Matches in Nanopublications for { ?s <http://purl.org/dc/terms/description> ?o ?g. }
- NP122015.RAh4115-Kju4gSa5vPMtWK4HO-aOdnFmlf0TwSUpzSapI130_assertion description "[HLA-DOA mutations were analyzed for association with autoimmune diseases and B-cell leukemias.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine." NP122015.RAh4115-Kju4gSa5vPMtWK4HO-aOdnFmlf0TwSUpzSapI130_provenance.
- NP122021.RAu7k1m4yRchvs1C9Gaipzsna5_0DjxMOfoq13SKiQhKI130_assertion description "[results indicate that the small ubiquitin-like protein 4 (SUMO4) is a more common autoimmune disease gene and a supplementary risk factor to type 1 diabetes ]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine." NP122021.RAu7k1m4yRchvs1C9Gaipzsna5_0DjxMOfoq13SKiQhKI130_provenance.
- NP122028.RAh1BSIT5ubz_x8nip1wPFT6yvb3ICiVvlnUwNPSuW1Cc130_assertion description "[Dcr3 transgenic mice provide a model system for the study of modulatory effect of Dcr3 on host immune response in patients suffering from cancers and autoimmune diseases ]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine." NP122028.RAh1BSIT5ubz_x8nip1wPFT6yvb3ICiVvlnUwNPSuW1Cc130_provenance.
- NP122030.RAgH39RaD4sV7QL7S9eX7N_60g2B1dfPYxDBnOfBaqv9M130_assertion description "[Review discusses clinical significance of different levels of SAP, its role in induction or protection from autoimmunity, and the presence of specific SAP autoantibodies in different autoimmune diseases.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine." NP122030.RAgH39RaD4sV7QL7S9eX7N_60g2B1dfPYxDBnOfBaqv9M130_provenance.
- NP122033.RAhUBDdTpdjWkYxNjiFLLdigs9jF4Je7_jmj4PW5FmBvQ130_assertion description "[These results provide a mechanism by which Fcgamma receptors can elevate circulating BLyS levels and promote autoantibody production in immune complex-mediated autoimmune diseases.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine." NP122033.RAhUBDdTpdjWkYxNjiFLLdigs9jF4Je7_jmj4PW5FmBvQ130_provenance.
- NP122034.RAsR1JTLPnWp0cw4o9TSxOX-9FsFcCoeUV5Zpg7OBoitc130_assertion description "[CD226 Gly307Ser association with multiple autoimmune diseases is reported.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine." NP122034.RAsR1JTLPnWp0cw4o9TSxOX-9FsFcCoeUV5Zpg7OBoitc130_provenance.
- NP122035.RAoamKuwBfbbDzs77g4QN0C7_qacgM8GVjnVleqoaJMW8130_assertion description "[Review/interaction between CD47 and SIRPalpha seems to be important to limit destruction of host cells in autoimmune diseases like autoimmune hemolytic anemia (AIHA), where macrophages destroy antibody or complement opsonized cells.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine." NP122035.RAoamKuwBfbbDzs77g4QN0C7_qacgM8GVjnVleqoaJMW8130_provenance.
- NP122038.RAiAqVc77X-gQYGv4snJdDfeQSkYY-eNL9JFjIB9rQ8D8130_assertion description "[Impaired apoptosis, extended duration of immune responses, and a lupus-like autoimmune disease in IEX-1-transgenic mice.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine." NP122038.RAiAqVc77X-gQYGv4snJdDfeQSkYY-eNL9JFjIB9rQ8D8130_provenance.
- NP122039.RAqFjeCA2V7w6oacZgpnsAWqPWM3iCN7mFTrhq0Xn3nsk130_assertion description "[Review discusses clinical significance of different levels of CRP, its role in induction or protection from autoimmunity, and the presence of specific CRP autoantibodies in different autoimmune diseases.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine." NP122039.RAqFjeCA2V7w6oacZgpnsAWqPWM3iCN7mFTrhq0Xn3nsk130_provenance.
- NP122044.RArUEwyrdIxypy0K2rdDQwHaLYuPzoP_XP9BbiSAqH2ys130_assertion description "[The differential activity of FCGR2B alleles suggests a novel mechanism of FcgammaRIIb regulation that may influence the risk of autoimmune disease.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine." NP122044.RArUEwyrdIxypy0K2rdDQwHaLYuPzoP_XP9BbiSAqH2ys130_provenance.
- NP122050.RAskeGypsTj7amxVbzbEC5fq8vEw3wLWT88w5mFJ6LBB0130_assertion description "[The spinal horn neurons stained with anti-FKBP 12 antibody was significantly decreased in the motor neuron disease cases compared to that in controls.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine." NP122050.RAskeGypsTj7amxVbzbEC5fq8vEw3wLWT88w5mFJ6LBB0130_provenance.
- NP122053.RAgtDc-9LH-SO7i-q_SM4jAPvaHcReRfWWlTJjxXeUzE0130_assertion description "[Spinal muscular atrophy and amyotropic lateral sclerosis patients have decreased SIP 1-alpha and increased SIP 1-beta expression levels compared to normal tissues.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine." NP122053.RAgtDc-9LH-SO7i-q_SM4jAPvaHcReRfWWlTJjxXeUzE0130_provenance.
