Matches in Nanopublications for { ?s <http://purl.org/nanopub/x/asSentence> ?o ?g. }
- assertion asSentence T-cadherin+transcriptionally+activated+Rac1+and+Cdc42. assertion.
- assertion asSentence RhoA+plays+an+antagonistic+role+to+Rac1%2FCdc42+in+the+control+of+mammary+epithelial+acinar+morphogenesis. assertion.
- assertion asSentence MT1-MMP+and+Cdc42+co-regulate+tumor+cell+invasion+in+3D+collagen+matrices. assertion.
- assertion asSentence Aberrant+expression+of+Annexin+A2+and+Cdc42+play+a+role+in+carcinogenesis%2C+differentiation+and+metastasis+of+esophageal+squamous+cell+carcinomas. assertion.
- assertion asSentence Cdc42+controls+actin+depletion+at+the+immunological+synapse. assertion.
- assertion asSentence Epithelial+junction+formation+and+morphogenesis+require+a+dual+activity+complex%2C+containing+SH3BP1+and+CapZ%2C+that+is+recruited+to+sites+of+active+membrane+remodeling+to+guide+Cdc42+signaling+and+cytoskeletal+dynamics. assertion.
- assertion asSentence Recovery+of+cellular+E-cadherin+precedes+replenishment+of+estrogen+receptor+and+estrogen-dependent+proliferation+of+breast+cancer+cells+rescued+from+a+death+stimulus. assertion.
- assertion asSentence Pulse-labeled+beta-catenin+replaces+the+beta-catenin+bound+to+the+cell+surface+prebiotinylated+E-cadherin+immediately+after+synthesis+or+arrives+at+the+plasma+membrane+in+a+complex+with+the+E-cadherin+precursor. assertion.
- assertion asSentence CDH1+inactivation+due+to+mutations%2C+LOH+and+methylation+is+associated+with+invasive+and+in+situ+lobular+breast+cancer. assertion.
- assertion asSentence Hypoxia+induces+down-regulation+of+E-cadherin+in+ovarian+carcinoma+cells%2C+via+up-regulation+of+the+transcriptional+repressor+SNAIL. assertion.
- assertion asSentence Decreased+E-cadherin+expression+is+an+independent+prognostic+factor+for+disease+progression+and+mortality+in+pathological+stage+I-III+endometrial+cancer. assertion.
- assertion asSentence Disruption+of+E-cadherin-mediated+cell-cell+contacts+at+high+cell+density+inhibits+the+induction+of+p27%28kip1%29+and+restores+proliferation+in+contact-inhibited+cells. assertion.
- assertion asSentence Increased+expression+of+delta-catenin+os+associated+with+the+down-regulation+and+redistibution+of+ECAD+and+p120ctn+in+prostatic+cancer. assertion.
- assertion asSentence Depressed+E-cadherin+correlates+with+HBxAg+trans-activation+function. assertion.
- assertion asSentence Reduced+E-cadherin+expression+is+related+to+a+poor+prognosis+through+hematogenous+metastasis+in+pulmonary+adenocarcinoma. assertion.
- assertion asSentence E-cadherin%2FCDH1+gene+methylation+is+an+important+cause+for+its+gene+silence+in+diffuse+variant+gastric+carcinoma. assertion.
- assertion asSentence Examination+of+E-cadherin+expression+and+distribution+in+colorectal+tumors+can+be+extremely+valuable+in+predicting+disease+recurrence. assertion.
- assertion asSentence Therefore%2C+a+loss+of+cell-cell+junctions%2C+a+key+process+that+occurs+during+the+epithelial-mesenchymal+transition%2C+should+have+a+broad+impact+on+ER+alpha+transcriptional+functions. assertion.
- assertion asSentence E-cadherin+mutant+missing+N-glycans+at+Asn554%2C+Asn566+and+Asn618+failed+to+induce+cell+cycle+arrest+in+G1+phase+and+to+suppress+cell+proliferation+in+comparison+with+wild-type+E-cadherin. assertion.
