Matches in Nanopublications for { ?s <http://purl.org/nanopub/x/asSentence> ?o ?g. }
- assertion asSentence EGFR-mediated+induction+of+enterocyte+proliferation+requires+MAPK-dependent+increase+in+p21%28waf1%2Fcip1%29+expression+in+intestinal+epithelial+cells. assertion.
- assertion asSentence RNPC1a+is+required+to+maintain+the+stability+of+p21+transcript+induced+by+p53. assertion.
- assertion asSentence Loss+of+p21%28WAF1%29+facilitates+AML1-ETO-induced+leukemogenesis. assertion.
- assertion asSentence p21+is+upregulated+after+radical+prostatectomy+for+prostatic+neoplasms. assertion.
- assertion asSentence p21+has+an+important+role+in+the+cellular+response+to+normal+replicative+stress+and+its+absence+leads+to+a+%22chronic+DNA+damage%22+state+that+primes+the+cell+for+p53-dependent+apoptosis. assertion.
- assertion asSentence The+culture+of+cells+in+the+Cl%28-%29-replaced+medium+significantly+increased+expressions+of+p21+mRNA+and+protein+without+any+effects+on+p53. assertion.
- assertion asSentence CDKN1A+expression+increased+with+increasing+grade+in+meningiomas. assertion.
- assertion asSentence The+procyanidin-mediated+induction+of+apoptosis+and+cell-cycle+arrest+in+esophageal+adenocarcinoma+cells+is+not+dependent+on+p21%28Cip1%2FWAF1%29. assertion.
- assertion asSentence Compounds+which+attenuate+p21+cause+renal+cell+carcinoma+cell+apotosis+and+sensitize+these+cells+to+DNA-damaging+chemotherapy. assertion.
- assertion asSentence Gene+and+protein+expression+of+p53+and+p21+in+fibroadenomas+and+adjacent+normal+mammary+tissue. assertion.
- assertion asSentence The+PKCalpha-ERK1%2F2+cascade+is+involved+in+PMA+induced+up-regulation+of+cyclin+D1+and+P21%28cip1%29+and+proliferation+in+human+airway+smooth+muscle+cells. assertion.
- assertion asSentence NORE1A+activates+p21%28CIP1%29+via+promoting+p53+nuclear+localization. assertion.
- assertion asSentence Loss+of+cip1+protein+is+associated+with+intravesical+recurrence+following+transurethral+resection+in+in+non-muscle-invasive+bladder+cancer. assertion.
- assertion asSentence p21Waf1%2FCip1+gene+expression+is+induced+in+estrogen+responsive+MCF-7+breast+cancer+cells+and+Sp1+is+involved+in+the+recruitment+of+ERa+to+the+p21Waf1%2FCip1+promoter. assertion.
- assertion asSentence Lkb1+heterozygosity+can+accelerate+KrasG12D-induced+pancratic+ductal+adenocarcinoma+formation+through+the+p53%2Fp21+pathway. assertion.
- assertion asSentence High+CDKN1A+is+associated+with+uterine+leiomyomas. assertion.
- assertion asSentence Low+CIP1+expression+is+associated+with+neuroblastoma. assertion.
- assertion asSentence A+total+of+124+of+160+glioma+samples+displayed+CpG+island+hypermethylation+of+both+p73+and+p21+genes+associated+with+the+loss+of+mRNA+expression. assertion.
- assertion asSentence Strategies+to+re-express+epigenetically+silenced+p15%28INK4b%29+and+p21%28WAF1%29+genes+in+acute+myeloid+leukemia. assertion.
- assertion asSentence Suppression+of+Polo+like+kinase+1+%28PLK1%29+by+p21%28Waf1%29+mediates+the+p53-dependent+prevention+of+caspase-independent+mitotic+death. assertion.
- assertion asSentence 4-O-methylhonokiol+causes+p21-mediated+human+colon+cancer+cell+growth+inhibition+through+suppression+of+NF-kappaB. assertion.
- assertion asSentence Zac1+is+able+to+interact+directly+with+the+Sp1-responsive+element+in+the+p21%28WAF1%2FCip1%29+gene+promoter. assertion.
- assertion asSentence Deficiency+of+p21+reduces+Apaf-1+protein+expression+and+inhibits+caspase+activation+in+curcumin-treated+cancer+cells. assertion.
- assertion asSentence Functional+blockade+of+the+voltage-gated+potassium+channel+Kv1.3+mediates+reversion+of+T+effector+to+central+memory+lymphocytes+through+SMAD3%2Fp21cip1+signaling. assertion.
