Matches in Nanopublications for { ?s <http://purl.org/nanopub/x/asSentence> ?o ?g. }
- assertion asSentence CUTL1+plays+a+central+role+in+coordinating+a+gene+expression+program+associated+with+cell+motility+and+tumor+progression. assertion.
- assertion asSentence GRIA3+plays+a+role+as+a+mediator+of+tumor+progression+in+pancreatic+cancer+downstream+CUX1. assertion.
- assertion asSentence cux1+is+associated+with+cell+functions+and+human+disease. assertion.
- assertion asSentence Fractalkine+and+CX3CR1+are+involved+in+the+recruitment+of+intraepithelial+lymphocytes+of+intrahepatic+bile+ducts. assertion.
- assertion asSentence Upregulation+of+CCL18+expression+and+downregulation+of+CX3CR1+expression+play+a+role+in+immune+responses+against+the+adult+t-cell+leukemia+cells. assertion.
- assertion asSentence The+common+CX3CR1-isoleucine249+allele+and+its+genetically+linked+partner+CX3CR1-methionine280+are+associated+with+attenuation+of+neurogenic+inflammation+and+reduced+risk+of+migraine+prevalence. assertion.
- assertion asSentence CX3CR1+deficiency+dramatically+decreases+the+cell+migration+of+human+bone+marrow+stromal+cells+to+the+ischemic+brain. assertion.
- assertion asSentence CX3CR1+is+functional%2C+as+all+the+tumor+cell+lines+adhere+to+immobilized+recombinant+CX3CL1+and+migrate+in+response+to+the+soluble+form+of+this+chemokine. assertion.
- assertion asSentence CX3CR1+as+a+key+microglial+pathway+in+protecting+against+AD-related+cognitive+deficits+that+are+associated+with+aberrant+microglial+activation+and+elevated+inflammatory+cytokines. assertion.
- assertion asSentence CCL2-CCR2+and+CXCL1-CXCR1+signaling+are+nvolved+in+age+related+macular+degeneration. assertion.
- assertion asSentence High+CX3CR1+lamina+propria+myeloid+cells+from+intestinal+transplant+recipients+with+NOD2+mutations+is+associated+with+allograft+loss. assertion.
- assertion asSentence Platelets+in+hyperlipidemic+mice+display+increased+CX%283%29CR1-expression+and+assemble+with+circulating+monocytes. assertion.
- assertion asSentence The+risk+of+early+onset+of+CAD+is+associated+with+a+genetic+variation+in+chemokine+receptor+CX3CR1. assertion.
- assertion asSentence Complement+protein+C1q+and+anti-hexon+antibodies+together+can+mediate+efficient+adenovirus+infection+in+coxsackie+and+adenovirus+receptor-negative+cell+types. assertion.
- assertion asSentence Adenoviral+drifting+motions+upstream+of+internalization+are+mediated+by+CAR. assertion.
- assertion asSentence Cytochrome+b5+can+alter+multiple+steps+in+the+catalytic+cycle+via+complex+interactions+with+CYP2C9+and+P450+reductase. assertion.
- assertion asSentence Increased+free+radical+production+in+hypertension+due+to+increased+expression+of+the+NADPH+oxidase+subunit+p22%28phox%29+in+lymphoblast+cell+lines. assertion.
- assertion asSentence Expression+of+CYBA+640A%3EG+is+consistently+associated+with+superoxide+production+in+granulocytes+of+healthy+Caucasian+volunteers. assertion.
- assertion asSentence Glucosamine+sulfate+downp-regulated+expression+of+p22-phox+protein+in+human+osteoarthritis+chondrocytes. assertion.
- assertion asSentence The+p22%28phox%29+C242T+single-nucleotide+polymorphism+is+associated+with+stroke+risk. assertion.
- assertion asSentence C242T+polymorphism+of+the+P22PHOX+subunit+can+influencw+the+cardio-pulmonary+fitness+in+trained+runners. assertion.
- assertion asSentence CYBA+%2B242C%2FT+and+PPARD+%2B294T%2FC+variants+modulate+risk+of+coronary+artery+disease+through+their+associations+with+atherogenic+serum+lipid+profiles. assertion.
- assertion asSentence A+polymorphism+of+NADPH+oxidase+p22+phox+is+associated+with+reduced+susceptibility+to+acute+rejection+in+renal+allograft+recipients. assertion.
- assertion asSentence A+previously+unrecognized+dual+role+of+NOX2+in+the+regulation+of+NF-kappaB+in+response+to+RSV+and+Sendai+virus+in+human+airway+epithelial+cells. assertion.
- assertion asSentence NAPDH+oxidase+activity+in+macrophages+is+important+for+the+induction+of+Tregs+to+regulate+T+cell-mediated+inflammation. assertion.
