Matches in Nanopublications for { ?s <http://purl.org/nanopub/x/asSentence> ?o ?g. }
- assertion asSentence Many+different+NBD1+modifications+improve+CFTR-DeltaF508+maturation. assertion.
- assertion asSentence F508del+mutation+in+the+CFTR+gene+respresents+a+risk+factor+for+the+development+of+chronic+pancreatitis. assertion.
- assertion asSentence Dab2+mediates+AP-2+independent+recruitment+of+CFTR+to+CCVs+in+polarized+human+airway+epithelial+cells. assertion.
- assertion asSentence Exposure+of+male+mice+to+chronically+elevated+levels+of+hCG+severely+affects+their+urogenital+tract+function+at+multiple+sites+and+causes+infertility%2C+but%2C+unlike+in+LH%2FhCG+overexpressing+female+mice%2C+it+is+not+tumorigenic. assertion.
- assertion asSentence Chorionic+gonadotropin+promotes+trophoblast+invasion+and+migration+through+activation+of+ERK+and+AKT+signaling+involving+their+downstream+effector+MMP-2. assertion.
- assertion asSentence GnRH+regulation+of+Jun+transcription+and+its+targets+such+as+Cga%2C+requires+a+functional+interaction+between+TCF%2FLEF+and+beta-catenin. assertion.
- assertion asSentence Endometrial+IGF-I+and+-II+are+differentially+regulated+during+decidualization+and+by+human+chorionic+gonadotropin. assertion.
- assertion asSentence Although%2C+beta-hCG+is+expressed+in+the+majority+of+pituitary+adenomas%2C+more+especially+in+NFPA%2C+it+is+un-related+to+the+risk+of+tumour+recurrence+or+cellular+proliferation+as+measured+by+Ki-67+nuclear+labelling. assertion.
- assertion asSentence Median+values+in+pregnant+smokers+versus+nonsmokers+does+not+affect+diagnosis+of+Down+syndrome+in+the+first+trimester. assertion.
- assertion asSentence Serum+hCG-beta+level+12+days+after+embryo+transfer+is+a+useful+predictor+of+subsequent+presence+of+fetal+cardiac+activity+and+live+birth+after+in+vitro+fertilization. assertion.
- assertion asSentence No+relationship+between+pattern+of+cholinergic+deficits+and+distribution+pattern+of+lesions+in+amygdala+of+patients+with+Alzheimer%27s+disease+or+dementia+with+Lewy+bodies. assertion.
- assertion asSentence Alzheimer%27s+disease+nucleus+basalis+forebrain+neurons%2C+hyperinnervated+by+galanin%2C+displays+a+significant+upregulation+in+choline+acetyltransferase. assertion.
- assertion asSentence HSV-1+replication+is+blocked+in+cell+line+tsBN2+encoding+a+temperature+sensitive+RCC1+protein. assertion.
- assertion asSentence Role+of+AKR1C4+in+the+metabolism+of+testosterone+and+progesterone+via+the+5beta-reductase+pathway. assertion.
- assertion asSentence An+ATM-independent+S-phase+checkpoint+response+involves+CHK1+pathway. assertion.
- assertion asSentence The+G2+checkpoint+in+irradiated+human+cells+derives+from+an+overactivation+of+the+ATR%2FCHK1+pathway. assertion.
- assertion asSentence Synthetized+inhibitors+are+synthetically+tractable+and+inhibit+Chk1+by+competing+for+its+ATP+site. assertion.
- assertion asSentence Gene+repair+directed+by+oligonucleotides+activates+a+pathway+that+prevents+corrected+cells+from+proliferating+in+cell+culture+through+the+activation+of+Chk1+and+Chk2. assertion.
- assertion asSentence Chk1+can+be+activated+in+a+claspin-dependent+manner+leading+to+cyclin+B1+down-regulation+and+providing+the+cells+of+an+additional+mechanism+to+inhibit+mitosis+entry+in+Hela+cells. assertion.