- assertion asSentence Inhibition+of+Notch3+signalling+induces+rhabdomyosarcoma+cell+differentiation+promoting+p38+phosphorylation+and+p21%28Cip1%29+expression+and+hampers+tumour+cell+growth+in+vitro+and+in+vivo. assertion.
- assertion asSentence The+balance+between+cancer+cell+death+and+arrest+after+p21+up-regulation+depends+on+the+specific+effects+of+p21-induced+ROS+on+the+mitochondria. assertion.
- assertion asSentence Genetic+polymorphisms+in+CDKN1A+gene+is+associated+with+autoimmune+disease. assertion.
- assertion asSentence The+activation+of+p21+transcription+required+an+intact+PCAF+HAT+domain. assertion.
- assertion asSentence p27%28Kip1%29+is+phosphorylated+on+serine+10+and+threonine+187+by+human+kinase+interacting+stathmin%2C+a+nuclear+protein+that+binds+the+C-terminal+domain+of+p27%28Kip1%29+and+phosphorylates+S10+in+vitro+and+in+vivo%2C+promoting+its+nuclear+export+to+the+cytoplasm. assertion.
- assertion asSentence Prolonged+adenovirus-mediated+expression+of+p27%28Kip1%29+down-regulates+integrin+alphav+beta5+expression+on+t%282%3B5%29-anaplastic+large+cell+lymphoma+cells. assertion.
- assertion asSentence CDKN1A+and+CDKN1B+variants+are+associated+with+advanced+prostate+cancer. assertion.
- assertion asSentence Hepatocyte+growth+factor+suppresses+HepG2+cell+proliferation+by+directly+increasing+p27+expression+and+indirectly+decreasing+Skp2+expression. assertion.
- assertion asSentence TGF-beta+induces+apoptosis+in+normal+thyrocytes+via+p27+reduction. assertion.
- assertion asSentence The+codon+109+B+allele+of+CDKN1B+is+associated+with+high-grade+breast+tumors. assertion.
- assertion asSentence Jab1+promotes+cell+growth+by+decreasing+p27+level+p8-dependently. assertion.
- assertion asSentence Phosphorylation+by+Src+impairs+the+Cdk2+inhibitory+action+of+p27+and+reduces+its+steady-state+binding+to+cyclin+E-Cdk2+to+facilitate+cyclin+E-Cdk2-dependent+p27+proteolysis. assertion.
- assertion asSentence P27Kip1+is+down-regulated+in+the+endometrium+of+women+with+endometriosis. assertion.
- assertion asSentence Simultaneous+knock-down+of+both+p21+and+p27+significantly+enhanced+doubling+time%2C+clonogenicity+and+cell+cycle+progression+in+a+prostate+cancer+cell+line. assertion.
- assertion asSentence Pim+kinases+promote+cell+cycle+progression+and+tumorigenesis+by+down-regulating+p27%28Kip1%29+expression+at+both+transcriptional+and+posttranslational+levels. assertion.
- assertion asSentence Antitumoral+activities+of+argyrin+A+depend+on+the+prevention+of+p27%28kip1%29+destruction+through+a+potent+inhibition+of+the+proteasome. assertion.
- assertion asSentence p27+promotes+cell+migration+in+metastatic+HCC+cells+through+the+regulation+of+RhoA+activity. assertion.
- assertion asSentence A+high+level+of+p27%28Kip1%29+expression+is+evident+from+early+stages+of+hepatocarcinogenesis. assertion.
- assertion asSentence Reduced+levels+of+p27Kip1+are+assicuated+with+colorectal+cancer. assertion.
- assertion asSentence The+elevation+of+cellular+miR181a+levels+abrogates+the+1%2C25-dihydroxyvitamin+D-induced+increase+in+Cyclin-Dependent+Kinase+Inhibitor+p27+at+both+mRNA+and+protein+levels. assertion.
- assertion asSentence Alteration+of+the+p27%28Kip1%29-interacting+cell-cycle+regulators+appeared+strongly+involved+in+the+progression+of+endometriosis-associated+ovarian+clear+cell+carcinogenesis+through+increasing+cell+proliferative+activity. assertion.
- assertion asSentence Laminarin+sulfate+can+inhibit+the+proliferation%2C+arrest+the+cell+cycle+in+the+S+phase+and+induce+apoptosis+of+prostate+cancer+PC-3+cells+by+increased+expressions+of+PTEN+and+P27kip1. assertion.
- assertion asSentence The+expression+of+the+cyclin-dependent+kinase+inhibitor+p27+is+increased+with+cisplatin+resistance+in+a+human+gastric+cancer+cell+line. assertion.
- assertion asSentence Hypermethylation+does+not+contribute+to+P2%28KIP1%29+silencing+in+gastric+cancer+in+a+northern+Brazil+population. assertion.