- NP122057.RAibmbMBm3_f4YSu4nwRXEQqxCTtJh4P9xx2bzIvaR19M130_assertion description "[Endoplasmic reticulum-golgi apparatus pathway is a predominant cellular site of aggregation of mutant SOD1 suggests that secretion could play a key role in pathogenesi of lateral sclerosis.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine." NP122057.RAibmbMBm3_f4YSu4nwRXEQqxCTtJh4P9xx2bzIvaR19M130_provenance.
- NP122060.RAlrloj-38egcT3euv6J2atGOy-P9zE3tnaEPPXmn4QxE130_assertion description "[A novel homozygous mutation in exon 7 (E163K) and a new homozygous mutation (g.168 _ 185dup) in the promoter region of the gene of parkinsonism-dementia-amyotrophic lateral sclerosis complex.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine." NP122060.RAlrloj-38egcT3euv6J2atGOy-P9zE3tnaEPPXmn4QxE130_provenance.
- NP122063.RAiyDCs_2fAkhw3CWcseSJIBNJ_GJkjlUTt43sSLS6we4130_assertion description "[TDP-43 immunoreactivity was detected in the hypoglossal nucleus in all cases of amyotrophic lateral sclerosis, all cases of frontotemporal lobar degeneration and some of cases of primary lateral sclerosis (PLS).]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine." NP122063.RAiyDCs_2fAkhw3CWcseSJIBNJ_GJkjlUTt43sSLS6we4130_provenance.
- NP122070.RAjKo1GzuX8MsVz59ksZtptXSWNocBlMz8l6fWEXu4EEw130_assertion description "[Lateral sclerosis G93A SOD1 amino acid substituted transgenic mice show a metabolic deficit and skeletal muscle hypermetabolism, controlled by a highly energetic diet which extended survival ]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine." NP122070.RAjKo1GzuX8MsVz59ksZtptXSWNocBlMz8l6fWEXu4EEw130_provenance.
- NP122071.RAsgCSZ0rvM1FCNo48WxWczp9Nt8S44XVMze37m8I393c130_assertion description "[The misfolded SOD1s directly perturb axonal transport or impair other functional properties of the dynein motor which may cause motor neuron death in lateral sclerosis.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine." NP122071.RAsgCSZ0rvM1FCNo48WxWczp9Nt8S44XVMze37m8I393c130_provenance.
- NP122072.RArLwPecwaN5NlF8kdsvhu58Htis_wuWzvuK9hibtDGE0130_assertion description "[SMN2 deletions could act as a susceptibility factor for sporadic lower motor neuron disease in adults ]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine." NP122072.RArLwPecwaN5NlF8kdsvhu58Htis_wuWzvuK9hibtDGE0130_provenance.
- NP122073.RAkigwEad6VNQwGQ9HN6OnAf0sNw9egUCRuKRGoknLGDE130_assertion description "[This study suggests that the functional HSPB1 variant may represent a genetic modifier in the pathogenesis of motor neuron disease ]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine." NP122073.RAkigwEad6VNQwGQ9HN6OnAf0sNw9egUCRuKRGoknLGDE130_provenance.
- NP122077.RAk6ZHhp9Wll9ux6GfyiT15ErVRI3IlgcjwJuTuOk6I6w130_assertion description "[detection of fourth allele (epsilon3r) in a Caucasian patient with motor neuron disease ]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine." NP122077.RAk6ZHhp9Wll9ux6GfyiT15ErVRI3IlgcjwJuTuOk6I6w130_provenance.
- NP122078.RAqimp0vBXIeUpuThXjyQKjrfX-DKt5pWynPl71-qdn4w130_assertion description "[We identified a homozygous missense mutation (c.1940 T-- > C [p.647 Phe-- > Ser]) of the Pleckstrin homology domain-containing, family G member 5 gene, PLEKHG5, in families with lower motor neuron disease.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine." NP122078.RAqimp0vBXIeUpuThXjyQKjrfX-DKt5pWynPl71-qdn4w130_provenance.
- NP122083.RAoDzBXGXyaqmkyJZORPFU3SQ_vlxdFDDXDcz8yNJnpOI130_assertion description "[These results indicate that binding to glycogen crucially regulates the stability of AGL and, further, that its ubiquitination may play an important role in the pathophysiology of both Lafora and Cori's disease.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine." NP122083.RAoDzBXGXyaqmkyJZORPFU3SQ_vlxdFDDXDcz8yNJnpOI130_provenance.
- NP122084.RAvrqviDUb4wKyi8U3zNVRqrvKPVNT1Duz0O5tcYxJQyc130_assertion description "[AGL gene mutations may have roles in glycogen storage disease type III ]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine." NP122084.RAvrqviDUb4wKyi8U3zNVRqrvKPVNT1Duz0O5tcYxJQyc130_provenance.
- NP122089.RArqb8upQvHLEVLhWDlw2FkUwS-mNWLCVEnMcL0kmllCc130_assertion description "[Homozygosity for multiple contiguous single-nucleotide polymorphisms as an indicator of large heterozygous deletions: identification of a novel heterozygous 8-kb intragenic deletion (IVS7-19 to IVS15-17) in a patient with glycogen storage disease type II ]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine." NP122089.RArqb8upQvHLEVLhWDlw2FkUwS-mNWLCVEnMcL0kmllCc130_provenance.
