Matches in Nanopublications for { ?s <http://purl.org/nanopub/x/asSentence> ?o ?g. }
- assertion asSentence Nuclear+CHC+is+required+for+the+transactivation+of+p53+target+genes+and+plays+a+distinct+role+from+clathrin-mediated+endocytosis. assertion.
- assertion asSentence The+clathrin+inhibitor+phenylarsine+oxide+prevented+SubAB+entry+and+BiP+cleavage+in+SubAB-treated+Vero%2C+HeLa+and+N2A+cells+demonstrating+that+SubAB+internalization+is+clathrin-dependent. assertion.
- assertion asSentence The+levels+of+tryptase+and+chymase+expression+are+greatly+increased+in+human+lung+tissue+of+anaphylactic+shock. assertion.
- assertion asSentence LZIP+binds+to+CCR1+and+the+interaction+between+CCR1+and+LZIP+participates+in+regulation+of+Lkn-1-dependent+cell+migration+without+affecting+the+chemotactic+activities+of+other+CC+chemokines+that+bind+to+CCR1. assertion.
- assertion asSentence The+expression+of+chemokine+receptor+CCR1+is+higher+in+the+orbital+fibroblasts+of+patients+with+thyroid+associated+ophthalmopathy+than+in+normal+controls. assertion.
- assertion asSentence Single+nucleotide+polymorphism+is+not+associated+with+atopic+dermatitis+in+Japanese. assertion.
- assertion asSentence GATA-1+controls+CCR3+transcription+by+interacting+dynamically+with+multiple+GATA+sites+in+the+regulatory+region+of+the+CCR3+gene. assertion.
- assertion asSentence CCR4+is+expressed+with+high+frequency+in+adult+T-cell+leukemia+and+human+T-cell+leukemia+virus+type+1-transformed+T+cells+and+in+ATL+skin+lesions. assertion.
- assertion asSentence Cholesterol+is+essential+for+macrophage+inflammatory+protein+1+beta+binding+and+signaling+and+conformational+integrity+of+CC+chemokine+receptor+5. assertion.
- assertion asSentence Frequency+of+the+HIV-protective+CC+chemokine+receptor+5-Delta32%2FDelta32+genotype+is+increased+in+hepatitis+C. assertion.
- assertion asSentence In+the+absence+of+any+stimulation%2C+human+fetal+astrocytes+express+mRNA+for+CCR5+receptor. assertion.
- assertion asSentence Mu-opioid+modulates+HIV-1+coreceptor+expression+and+HIV-1+replication. assertion.
- assertion asSentence CCR5+deletion+is+not+common+in+mexican+populations+and+does+not+support+an+important+role+in+the+pathogenesis+of+development+of+severe+rheumatoid+arthritis. assertion.
- assertion asSentence Macrophages+are+activated+through+CCR5-+and+CXCR4-mediated+HIV+gp120-elicited+signaling+pathways. assertion.
- assertion asSentence Plays+an+important+role+in+lymphocyte+trafficking+to+CSF+during+HIV-1+infection. assertion.
- assertion asSentence CCR5+receptors+polymorphism+is+associated+with+the+risk+of+developing+abdominal+aortic+aneurysm+and+arterial+occlusive+diseases. assertion.
- assertion asSentence Recruitment+of+T+cells+expressing+CCR5+into+the+invasive+margin+of+colorectal+cancer. assertion.
- assertion asSentence Strong+association+between+CCR5+haplotype+HHC+and+persistent+lung+involvement+in+sarcoidosis. assertion.
- assertion asSentence The+CCR532+variant+confers+acute+myocardial+infarction+resistance+and+promotes+longevity+in+Sicilians. assertion.
- assertion asSentence CCR5-delta32+mutation+protects+against+nonatopic+asthma. assertion.
- assertion asSentence C1-C4+region+of+HIV2+SU+glycoprotein+impairs+utilization+of+the+CCR5+and+CXCR4+for+viral+entry. assertion.
