Matches in Nanopublications for { ?s <http://purl.org/nanopub/x/asSentence> ?o ?g. }
- assertion asSentence Mutations+in+COL6A3+cause+severe+and+mild+phenotypes+of+Ullrich+congenital+muscular+dystrophy. assertion.
- assertion asSentence Methylation-based+COL10A1+gene+silencing+is+established+in+cartilage+tissue+and+human+articular+chondrocytes+during+chondrogenesis. assertion.
- assertion asSentence Two+widely+separated+coiled-coil+domains+of+type+XIII+and+related+collagens+function+as+independent+oligomerization+domains+participating+in+the+folding+of+distinct+areas+of+the+molecule. assertion.
- assertion asSentence Type+XV+and+XVIII+collagens+are+expressed+in+specialized+basement+membranes. assertion.
- assertion asSentence Overexpression+of+type+XVI+collagen+in+aberrant+oral+keratinocytes+leads+to+Kindlin-1+induction%2C+increased+Kindlin-1%2Fbeta1-integrin+interaction%2C+integrin+activation+and+subsequently+to+a+proliferative+cellular+phenotype. assertion.
- assertion asSentence C-terminus+of+collagen+XVII+binds+to+laminin+5%2C+revealing+the+role+of+collagen+XVII+in+the+regulation+of+keratinocyte+migration. assertion.
- assertion asSentence Three+epidermolysis+bullosa+associated+mutations+affecting+NC4+domain+do+not+grossly+affect+structure+or+stability+of+BP180. assertion.
- assertion asSentence Presence+of+minor+amounts+of+collagen+XVII+protein+in+JEB+skin+is+associated+with+mild+phenotypic+manifestations. assertion.
- assertion asSentence Serum+COMP+early+in+disease+is+a+predictor+of+mortality+in+systemic+sclerosis+patients. assertion.
- assertion asSentence The+Catechol-o-methyltransferase+gene+polymorphism+is+not+associated+with+the+generation+and+the+severity+of+pregnancy+induced+hypertension. assertion.
- assertion asSentence The+Catechol+O-methyltransferase+Val158Met+polymorphism+is+associated+with+cognitive+performance+in+nondemented+adults. assertion.
- assertion asSentence The+COMT+val158met+polymorphism+correlated+positively+with+activity+in+control-+and+task-related+regions+during+performance+under+emotional+distraction. assertion.
- assertion asSentence Catechol-O-methyltransferase+gene+polymorphisms+are+associated+with+multiple+pain-evoking+stimuli. assertion.
- assertion asSentence Catechol+O-methyltransferase+genotype+impacts+on+executive+function+in+Parkinson+Disease+patients+through+directly+influencing+frontoparietal+activation. assertion.
- assertion asSentence Leukocyte+exposure+to+morphine+down-regulated+catechol-O-methyl+transferase+%28COMT%29+and+CYP2D6+by+approximately+50%25+compared+with+control+values. assertion.
- assertion asSentence The+important+role+of+COMT+gene+expression+in+protecting+against+E%282%29-induced+endometrial+cancer. assertion.
- assertion asSentence Haplotypes+of+the+phenylethanolamine+N-methyltransferase+%28PNMT%29%2C+catechol-O-methyltransferase+%28COMT%29+have+functionally+important+effects+on+alcohol-induced+cardiovascular+symptoms+by+affecting+blood+catecholamine+levels. assertion.
- assertion asSentence COMT+gene+polymorphism+is+associated+with+non-small+cell+lung+cancer. assertion.
- assertion asSentence Over-expression+of+TXNRD2%2C+COMT+and+ARVCF+affects+incentive+learning+and+working+memory+in+transgenic+mice. assertion.
- assertion asSentence Genotype+is+not+related+with+alterations+in+baseline+D2+receptor+availability+in+vivo+in+the+cortex+or+the+striatum. assertion.
- assertion asSentence COMT+encodes+catechol-O-methyltransferase%2C+an+enzyme+important+for+the+degradation+of+central+nervous+system+catecholamines+and+critical+for+degradation+of+dopamine+in+the+prefrontal+cortex. assertion.
- assertion asSentence The+COMT+gene+plays+a+role+in+personality+traits+for+males%2C+contributing+to+the+growing+literature+on+sex+differences+in+gene-behavior+connections. assertion.
- assertion asSentence COMT+overexpression+combined+with+4-OHE%282%29+induces+upregulation+of+growth+arrest-+and+DNA+damage-inducible+protein+alpha+%28GADD45alpha%29. assertion.
- assertion asSentence COMT+Val158Met+genotype+influences+neurodegeneration+within+dopamine-innervated+brain+structures. assertion.
- assertion asSentence Diminished+expression+of+KLF6+correlates+with+poor+prognosis+and+high+probability+of+therapy+failure+in+prostate+cancer+patients. assertion.