- assertion asSentence Differences+in+expression+levels+of+apoptosis-+and+proliferation-controlling+proteins+define+distinct+prognostic+subgroups+of+chronic+lymphocytic+leukemia+and+uncover+a+correlation+of+levels+of+CDK4%2C+P27+and+P53+proteins+with+higher+hierarchical+risk. assertion.
- assertion asSentence p27+down+regulation+following+GSK-3+depletion+%2F+inactivation+plays+a+critical+role+in+promoting+beta-cell+replication. assertion.
- assertion asSentence Loss+of+P27KIP1+is+associated+with+melanoma. assertion.
- assertion asSentence Knockdown+of+the+serine%2Fthreonine+phosphatase+PPM1H+confers+trastuzumab+resistance+via+reduction+in+protein+levels+of+the+tumor+suppressor+p27. assertion.
- assertion asSentence Expression+of+p57kip2%2C+Rb+protein+and+PCNA+and+their+relationships+with+clinicopathology+in+human+pancreatic+cancer. assertion.
- assertion asSentence The+p57%28Kip2%29+control+of+LIMK-1+ultimately+affects+cell+mobility+negatively. assertion.
- assertion asSentence High+levels+of+CDKN1C+expression+are+common+in+human+retinoblastoma+tumors+%28RB%29. assertion.
- assertion asSentence Inactivation+of+p16%2FCDKN2+and+p15%2FMTS2+is+associated+with+prognosis+and+response+to+chemotherapy+in+ovarian+cancer. assertion.
- assertion asSentence Sensor+of+morphological+changes+and+of+short-lived+perturbations+in+cell+cycle+and+in+nucleolar+function. assertion.
- assertion asSentence p16%28INK4a%29+plays+a+role+in+maintaining+homeostasis+during+erythroid+differentiation. assertion.
- assertion asSentence p16INK4A+gene+plays+an+important+role+in+the+pathogenesis+of+hepatocellular+carcinoma. assertion.
- assertion asSentence For+both+p16%28INK4a%29+and+p14%28ARF%29%2C+promoter+methylation+is+the+commonest+mechanism+of+gene+inactivation. assertion.
- assertion asSentence p14ARF+contributes+to+the+p53+DNA+damage+response+following+ionizing+irradiation. assertion.
- assertion asSentence A+role+for+the+p14ARF-Topo+I+complex+in+rRNA+transcription+and%2For+maturation. assertion.
- assertion asSentence MITF+regulates+p16INK4A+expression+in+melanocytes. assertion.
- assertion asSentence ARF+induces+the+ATR-+and+Chk1-dependent+phosphorylation+of+the+RelA+transactivation+domain+at+threonine+505%2C+a+site+required+for+ARF-dependent+repression+of+RelA+transcriptional+activity. assertion.
- assertion asSentence p16+methylation+occurred+in+every+stage+of+leukoplakia+cancerization+and+oral+squamous+cell+carcinoma+progression. assertion.
- assertion asSentence The+A148T+variant+of+the+CDKN2A+gene+is+not+associated+with+melanoma+risk+in+the+French+and+Italian+populations. assertion.
- assertion asSentence The+variation+in+CDKN2A+mutations+is+consistent+with+the+lower+melanoma+incidence+rates+in+Europe+and+higher+rates+of+sporadic+melanoma+in+Australia. assertion.
- assertion asSentence Immunohistochemical+overexpression+of+p16+is+linked+to+the+presence+and+pathologic+grade+of+human+papillomavirus-induced+precancerous+cervical+lesions. assertion.
- assertion asSentence Combined+with+screening+of+K-ras+mutations+and+allelic+losses+of+tumor+suppressors+p16+and+DPC4+represents+a+very+sensitive+approach+in+screening+for+pancreatic+malignancy. assertion.
- assertion asSentence ARF+pathway+is+required+for+the+elimination+of+cells+with+aberrant+CD43+expression. assertion.
- assertion asSentence There+is+more+frequent+p16+hypermethylation+in+mantle+cell+lymphoma+and+p15+or+Rb1+hypermethylation+in+follicular+lymphoma. assertion.
- assertion asSentence There+is+an+increased+melanocytic+nevi+and+nevus+density+in+a+G-34T+CDKN2A%2Fp16+melanoma-prone+pedigree. assertion.
- assertion asSentence Oncolytic+herpes+virus+with+defective+ICP6+specifically+replicates+in+quiescent+cells+with+homozygous+genetic+mutations+in+p16. assertion.
- assertion asSentence Aberrant+BRAF+and+INK4A+functionally+interact+to+promote+growth+and+survival+of+melanoma+cells. assertion.