- assertion asSentence CCR5+Delta+32+polymorphism+attenuates+the+adverse+effects+of+inflammation+on+overall+and+cardiovascular+mortality+in+ESRD. assertion.
- assertion asSentence The+combination+of+primary+sclerosing+cholangitis+and+CCR5-Delta32+in+recipients+is+strongly+associated+with+the+development+of+nonanastomotic+biliary+strictures+after+liver+transplantation. assertion.
- assertion asSentence Reduced+CCR5+expression+in+circulating+immune-damaged+lymphocytes+during+epilepsy+reflects+interfering+RNA+of+viral+vector+which+targets+CCR5+and+alters+lymphocyte+adhesion+to+microvasculature%2C+preventing+cell+participation+in+inflammatory+processes. assertion.
- assertion asSentence Maraviroc+inserts+deeply+in+CCR5+transmembrane+cavity+where+it+can+occupy+three+different+binding+sites. assertion.
- assertion asSentence The+Delta32+CCR5+allele+is+associated+with+a+reduction+of+the+risk+of+all-cause+mortality+in+HIV+%28%2B%29+patients. assertion.
- assertion asSentence Progesterone+participates+in+the+acquisition+and+progression+of+HIV-1+infection+by+modulating+CCR5+and+CXCR4+expression. assertion.
- assertion asSentence Key+role+of+CCL5%2FCCR5+in+the+invasiveness+of+basal+breast+cancer+cells. assertion.
- assertion asSentence Inhibition+of+retinoblastoma+protein+activity+in+HIV-1+R5+viral-exposed+monocytes+leads+to+increased+apoptosis+sensitivity. assertion.
- assertion asSentence Clustering+of+CCR6+and+coassociation+with+critical+integrins+such+as+CD18%2Fbeta2+integrin+serve+to+strengthen+adhesion+between+T+cells+and+activated+dermal+microvascular+endothelial+cells+in+vitro. assertion.
- assertion asSentence Expression+levels+of+CCR6+in+prostate+cancer+are+associated+with+clinical+and+pathologic+features+of+more+advanced+and+aggressive+prostate+cancer. assertion.
- assertion asSentence The+CCR6-CCL20+axis+in+the+choroid+plexus+controls+immune+surveillance+of+the+CNS. assertion.
- assertion asSentence CCR6+ligands+inhibit+HIV+by+inducing+APOBEC3G. assertion.
- assertion asSentence The+tested+CCR6+gene+polymorphisms+are+not+associated+with+the+susceptibility+to+Behcet%27s+disease+in+the+tested+Chinese+Han+populations. assertion.
- assertion asSentence CCR7+induces+lymph+node+metastasis+of+non-small+cell+lung+cancer+via+upregulating+MMP-9+expression. assertion.
- assertion asSentence Plasmacytoid+dendritic+cells+%28pDCs%29+constitutively+migrate+into+the+splenic+white+pulp+in+a+manner+dependent+on+chemokine+receptors+CCR7+and+CXCR4. assertion.
- assertion asSentence CCR8+is+expressed+by+a+small+and+heterogeneous+population+of+peripheral+blood+CD4+memory+T+cells+enriched+in+T+helper+type+2+%28Th2%29+effector+and+T+regulatory+%28Treg%29+cells. assertion.
- assertion asSentence Leukotriene+B%284%29+receptors+%28BLT%281%29+and+BLT%282%29%29+are+differently+expressed+in+fibroblast+from+peripheral+versus+central+airways+in+asthmatics+and+healthy+controls. assertion.
- assertion asSentence Dysfunction+or+loss+of+the+multidrug+resistance+protein+2+%28MRP2%29+is+the+molecular+basis+of+Dubin-Johnson+syndrome+%28DJS%29. assertion.