- NP122091.RArtFdvJrE7oyDPVRpq4RRQ_ySbTMoIhK1lEcoD739duQ130_assertion description "[Despite a common genotype, patients present with a wide variability in residual enzyme activity, age of appearance of clinical signs and rate of disease progression suggesting other factors in Pompe disease.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine." NP122091.RArtFdvJrE7oyDPVRpq4RRQ_ySbTMoIhK1lEcoD739duQ130_provenance.
- NP122094.RAoxJkly9udjAOGeG6SHjSfoJ28oOyMb_8HJL0gAmuWpw130_assertion description "[mutations in the alpha glucosidase gene is associated with infantile onset glycogen storage disease type II.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine." NP122094.RAoxJkly9udjAOGeG6SHjSfoJ28oOyMb_8HJL0gAmuWpw130_provenance.
- NP122097.RAtmLTYtI-nDb5ZCEEIeiOOcvaSfp8wFd1gJJxRH1LTig130_assertion description "[Acid-alpha-glucosidase activity and specific activity, and lysosomal glycogen content are useful predictors of age of onset in Pompe disease ]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine." NP122097.RAtmLTYtI-nDb5ZCEEIeiOOcvaSfp8wFd1gJJxRH1LTig130_provenance.
- NP122107.RApV2uFff3P0cVgvxw3kvhEVAWHuk0FiFLhfuWA5KhhfQ130_assertion description "[Four novel heterozygous missense mutations were identified in 4 of the 15 patients/in GJA5 may predispose patients to idiopathic atrial fibrillation by impairing gap-junction assembly or electrical coupling.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine." NP122107.RApV2uFff3P0cVgvxw3kvhEVAWHuk0FiFLhfuWA5KhhfQ130_provenance.
- NP122110.RAlyqu-H2SDlbmjbBMfvqxegrYscEki4FPw_seLu2CzMg130_assertion description "[Atrial fibrillation is associated with an increase in the expression of ADAM10 in the heart atrium ]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine." NP122110.RAlyqu-H2SDlbmjbBMfvqxegrYscEki4FPw_seLu2CzMg130_provenance.
- NP122116.RAuH5kkwzz9E4XNklYjcFyGlLdxfrTM0y0xXPn14xUYEI130_assertion description "[Increase in AngII and decrease in substance P after coronary artery bypass grafting may play role in occurrence of postoperative atrial fibrillation.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine." NP122116.RAuH5kkwzz9E4XNklYjcFyGlLdxfrTM0y0xXPn14xUYEI130_provenance.
- NP122118.RAmIbrWyUopHqEOB1Yg9vFGooPaEaD4qJ4yCYkGGKudSs130_assertion description "[Endothelial dysfunction exists in atrial fibrillation and is related to dysfuncion of E selectin levels.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine." NP122118.RAmIbrWyUopHqEOB1Yg9vFGooPaEaD4qJ4yCYkGGKudSs130_provenance.
- NP122119.RArLwXVt-2dT5_U8ZxI3BZ8S1iAGZFrYBPowcvzzCxOo4130_assertion description "[large genomic deletion in RYR2 leads to extended clinical phenotypes eg, sinoatrial node and atrioventricular node dysfunction, atrial fibrillation, atrial standstill, and dilated cardiomyopathy ]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine." NP122119.RArLwXVt-2dT5_U8ZxI3BZ8S1iAGZFrYBPowcvzzCxOo4130_provenance.
- NP122129.RAtZG3JEz77HlKlA8W3YTRKTlD4afjeoWpfSwXwvw9HdE130_assertion description "[Finds an increase in drug failure rates for atrial fibrillation in patients with ACE II, ID, and DD genotypes.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine." NP122129.RAtZG3JEz77HlKlA8W3YTRKTlD4afjeoWpfSwXwvw9HdE130_provenance.
- NP122131.RAkKTAzRb79elUXBThSb1uiuZ_lvleXUfH2Rb0c1vqekQ130_assertion description "[Compared with double noncarriers (angiotensinogen -20aa and ACE II), double heterozygotes (ac-I/D genotype), and double homozygotes (cc-DD) had hazard ratios for atrial fibrillation of 1.2 (0.9-1.6; P = 0.06) and 2.4 (1.4-4.1; P = 0.001).]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine." NP122131.RAkKTAzRb79elUXBThSb1uiuZ_lvleXUfH2Rb0c1vqekQ130_provenance.
- NP122134.RAmJ95TgzZD7zmkiTX3lOnra12u9NbqooYnPoYDhROqGQ130_assertion description "[A novel association between anti-heat shock protein 65 autoantibodies and occurrence of postoperative atrial fibrillation.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine." NP122134.RAmJ95TgzZD7zmkiTX3lOnra12u9NbqooYnPoYDhROqGQ130_provenance.
- NP122137.RAiZsAdAytPYP-AyVAwqps_hOp0Ibj1NQZ6qtvuE-lVBk130_assertion description "[The Ang II/Rac1/STAT3 pathway is an important signaling pathway in the atrial myocardium to mediate atrial structural remodeling, and losartan and statin may be able to reverse Ang II-induced atrial structural remodeling in atrial fibrillation.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine." NP122137.RAiZsAdAytPYP-AyVAwqps_hOp0Ibj1NQZ6qtvuE-lVBk130_provenance.
- NP122142.RAueXxosG5_sSRJhZRUdk5KgupbV_seegG35fyvuaP2WY130_assertion description "[mutation of EMD can underlie X-linked familial atrial fibrillation; Lys37del is associated with epithelial cell emerin deficiency, as in Emery-Dreifuss muscular dystrophy, yet it causes electrical atriomyopathy in the absence of skeletal muscle disease ]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine." NP122142.RAueXxosG5_sSRJhZRUdk5KgupbV_seegG35fyvuaP2WY130_provenance.