- assertion asSentence Chk1+regulates+the+density+of+active+replication+origins+during+the+vertebrate+S+phase. assertion.
- assertion asSentence CHK1+is+a+histone+H3+threonine+11+kinase+that+requires+DNA+damage-induced+transcriptional+repression. assertion.
- assertion asSentence Chk1+affects+Cdc25A+via+rapid+phosphorylation+and+protein+turnover%2C+inhibition+of+Cdc25A+transcription+by+p53-ATF3+is+required+for+the+maintenance+of+cell+cycle+arrest. assertion.
- assertion asSentence A+direct+role+of+Chk1+in+maintaining+normal+hematopoiesis+in+the+bone+marrow. assertion.
- assertion asSentence WRN+is+required+for+the+CHK1-mediated+intra-S-phase+checkpoint. assertion.
- assertion asSentence Human+embryonic+stem+cells+fail+to+activate+CHK1+and+commit+to+apoptosis+in+response+to+DNA+replication+stress. assertion.
- assertion asSentence CHK1+phosphorylation+of+SYK%28L%29+promoted+its+subsequent+proteasomal+degradation. assertion.
- assertion asSentence In+endothelial+cells+VS-1+acts+as+a+cell+penetrating+peptide%2C+binding+to+heparan+sulfate+proteoglycans+%28HSPGs%29+and+activating+eNOS+phosphorylation+%28Ser1179%29+through+a+PI3K-dependent%2C+endocytosis-coupled+mechanism. assertion.
- assertion asSentence Chromogranin+A+is+a+reliable+biomarker+for+gastroenteropancreatic+neuroendocrine+tumors. assertion.
- assertion asSentence NCAM1%2C+SYPT+and+CGA+expressions+are+differently+regulated+by+neuroendocrine+phenotype-specific+transcription+factors+in+lung+cancer+cells. assertion.
- assertion asSentence Role+of+YKL-40+as+a+marker+of+inflammation+in+the+gradually+progressing+vascular+complications+in+patients+with+type+1+diabetes. assertion.
- assertion asSentence YKL-40+is+directly+produced+by+tumor+cells+and+is+inversely+linked+to+EGFR+in+glioblastomas. assertion.
- assertion asSentence Mechanical+stress+potently+induces+CHI3L1+expression+leading+to+increased+secretion+of+YKL-40+protein+in+an+EGFR+and+MEK1%2F2-dependent+pathway. assertion.
- assertion asSentence High+serum+YKL-40+is+associated+with+high-grade+gliomas. assertion.
- assertion asSentence ERK1%2F2+phosphorylation+by+CHI3L1+leads+to+a+proliferative+signal. assertion.
- assertion asSentence Serum+chitotriosidase+enzyme+activity+has+limited+utility+as+a+biomarker+in+Wegener%27s+granulomatosis+patients. assertion.
- assertion asSentence In+vitro+assembly+and+purification+of+the+stoichiometric+ternary+complex+of+RabGGTase+with+REP-1+stabilized+by+a+hydrolysis-resistant+phosphoisoprenoid+analog--farnesyl+phosphonyl%28methyl%29phoshonate. assertion.
- assertion asSentence The+C+terminus+of+the+REP-1+molecule+functions+as+a+mobile+lid+covering+a+conserved+hydrophobic+patch+on+the+surface+of+REP-1+that+in+the+complex+coordinates+the+C+terminus+of+Rab+proteins. assertion.
- assertion asSentence Role+of+M1+and+M2+muscarinic+receptors+expressed+by+human+L+cells+in+the+control+of+GLP-1+secretion. assertion.
- assertion asSentence mRNA+of+muscarinic+acetylcholine+receptor-1+is+expressed+in+human+scleral+fibroblasts. assertion.
- assertion asSentence The+S2+and+S4+polymorphisms+of+CHRM1+are+associated+with+susceptibility+for+developing+high+myopia. assertion.