- assertion asSentence Inherited+human+gp91phox+deficiency+is+associated+with+impaired+isoprostane+formation+and+platelet+dysfunction. assertion.
- assertion asSentence IFN-gamma+enhances+interaction+of+GCN5+histone+acetyltransferase+with+gp91-phox+gene+promoter+and+acetylation+levels+of+histone-2+and+histone-3+lysine+residues+surrounding+the+promoter. assertion.
- assertion asSentence Nox2-containing+NADPH+oxidase+deficiency+protects+against+hypercholesterolemia-induced+impairment+of+neovascularization. assertion.
- assertion asSentence Decreased+electron+Transport+Complex+IV+activity+is+associated+with+ulcerative+colitis. assertion.
- assertion asSentence CYLD+enhances+tubulin+polymerization+into+microtubules+by+lowering+the+critical+concentration+for+microtubule+assembly. assertion.
- assertion asSentence Biallelic+CYLD+mutations+are+rarely+involved+in+classical+Hodgkin+lymphoma+pathogenesis. assertion.
- assertion asSentence Loss+of+CYLD+is+associated+with+skin+tumorigenesis+and+metastasis. assertion.
- assertion asSentence Reduced+CYLD+is+associated+with+chronic+lymphocytic+leukemia. assertion.
- assertion asSentence Effect+of+genotype+on+steady-state+CYP1A1+gene+expression+in+human+peripheral+lymphocytes. assertion.
- assertion asSentence CYP1A1+polymorphism+is+associated+with+the+susceptibility+to+psoriatic+arthritis+in+taiwan. assertion.
- assertion asSentence Concerted+role+of+CYP1A1+and+GSTM1+at-risk+genotypes+in+squamous+cell+lung+carcinoma+predisposition. assertion.
- assertion asSentence Time-dependent+differences+in+CYP1A1+expression+in+placental+cells+exposed+to+TCDD+and+PCDD%2FPCDF+mixture. assertion.
- assertion asSentence Used+shuffled+CYP1A1+library+to+examine+genotype%2Fphenotype+of+mutant+forms. assertion.
- assertion asSentence Benzo%28k%29fluoranthene+and+benzo%28a%29pyrene+induced+CYP1A1+and+CYP1B1+in+T-47D+human+breast+cancer+cells. assertion.
- assertion asSentence CYP1A1+induction+and+CYP3A4+inhibition+by+the+fungicide+imazalil+in+the+human+intestinal+Caco-2+cells-comparison+with+other+conazole+pesticides. assertion.
- assertion asSentence Anticancer+effects+of+the+flavonoid+diosmetin+on+cell+cycle+progression+and+proliferation+of+MDA-MB+468+breast+cancer+cells+due+to+CYP1A1+activation. assertion.
- assertion asSentence CYP1A2+-3860G%3EA+polymorphism+modifies+the+smoking-related+hepatocellular+carcinoma+risk+among+chronic+liver+disease+Japanese. assertion.
- assertion asSentence The+CYP1A1%2A2A+gene+cannot+be+linked+with+lung+cancer+risk+in+Brazilian+patients+at+this+time. assertion.
- assertion asSentence The+CYP1A1+rs1048943+genotype+affectS+the+risk+of+non-Hodgkin%27s+lymphoma+in+Korea. assertion.
- assertion asSentence CYP1A1+gene+polymorphisms+are+not+associated+with+cervical+cancer. assertion.
- assertion asSentence Genetic+peculiarities+particularly+xenobiotic+detoxification+enzymes+CYP1A1%2C+CYP2E1%2C+EPHX1+and+GSTM1%2C+GSTT1+play+important+role+in+pulmonary+diseases+development. assertion.
- assertion asSentence In+utero+tobacco+exposure+significantly+increases+placental+CYP1A1+expression+in+association+with+differential+methylation+at+a+critical+xenobiotic+response+element. assertion.
- assertion asSentence Genetic+polymorphisms+of+CYP1A1+is+not+associated+with+gastric+carcinoma. assertion.
- assertion asSentence Increased+risk+for+acute+lymphoblastic+leukemia+in+children+with+cytochrome+P450A1+%28CYP1A1%29-+and+NAD%28P%29H%3Aquinone+oxidoreductase+1+%28NQO1%29-inherited+gene+variants. assertion.
- assertion asSentence CYP1A1+MspI+polymorphism+has+no+association+with+the+development+of+head+and+neck+cancer. assertion.
- assertion asSentence Women+in+Siberia+with+SNPS+in+CYP1A1+gene%2C+in+CYP1A2+gene%2Cand+in+the+SULT1A1+gene+have+an+increased+risk+of+development+of+breast+cancer+. assertion.
- assertion asSentence Polymorphisms+of+cytochrome+P450+mono-oxygenase+are+weakly+associated+with+clear+cell+renal+cell+carcinoma+risk+in+Chinese+subjects. assertion.