- NP122144.RAhFe4Vs_HQFj_r2UD6teENYOeS1FOBqeFeYgIKbVWzE4130_assertion description "[Kir2.1 gain-of-function mutation may have a role in development of familial atrial fibrillation ]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine." NP122144.RAhFe4Vs_HQFj_r2UD6teENYOeS1FOBqeFeYgIKbVWzE4130_provenance.
- NP122147.RAij1jQeLt66zA86HIn2XGKI55eiqnYEpt_krBm0XKSWo130_assertion description "[Heritable SCN5A defects are associated with susceptibility to early-onset DCM and atrial fibrillation/or even identical mutations may lead to heart failure, arrhythmia, or both.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine." NP122147.RAij1jQeLt66zA86HIn2XGKI55eiqnYEpt_krBm0XKSWo130_provenance.
- NP122150.RAhfRmIej1myJysVNj1mOkbL8x7q-kPE-q35xUTkVJSrs130_assertion description "[Compared with double noncarriers (angiotensinogen -20aa and ACE II), double heterozygotes (ac-I/D genotype), and double homozygotes (cc-DD) had hazard ratios for atrial fibrillation of 1.2 (0.9-1.6; P = 0.06) and 2.4 (1.4-4.1; P = 0.001).]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine." NP122150.RAhfRmIej1myJysVNj1mOkbL8x7q-kPE-q35xUTkVJSrs130_provenance.
- NP122152.RAjaWicle8lm41jhFa2BpB1aEMfFgahNPYdbq7piQgExM130_assertion description "[Identified a novel mutation (Arg531Gly) in the PRKAG2 of AMP-activated protein kinase (AMPK) to be responsible for a syndrome associated with ventricular preexcitation and early onset of atrial fibrillation and conduction disease.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine." NP122152.RAjaWicle8lm41jhFa2BpB1aEMfFgahNPYdbq7piQgExM130_provenance.
- NP122165.RAlPVtMLnDkYogUmxmuRdEboXltLmeCAkKoATk2yLOTmc130_assertion description "[Ghrelin, TNF-alpha, and IL-6 may have roles in cyanotic and acyanotic congenital heart disease in children ]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine." NP122165.RAlPVtMLnDkYogUmxmuRdEboXltLmeCAkKoATk2yLOTmc130_provenance.
- NP122167.RAq4Yr7n6ddVU-ooqgP_YnsnQrcQtoXoiBIeOOotahHIw130_assertion description "[Novel point mutation is associated with congenital heart disease.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine." NP122167.RAq4Yr7n6ddVU-ooqgP_YnsnQrcQtoXoiBIeOOotahHIw130_provenance.
- NP122169.RAthoW9XXyMNylbZfcfvYM064QkeyfgsDfcy2ch8vYOEk130_assertion description "[role in congenital heart disease ]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine." NP122169.RAthoW9XXyMNylbZfcfvYM064QkeyfgsDfcy2ch8vYOEk130_provenance.
- NP122173.RAiNgfP1Zj6x--iJxa-W4MrgF-_7JTzNfRROPuPYQy6_s130_assertion description "[Ghrelin, TNF-alpha, and IL-6 may have roles in cyanotic and acyanotic congenital heart disease in children ]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine." NP122173.RAiNgfP1Zj6x--iJxa-W4MrgF-_7JTzNfRROPuPYQy6_s130_provenance.
- NP122175.RAn-A-UD56lFWLaqMxYhPgu4TOkyGOxjZ1zWCOWtpBNSI130_assertion description "[the ET-1 cascade has a role in the development of altered pulmonary vascular tone and reactivity that occurs with congenital heart disease and its repair, following the use of cardiopulmonary bypass [review]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine." NP122175.RAn-A-UD56lFWLaqMxYhPgu4TOkyGOxjZ1zWCOWtpBNSI130_provenance.
- NP122176.RAsCvdQ-3VZ0E7CJPFuRGqTy53LnVU0tv6uT99IVx_D-U130_assertion description "[Presence of the ET-1 genotype (++) in patients with structural heart disease, severe left ventricular dysfunction and malignant ventricular arrhythmias increases the risk for these patients of hemodynamic collapse during these arrhythmias.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine." NP122176.RAsCvdQ-3VZ0E7CJPFuRGqTy53LnVU0tv6uT99IVx_D-U130_provenance.
- NP122179.RAu67MOLWmhcoryVSN_19N_OVfBes6ejxNLcXnB0YSRic130_assertion description "[The A17860G located in 3'flanking sequence of HOXC5 gene is associated with simple congenital heart disease; the haplotype of 3 SNPs may be linked with the susceptible gene of simple CHD.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine." NP122179.RAu67MOLWmhcoryVSN_19N_OVfBes6ejxNLcXnB0YSRic130_provenance.
- NP122181.RAiUT_RWLk0HDHQ6oZPgioxGiBBV8_ghP4NFjmj5hq2mk130_assertion description "[findings are useful in understanding the prevalence of GATA4 mutations and the correlation between the GATA4 genotype and the congenital heart disease phenotype in Chinese patients ]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine." NP122181.RAiUT_RWLk0HDHQ6oZPgioxGiBBV8_ghP4NFjmj5hq2mk130_provenance.