- assertion asSentence Expression+of+S100A4+protein+and+loss+of+E-cadherin+protein+expression+are+significantly+associated+with+tumor+progression+in+non-small+cell+lung+cancer. assertion.
- assertion asSentence Positive+staining+for+E-cadherin+should+not+preclude+a+diagnosis+of+lobular+in+favor+of+ductal+carcinoma. assertion.
- assertion asSentence Loss+of+E-cadherin-mediated+adhesion+led+to+acquisition+of+phenotypic+properties+that+augmented+cell+motility+and+directed+transition+from+precancer+to+cancer+in+skin-like+tissues. assertion.
- assertion asSentence In+hepatocellular+carcinoma+%28HCC%29%2C+there+is+a+negative+correlation+between+the+positive+expression+of+p130Cas+and+the+normal+expression+of+E-cadherin%2Fbeta-catenin.+p130Cas+plays+important+roles+in+the+invasion%2C+metastasis+and+prognosis+of+HCC. assertion.
- assertion asSentence The+over-expression+of+EphA2+or+the+down-expression+of+E-cadherin+is+correlated+with+cancer+progression+and+lymphogenous+metastasis+in+gastric+cancer. assertion.
- assertion asSentence Polyamines+regulate+E-cadherin+transcription+through+c-Myc+modulating+intestinal+epithelial+barrier+function. assertion.
- assertion asSentence Cell+separation+or+abrogation+of+E-cadherin-mediated+cell-cell+contacts+both+cause+a+dramatic+increase+in+accumulation+of+the+c-Jun+protein. assertion.
- assertion asSentence Low+Cdh1+expression+is+associated+with+breast+cancer. assertion.
- assertion asSentence Changes+in+the+Akt%2Fbeta-catenin+pathway+play+key+roles+in+the+regulation+of+E-cadherin+through+the+transactivation+of+the+Slug+gene+in+uterine+carcinosarcomas. assertion.
- assertion asSentence PRL-3+promoted+downregulation+of+E-cadherin. assertion.
- assertion asSentence Mtation+of+E-cadherin+influences+Rac1+and+Rho+activation+in+opposite+directions. assertion.
- assertion asSentence In+gastric+carcinoma%2C+up-regulation+of+CD147+and+down-regulation+of+E-cadherin+are+in+a+negative+correlation. assertion.
- assertion asSentence Loss+of+E-cadherin+expression+is+associated+with+non-muscle-invasive+bladder+cancer. assertion.
- assertion asSentence Elevated+levels+of+serum+E-cadherin+is+associated+with+late-stage+colorectal+carcinoma+and+familial+adenomatous+polyposis. assertion.
- assertion asSentence The+majority+of+patients+with+germline+CDH1+mutation+have+foci+of+noninvasive+or+invasive+gastric+cancer+by+middle+age. assertion.
- assertion asSentence The+sequential+actions+of+the+APC-c%28Cdc20%29+and+APC-c%28Cdh1%29+ubiquitin+ligases+regulate+the+clearance+of+Mps1+levels+and+are+critical+for+Mps1+functions+during+the+cell+cycle+in+human+cells. assertion.
- assertion asSentence E-cadherin+proteolyis+and+nuclear+translocation+associates+with+aggressive+foci+growth+only+in+the+peritoneal+microenvironment+in+colorectal+cancer. assertion.
- assertion asSentence E-cadherin+expression+in+nasopharyngeal+carcinoma+is+negatively+correlated+with+the+numbers+of+the+lymph+node+metastases+and+the+metastasis+distance. assertion.
- assertion asSentence Substrates+are+recruited+to+the+Anaphase-promoting+complex+by+binding+to+a+bipartite+substrate+receptor+composed+of+Cdh1+and+Doc1. assertion.
- assertion asSentence Hakai+mediates+E-cadherin+ubiquitination+and+degradation+triggered+by+Slit-Robo+signaling+during+colorectal+epithelial+cell+carcinogenesis. assertion.
