Matches in Nanopublications for { ?s <http://purl.org/nanopub/x/asSentence> ?o ?g. }
- assertion asSentence Ligation+of+CTLA-4+with+either+soluble+B7.1+immunoglobulin+%28Ig%29+%28but+not+B7.2+Ig%29+or+with+a+recombinant+bispecific+in-tandem+single+chain+Fv+antibody+induces+T+cell+receptor-independent+T+cell+activation+and+has+important+therapeutic+implications. assertion.
- assertion asSentence A+role+for+CTLA-4+in+limiting+the+interaction+between+T+cell+and+APC+that+is+needed+for+optimal+activation. assertion.
- assertion asSentence CTLA4+blockade+with+ipilimumab+induces+significant+clinical+benefit+in+a+female+with+melanoma+metastases+to+the+CNS. assertion.
- assertion asSentence No+significant+associations+between+CTLA4+exon+1+polymorphism+and+neither+multiple+sclerosis+nor+any+of+its+subtypes. assertion.
- assertion asSentence CTLA-4+CT60+polymorphism+is+associated+with+polyglandular+autoimmunity. assertion.
- assertion asSentence Humoral+autoimmunity+is+correlated+with+49A%2FG+and+CT60+polymorphisms+of+the+CTLA-4+gene. assertion.
- assertion asSentence Distribituion+of+CTLA4+single-nucleotide+polymorphism+variation+between+type+1+diabetes+and+controls+in+Croatia. assertion.
- assertion asSentence Relationship+between+CTLA-4+gene+polymorphisms+and+renal+transplant+outcomes+by+genotyping+kidney+transplant+outcome+and+healthy+controls. assertion.
- assertion asSentence CTLA-4+gene+does+not+play+a+major+role+in+the+genetic+susceptibility+to+the+development+of+systemic+lupus+erythematosus+in+the+Malaysian+population. assertion.
- assertion asSentence Decreased+expression+of+CTLA-4+on+T+cells+in+children+with+Hashimoto%27s+thyroiditis+is+not+dependent+on+polymorphic+changes+at+position+%2B49+of+CTLA-4+gene. assertion.
- assertion asSentence The+%2B49A%3EG+CTLA-4+polymorphism+is+a+genetic+marker+of+susceptibility+for+rheumatoid+arthritis+in+western+Mexican+population. assertion.
- assertion asSentence In+patients+with+perennial+forms+of+allergic+rhinitis+the+rate+of+functional+%22unfavourable+allele%22+49A%2FG+gene+CTLA4+increased+in+1%2C3+times+in+comparison+with+the+group+with+seasonal+form+and+slightly+in+the+control+group. assertion.
- assertion asSentence CT60+A%2FG+dimorphism+within+the+3%27-UTR+of+CTLA4+gene+does+not+influence+acute+rejection+development+in+liver+transplant. assertion.
- assertion asSentence Two+single-nucleotide+polymorphisms+in+the+CTLA-4+gene+are+not+associated+with+susceptibility+to+Idiopathic+thrombocytopenic+purpura+%28ITP%29+in+a+Chinese+population. assertion.
- assertion asSentence CD40+C%2FT%28-1%29+and+CTLA-4+A%2FG%2849%29+SNPs+are+associated+with+autoimmune+thyroid+diseases+in+the+Chinese+population. assertion.
- assertion asSentence Cytotoxic+T-lymphocyte+antigen+4+gene+%2B49A%2FG+polymorphism+is+significantly+associated+with+susceptibility+to+primary+biliary+cirrhosis. assertion.
- assertion asSentence CTLA-4+polymorphism+contributes+to+the+susceptibility+of+type+1+diabetes+mellitus. assertion.
- assertion asSentence Allelic+imbalance+occurs+at+two+distinct+regions+of+which+one+includes+the+CTNNA1+gene+in+ovarian+cancer. assertion.