- NP122192.RAsmxnv9cC40SmT7-6J3z3OWspt9SFq84S68TaCbZgPNo130_assertion description "[The APOE epsilon2 allele was in linkage disequilibrium with the -427C allele in atherosclerosis diseases, and the -219T allele was associated with the epsilon4 allele in the ischemia heart disease group.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine." NP122192.RAsmxnv9cC40SmT7-6J3z3OWspt9SFq84S68TaCbZgPNo130_provenance.
- NP122202.RAl1Fn880MfnpBEnqdAW-iasqvKhctBDOltDCNBDkUC6c130_assertion description "[Role of thrombomodul in the pathogenesis of coagulopathy or thrombosis in cyanotic congenital heart disease ]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine." NP122202.RAl1Fn880MfnpBEnqdAW-iasqvKhctBDOltDCNBDkUC6c130_provenance.
- NP122206.RAiDtLj05lY1e_lKgGLb8yrd1tppaRrybi2N-BE4u1AkU130_assertion description "[expression of titin isoforms switch in ischemic human heart disease ]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine." NP122206.RAiDtLj05lY1e_lKgGLb8yrd1tppaRrybi2N-BE4u1AkU130_provenance.
- NP122215.RArpBw78N579-d5dcS5CYjM-tp0PBB-nUaqm33us4MPVw130_assertion description "[E150K opsin is partially colocalized with the cis/medial Golgi compartment but not with the trans-Golgi network; results are consistent with recessive pattern of inheritance; retinal degeneration results from deficient export of opsin from the Golgi ]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine." NP122215.RArpBw78N579-d5dcS5CYjM-tp0PBB-nUaqm33us4MPVw130_provenance.
- NP122217.RAp-xZ9ONJwufPkI6Ugjb-Em5uEXaXIsBGNzvQmqJQVIw130_assertion description "[The cardinal feature of retinal degeneration in BBS1 can show a wide spectrum of disease expression.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine." NP122217.RAp-xZ9ONJwufPkI6Ugjb-Em5uEXaXIsBGNzvQmqJQVIw130_provenance.
- NP122220.RAn8RCjYSG25w0QfrcX_Hi3fwqSfCTeD-QxOBtkaQKnys130_assertion description "[A mutation in this gene causes X-linked cone dystrophy/type of hereditary retinal degeneration is distinct from retinitis pigmentosa.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine." NP122220.RAn8RCjYSG25w0QfrcX_Hi3fwqSfCTeD-QxOBtkaQKnys130_provenance.
- NP122226.RAvynLNOiB7axO92PieAm5jE0J8xTNtyip9Fytr09BByY130_assertion description "[Polyglutamine-expanded ataxin-7 inhibits STAGA histone acetyltransferase activity to produce retinal degeneration in Spinocerebellar ataxia type 7.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine." NP122226.RAvynLNOiB7axO92PieAm5jE0J8xTNtyip9Fytr09BByY130_provenance.
- NP122236.RAgDXl-2gKfv7zwKuf9vxgfGKFEbeK_xSRW4Rl_3AuxEQ130_assertion description "[Deletion in the pre-mRNA splicing gene PRPF31 causes autosomal dominant retinitis pigmentosa ]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine." NP122236.RAgDXl-2gKfv7zwKuf9vxgfGKFEbeK_xSRW4Rl_3AuxEQ130_provenance.
- NP122237.RAihHrLfD1c6DIpvihhiYASiHQoaFgrzwFsbcL3y39Jug130_assertion description "[A novel splice site mutation in the PRPF31 gene caused retinitis pigmentosa (RP) in the four-generation Chinese RP family.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine." NP122237.RAihHrLfD1c6DIpvihhiYASiHQoaFgrzwFsbcL3y39Jug130_provenance.
- NP122239.RAsgc5lz0sNc3bq8bwL7M1sSimVYAhtyHVDxFf0IzfZZk130_assertion description "[RHO, PRPF31, RP1, and IMPDH1 were screened and causative mutations were identifiedin 4% of isolated and 2% of autosomal dominant forms of retinitis pigmentosa patients from India.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine." NP122239.RAsgc5lz0sNc3bq8bwL7M1sSimVYAhtyHVDxFf0IzfZZk130_provenance.
- NP122244.RAqbNDAeOaouEv8mKU1im77UDkCIwr7_p65in3_3IONkA130_assertion description "[Six of 12 families had an RHO mutation/mutation V345M and the novel mutation 1003delG both caused classical Retinitis Pigmentosa.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine." NP122244.RAqbNDAeOaouEv8mKU1im77UDkCIwr7_p65in3_3IONkA130_provenance.
- NP122246.RAr8HSRzrLx2-glhnriOUcMsxOHo3I3IH4ATWjRoRBrRc130_assertion description "[Frequency and pattern of rhodopsin point mutations in Chinese patients with autosomal dominant retinitis pigmentosa.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine." NP122246.RAr8HSRzrLx2-glhnriOUcMsxOHo3I3IH4ATWjRoRBrRc130_provenance.
- NP122248.RAiEqKqRJ41E-8CNrxOHMn5f06SoKnJgDHcmrxjib28rQ130_assertion description "[Our results demonstrate that mutations in PRPF31 gene affect rhodopsin (RHO) pre-mRNA splicing and reveal a link between PRPF31 and RHO, two major genes in autosomal dominant retinitis pigmentosa.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine." NP122248.RAiEqKqRJ41E-8CNrxOHMn5f06SoKnJgDHcmrxjib28rQ130_provenance.