- assertion asSentence CDH1+mutation+are+associated+with+signet+ring+cell+adenocarcinoma+of+the+stomach. assertion.
- assertion asSentence Single+nucleotide+polymorphisms+in+the+CDH1+gene+promoter+is+associated+with+development+of+hepatocellular+carcinoma. assertion.
- assertion asSentence Low+E-cadherin+is+associated+with+metastasis+in+colorectal+cancer. assertion.
- assertion asSentence Loss+of+E-cadherin+is+associated+with+invasion+in+esophageal+cancers. assertion.
- assertion asSentence CRYAB+functions+to+suppress+nasopharyngeal+carcinoma+progression+by+associating+with+the+cadherin%2Fcatenin+adherens+junction+and+modulating+the+beta-catenin+function. assertion.
- assertion asSentence Loss+of+decorin+and+E-cadherin+accelerated+colon+cancer+cell+growth+and+invasion+in+Dcn%28-%2F-%29+mice. assertion.
- assertion asSentence In+senescent+cells%2C+the+DNA+damage+response+induces+proteasomal+degradation+of+G9a+and+GLP%2C+histone+methyltransferases%2C+through+Cdc14B-+and+p21%28Waf1%2FCip1%29-dependent+activation+of+APC%2FC%28Cdh1%29+ubiquitin+ligase. assertion.
- assertion asSentence Snail+interacted+with+G9a+and+recruited+G9a+and+DNA+methyltransferases+to+the+E-cadherin+promoter+for+DNA+methylation. assertion.
- assertion asSentence In+human+melanocytic+tumors%2C+a+causative+role+of+%28loss+of+%29+E-cadherin+or+%28gain+of+%29+N-cadherin+for+melanocytic+tumor+progression+still+remains+to+be+proven. assertion.
- assertion asSentence Active+matrix+metalloproteinase-2+promotes+apoptosis+of+hepatic+stellate+cells+via+the+cleavage+of+cellular+N-cadherin. assertion.
- assertion asSentence Induced+P-cadherin+expression%2C+especially+in+mucosal+damage%2C+leads+to+an+increased+rate+of+crypt+fission%2C+a+common+feature+of+clonal+expansion+in+gastrointestinal+dysplasia. assertion.
- assertion asSentence TNF-alpha+affects+VE-cadherin+gene+expression+on+the+transcriptional+level%2C+inducing+a+downregulation+of+the+VE-cadherin+expression. assertion.
- assertion asSentence VE-cadherin+and+EphA2+act+in+a+coordinated+manner+as+a+key+regulatory+element+in+the+process+of+melanoma+vasculogenic+mimicry. assertion.
- assertion asSentence Mesenchymal+stem+cells+increased+VE-cadherin+levels+and+enhanced+recruitment+of+both+VE-cadherin+and+beta-catenin+to+the+plasma+membrane. assertion.
- assertion asSentence mRNA+levels+of+CD31%2C+CD144%2C+CD146+and+vWf+in+whole+blood+as+detected+by+real+time+RT-PCR+cannot+be+used+as+biomarkers+for+end-stage+endothelial+cells+such+as+circulating+endothelial+cells. assertion.
- assertion asSentence FadA+binds+vascular+endothelial+cadherin+and+alters+endothelial+integrity. assertion.
- assertion asSentence Coating+of+culture+plates+with+recombinant+T-cad+protein+or+with+antibody+against+the+first+amino-terminal+domain+of+T-cad+%28anti-EC1%29+significantly+decreased+adhesion+and+spreading+of+smooth+muscle+cells+and+HUVEC. assertion.
- assertion asSentence T-cadherin+acts+as+an+endogenous+negative+regulator+of+keratinocyte+proliferation+and+its+inactivation+is+the+cause+for+keratinocyte+hyperproliferation+in+squamous+cell+carcinoma+or+in+psoriasis+vulgaris. assertion.
