+mitosis. assertion.
- assertion asSentence Deregulation+of+cdc2+kinase+activity+can+trigger+apoptotic+machinery+that+leads+to+caspase-3+activation+and+apoptosis. assertion.
- assertion asSentence Inhibition+of+Cdc2+activity+and+the+subsequent+downregulation+of+survivin+and+XIAP+by+subtoxic+doses+of+rottlerin+contribute+to+amplification+of+caspase+cascades. assertion.
- assertion asSentence Cyclin+B1-Cdk1+activation+continues+after+centrosome+separation+to+control+mitotic+progression. assertion.
- assertion asSentence CDC2+gene+plays+an+important+role+in+the+proliferation+of+human+gliomas. assertion.
- assertion asSentence Cyclin-dependent+kinases+%28Cdks%29%2C+especially+Cdk1+and+Cdk2%2C+promote+interphase+nuclear+pore+complex+formation+in+human+dividing+cells. assertion.
- assertion asSentence Estrogen+receptor+beta+causes+a+G2+cell+cycle+arrest+by+inactivating+CDK1+through+the+repression+of+cyclin+B1+and+stimulation+of+GADD45A+and+BTG2+expression. assertion.
- assertion asSentence cdc2+appeared+to+be+involved+in+the+genesis+or+progression+of+breast+cancers. assertion.
- assertion asSentence The+phosphorylation+of+rpS3+by+Cdk1+occurs+at+Thr221+during+G2%2FM+phase. assertion.
- assertion asSentence DDR+is+suppressed+by+the+high+CDK1+activity+in+mitotic+mammalian+cells. assertion.
- assertion asSentence Treatment+with+myricetin+led+to+G2%2FM+cell+cycle+arrest+in+T24+bladder+cancer+cells+by+downregulation+of+Cyclin+B1+and+cyclin-dependent+kinase+cdc2. assertion.
- assertion asSentence By+consecutively+acting+as+a+protease+and+a+cdk1+inhibitor%2C+separase+coordinates+two+key+processes+to+achieve+simultaneous+and+abrupt+separation+of+sister+chromatids. assertion.
- assertion asSentence CDK11%28p58%29+is+involved+in+the+negative+regulation+of+VDR. assertion.
- assertion asSentence Demonstrate+connection+between+septins%2FSOCS7%2FNCK+signaling+and+the+DNA+damage+response. assertion.
- assertion asSentence The+Cdc6+protein%2C+a+key+DNA+replication+initiation+factor%2C+contributes+to+the+long-term+maintenance+of+the+S-phase+checkpoint+by+anchoring+the+Rad3-Rad26+complex+to+chromatin. assertion.
- assertion asSentence Mps1+directs+the+assembly+of+Cdc20+inhibitory+complexes+during+interphase+and+mitosis+to+control+M+phase+timing+and+spindle+checkpoint+signaling. assertion.
- assertion asSentence Ubiquitination+and+degradation+of+CDC25A+protein+depend+on+the+TGF-beta-Smad3+pathway. assertion.
- assertion asSentence The+expression+of+the+dual+specificity+phosphatase+CDC25A%2C+is+deregulated+in+Ba%2FF3+cells+expressing+the+oncogenic+protein+NPM%2FALK+and+in+human+cell+lines+derived+from+NPM%2FALK-positive+anaplastic+large+cell+lymphomas. assertion.
- assertion asSentence 14-3-3+protein+gamma+mediates+the+interaction+between+Checkpoint+kinase+1+and+Cdc25A. assertion.
- assertion asSentence CDC25B+a+minor+role+in+the+pathogenesis+and%2For+progression+of+vulvar+squamous+cell+carcinomas. assertion.
- assertion asSentence Phosphorylation+of+cdc25c+can+be+used+to+test+whether+a+pharmacologic+inhibitor+of+Plk1+would+exert+the+same+cellular+effects+as+interference+with+Plk1+on+an+mRNA+level. assertion.
- assertion asSentence Partial+or+complete+loss+of+Lzts1+downregulates+Cdc25C+and+inhibits+Cdk1+activity+during+mitosis%2C+leading+to+premature+transition+from+metaphase+to+anaphase. assertion.
- assertion asSentence Inhibition+of+CK2+activity+by+three+different+inhibitors+led+to+a+down-regulation+of+the+level+of+cdc25C. assertion.
- assertion asSentence MMEQ+induced+G2%2FM+arrest+through+the+promotion+of+cdc25c+in+TSGH8301+cells. assertion.
- assertion asSentence Phosphorylation+of+Cdc27+by+CKII+is+involved+in+TGF-beta-induced+activation+of+APC. assertion.
- assertion asSentence The+acidic+tail+of+the+Cdc34+ubiquitin-conjugating+enzyme+functions+in+both+binding+to+and+catalysis+with+ubiquitin+ligase+SCFCdc4. assertion.
- assertion asSentence Rac%2FCdc42-dependent+activation+of+MAPK%2FERK+is+a+critical+event+in+the+immediate+phagocytic+response+of+PMNs+to+microbial+challenge. assertion.
- assertion asSentence VE-cadherin+can+serve+as+a+scaffold+involved+in+Cdc42+activation+at+the+endothelial+plasma+membrane. assertion.
- assertion asSentence Rho+family+GTPases+play+a+distinct+role+in+Salmonella-induced+cellular+responses. assertion.
- assertion asSentence C.+jejuni+invade+host+target+cells+by+a+unique+mechanism+and+the+activation+of+the+Rho+GTPase+members+Rac1+and+Cdc42+plays+a+crucial+role+in+this+entry+process. assertion.
- assertion asSentence FGFR-mediated+phosphorylation+of+ephexin1+enhances+the+guanine+nucleotide+exchange+activity+toward+RhoA+without+affecting+the+activity+to+Rac1+or+Cdc42. assertion.
- assertion asSentence Strongly+activated+in+HTLV-1+infected+T+cell+lines+derived+from+HAM%2FTSP+patients. assertion.