- NP122250.RAoShuPM9SAbzvpmxmudJa6erb5iMGNQ1ht-zDcCahsEM130_assertion description "[A homozygous rhodopsin splice-site mutation is associated with retinitis pigmentosa ]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine." NP122250.RAoShuPM9SAbzvpmxmudJa6erb5iMGNQ1ht-zDcCahsEM130_provenance.
- NP122252.RAijoVHvr3JQ-67Y9AQA7Grz7A8sBbP9n-CXywPvXkdF4130_assertion description "[is a truncated thioredoxin-like protein specifically expressed by photoreceptors/identification of this protein offers new treatment possibilities for retinitis pigmentosa ]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine." NP122252.RAijoVHvr3JQ-67Y9AQA7Grz7A8sBbP9n-CXywPvXkdF4130_provenance.
- NP122261.RAmNLTXAovMS2TAy3DiYUvgcSWt3umAdMAJ7r-ex9rBoQ130_assertion description "[We identified and characterised an endemic form of early onset rod-cone dystrophy in a consanguineous population from northeastern Tunisia, due to the prevalence of a single RPE65 mutation.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine." NP122261.RAmNLTXAovMS2TAy3DiYUvgcSWt3umAdMAJ7r-ex9rBoQ130_provenance.
- NP122264.RAsR9aM5Vgq9J4yW7PhmeoceIgZNhLKPCUnUrIH1Lz4KQ130_assertion description "[Associated with retinitis pigmentosa in all hemizygous males and four of five heterozygous female carriers in Chinese family/results revealed broader xlRP genotypic and phenotypic spectrum of RPGR mutations.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine." NP122264.RAsR9aM5Vgq9J4yW7PhmeoceIgZNhLKPCUnUrIH1Lz4KQ130_provenance.
- NP122266.RAtnQ9I6NC9Oc_q5BBcqnAeY_EV1pXxnDWoATlrua_jNg130_assertion description "[26 new mutations in RP2 and RPGR patients with X-linked Retinitis Pigmentosa.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine." NP122266.RAtnQ9I6NC9Oc_q5BBcqnAeY_EV1pXxnDWoATlrua_jNg130_provenance.
- NP122273.RAnk1qsNu6HGRIIfi_2Hc_Dr3N9wT8jeLbOLHgzYxNGmk130_assertion description "[These results provide strong evidence that mutations in RP1 can result in recessive as well as dominant retinitis pigmentosa.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine." NP122273.RAnk1qsNu6HGRIIfi_2Hc_Dr3N9wT8jeLbOLHgzYxNGmk130_provenance.
- NP122282.RAkdNJ8m0VNx2pK0FU8byZ2_AMT7_idmAA16v865UudZ0130_assertion description "[A missense mutation in this isozyme causes human autosomal retinitis pigmentosa.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine." NP122282.RAkdNJ8m0VNx2pK0FU8byZ2_AMT7_idmAA16v865UudZ0130_provenance.
- NP122293.RAtnSoaeOFcvMNvyFXTPKru-K_wrbjDRnhDbZqeJ0VTFQ130_assertion description "[Mutations in the gene for topoisomerase I-binding RS protein (TOPORS) in patients with autosomal dominant retinitis pigmentosa (adRP) linked to chromosome 9p21.1 (locus RP31), is reported.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine." NP122293.RAtnSoaeOFcvMNvyFXTPKru-K_wrbjDRnhDbZqeJ0VTFQ130_provenance.
- NP122294.RAidJ5VfETfcmfch8dNyYxVGG4gZq6x7xYSozuWcb7Ado130_assertion description "[Point mutations and small insertions or deletions in TOPORS cause approximately 1% of autosomal dominant retinitis pigmentosa.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine." NP122294.RAidJ5VfETfcmfch8dNyYxVGG4gZq6x7xYSozuWcb7Ado130_provenance.
- NP122296.RAhyn90bFCoexpXvCoUNn4W-nj-iUXUSTuXwKTBWGfDm0130_assertion description "[On average, USH2A patients lose visual acuity faster than rhodopsin patients and slower than (retinitis pigmentosa GTPase regulator) RPGR patients.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine." NP122296.RAhyn90bFCoexpXvCoUNn4W-nj-iUXUSTuXwKTBWGfDm0130_provenance.
- NP122300.RAvj2edfUWO7nO5iMf2kk9KA_T0j84awxchnMmAVWaQQs130_assertion description "[EYS is identified as a human ortholog of Drosopbhila eys, which is mutated in patients with retinitis pigmentosa.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine." NP122300.RAvj2edfUWO7nO5iMf2kk9KA_T0j84awxchnMmAVWaQQs130_provenance.
- NP122314.RAic1OQ2PjWbvT3hvIszdMPTTGRFzm6YeDdqEHt5wQBss130_assertion description "[Gain-of-function mutations in the NRL gene cause autosomal dominant retinitis pigmentosa [RP]while loss-of-function mutations cause autosomal recessive RP/phosphorylation of NRL fine-tunes its transcriptional regulatory activity.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine." NP122314.RAic1OQ2PjWbvT3hvIszdMPTTGRFzm6YeDdqEHt5wQBss130_provenance.