- assertion asSentence Methylation+of+the+promoter+region+of+CDH13+in+patients+with+stage+I+NSCLC+treated+with+curative+intent+by+means+of+surgery+is+associated+with+early+recurrence. assertion.
- assertion asSentence CDH13+gene+methylation+is+associated+with+colorectal+cancer. assertion.
- assertion asSentence CDK2%2Fcyclin+E+is+required+for+Tat-dependent+transcription+in+vitro. assertion.
- assertion asSentence Breast+cancer+cells+lacking+cancer+predisposition+genes+BRCA1+are+more+sensitive+to+CDK2+inhibitors. assertion.
- assertion asSentence cdk2+activity+is+necessary+for+the+survival+of+human+DLBCL. assertion.
- assertion asSentence Disruption+of+Smad2+function+by+CDK2+phosphorylation+acts+as+a+mechanism+for+TGF-beta+resistance+in+multiple+myeloma. assertion.
- assertion asSentence Cellular+production+of+IGFBP-3+leads+to+G1+cell+cycle+arrest+with+inhibition+of+CDK2+and+CDK4. assertion.
- assertion asSentence FUS-DDIT3+and+the+normal+DDIT3+bind+CDK2. assertion.
- assertion asSentence Hr+and+VDR+interact+via+multiple+protein-protein+interfaces%2C+catalyzing+histone+demethylation+to+effect+chromatin+remodeling+and+repress+the+transcription+of+VDR+target+genes+that+control+the+hair+cycle. assertion.
- assertion asSentence Excess+of+MCM3+up-regulates+the+phosphorylation+of+CHK1+Ser-345+and+CDK2+Thr-14. assertion.
- assertion asSentence Rarity+of+CDK4+germline+mutations+in+familial+melanoma. assertion.
- assertion asSentence Expression+levels+of+CDK4+predict+the+cellular+effects+ofmTOIR+inhibitors+in+ovarian+carcinoma. assertion.
- assertion asSentence Variants+are+associated+with+multiple+primary+cutaneous+melanomas+in+a+Norwegian+population. assertion.
- assertion asSentence Cdk5+kinase+supports+the+proliferation+of+the+medullary+thyroid+carcinoma+cells. assertion.
- assertion asSentence CDK5+promoter+polymorphisms+contribute+to+the+genetic+susceptibility+to+lung+cancer+in+the+Korean+population. assertion.
- assertion asSentence Nucleocytoplasmic+cyclin-dependent+kinase%2C+Cdk5%2C+is+involved+in+neuronal+cell+cycle+and+death+in+post-mitotic+neurons. assertion.
- assertion asSentence Cdk5+is+an+important+modulator+of+AR+and+contributes+to+prostate+cancer+growth. assertion.
- assertion asSentence S-nitrosylation+of+Cdk5+contributes+to+amyloid-beta+%28Abeta%29+peptide-induced+dendritic+spine+loss. assertion.
- assertion asSentence CDK5-mediated+hyperphosphorylation+of+SIRT1+facilitates+development+of+endothelial+senescence+and+atherosclerosis. assertion.
- assertion asSentence Overexpression+of+CDK6+correlated+significantly+with+poor+prognosis+and+represented+an+independent+prognostic+marker+of+overall+survival+in+medulloblastoma. assertion.
- assertion asSentence CDK6+delays+senescence+by+kinase-dependent+and+p16INK4a-independent+mechanisms. assertion.
- assertion asSentence MicroRNA+repression+is+associated+with+repression+of+CDK6+in+pancreatic+cancer. assertion.
- assertion asSentence High+CDK6+is+associated+with+gastric+cancer+invasion. assertion.
- assertion asSentence The+cyclin+H%2Fcdk7%2FMat1+kinase+activity+is+regulated+by+CK2+phosphorylation+of+cyclin+H. assertion.
- assertion asSentence Role+in+regulation+of+HIV-1+transcription+elongation+and+histone+methylation. assertion.