- assertion asSentence Transcriptional+activation+of+the+insulin-like+growth+factor+I+receptor+gene+by+the+Kruppel-like+factor+6+%28KLF6%29+tumor+suppressor+protein. assertion.
- assertion asSentence Expression+of+Sp1+and+KLF6+is+developmentally+regulated%2C+providing+basis+for+further+investigations+on+regulation+of+Sp1+and+KLF6+gene+during+course+of+corneal+development+and+in+corneal+diseases+such+as+keratoconus. assertion.
- assertion asSentence Increased+expression+of+KLF6-SV1+is+associated+with+decreased+survival+in+patients+with+lung+adenocarcinoma. assertion.
- assertion asSentence Energy+restriction-mimetic+agents+induce+apoptosis+in+prostate+cancer+cells+in+part+through+epigenetic+activation+of+KLF6+tumor+suppressor+gene+expression. assertion.
- assertion asSentence Hormones+have+a+role+in+the+formation+of+the+active+hCTR1+protein+in+human+placental+cells. assertion.
- assertion asSentence Copper-dependent+internalization+and+recycling+of+hCTR1+provides+an+acute+and+reversible+mechanism+for+the+regulation+of+cellular+copper+entry. assertion.
- assertion asSentence Ctr1+is+an+important+transport+protein+in+the+accumulation+of+silver+in+mammalian+cells. assertion.
- assertion asSentence Intravitreous+somatostatin-like+immunoreactivity+deficit+occurs+in+ptients+with+proliferative+diabetic+retinopathy. assertion.
- assertion asSentence Oncoprotein+Cot1+represses+kinase+suppressors+of+Ras1%2F2+and+1%2C25-dihydroxyvitamin+D3-induced+differentiation+of+human+acute+myeloid+leukemia+cells. assertion.
- assertion asSentence The+expression+of+the+AOX%2C+well-tolerated+by+the+cells%2C+compensates+for+both+the+growth+defect+and+the+pronounced+oxidant-sensitivity+of+COX-deficient+human+cells. assertion.
- assertion asSentence Urinary+levels+are+increaed+in+normoalbuminuric+type+2+diabetic+patients. assertion.
- assertion asSentence Ceruloplasmin+gene+is+regulated+by+activator+protein-1+site+in+the+gene+by+redox+active+copper. assertion.
- assertion asSentence Younger-onset+Parkinson%27s+disease+%28PD%29+patients+have+significantly+lower+levels+of+serum+ceruloplasmin+compared+to+those+with+older-onset+PD. assertion.
- assertion asSentence Ceruloplasmin+fragmentation+is+implicated+in+%27free%27+copper+deregulation+of+Alzheimer%27s+disease. assertion.
- assertion asSentence There+is+an+association+between+levels+and+activated+protein+C+in+normotensive+type+2+diabetic+patients. assertion.
- assertion asSentence Dabigatran%2C+at+clinically+relevant+concentrations%2C+enhances+the+susceptibility+of+plasma+clots+to+t-PA-induced+lysis+by+reducing+TAFI+activation+and+by+altering+the+clot+structure. assertion.
- assertion asSentence TAFI+activation+is+one+major+mechanism+whereby+platelets+make+clots+resistant+to+fibrinolysis. assertion.
- assertion asSentence Either+high+glucose+or+insulin+%28with+low+glucose%29+up-regulates+beta-cell+CPD+%28but+not+CPE%29. assertion.
- assertion asSentence Neither+high+glucose+nor+insulin+%28with+low+glucose%29+regulates+beta-cell+CPE+%28but+either+up-regulates+CPD%29. assertion.
- assertion asSentence Claudin+4+is+downregulated+in+lobular+carcinoma+in+situ+compated+with+normal+breast+epithelium+and+stroma. assertion.
- assertion asSentence Low+expression+of+claudin-4+is+associated+with+esophageal+squamous+cell+carcinoma. assertion.
- assertion asSentence Dow-regulation+of+Claudin-3+is+associated+with+the+progression+of+early+gastric+adenocarcinomas. assertion.
- assertion asSentence Loss+of+claudin-1+expression+proved+to+be+a+strong+predictor+of+disease+recurrence+and+poor+patient+survival+in+stage+II+colon+cancer. assertion.
- assertion asSentence When+compared%2C+adenocarcinomas+and+squamous+cell+carcinomas+revealed+significant+differences+in+CLDN7+expression. assertion.
- assertion asSentence Increased+expression+of+claudin-6%2C+claudin-7%2C+or+claudin-9+is+sufficient+to+enhance+tumorigenic+properties+of+a+gastric+adenocarcinoma+cell+line. assertion.
- assertion asSentence CPOX+polymorphisms+are+associated+with+biological+media+contamination+and+apoptosis+disorders. assertion.