- NP122315.RApjY_iVCtOePOWD3O7MG0DSRE5RxJE6PJ2n6iljDFivc130_assertion description "[The mutation 358C-- > T is useful in analyzing the function of RP2 protein and gene diagnosis of X-linked retinitis pigmentosa (XLRP).]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine." NP122315.RApjY_iVCtOePOWD3O7MG0DSRE5RxJE6PJ2n6iljDFivc130_provenance.
- NP122320.RAmizzgJLt_XHbzpLq01vsyObnxgwMJz5B8R9wFfJrllQ130_assertion description "[This 30 kb deletion contains the exons coding for the RCC1-like domain of RPGR/is the first report of a macrodeletion that spans the entire RCC1-like domain of RPGR in X-linked retinitis pigmentosa patients ]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine." NP122320.RAmizzgJLt_XHbzpLq01vsyObnxgwMJz5B8R9wFfJrllQ130_provenance.
- NP122330.RAntdEhHqoCi2jtWGzmBJ-qAGyjRXW5R9gvCJz7XZihA4130_assertion description "[analysis of a homozygous mutation in exon 13 of inversin (INVS) (C2719T, R907X) in a patient with retinitis pigmentosa and renal failure [case report]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine." NP122330.RAntdEhHqoCi2jtWGzmBJ-qAGyjRXW5R9gvCJz7XZihA4130_provenance.
- NP122332.RAiuT24X5fW9kXqbljcbm4lpar_Pb9ZCn9ZAWCnQaQNBw130_assertion description "[Gly56Arg mutation in NR2E3 accounts for approximately 1%-2% of adRP, making it one of the more common single mutations in autosomal dominant retinitis pigmentosa.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine." NP122332.RAiuT24X5fW9kXqbljcbm4lpar_Pb9ZCn9ZAWCnQaQNBw130_provenance.
- NP122337.RAi-m5kYDLkQbjzk5vXJsYp9hKdnF7-MWuP9DN3_uZc6o130_assertion description "[patients with mutations in CDH23 display a wide range of hearing loss and retinitis pigmentosa phenotypes ]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine." NP122337.RAi-m5kYDLkQbjzk5vXJsYp9hKdnF7-MWuP9DN3_uZc6o130_provenance.
- NP122338.RAkWxKk-72V0YCR03Lr83paQ6FB7DwP7PLrHlnVQIb7LM130_assertion description "[AIPL1, CRB1, GUCY2D, RPE65, and RPGRIP1 mutations may have roles in juvenile retinitis pigmentosa ]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine." NP122338.RAkWxKk-72V0YCR03Lr83paQ6FB7DwP7PLrHlnVQIb7LM130_provenance.
- NP122340.RAvv7L29AVZqG_oUG_B82LHDagZtCpYw9q0uwHMRaG624130_assertion description "[Phenotype-genotype correlations of AIPL1-associated Leber's congenital amaurosis (LCA) ]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine." NP122340.RAvv7L29AVZqG_oUG_B82LHDagZtCpYw9q0uwHMRaG624130_provenance.
- NP122344.RAgQBmrQfJHmZUk-RUG-ALwPaWH5QMhrXyp5x6RZXRP00130_assertion description "[The demonstration that mutations in a gene previously associated with recessive Leber congenital amaurosis can also cause dominant RP illustrates the wide phenotypic variability of retinal degeneration genes.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine." NP122344.RAgQBmrQfJHmZUk-RUG-ALwPaWH5QMhrXyp5x6RZXRP00130_provenance.
- NP122347.RAiUDtCf56MI8M9XdUlfbeTPIasglb0YaGAv5TaSbzAJo130_assertion description "[LCA (leber congenital amaurosis) is caused by the modifying effect of a heterozygous GUCY2D mutation observed against the disease background of a homozygous RPE65 mutation.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine." NP122347.RAiUDtCf56MI8M9XdUlfbeTPIasglb0YaGAv5TaSbzAJo130_provenance.
- NP122349.RAr4ZO_Aclr2SyeTKM13qrVsiinlyX5rL0sQE4P9-LUuQ130_assertion description "[CEP290 mutations represent one of the most frequent causes of Leber congenital amaurosis identified so far.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine." NP122349.RAr4ZO_Aclr2SyeTKM13qrVsiinlyX5rL0sQE4P9-LUuQ130_provenance.
- NP122350.RArnSwb_V71r3auU8IqswH1xE683jJOBTTjqzHzR9Jl4I130_assertion description "[multiplex PCR follwed by sequencing to screen for mutations in the 14 exons of the RPE65 gene in early-childhood-onset autosomal recessive retinitis pigmentosa and Leber's congenital amaurosis patients ]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine." NP122350.RArnSwb_V71r3auU8IqswH1xE683jJOBTTjqzHzR9Jl4I130_provenance.
- NP122351.RAi2T6MpK4o1SFhQ-7PM7Fcf5h433UU566AgZfZRnW0vI130_assertion description "[Mutations in the RPE65 gene are rare in patients with leber congenital amaurosis ]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine." NP122351.RAi2T6MpK4o1SFhQ-7PM7Fcf5h433UU566AgZfZRnW0vI130_provenance.
- NP122352.RAnsBGagaG-y9JDqYyU36cWxhPUKo_cRM-GUwebrwA_Sk130_assertion description "[novel mutations in patients with Leber congenital amaurosis ]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine." NP122352.RAnsBGagaG-y9JDqYyU36cWxhPUKo_cRM-GUwebrwA_Sk130_provenance.