- assertion asSentence CYP1A1+Ile462Val+polymorphism+is+associated+with+dystrophic+eye+diseases. assertion.
- assertion asSentence Comparative+aflatoxin+B%281%29+activation+and+cytotoxicity+in+human+bronchial+cells+expressing+cytochromes+P450+1A2+and+3A4. assertion.
- assertion asSentence No+associations+with+polymorphisms+of+CYP1A2+gene+and+Tardive+dyskinesia+in+Japanese+patients+with+schizophrenia. assertion.
- assertion asSentence CYP1A2-T2467delT+polymorphism+has+an+important+role+in+lung+carcinogenesis%2C+especially+SCC%2C+among+smokers. assertion.
- assertion asSentence CYP1A2+is+the+main+caffeine+metabolizing+enzyme. assertion.
- assertion asSentence Transcription+factors+with+an+affinity+for+Sp1+sites+mediate+transcriptional+activation+of+the+CYP1B1+gene+in+biotin-supplemented+T+cells%2C+increasing+the+occurrence+of+single-stranded+DNA+breaks. assertion.
- assertion asSentence CYP1B1+432GG%2C+119TT+and+48GG+genotypes+are+low-penetrance+risk+factors+for+developing+lung+cancer. assertion.
- assertion asSentence CYP1B1+mutations+are+the+predominant+cause+of+primary+congenital+glaucoma+in+the+Saudi+Arabian+population+with+G61E+as+the+dominant+disease-associated+allele. assertion.
- assertion asSentence CTY2A6+deletion+is+associated+with+gastric+adenocarcinoma+among+Japanese+populations. assertion.
- assertion asSentence Human+P450+2A6+displays+a+small+active+site+that+is+well+adapted+for+the+oxidation+of+small+planar+substrates. assertion.
- assertion asSentence Detected+by+polymerase+chain+reaction+in+prostate+tissue. assertion.
- assertion asSentence The+two+cis-acting+elements%2C+the+distal+PBREM+and+the+proximal+OARE%2C+within+the+chromatin+structure+are+both+regulated+by+CAR+in+response+to+okadaic+acid+and+TCPOBOP+to+maximally+induce+the+CYP2B6+promoter. assertion.
- assertion asSentence SMC1+binding+represses+OARE+%5BOA+%28okadaic+acid%29+response+element%5D+activity+and+its+dissociation+allows+the+recruitment+of+CAR%28constitutive+active%2Fandrostane+receptor%29+to+the+OARE%2C+synergizing+the+expression+of+the+CYP2B6+gene. assertion.
- assertion asSentence CYP2B6+G15631T+polymorphism+is+associated+with+acute+leukemia+susceptibility. assertion.
- assertion asSentence Variant+alleles+in+the+ABCB1%2C+SLC22A16+and+CYP2B6+genes+are+associated+with+response+to+AC+therapy+in+the+treatment+of+breast+cancer. assertion.
- assertion asSentence There+are+significantly+higher+serum+concentrations+associated+with+alleles+encoding+defective+CYP2C19+metabolism+in+psychiatric+patients. assertion.
- assertion asSentence Single+nucleotide+polymorphisms+in+the+CYP2C19+is+Associated+with+premenopausal+breast+cancer+women. assertion.
- assertion asSentence CYP2C19%2A17+carrier+status+is+significantly+associated+with+enhanced+response+to+clopidogrel+and+an+increased+risk+of+bleeding. assertion.
- assertion asSentence There+is+no+association+between+polymorphisms+in+the+CYP2C19+gene+and+severity+of+endometriosis. assertion.
- assertion asSentence Increased+and+tailored+clopidogrel+loading+dose+according+to+platelet+reactivity+monitoring+overcome+HTPR+in+carriers+of+the+loss-of-function+CYP2C19%2A2+polymorphism. assertion.
- assertion asSentence In+patients+with+high+on-treatment+platelet+reactivity+after+PCI%2C+prasugrel+is+more+effective+compared+with+high+clopidogrel+in+reducing+platelet+reactivity%2C+particularly+in+CYP2C19%2A2+carriers. assertion.
- assertion asSentence The+CYP2C19%2A2+loss-of-function+polymorphism+is+associated+with+a+more+frequent+occurrence+of+HPR. assertion.
- assertion asSentence In+CYP2C19+carriers%2Chigher+clopidogrel+maintenance+doses+overcame+clopidogrel+low+response+in+fewer+than+half+of+clopidogrel+low+responders+who+underwent+percutaneous+coronary+intervention+for+non-ST-segment+elevation+acute+coronary+syndrome. assertion.
- assertion asSentence The+efficacy+of+ilaprazole+is+not+affected+by+CYP2C19+polymorphisms. assertion.