- assertion asSentence The+major+canalicular+transporter+genes+are+expressed+at+mid-gestational+stage+during+human+fetal+development. assertion.
- assertion asSentence ABCC2+genotype+is+one+of+the+predictors+of+the+variability+of+irinotecan+pharmacokinetics+in+Japanese+patients+with+metastatic+colorectal+cancer+receiving+FOLFIRI. assertion.
- assertion asSentence Small+intestinal+efflux+mediated+by+MRP2+and+BCRP+shifts+sulfasalazine+intestinal+permeability+from+high+to+low%2C+enabling+its+colonic+targeting. assertion.
- assertion asSentence The+5%27-untranslated+region+of+MRP2+markedly+influences+MRP2+mRNA+translation+regulation. assertion.
- assertion asSentence Ezrin+is+required+for+the+apical+cell+surface+localization+of+MRP2+during+Salmonella+typhimurium+infection. assertion.
- assertion asSentence High+nuclear+expression+of+ABCC2+is+associated+with+aggressive+breast+carcinoma. assertion.
- assertion asSentence The+C1515Y+amino+acid+substitution+caused+by+the+4544G%3EA+SNP+in+ABCC2+impairs+its+ATPase+activity+and+is+associated+with+higher+cellular+accumulation+of+ABCC2+substrates. assertion.
- assertion asSentence Phospholipid+metabolism+and+exogenously+applied+phosphatidylinositol+3%2C4%2C5-trisphosphate+can+modulate+heterologously+expressed+cone+CNG+channels. assertion.
- assertion asSentence The+point+mutation+S175T+exhibited+more+resistance+to+actin+rearrangement+by+cytochalasin+D+and+PDBu+than+intact+CNh1%2C+suppressing+cell+motility+induced+by+PDBu. assertion.
- assertion asSentence Role+of+intracellular+loops+of+cannabinoid+CB1+receptor+in+functional+interaction+with+Galpha16. assertion.
- assertion asSentence 4+SNPs+in+the+CNR1+gene+are+found+to+be+positively+associated+with+striatal+response+to+happy+faces+%28and+not+to+disgust+faces%29+in+humans%2C+using+fMRI. assertion.
- assertion asSentence CNR1+variations+increase+the+risk+for+obesity+and+modulate+body+mass+index+in+European+population. assertion.
- assertion asSentence Reduced+cortical+cannabinoid+1+receptor+messenger+RNA+found+in+schizophrenia. assertion.
- assertion asSentence Increase+in+genetic+expression+serve+as+a+prognostic+factor+in+prostate+cancer. assertion.
- assertion asSentence Very+low+or+absent+FAAH+and+high+CB1+levels+correspond+with+spontaneous+miscarriage. assertion.
- assertion asSentence Cannabinoid+receptor+type+1-+and+2-mediated+increase+in+cyclic+AMP+inhibits+T+cell+receptor-triggered+signaling. assertion.
- assertion asSentence The+Cnr1+A3813G+variant+is+associated+with+different+levels+of+CB1+mRNA+in+perirenal+visceral+adipose+tissue. assertion.
- assertion asSentence Cyanidin+and+delphinidin+are+ligands+with+moderate+affinity+to+human+CB1and+CB2. assertion.
- assertion asSentence Hepatitis+C+virus+infection+induces+the+expression+of+cannabinoid+receptor+1. assertion.
- assertion asSentence Further+genotyping+of+the+endocannabinoid+receptor+gene+cannot+be+used+as+a+significant+marker+of+predisposition+to+cardiovascular+diseases+in+postmenopausal+women. assertion.
- assertion asSentence Variability+within+the+CNR1+gene+locus+contributes+to+gender-related+differences+in+the+HDL-cholesterol+response+to+change+in+dietary+fat+intake. assertion.
- assertion asSentence CB1+and+CB2+receptor+mRNA+expression+in+human+peripheral+blood+mononuclear+cells+%28PBMC%29+from+various+donor+types. assertion.