- NP122356.RAjr4Vk3A35vOxfcNhYV9ruTU07J8kskqG91zC19bXPZU130_assertion description "[Recessive retinitis pigmentosa and Leber congenital amaurosis are rarely if ever associated with changes in the ELOVL4 gene.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine." NP122356.RAjr4Vk3A35vOxfcNhYV9ruTU07J8kskqG91zC19bXPZU130_provenance.
- NP122362.RAqhNF-xS1zyc50gUcdH68qEO_ZcT51f0jAyeKYkVl1Y8130_assertion description "[Two patients with Leber congenital amaurosis who carried heterozygously one of two novel frameshift mutations.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine." NP122362.RAqhNF-xS1zyc50gUcdH68qEO_ZcT51f0jAyeKYkVl1Y8130_provenance.
- NP122363.RAirv69u4UEa7zB7LyJDwysRz--G7SYbIrVqiBsKioZlM130_assertion description "[interaction between NUB1 and AIPL1 is affected in patients with Leber congenital amaurosis ]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine." NP122363.RAirv69u4UEa7zB7LyJDwysRz--G7SYbIrVqiBsKioZlM130_provenance.
- NP122365.RAgA5gVKbbGVyaGrxFjPVkpauhjvxM07NF71tVgZGjrJg130_assertion description "[RPE65 replacement in two human trials with a total of six LCA (Leber congenital amaurosis) patients were documented by visual acuity measurements.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine." NP122365.RAgA5gVKbbGVyaGrxFjPVkpauhjvxM07NF71tVgZGjrJg130_provenance.
- NP122369.RApJU-wjEMWbVKfZSppqZtr7yLVO_YiXrChnVOjGkTnQk130_assertion description "[three siblings of congenital disorder of glycosylation type 1a are compound heterozygotes for R141H and L32R mutations in the PMM2 gene.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine." NP122369.RApJU-wjEMWbVKfZSppqZtr7yLVO_YiXrChnVOjGkTnQk130_provenance.
- NP122375.RAj5gxQBOEALcESX5NHxPHhWLBkMqCWRJawRQWPXR3UBE130_assertion description "[deficiency results in congenital disorders of glycosylation type Ig ]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine." NP122375.RAj5gxQBOEALcESX5NHxPHhWLBkMqCWRJawRQWPXR3UBE130_provenance.
- NP122381.RAjKjT2Hq9-h4nOf9tpNtuuZr-bbNao0RKTwSy2EMi0vQ130_assertion description "[aspartylglucosaminidase may have a role in development of congenital disorders of glycosylation type I ]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine." NP122381.RAjKjT2Hq9-h4nOf9tpNtuuZr-bbNao0RKTwSy2EMi0vQ130_provenance.
- NP122386.RAtcgreFUVhGitdTNK8TSn8hXIfIyYKGk8HUwV7NC0zOc130_assertion description "[Dimeric bond clusters of LFA-1/intercellular adhesion molecule-1 (ICAM-1) provide a key outside-in signal for orienting cytoskeletal dynamics that direct neutrophil extravasation at sites of inflammation.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine." NP122386.RAtcgreFUVhGitdTNK8TSn8hXIfIyYKGk8HUwV7NC0zOc130_provenance.
- NP122387.RAtda62T9LUsiKXDDQyVcp2Wp_MW-1T_U0JUbIK-57JB4130_assertion description "[Increased expression of mucosal SOCS3, but not of SOCS1, may play a critical role in the development of the colonic inflammation of ulcerative colitis.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine." NP122387.RAtda62T9LUsiKXDDQyVcp2Wp_MW-1T_U0JUbIK-57JB4130_provenance.
- NP122390.RAkP0aegqH9x1de7t4JJfWQvThZsdcQPn0dWKhCpLC5Fo130_assertion description "[Increased CYP7B activity leads to higher levels of 7alpha-OH-DHEA in synovial fluid which may contribute to the maintenance of chronic inflammation observed in rheumatoid arthritis patients.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine." NP122390.RAkP0aegqH9x1de7t4JJfWQvThZsdcQPn0dWKhCpLC5Fo130_provenance.
- NP122392.RAqJjvx7p6ad6oPifMZEIhIMX1L3gg3Uej0E7BbssHWrY130_assertion description "[Low levels of IL-17 in combination with IL-1 beta can act on myoblasts and muscle tissue leading to the expression or production of factors involved in muscle inflammation.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine." NP122392.RAqJjvx7p6ad6oPifMZEIhIMX1L3gg3Uej0E7BbssHWrY130_provenance.
- NP122394.RAvSm6YMreoRqk0ScbvevRF4QiG-d0gJ4E4ZtRXpLg3ZI130_assertion description "[RORgamma controls IL-17A and IL-17F production, and these cytokines have a redundant but highly pathogenic role in gut inflammation.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine." NP122394.RAvSm6YMreoRqk0ScbvevRF4QiG-d0gJ4E4ZtRXpLg3ZI130_provenance.
- NP122395.RAmzmoBklNQ91al3fX7sLRrdk8fj2mgUbCLct8XB6vv_4130_assertion description "[Levels of IL-23, IL-17, and IFN-gamma are elevated in Behcet disease (BD) with active uveitis// IL-17 pathway together with IFN-gamma is associated with active intraocular inflammation in BD patients.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine." NP122395.RAmzmoBklNQ91al3fX7sLRrdk8fj2mgUbCLct8XB6vv_4130_provenance.