- assertion asSentence Methylation+and+inactivation+of+CTNNA1+is+associated+with+advanced+myeloid+malignancies. assertion.
- assertion asSentence CTNNB1+signaling+plays+a+critical+role+in+the+development+of+a+significant+fraction+of+prostate+cancers. assertion.
- assertion asSentence Anticancer-drug-induced+apoptotic+cell+death+in+leukemia+cells+is+associated+with+proteolysis+of+beta-catenin.+beta-Catenin+plays+a+role+in+promoting+Jurkat+survival. assertion.
- assertion asSentence p53-mediated+reduction+in+beta-catenin+involves+enhanced+phosphorylation+of+beta-catenin+on+key+NH%282%29-terminal+serines. assertion.
- assertion asSentence High+Pin1+expression+in+primary+prostate+cancer+markedly+inhibits+the+beta-catenin+interaction+with+androgen+receptor. assertion.
- assertion asSentence When+beta-catenin+is+activated+in+transgenic+En1+expressing+cells%2C+it+induces+Dermo1+expression+in+all+cells+of+the+En1+domain+and+disrupts+muscle+gene+expression. assertion.
- assertion asSentence Mutations+in+the+CTNNB1+gene+most+frequently+coexisted+with+mutations+in+the+PTEN+gene+%287%2F9%2C+77.8%25%29. assertion.
- assertion asSentence Glis2+functions+as+a+negative+modulator+of+beta-catenin%2FTCF-mediated+transcription. assertion.
- assertion asSentence FLT3+activation+induces+beta-catenin+tyrosine+phosphorylation+and+nuclear+localization. assertion.
- assertion asSentence HER-2%2Fneu+transcriptionally+activates+Jab1+expression+via+the+AKT%2Fbeta-catenin+pathway+in+breast+cancer+cells. assertion.
- assertion asSentence Sporadic+desmoids+are+usually+associated+with+somatic+mutations+in+codons+41+or+45+of+exon+3+of+beta-catenin+%28CTNNB1%29. assertion.
- assertion asSentence Betaenin+can+be+involved+in+polyphenol+mediated+down+regulation+of+AKT1. assertion.
- assertion asSentence Core-fucosylated+E-cadherin+regulated+nuclear+beta-catenin+accumulation+in+lung+cancer+cells. assertion.
- assertion asSentence Rather+than+being+translocated+to+the+nucleus+for+regulating+the+target+gene+transcription%2C+Smad7-stabilized-beta-catenin+is+shunted+to+the+E-cadherin+complex+to+modulate+cell-cell+adhesion. assertion.
- assertion asSentence CTNNB1+mutations+are+highly+common+in+desmoid+tumors. assertion.
- assertion asSentence The+combined+pattern+of+positive+KL-6+expression+and+decreased+membranous+beta-catenin+expression+by+colorectal+carcinoma+is+a+useful+biomarker+for+distinguishing+a+subgroup+of+patients+with+a+worse+prognosis. assertion.
- assertion asSentence Mutations+in+CTNNB1+gene+is+associated+with+Wilms+tumor. assertion.
- assertion asSentence Mutations+in+CTNNB1+protein+is+associated+with+Colorectal+Carcinoma. assertion.
- assertion asSentence Beta-catenin+and+TCF4+activate+the+human+StarD7+gene+interacting+with+its+promoter+region+through+Wnt%2Fbeta-catenin+signalling. assertion.
- assertion asSentence Increased+beta-catenin+expression+is+associated+with+hepatocellular+carcinoma. assertion.
- assertion asSentence HMGA1+is+involved+in+proliferation+and+gastric+tumor+formation+via+the+Wnt%2Fbeta-catenin+pathway. assertion.
- assertion asSentence Biphasic+aspect+of+Wnt%2Fbeta-catenin+signaling+with+strong+decrease+up+to+40+h+after+stretch+induction%2C+is+important+for+anabolic+effects+of+mechanical+stretch+on+bone. assertion.