- assertion asSentence CDKN2A+can+be+implicated+in+the+carcinogenesis+process+of+only+a+subset+of+gastric+neoplasias. assertion.
- assertion asSentence Promoter+hypermethylation+of+the+p16+gene+is+associated+with+poor+prognosis+in+recurrenct+early-stage+hepatocellular+carcinoma. assertion.
- assertion asSentence Phenylhexyl+isothiocyanate+can+reduce+the+methylation+level+of+p16+gene+in+U266+cells. assertion.
- assertion asSentence CDKN2A+CDKN2B+and+ANRIL+is+the+susceptibility+locus+for+coronary+heart+disease+%28CHD%29+and+periodontitis. assertion.
- assertion asSentence Hypermethylation+of+CDKN2A+is+associated+with+acute+lymphoblastic+leukemia+of+childhood. assertion.
- assertion asSentence The+combination+of+L1+and+p16%28INK4a%29+has+a+higher+diagnostic+accuracy+than+L1+or+p16%28INK4a%29+alone+in+diagnosis+of+cervical+lesions. assertion.
- assertion asSentence There+is+over-expression+of+E2F-1+gene+and+deletion+of+p14%28ARF%29+gene+in+the+tumorigenesis+of+the+lung+cancer+in+Gejiu+and+Xuanwei+regions+in+Yunnan+Province. assertion.
- assertion asSentence ANRIL+%28INK4+locus%29+expression+is+associated+with+atherosclerosis+risk+at+chromosome+9p21. assertion.
- assertion asSentence p16INK4A+hypermethylation+is+the+principal+mechanism+of+p16+protein+underexpression+and+plays+an+important+role+in+esophageal+squamous+cell+carcinoma+development. assertion.
- assertion asSentence As2O3+up-regulates+the+expression+of+p16+and+reverses+its+hypermethylation+in+the+lymphoma+cell+line+CA46. assertion.
- assertion asSentence CDKN2A+loss+is+associated+with+diffuse+large+B-cell+lymphomas. assertion.
- assertion asSentence Mutations+in+CDKN2A+is+associated+with+cutaneous+malignant+melanoma. assertion.
- assertion asSentence HBP1+targets+P16%28INK4A%29%2C+upregulating+its+expression+and+consequently+is+involved+in+Ras-induced+premature+senescence. assertion.
- assertion asSentence Hypermethylation+of+P14ARF+is+associated+with+bladder+cancer. assertion.
- assertion asSentence The+pattern+of+the+p14%28ARF%29+expression+is+not+associated+with+the+alterations+of+other+TP53+pathway+members+in+advanced-stage+human+Endometrial+carcinomas. assertion.
- assertion asSentence CDKN2A+mutations+%2For+deletions+are+not+associated+with+gastric+cancers. assertion.
- assertion asSentence Increased+p16%2FCDKN2A+staining+is+strongly+associated+with+high-grade+squamous+neoplasia+in+anal+intraepithelial+neoplasia. assertion.
- assertion asSentence By+epigenetic+silencing+of+the+p16INK4a+gene%2C+complete+inactivation+of+the+locus+is+achieved+via+ubiquitin-mediated+protein+degradation. assertion.
- assertion asSentence p16%28INK4A%29+and+p27%28Kip1%29+are+key+targets+in+the+Atr-dependent+signaling+pathway+in+response+to+UV+damage. assertion.
- assertion asSentence Promoter+hypermethylation+of+p16+occurs+at+an+early+stage+of+cervical+neoplastic+progression. assertion.
- assertion asSentence Increase+in+p16%28INK4a%29+methylation+in+serum+is+associated+with+recurrence+of+colorectal+cancer. assertion.
- assertion asSentence rs10811661+of+CDKN2A%2FB+confers+risk+for+type+2+diabetes. assertion.
- assertion asSentence CDKN2A+p.A148T+is+a+melanoma+susceptibility+allele+in+Southern+Brazil+and+is+particularly+common+in+patients+with+melanoma+of+predominantly+European+ancestry. assertion.
- assertion asSentence High+expression+of+the+p14ARF+gene+is+associated+with+chronic+lymphocytic+leukemia. assertion.
- assertion asSentence Cigarette+smoking+is+positively+correlated+to+p16%28INK4alpha%29+gene+hypermethylation+in+non-small+cell+lung+carcinoma+patients. assertion.
- assertion asSentence The+comparable+frequency+of+methylation+of+p15INK4b+and+p16INK4a+underscores+the+widespread+importance+of+the+mechanism+of+p15INK4b+and%2For+p16INK4a+inactivation+in+the+development+of+oral+carcinomas. assertion.