- assertion asSentence Muscarinic+cholinoceptor+activation+by+pilocarpine+triggers+apoptosis+in+human+skin+fibroblast+cells. assertion.
- assertion asSentence Role+of+M1+and+M2+muscarinic+receptors+expressed+by+human+L+cells+in+the+control+of+GLP-1+secretion. assertion.
- assertion asSentence Associated+with+multiple+single+nucleotide+polymorphisms+across+CHRM2+and+Performance+IQ%2C+as+measured+by+the+Wechsler+Adult+Intelligence+Scale. assertion.
- assertion asSentence R1836X+mutation+in+the+LYST+gene+is+associated+with+Chediak+Higashi+syndrome. assertion.
- assertion asSentence C+allele+as+associated+with+a+reduced+acute+insulin+response+and+modestly+associated+with+increased+risk+of+early-onset+type+2+diabetes+in+Pima+Indians. assertion.
- assertion asSentence Neither+the+linear+M3R+peptide+nor+M3R+transfectants+represent+suitable+tools+for+discrimination+of+pathogenic+from+natural+autoantibodies+in+Sjogren%27s+syndrome. assertion.
- assertion asSentence Use+muscarinic+antagonists+to+demonstrate+that+muscarinic+M3+receptors+mediate+the+excitatory+effects+of+acetylcholine+on+small+intestinal+and+colonic+transit+in+humans. assertion.
- assertion asSentence Muscarinic+acetylcholine+receptor+M3%281q41-q44%29+homozygous+frameshift+mutation+in+familial+congenital+bladder+malformation+associated+with+a+prune-belly-like+syndrome%2C+defining+an+isolated+gene+defect+underlying+this+sometimes+devastating+disease. assertion.
- assertion asSentence Changes+in+nicotinic+acetylcholine+receptor+subunits+expression+in+brain+of+patients+with+Down+syndrome+and+Alzheimer%27s+disease. assertion.
- assertion asSentence The+alpha3+subunit+is+expressed+in+every+terminally+differentiated+ganglionic+cell%2C+this+is+the+first+example+of+a+%22pan-autonomic%22+gene+whose+expression+is+regulated+by+PHOX2+proteins. assertion.
- assertion asSentence Genetic+variation+at+CHRNA5%2FCHRNA3%2FCHRNB4+cluster+influences+blood+nicotine+level. assertion.
- assertion asSentence CHRNA5-CHRNA3-CHRNB4+is+involved+in+the+transition+toward+heavy+smoking+in+mid-adulthood+and+in+smoking+persistence. assertion.
- assertion asSentence CHRNA4%3Ars1044396+genotypes+do+not+significantly+influence+the+attentional+deficit+found+in+PD+patients. assertion.
- assertion asSentence The+alpha5+and+alpha3+subunits+play+a+significant+role+in+both+nicotine+dependence+and+alcohol+abuse%2Fdependence. assertion.
- assertion asSentence Genetic+variant+in+the+CHRNA5-CHRNA3-CHRNB4+gene+cluster+is+associated+with+smoking+cessation+during+pregnancy. assertion.
- assertion asSentence A+variation+in+the+alpha5+subunit+of+nicotinic+acetylcholine+receptors+increases+the+risk+of+nicotine+dependence+and+lung+cancer. assertion.
- assertion asSentence Changes+in+nicotinic+acetylcholine+receptor+subunits+expression+in+brain+of+patients+with+Down+syndrome+and+Alzheimer%27s+disease. assertion.
- assertion asSentence Expression+of+an+alpha7+duplicate+nicotinic+acetylcholine+receptor-related+protein+in+human+leukocytes. assertion.
- assertion asSentence A+comparison+of+alpha7+nAChR+levels+in+lymphocytes+from+Alzeimer+disease+patients+and+control+subjects. assertion.
- assertion asSentence The+uncoupling+between+N-terminal+domain+and+transmembrane+domain%2C+governed+by+the+balance+of+coupling+strength+and+gate+tightness%2C+underlies+the+mechanism+of+desensitization+for+the+alpha7+nAChR. assertion.