- assertion asSentence Cyclin+T1+acetylation+triggers+dissociation+of+Hexim1+and+7SK+snRNA+from+cyclin+T1%2FCDK9+and+activates+the+transcriptional+activity+of+P-TEFb. assertion.
- assertion asSentence Tat+efficiently+replaces+HEXIM1+on+the+7SK+snRNA+in+vivo+and+it+promotes+the+disassembly+of+the+7SK%2FHEXIM%2FP-TEFb+negative+transcriptional+regulatory+snRNP+to+augment+the+nuclear+level+of+active+P-TEFb. assertion.
- assertion asSentence Overexpression+of+p21%28WAF1%2FCIP1%29+is+an+early+event+in+the+development+of+pancreatic+intraepithelial+neoplasia. assertion.
- assertion asSentence The+onset+of+ATRA-induced+G%280%29%2FG%281%29+arrest+of+U-937+cells+is+linked+to+an+increase+in+p21%28WAF1%2FCIP1%29+expression. assertion.
- assertion asSentence Specific+inhibition+of+p21%28Waf1%2FCip1%29+protein+with+the+antisense+oligodeoxynucleotide+markedly+reduces+the+production+and+secretion+of+the+matrix+proteins+fibronectin+and+laminin%2C+both+in+the+presence+and+absence+of+TGF-beta+stimulation. assertion.
- assertion asSentence Expression+of+p21WAF1+is+dependent+on+the+activation+of+ERK+during+vitamin+E-succinate-induced+monocytic+differentiation. assertion.
- assertion asSentence Correlation+of+p21+gene+codon+31+polymorphism+and+TNF-alpha+gene+polymorphism+with+nasopharyngeal+carcinoma. assertion.
- assertion asSentence H%282%29O%282%29-induced+AP-1+activation+and+its+effect+on+p21%28WAF1%2FCIP1%29-mediated+G2%2FM+arrest+in+a+p53-deficient+human+lung+cancer+cell. assertion.
- assertion asSentence Egr1+controls+p21Cip1+expression+by+directly+interacting+with+a+specific+sequence+on+its+gene+promoter. assertion.
- assertion asSentence p21waf1%2Fcip1+is+down-regulated+in+the+lymphocytes+of+rheumatoid+arthritis+patients. assertion.
- assertion asSentence Mutant+p53+can+delay+growth+arrest+in+senescing+fibroblasts+without+reducing+p21%28WAF1%29+expression. assertion.
- assertion asSentence p53RFP%2C+a+p53-inducible+RING-finger+protein%2C+regulates+the+stability+of+p21WAF1. assertion.
- assertion asSentence Exposure+in+vitro+to+hyperoxia+exerts+G%281%29+arrest+through+p53-dependent+induction+of+p21+that+suppresses+Cdk+and+PCNA+activity. assertion.
- assertion asSentence Transactivation+of+the+CIP1+promotor+by+fetal+liver+kinase-3+mutations+involves+stat5+binding+site. assertion.
- assertion asSentence In+human+colon+cancer+cell+lines%2C+HDAC+inhibitors+stimulate+the+p21%28WAF1%29+gene+expression+by+selectively+increasing+the+degree+of+acetylation+of+the+gene-associated+histones. assertion.
- assertion asSentence Temporal+ectopic+expression+of+p21%28Cip1%29+arrested+cell+proliferation%2C+inhibited+Cdk2+and+Cdk4+activities%2C+suppressed+retinoblastoma+phosphorylation+and+arrested+cells+in+both+G1+and+G2+cell+cycle+phases. assertion.
- assertion asSentence Hyperphosphorylated+p21+activates+the+Cdc2+kinase+in+the+G2%2FM+transition. assertion.
- assertion asSentence The+p21%28waf1%2Fcip1%29+gene+is+a+primary+1alpha%2C25%28OH%292D3-responding+gene+with+at+least+three+VDR+binding+promoter+regions%2C+in+two+of+which+also+p53+co-localizes. assertion.