- assertion asSentence SALL4+plays+a+critical+role+in+the+pathogenesis+of+MDS+by+causing+the+aberrant+activation+of+the+Wnt%2Fbeta-catenin+pathway. assertion.
- assertion asSentence Beta-catenin+is+involved+in+alterations+in+mitochondrial+activity+in+non-transformed+intestinal+epithelial+and+colon+cancer+cells. assertion.
- assertion asSentence NS5A+mediates+activation+of+beta-catenin+in+a+phosphoinositide-3+kinase-dependent+fashion. assertion.
- assertion asSentence Hypermethylation+of+APC+promoter+1A%2C+instead+of+mutations+involving+APC+and+beta-catenin%2C+contributes+to+moderate+activation+of+Wnt+signalling+in+a+subset+of+serrated+adenomas+. assertion.
- assertion asSentence ZEB2+and+CTNNB1+are+the+functional+downstream+targets+of+miR-200a+and+they+play+distinct+roles+in+regulating+nasopharyngeal+carcinoma+development. assertion.
- assertion asSentence The+EGFR-ERK-CK2-mediated+phosphorylation+of+alpha-catenin+promotes+beta-catenin+transactivation+and+tumor+cell+invasion. assertion.
- assertion asSentence HDAC7+interacts+with+beta-catenin+keeping+endothelial+cells+in+a+low+proliferation+stage. assertion.
- assertion asSentence Loss+of+CYLD+instigates+tumor+growth+in+human+cylindromatosis+through+a+mechanism+in+which+hyperubiquitination+of+polymerized+Dvl+drives+enhancement+of+Wnt3%2Fbeta-catenin+responses. assertion.
- assertion asSentence Increased+nuclear+expression+of+localized+pbeta-catenin-S552+is+associated+with+atypical+lymphoid+hyperplasia+and+extranodal+marginal+zone+lymphoma. assertion.
- assertion asSentence Collagen+type+I+contributes+to+invasion+and+metastasis+by+regulating+beta-catenin+tyrosine+phosphorylation+and+nuclear+translocation+to+promote+migration+and+proliferation+of+gastric+carcinoma+cells. assertion.
- assertion asSentence Activated+beta-catenin+is+associated+with+Peutz-Jeghers+syndrome+polyps. assertion.
- assertion asSentence Nuclear+beta-catenin+upregulation+is+associated+with+invasive+cell+populations+of+breast+cancer. assertion.
- assertion asSentence Beta-catenin+expression+is+upregulated+rapidly+after+T+cell+receptor+%28TCR%29+stimulation. assertion.
- assertion asSentence Activating+mutations+of+CTNNB1+is+associated+with+a+group+of+aggressive+adrenocortical+cancers. assertion.
- assertion asSentence ID3+plays+a+role+as+an+apoptosis+inducer+in+response+to+X-ray+irradiation+via+the+regulation+of+endogenous+beta-catenin+level. assertion.
- assertion asSentence PIK3CA+mutations+tended+to+be+associated+with+CTNNB1+mutations. assertion.
- assertion asSentence High-frequency+canonical+Wnt+activation+in+multiple+sarcoma+subtypes+drives+proliferation+through+a+TCF%2Fbeta-catenin+target+gene%2C+CDC25A. assertion.
- assertion asSentence Low+CTNNB1+is+associated+with+low+vincristine+and+lomustine+response+in+medulloblastoma. assertion.
- assertion asSentence CTNNB1+genotyping+can+be+very+useful+in+%27difficult+to+diagnose%27+lesions+when+the+differential+diagnosis+includes+desmoid+tumours. assertion.
- assertion asSentence The+TR%2FDKK4%2FWnt%2Fbeta-catenin+cascade+influences+the+proliferation+and+migration+of+hepatoma+cells+during+the+metastasis+process+and+support+a+tumor+suppressor+role+of+the+thyroid+hormone+receptor. assertion.