- assertion asSentence Patient+with+chronic+hepatitis+C%2C+carrying+the+CPT1A+minor+allele+are+at+the+decreased+risk+of+developing+advanced+liver+fibrosis. assertion.
- assertion asSentence CR1+multimeric+ligand+inhibits+the+proliferation+of+tonsil+B+cells+activated+with+a+suboptimal+dose+of+anti-IgM+F%28ab%27%292. assertion.
- assertion asSentence The+changes+in+CR1+quantitative+expression+and+adhering+activity+are+consanguineously+related+to+the+development+and+metastasis+in+gallbladder+carcinoma. assertion.
- assertion asSentence Susceptibility+to+sarcoidosis+or+its+clinical+course+is+not+associated+with+the+presence+of+the+complement+receptor+1+%28CR1%295507%2AG+allele+in+Czech+and+Dutch+patients. assertion.
- assertion asSentence The+partly+folded+back+solution+structure+of+the+30+SCR+domains+in+human+CR1+permits+access+to+its+C3b+and+C4b+ligands. assertion.
- assertion asSentence CR1+A%283650%29G+RsaI+polymorphism+plays+an+important+role+in+conferring+genetic+susceptibility+to+gallbladder+cancer+in+north+Indian+population. assertion.
- assertion asSentence Polymorphisms+of+CR1+are+not+associated+with+significant+protection+against+P.+falciparum+blood-stage+infection+or+uncomplicated+malaria+in+school-aged+children. assertion.
- assertion asSentence The+SNP+genotype+pattern+at+the+CR1+gene+is+associated+with+episodic+memory. assertion.
- assertion asSentence Complement+receptor+2-mediated+targeting+of+complement+inhibitors+to+sites+of+complement+activation. assertion.
- assertion asSentence Shedding+of+CD21+and+CD62L+is+mediated+via+the+P2X7R. assertion.
- assertion asSentence Premature+transgenic+CR2+expression+and+the+consequences+thereof+during+B+cell+development+intrinsically+alters+the+way+mature+B+cells+develop+and+subsequently+respond+to+antigen+through+the+B+cell+receptor+signaling+complex. assertion.
- assertion asSentence CD21%28low%29+B+cells+represent+a+human+innate-like+B+cell+population. assertion.
- assertion asSentence Prevalence+of+pulmonary+fibrosis+in+patients+with+diffuse+cutaneous+systemic+sclerosis+inversely+correlates+with+soluble+cluster+of+differentiation+21+%28sCD21%29+levels. assertion.
- assertion asSentence Retinoic+acid+and+retinol+regulate+expression+of+cellular+retinol+binding+protein+1+and+cellular+RA+binding+protein+2+in+fibroid+and+myometrial+cells. assertion.
- assertion asSentence CREB+and+sterol+regulatory+element+binding+protein+cooperate+in+transactivating+CYP51. assertion.
- assertion asSentence CREB1+associates+with+TIF2+and+is+essential+for+cell+transformation. assertion.
- assertion asSentence The+expression+of+p-CREB+is+related%2C+in+asthma%2C+to+the+persistent+inflammation+according+to+the+disease+severity.+p-CREB+expression+can+be+modulated+by+glucocorticoids+in+responsive+patients. assertion.
- assertion asSentence Lyl1+interacts+with+CREB1+and+alters+expression+of+CREB1+target+genes. assertion.
- assertion asSentence TORC2%2C+a+coactivator+of+cAMP-response+element-binding+protein%2C+promotes+Epstein-Barr+virus+reactivation+from+latency+through+interaction+with+viral+BZLF1+protein. assertion.
- assertion asSentence RGS17%2C+an+overexpressed+gene+in+human+lung+and+prostate+cancer%2C+induces+tumor+cell+proliferation+through+the+cyclic+AMP-PKA-CREB+pathway. assertion.
- assertion asSentence ATF%2FCREB+and+NGFI-B+family+members+play+a+crucial+role+in+the+transcriptional+regulation+of+CYP11B2+and+adrenal+cell+capacity+to+produce+aldosterone. assertion.
- assertion asSentence Bile+acid+regulates+MUC2+transcription+in+colon+cancer+cells+via+positive+EGFR%2FPKC%2FRas%2FERK%2FCREB%2C+PI3K%2FAkt%2FIkappaB%2FNF-kappaB+and+p38%2FMSK1%2FCREB+pathways+and+negative+JNK%2Fc-Jun%2FAP-1+pathway. assertion.
- assertion asSentence Intracellular+CMTM2+can+negatively+regulate+HIV-1+transcription%2C+at+least+in+part%2C+by+targeting+the+AP-1+and+CREB+pathways. assertion.