- assertion asSentence CHRFAM7A+acts+as+a+dominant+negative+modulator+of+CHRNA7+function+and+is+critical+for+receptor+regulation+in+humans. assertion.
- assertion asSentence Alpha+7+nAChRs+are+functionally+expressed+and+contribute+to+exocytosis+of+secretory+vesicles+in+human+chromaffin+cells. assertion.
- assertion asSentence CHRNA4+and+CHRNB2+do+not+play+a+major+role+in+Japanese+schizophrenia. assertion.
- assertion asSentence CHRNB3+and+CHRNA6+polymorphisms+are+associated+with+smoking+behavior+and+lung+cancer+susceptibility+in+Chinese+Han+population. assertion.
- assertion asSentence Variation+in+the+nicotinic+acetylcholine+receptor+gene+cluster+CHRNA5-CHRNA3-CHRNB4+influences+cognitive+flexibility+differently+in+African+Americans+and+European+Americans. assertion.
- assertion asSentence CHRNA5-CHRNA3-CHRNB4+is+involved+in+the+transition+toward+heavy+smoking+in+mid-adulthood+and+in+smoking+persistence. assertion.
- assertion asSentence TNF-induced+recruitment+and+activation+of+the+IKK+complex+require+Cdc37+and+Hsp90. assertion.
- assertion asSentence Lipopolysaccharide-mediated+interferon+regulatory+factor+activation+involves+TBK1-IKKepsilon-dependent+Lys%2863%29-linked+polyubiquitination+and+phosphorylation+of+TANK%2FI-TRAF. assertion.
- assertion asSentence Notch-1+stimulates+NF-kappaB+activity+in+CaSki+cervical+cancer+cells+by+associating+with+the+IKK+signalosome+through+IKKalpha. assertion.
- assertion asSentence Berberine+modifies+cysteine+179+of+IkappaBalpha+kinase. assertion.
- assertion asSentence SGK1+phosphorylation+of+IkappaB+Kinase+alpha+and+p300+Up-regulates+NF-kappaB+activity+and+increases+N-Methyl-D-aspartate+receptor+NR2A+and+NR2B+expression. assertion.
- assertion asSentence Gamma%281%2934.5+recruits+both+IKKalpha%2Fbeta+and+protein+phosphatase+1%2C+forming+a+complex+that+dephosphorylates+two+serine+residues+within+the+catalytic+domains+of+IkappaB+kinase. assertion.
- assertion asSentence BAG3+promotes+the+emergence+of+castration+resistant+prostate+cancer+by+modulating+IKKalpha+nuclear+translocation. assertion.
- assertion asSentence Polyubiquitination+is+involved+in+HTLV-1+Tax-induced+IKK+alpha%2Fbeta+activation. assertion.
- assertion asSentence The+asymmetric+unit+contained+two+molecules+of+CKB%2C+giving+a+crystal+volume+per+protein+mass+%28Vm%29+of+1.80+A3+Da-1+and+a+solvent+content+of+31.6%25. assertion.
- assertion asSentence Variants+of+CISH+are+associated+with+susceptibility+to+diseases+caused+by+diverse+infectious+pathogens. assertion.
- assertion asSentence The+researchers+found+no+association+between+the+CK+response+after+exercise+and+the+presence+of+the+CK-MM+NcoI+polymorphism. assertion.
- assertion asSentence A+single+troponin+I+value+at+3+days+from+symptom+onset+is+a+better+predictor+of+infarct+size+compared+to+peak+values+and+CK-MB. assertion.
- assertion asSentence Over-expression+of+CKS1B+activates+both+MEK%2FERK+and+JAK%2FSTAT3+signaling+pathways+and+promotes+myeloma+cell+drug-resistance. assertion.