- assertion asSentence There+is+an+association+between+the+Q63R+polymorphism+of+the+CB2+gene+and+alcoholism+in+a+Japanese+population. assertion.
- assertion asSentence CB2+is+densely+present+in+somatostatin-secreting+pancreatic+delta+cells. assertion.
- assertion asSentence Association+of+polymorphisms+with+low+bone+density%2C+specificaly+hand+bone+strength+phenotypes. assertion.
- assertion asSentence CB2+polymorphic+receptors+are+able+to+bind+cannabinoid+ligands+and+mediate+signal+transduction. assertion.
- assertion asSentence CB1%2FCB2+participate+in+the+regulation+of+lipid+metabolism+in+human-derived+immortalized+hepatocytes+by+regulating+the+expression+of+key+enzymes+of+lipid+synthesis+and+transport. assertion.
- assertion asSentence CB2+is+a+potent+regulator+of+immune+responses+making+it+a+prime+target+for+the+treatment+of+inflammatory+diseases. assertion.
- assertion asSentence Cannabinoid+receptor+type+2+Q63R+variant+increases+more+than+six-fold+the+risk+for+celiac+disease. assertion.
- assertion asSentence CNTF-mediated+signaling+is+a+molecular+switch+for+neuronal+versus+glial+differentiation+of+retinal+stem+cells%2Fprogenitors. assertion.
- assertion asSentence Peptide+6c%2C+corresponding+to+human+CNTF+amino+acid+residues+147-150%2C+induces+neurogenesis%2C+neuronal+activity+and+proliferation+of+immature+neurons+in+the+dentate+gyrus+and+improvement+of+spatial+reference+memory+in+mice. assertion.
- assertion asSentence The+%22s%22+allele+of+COLIA1+gene+in+combination+with+the+Px+haplotype+of+the+ER+alpha+gene+contributes+to+reduced+BMD+in+females. assertion.
- assertion asSentence The+COL1A1+polymorphism+is+independently+associated+with+bone+density+in+postmenopausal+Spanish+women. assertion.
- assertion asSentence Two+haplotypes+defined+by+polymorphisms+in+the+5%27+flank+of+the+COLIA1+regulate+BMD+in+a+bidirectional+manner+in+women. assertion.
- assertion asSentence Disruptions+of+COL1A1+are+associated+with+high+myopia+in+Japanese. assertion.
- assertion asSentence Advanced+glycation+end+products+inhibited+human+gingival+fibroblast+proliferation+and+type+I+collagen+synthesis. assertion.
- assertion asSentence Collagen+I+appeared+in+the+myocardium+of+early+acute+myocardial+ischemia+of+human. assertion.
- assertion asSentence Common+genetic+variants+in+the+5%27+regulatory+region+of+COL1A1+are+associated+with+biomechanical+properties+of+bone+and+reduced+bone+quality+by+mechanisms+independent+of+their+effects+on+bone+mineral+density. assertion.
- assertion asSentence Leptin+upregulates+col1a1+expression+in+osteolbast-like+cells. assertion.
- assertion asSentence Single+nucleotide+polymorphisms+in+COL1A1+are+not+significantly+associated+with+high+myopia+in+the+Han+Chinese+population. assertion.
- assertion asSentence COL1A2+status+distinguished+infant+medulloblastomas+of+the+desmoplastic+histopathological+subtype. assertion.
- assertion asSentence CpG+hypermethylation+of+collagen+type+I+alpha+2+contributes+to+proliferation+and+migration+activity+of+human+bladder+cancer. assertion.
- assertion asSentence COL2A1+gene+expression+in+differentiating+chondrocytes+can+be+modulated+by+culture+conditions+so+that+its+transcriptional+activity+is+repressed+in+monolayer+cultures+and+rescued+to+some+extent+when+the+cells+are+switched+to+polyHEMA+substrata. assertion.