- assertion asSentence FasL+%28TCF%2FLEF1%29+binding+elements+formed+complexes+with+the+TCF-4+and+beta-catenin+transcription+factors+in+vitro+and+in+vivo. assertion.
- assertion asSentence Levels+of+renal+MMP-7+correlate+with+Wnt%2Fbeta-catenin+activity. assertion.
- assertion asSentence Mutations+detected+in+CTNNB1+in+microdissected+samples+from+different+areas+of+the+same+tumor+%28colon+cancer%29+differed+according+to+immunophenotype. assertion.
- assertion asSentence Loss+of+beta+catenin+is+associated+with+liposarcoma. assertion.
- assertion asSentence Nuclear+EBP50+facilitates+colon+tumorigenesis+by+modulating+the+interaction+between+beta-catenin+and+TCF-1. assertion.
- assertion asSentence Inhibition+of+beta-catenin+signaling+diminished+both+the+response+of+astrocytes+to+injury+and+induction+of+the+malignant+phenotype+of+astrocytomas. assertion.
- assertion asSentence Phospho-GSK-3beta%2Fbeta-catenin+signaling+regulates+alpha-smooth+muscle+actin+expression%2C+a+marker+of+myofibroblast+differentiation%2C+in+vitro+and+in+vivo. assertion.
- assertion asSentence Catenin+p120ctn+inhibits+association+of+Kaiso+with+the+matrilysin+promoter. assertion.
- assertion asSentence PDGFR-mediated+phosphorylation+at+this+site+is+dependent+on+PKCalpha%2C+a+conventional+PKC+isoform+implicated+previously+in+disruption+of+adherens+junctions. assertion.
- assertion asSentence Different+expression+patterns+of+E-cadherin+and+p120-catenin+proteins+can+be+helpful+to+distinguish+infiltrating+lobular+carcinoma+from+ductal+carcinoma+of+the+breast. assertion.
- assertion asSentence p120+is+required+for+maintaining+VE-cadherin+expression+and+transendothelial+resistance+independently+of+its+NH%282%29+terminus+and+its+role+in+regulating+Rho. assertion.
- assertion asSentence Increased+delta-catenin+expression+is+critical+for+maintenance+of+the+malignant+phenotype+of+lung+cancer%2C+making+delta-catenin+a+candidate+target+protein+for+future+cancer+therapeutics. assertion.
- assertion asSentence S-nitrosation+correlated+with+diminished+abundance+of+beta-catenin+and+p120+at+the+adherens+junction+and+with+hyperpermeability. assertion.
- assertion asSentence Increased+expression+of+delta-catenin+is+associated+with+the+down-regulation+and+redistribiution+of+ECAD+and+p120ctn+in+prostatic+cancer. assertion.
- assertion asSentence Cathepsin+B+is+involved+in+the+motor+neuron+degeneration+in+ALS. assertion.
- assertion asSentence Central+role+for+the+lysosomal+protease+cathepsin+B+in+mediating+cell+death+in+lung+cancer+cells. assertion.
- assertion asSentence Induction+of+cathepsin+B+is+associated+with+the+activation+of+protein+p38+MAP+kinase. assertion.
- assertion asSentence Simultaneous+high+expression+of+Cathepsins+B+and+K+is+associated+with+recurrence+in+pulmonary+adenocarcinomas+and+squamous+cell+carcinomas. assertion.
- assertion asSentence Cathepsin+B+and+uPAR+downregulation+reduced+tumor+growth+and+increased+p27+nuclear+expression+in+vivo. assertion.
- assertion asSentence Elevated+cathepsin+B+level+is+associated+with+invasive+glioblastoma. assertion.
- assertion asSentence Polymorphism+unrelated+to+Alzheimer+disease+in+a+Spanish+population. assertion.