- assertion asSentence TOX3+induces+transcription+in+neuron+depending+on+the+presence+of+CITED1+or+phosphorylated+CREB+in+the+transcriptionally+active+complex. assertion.
- assertion asSentence Epigenetic+regulation+of+the+IL-13-induced+human+eotaxin-3+gene+by+CREB-binding+protein-mediated+histone+3+acetylation. assertion.
- assertion asSentence Increasing+CREB+function+in+the+CA1+region+of+dorsal+hippocampus+of+transgenic+TgCRND8+mice+is+sufficient+to+restore+function+in+key+hippocampal+domains. assertion.
- assertion asSentence Impaired+expression+of+ICER+contributes+to+elevation+in+CREB+target+genes+and%2C+therefore%2C+to+the+development+of+insulin+resistance+in+obesity. assertion.
- assertion asSentence The+effect+of+norepinephrine+on+amyloid+beta%281-42%29+peptide-induced+responses+in+migroglia-like+THP-1+cells+is+contingent+on+cyclic+AMP%2Fprotein+kinase+%28PK%29A+pathways+and+cAMP+responsive+element+binding+protein+%28CREB%29+activation. assertion.
- assertion asSentence Sox4+and+CREB+cooperate+and+contribute+to+increased+proliferation+of+hematopoietic+progenitor+cells. assertion.
- assertion asSentence Gamma-gene+induction+by+butyrate+and+trichostatin+A+involves+ATF-2+and+CREB1+activation+via+p38+MAPK+signaling. assertion.
- assertion asSentence Stability+and+DNA-binding+ability+of+the+bZIP+dimers+formed+by+the+ATF-2+and+c-Jun. assertion.
- assertion asSentence The+KID-interacting+domain+of+human+coactivator+CREB-binding+protein+%28CBP%29+is+the+CBP+domain+that+is+targeted+by+HIV-1+Tat+during+HIV-1+propagation. assertion.
- assertion asSentence CREB+phosphorylation+and+CRE-regulated+gene+expression+are+activated+by+kinases. assertion.
- assertion asSentence CBP%2Fp300+has+an+evolutionarily+conserved+role+as+a+buffer+regulating+TCF-beta-cat%2FArm+binding. assertion.
- assertion asSentence Cyclosporine+impairs+CREB+DNA+binding+activity. assertion.
- assertion asSentence Brucella+controls+host+defenses+by+impairing+macrophage+responses+to+IFNgamma+induced+STAT1-CBP%2FP300+association. assertion.
- assertion asSentence CBP-mediated+post-translational+N-glycosylation+of+BRCA2. assertion.
- assertion asSentence p300+and+CBP+are+implicated+in+regulation+of+ER-beta+activity+and+cellular+migration+in+prostate+cancer. assertion.
- assertion asSentence BDNF-+and+seizure-dependent+phosphorylation+of+STAT3+cause+the+adenosine+3%27%2C5%27-monophosphate+%28cAMP%29+response+element-binding+protein+%28CREB%29+family+member+ICER+%28inducible+cAMP+early+repressor%29+to+bind+with+phosphorylated+CREB+at+the+Gabra1%3ACRE+site. assertion.
- assertion asSentence cAMP-responsive+element+modulator+alpha+%28CREMalpha%29+suppresses+IL-17F+protein+expression+in+T+lymphocytes+from+patients+with+systemic+lupus+erythematosus+%28SLE%29. assertion.
- assertion asSentence Acute+GES+reduces+the+number+of+CRF-producing+neurons+and+decreases+CRF+expression+in+PVN+during+post-operative+gastric+ileus. assertion.
- assertion asSentence A+rationale+for+the+use+of+CRH+in+predicting+preterm+birth. assertion.
- assertion asSentence CRH-R1+and+CRH-R2+receptors+and+their+endogenous+ligands+have+a+role+in+the+biology+of+human+endometrial+cancer. assertion.
- assertion asSentence Variation+in+CRHR1+moderates+the+association+of+maltreatment+with+neuroticism. assertion.
- assertion asSentence An+interaction+between+CRHR1+and+BDNF+genes+constitutes+susceptibility+to+recurrent+major+depressive+disorder. assertion.
- assertion asSentence Association+of+corticotropin-releasing+hormone+receptor-2+genetic+variants+with+acute+bronchodilator+response+in+asthma. assertion.
- assertion asSentence Receptors+couple+to+different+G-proteins+in+stably+transfected+human+cells%2C+leading+to+transient+divalent+calcium+ion+mobilization+on+top+of+the+natural+increase+in+cyclic+AMP+stimulation. assertion.
- assertion asSentence CRIP1+expression+is+associated+with+long-term+survival+and+no+metastases+in+osteosarcoma+patients. assertion.
- assertion asSentence The+SH2-SH3+adaptor+protein+Crk+is+an+essential+target+of+GIT2+inhibition. assertion.