- assertion asSentence Posterior+chorioretinal+atrophy+and+vitreous+phenotype+in+a+family+with+Stickler+syndrome+from+a+mutation+in+the+COL2A1+gene. assertion.
- assertion asSentence In+comparison+with+healthy+cartilage%2C+Osteoarthritis+articular+chondrocytes+exhibit+increased+in+vivo+synthesis+of+collagen+prolyl-4-hydroxylase+type+II%2C+a+pivotal+enzyme+in+collagen+triple+helix+formation. assertion.
- assertion asSentence The+catalytic+domain+of+MMP-12+binds+to+the+triple+helix+and+cleaves+the+typical+sites+-Gly%28775%29-Leu%28776%29-+in+alpha-2+type+I+collagen+and+-Gly%28775%29-Ile%28776%29-+in+alpha-1+type+I+and+type+III+collagens+and+at+multiple+other+sites+in+both+collagen+types. assertion.
- assertion asSentence Patients+presenting+a+significant+increase+in+maximum+ascending+aortic+aneurysm+size+have+a+significantly+higher+type+III+procollagen+level+than+those+demonstrating+no+or+limited+growth+in+maximum+aneurysm+diameter. assertion.
- assertion asSentence Neonatal+porencephaly+and+adult+stroke+related+to+mutations+in+collagen+IV+A1. assertion.
- assertion asSentence Dominantly+inherited+mutation+in+collagen+%28COL4A1%29+causing+childhood+onset+stroke+without+porencephaly. assertion.
- assertion asSentence The+clinical+heterogeneity+of+Cerebrovascular+disease+in+the+phenotypic+expression+of+disorders+related+to+COL4A1+mutations. assertion.
- assertion asSentence In+COL4A1+stroke+syndrome+most+mutations+are+missense+mutations+involving+a+glycine+residue. assertion.
- assertion asSentence E1B-55kD-deleted+oncolytic+adenovirus+armed+with+canstatin+gene+yields+an+enhanced+anti-tumor+efficacy+on+pancreatic+cancer. assertion.
- assertion asSentence Persistent+familial+hematuria+in+children+often+occurs+at+the+COL4A3+locus+for+thin+membrane+nephropathy. assertion.
- assertion asSentence COL4A3%2FCOL4A4+mutations+predispose+some+patients+to+FSGS+and+chronic+renal+failure. assertion.
- assertion asSentence Mutations+in+the+signal+peptide+%28SP%29+domain+of+the+preproa1%28V%29-collagen+chain+cause+classic+Ehlers-Danlos+syndrome. assertion.
- assertion asSentence In+the+eye%2C+COL5A1+and+COL5A2+mutations+manifest+as+abnormally+thin+and+steep+corneas+with+floppy+eyelids. assertion.
- assertion asSentence The+failure+of+collagen+VI+to+anchor+the+basal+lamina+to+the+interstitium+is+the+cause+of+Ullrich+disease. assertion.
- assertion asSentence Major+promoter+and+enhancer+sequences+regulating+COL6A1+expression+are+present+in+this+bacterial+artificial+chromosome+clone. assertion.
- assertion asSentence In+Ullrich+syndrome%2C+a+heterozygous+G-to-A+substitution+at+position+%2B5+in+intron+23+%26+the+corresponding+heterozygous+6-bp+deletion+in+exon+26+which+deleted+1+of+the+2+tandem+repeats+of+the+sequence+CATCGG+in+nt+2268-2273+%26+2274-2279+in+COL6A2+ORF. assertion.
- assertion asSentence Dominant+mutations+are+common+in+Ullrich+congenital+muscular+dystrophy+%28UCMD%29. assertion.
- assertion asSentence The+alpha2%28VI%29+chain+modulates+matrix-metalloproteinase+%28MMP%29+availability+by+sequestering+proMMPs+in+the+extracellular+matrix%2C+blocking+proteolytic+activity. assertion.