- assertion asSentence Cerebrospinal+fluid+levels+of+beta-amyloid%2842%29+in+patients+with+Alzheimer%27s+disease+are+related+to+the+exon+2+polymorphism+of+the+cathepsin+D+gene. assertion.
- assertion asSentence QTL+associated+with+general+intelligence+is+located+within+exon+2+of+the+cathepsin+D+%28CTSD%29+gene. assertion.
- assertion asSentence Possession+of+the+CTSD+T+allele+has+a+modulating+effect+on+the+pathogenesis+of+Alzheimer+disease+by+increasing+the+amount+of+Abeta+deposited+as+senile+plaques+in+the+brain. assertion.
- assertion asSentence Cathepsin+D+and+eEF1+are+promising+markers+for+the+detection+of+cellular+senescence+induced+by+a+variety+of+treatments. assertion.
- assertion asSentence Cathepsin+D+expression+in+ovarian+endometriosis. assertion.
- assertion asSentence Cathepsin+D+is+able+to+initiate+the+caspase+cascade+by+direct+activation+of+caspase-8. assertion.
- assertion asSentence Cathepsin+G+initializes+and+dominates+the+destruction+of+intact+myelin+basic+protein+%28MBP%29+by+B+cell-derived+lysosomal+extracts%2C+degrading+immunodominant+MBP+epitope+and+eliminating+both+its+binding+to+HLA-DRB1%2A1501+and+MBP-specific+T+cell+response. assertion.
- assertion asSentence Substrate+specificity+for+cathepsin+G+is+greatly+enhanced+when+an+aromatic+side+chain+and+a+strong+positive+charge+are+incorporated+in+residue+P%281%29. assertion.
- assertion asSentence Cathepsin+G+is+one+of+the+mediators+responsible+for+complement-dependent+opsonophagocytic+killing+of+Streptococcus+pneumoniae+by+human+neutrophils. assertion.
- assertion asSentence Cathepsin+K+co-localized+with+TRAP+in+osteoclast-resorptive+compartments%2C+supporting+a+role+for+cathepsin+K+in+the+extracellular+processing+of+monomeric+TRAP+in+the+resorption+lacuna. assertion.
- assertion asSentence Suppression+of+cathepsin+L+expression+in+A549+cells+leads+to+a+growth+inhibition+which+is+partially+compensated+by+an+upregulation+of+IL-8+production. assertion.
- assertion asSentence Peptide+fragment+of+p47+SEP+is+a+reversible+competitive+inhibitor+of+cathepsin+L. assertion.
- assertion asSentence Cathepsin+L+has+a+strong+preference+for+aromatic+and%2C+to+a+slightly+lesser+extent%2C+aliphatic+residues. assertion.
- assertion asSentence Human+cathepsin+V+compensates+for+murine+cathepsin+L+in+mouse+epidermis+and+hair+follicles. assertion.
- assertion asSentence Cathepsin+S+activity+is+required+for+efficient+surface+display+of+MHC+class+II+in+myoblasts+from+patients+with+inflammatory+myopathies+and+on+myoblasts+stimulated+by+IFN-gamma. assertion.
- assertion asSentence Cysteine+cathepsins+S+and+L+modulate+anti-angiogenic+activities+of+human+endostatin. assertion.
- assertion asSentence Cathepsin+S+plays+an+important+role+in+the+regulation+of+cell+autophagy+through+interference+with+the+EGFR-ERK%2FMAPK-signaling+pathway. assertion.
- assertion asSentence Lack+of+LF+expression+in+the+acute+promyelocytic+leukemia+cell+line+NB4+is+associated+with+the+persistent+binding+of+the+silencer+CCAAT+displacement+protein+%28CDP%2Fcut%29+to+the+LF+promoter+in+these+cells. assertion.
- assertion asSentence Interaction+of+G9a+with+a+sequence-specific+transcription+factor+that+regulates+gene+repression+through+CDP%2Fcut. assertion.