- assertion asSentence AP-2+and+clathrin+participate+in+MHC-II+molecule+trafficking+to+antigen-processing+compartments. assertion.
- assertion asSentence Phosphorylation+of+AP-2+mu2+subunit+is+essential+for+Na%2B%2CK%2B-ATPase+endocytosis+in+response+to+a+variety+of+signals%2C+such+as+dopamine+or+reactive+oxygen+species. assertion.
- assertion asSentence Multiple+interactions+between+PIPKI+gamma-p90+and+AP-2+lead+to+spatiotemporally+controlled+PI%284%2C5%29P%282%29+synthesis+during+clathrin-mediated+synaptic+vesicle+endocytosis. assertion.
- assertion asSentence Isolation+and+description+of+the+rat+and+mouse+genes. assertion.
- assertion asSentence Phenotypic+variability+of+autosomal+dominant+myotonia+congenita+in+a+family+with+muscle+chloride+channel+%28CLCN1%29+mutation. assertion.
- assertion asSentence Statins+and+fenofibrate+affect+skeletal+muscle+chloride+conductance+in+rats+by+differently+impairing+ClC-1+channel+regulation+and+expression. assertion.
- assertion asSentence A+functional+interaction+between+the+ClC-2+chloride+channel+and+the+retrograde+motor+dynein+complex. assertion.
- assertion asSentence ClC-2+plays+an+important+role+in+the+modulation+of+tight+junctions+by+influencing+caveolar+trafficking+of+tight+junction+protein+occludin. assertion.
- assertion asSentence An+essential+role+of+sClC-3+in+native+volume-sensitive+outwardly+rectifying+anion+channels+function+in+mouse+atrial+myocytes. assertion.
- assertion asSentence ClC-5+channel+activity+can+be+restored+for+specific+Dent%27s+mutations+by+expression+of+the+missing+portion+of+the+ClC-5+molecule. assertion.
- assertion asSentence Clusterin+as+a+predictor+for+chemoradiotherapy+sensitivity+and+patient+survival+in+esophageal+squamous+cell+carcinoma. assertion.
- assertion asSentence Clusterin+%28apolipoprotein+J%29%2C+a+molecular+chaperone+that+facilitates+degradation+of+the+copper-ATPases+ATP7A+and+ATP7B. assertion.
- assertion asSentence Participants+with+the+clusterin+risk+genotype+have+higher+brain+activity+than+participants+with+the+protective+allele+in+frontal+and+posterior+cingulate+cortex+and+the+hippocampus%2C+particularly+during+high+memory+demand. assertion.
- assertion asSentence Glycosylated+serum+Apo-J+is+associated+with+hepatocellular+carcinoma. assertion.
- assertion asSentence nCLU+also+exerts+a+strong+anti-migratory%2Fanti-invasive+activity+in+prostate+cancer+cells%2C+by+interfering+with+the+cytoskeletal+components+and+by+decreasing+MMP-2+activity. assertion.
- assertion asSentence Localisation+is+key+for+CLU+physiology%2C+explaining+the+wide+range+of+effects+in+cell+survival+and+transformation. assertion.
- assertion asSentence Clusterin+and+COMMD1+independently+regulate+degradation+of+the+mammalian+copper+ATPases+ATP7A+and+ATP7B. assertion.
- assertion asSentence The+SNP+genotype+pattern+at+the+CLU+gene+is+associated+with+episodic+memory. assertion.
- assertion asSentence Cdc2-like+kinases+and+DNA+topoisomerase+I+regulate+alternative+splicing+of+tissue+factor+in+human+endothelial+cells. assertion.
- assertion asSentence Cdc2-like+kinases+and+DNA+topoisomerase+I+regulate+alternative+splicing+of+tissue+factor+in+human+endothelial+cells. assertion.
- assertion asSentence The+CLN5%2FmRNA+expression+level+reduced+to+45%25+supports+the+existence+of+one+mRNA+non-producing+allele%2C+further+noticeable+at+the+protein+level. assertion.