- assertion asSentence The+CYP2C19%2A3+gene+polymorphism+is+associated+with+breast+cancer+risk+in+Chinese+Han+women. assertion.
- assertion asSentence CYP2C19+polymorphism+does+not+influence+the+effectiveness+of+ticagrelor+for+coronary+heart+disease. assertion.
- assertion asSentence Efavirenz+enhances+omeprazole+metabolism+in+a+nonstereoselective+manner+through+induction+of+CYP3A+and+CYP2C19+activity. assertion.
- assertion asSentence In+sigmoid+colon%2C+protein+levels+of+CYP2C8+are+significantly+higher+by+~73%25+than+in+the+descending+colon. assertion.
- assertion asSentence Increased+reactive+oxygen+species+and+enhanced+dihydroxyoctadecenoic+acid+synthesis+by+endothelial+CYP2C8+impair+functional+recovery+and+mask+the+effects+of+increased+epoxyeicosatrienoic+acids+after+ischemic-reperfusion+injury. assertion.
- assertion asSentence Allele+frequencies+of+functionally+important+CYP2C8+variants+in+the+Czech+population+are+similar+to+that+of+other+Caucasian+populations. assertion.
- assertion asSentence Polymorphism+of+CYP2C9+gene+is+involved+in+the+metabolism+of+various+drugs+used+clinically. assertion.
- assertion asSentence Carriers+of+CYP2C9x2+and+CYP2C9x3+alleles+more+rapidly+achieved+therapeutic+levels+of+hypocoagulation+and+required+significantly+lower+weekly+doses+of+warfarin. assertion.
- assertion asSentence CYP2C+metabolites+contribute+to+endothelium-mediated+vasodilation+of+peripheral+conduit+arteries+in+vivo. assertion.
- assertion asSentence CYP2C9+polymorphisms+are+associated+with+warfarin+dose+requirements+in+Turkish+patients. assertion.
- assertion asSentence Found+no+association+between+CYP2C9%28%2A%292%2F3+polymorphisms+and+risk+of+subclinical+atherosclerosis%2C+ischemic+vascular+disease+or+death+after+ischemic+heart+disease. assertion.
- assertion asSentence Patients+with+the+VKORC1+BB+haplotype+and+CYP2C9%2A1%2F%2A1+required+about+twice+the+warfarin+dose+compared+to+those+with+the+VKORC1+AA+haplotype+and+CYP2C9%2A1%2F%2A1. assertion.
- assertion asSentence There+is+no+cardiovascular+risk+associated+with+CYP2C9+variants+in+a+population+undergoing+coronary+angiography. assertion.
- assertion asSentence The+use+of+higher+clopidogrel+doses+can+attenuate+the+effect+of+CYP2C19+loss-of-function+variants. assertion.
- assertion asSentence Extreme+sensitivity+to+acenocoumarol+therapy+in+patient+with+both+VKORC.-1639+A%2FA+and+CYP2C9%2A1%2F%2A3+genotypes. assertion.
- assertion asSentence CYP2C9+and+VKORC1+polymorphisms+affect+suppoting+dose+of+warfarin+and+rate+of+hemorrhage+in+patients+with+venous+thromboembolic+complications+in+Moscow+population. assertion.
- assertion asSentence There+are+no+interactions+between+the+CYP2C9+and+VKORC1+genotypes+affecting+the+maintenance+dose%2C+time+to+severe+over-anticoagulation+and+time+to+achieve+stability+for+phenprocoumon+and+acenocoumarol. assertion.
- assertion asSentence Polymorphisms+in+VKORC1+have+more+impact+than+CYP2C9+polymorphisms+on+early+warfarin+International+Normalized+Ratio+control+and+bleeding+rates. assertion.
- assertion asSentence CYP2D6+catalyzes+the+major+metabolic+pathway+of+fluvoxamine. assertion.
- assertion asSentence The+pronounced+effect+of+the+CYP2D6+genotype+persists+during+long-term+therapy%2C+affecting+both+metabolic+ratio+and+metoprolol+plasma+concentration. assertion.
- assertion asSentence The+prevalence+of+CYP2D6+mutations+of+allelic+variants+predict+genotype+frequency+in+the+Croatian+population. assertion.
- assertion asSentence Duplications+and+multiplications+of+active+CYP2D6+genes+can+cause+ultrarapid+drug+metabolism+and+lead+to+therapeutic+failure+or+unwanted+side+effects. assertion.
- assertion asSentence CYP2c19+and+CYP2d6+genotypes+can+be+used+to+predict+imipramine%2Bdesipramine+plasma+levels+in+in+depressed+patients. assertion.
- assertion asSentence The+presence+of+the+APOE-4+allele+and+CYP2D6+genotype+to+deteriorate+the+cholinesterase+inhibitors+therapeutic+outcome+in+Alzheimer%27s+disease. assertion.