Matches in Nanopublications for { ?s <http://purl.org/nanopub/x/asSentence> ?o ?g. }
- assertion asSentence The+major+metabolites+formed+by+the+P450+BM3+mutants+differ+from+those+formed+by+human+cytochrome+P450+2D6. assertion.
- assertion asSentence Metoprolol+disposition+and+effects+are+mainly+controlled+by+CYP2D6+genotype. assertion.
- assertion asSentence Reduced-activity+alleles+of+CYP2D6+is+associated+with+tamoxifen+metabolism+in+breast+cancer. assertion.
- assertion asSentence CYP2D6+polymorphism+is+an+important+predictor+for+the+prognosis+of+patients+with+breast+cancer+treated+with+tamoxifen. assertion.
- assertion asSentence Genotypes+of+CYP2B6%2C+GSTP1+and+CYP2D6+are+related+to+susceptibility+to+the+metabolism+of+styrene+in+human. assertion.
- assertion asSentence CYP2D6+genotype+and%2C+to+a+lesser+degree%2C+urine+pH+contribute+to+the+variability+in+pharmacokinetic+profiles+of+dextromethorphan. assertion.
- assertion asSentence Harmine%2C+harmaline%2C+harmol+and+harmane+exhibited+noncompetitive+inhibition+on+the+activity+of+CYP2D6. assertion.
- assertion asSentence Compared+with+the+CYP2D6+wt%2Fwt+group%2C+the+area+under+the+plasma+concentration-time+curve+%28AUC%280-infinity%29%29+values+for+lovastatin+lactone+increased. assertion.
- assertion asSentence Genetic+variants+in+CYP2D6+are+associated+with+Ecstasy-induced+hyponatraemia. assertion.
- assertion asSentence The+unliganded+CYP2D6+is+compressible%2C+quinidine+binding+significantly+rigidifies+the+CYP2D6+active+site. assertion.
- assertion asSentence There+is+a+correlation+between+the+RsaI+polymorphism+homozygous+uncut+genotype+in+the+CYP2E1+gene+and+a+higher+relative+risk+of+nasopharyngeal+carcinoma+development+in+the+Thai+or+Chinese+populations+in+Thailand. assertion.
- assertion asSentence Chlorzoxazone+metabolism+in+vivo+remains+the+only+available+method+for+CYP2E1+phenotyping. assertion.
- assertion asSentence The+CYP2E1+c2%2Fc2+genotype+increases+susceptibility+to+rectal+cancer+and+the+gene-environmental+interactions+between+the+CYP2E1+polymorphism+and+smoking+or+alcohol+drinking+exist+for+colorectal+neoplasia+in+general. assertion.
- assertion asSentence Variation+in+activity+and+inducibility+of+CYP2E1+contribute+to+the+development+of+colorectal+carcinogenesis. assertion.
- assertion asSentence Genetic+peculiarities+particularly+xenobiotic+detoxification+enzymes+CYP1A1%2C+CYP2E1%2C+EPHX1+and+GSTM1%2C+GSTT1+play+important+role+in+pulmonary+diseases+development. assertion.
- assertion asSentence Subjects+with+ADH1C%2A1%2F%2A1+and+CYP2E1%2Ac1%2F%2Ac2+genotypes+become+alcohol+dependent+at+a+considerably+younger+age+than+the+subjects+with+ADH1C%2A1%2F%2A2%2C+ADH1C%2A2%2F%2A2+and+CYP2E1%2Ac1%2F%2Ac1+genotypes. assertion.
- assertion asSentence Cytochrome+P450+2E1+polymorphism+is+associated+with+chromosomal+instability+of+1%2C3-butadiene+exposed+workers. assertion.
- assertion asSentence CYP2E1+single+nucleotide+polymorphism+is+not+associated+with+colorectal+cancer. assertion.
- assertion asSentence The+c-Jun-responsive+module+between+-122+and+-50+in+the+CYP2J2+proximal+promoter+contains+an+atypical+AP-1+element+at+-105%2F-95+that+has+a+major+role+in+c-Jun+transactivation+and+acts+in+conjunction+with+the+-56%2F-63+element+to+regulate+expression. assertion.
- assertion asSentence CYP3A5%2A3+polymorphism+is+associated+with+pharmacokinetics+of+the+immunosuppressive+agents%2C+tacrolimus+and+sirolimus. assertion.
- assertion asSentence Rrutaecarpine+and+limonin+are+mechanism-based+inhibitors+of+CYP3A4+from+liver+microsomes. assertion.
- assertion asSentence Fast+and+reliable+in+silico+methods+predicting+CYP+inhibition+from+calculated+molecular+properties+are+an+important+tool+which+can+be+applied+to+assess+value+of+inhibitors. assertion.
- assertion asSentence Valproic+acid+up-regulates+CYP3A4+by+activating+CAR+and%2For+PXR+pathways+and+synergistically+augments+the+effect+of+rifampicin+in+transactivation+of+CYP3A4. assertion.
- assertion asSentence Common+polymorphisms+on+CYP3A4+and+CYP3A5+genes+do+not+modify+the+risk+of+developing+digestive+cancers+in+Western+Europe. assertion.
- assertion asSentence The+6bp-deletion+affects+the+PAR-2%28SV1%29+expression+greatly%2C+contributing+to+the+adjustment+of+expression+and+function+of+total+PXR--which+leads+to+the+changed+target+gene+expressions%2C+partly+explaining+interindividual+variations+in+CYP3A4+and+MDR1. assertion.
- assertion asSentence The+CYP3A4%2A1B+G+allele+is+associated+with+a+lower+risk+of+elevated+statin+plasma+levels%2C+particularly+in+women+and+in+users+with+the+ABCB1+3435T+variant+allele. assertion.
- assertion asSentence CYP3A4+plays+a+significant+role+in+clozapine+biotransformation+in+patients+with+schizophrenia. assertion.
- assertion asSentence Harmine%2C+harmol+and+harmane+exhibited+noncompetitive+inhibition+on+the+activity+of+CYP3A4. assertion.
- assertion asSentence Single+Nucleotide+Polymorphisms+in+CYP3A4+gene+is+associated+with+prostate+cancer. assertion.
- assertion asSentence CYP3A4%2A22+constitutes+a+risk+factor+for+DGF+and+worse+creatinine+clearance+in+patients+receiving+Cyclosporine+A-based+immunosuppressive+therapy. assertion.
- assertion asSentence mRNA+level+of+CYP3A5+is+significantly+lower+in+the+ascending+colon+in+comparison+to+the+descending+and+sigmoid+colon. assertion.
- assertion asSentence Attractive+candidate+for+a+pharmacogenetic+strategy+is+tacrolimus+dosing+based+on+the+CYP3A5+genotype+in+transplantation+mimunology. assertion.
- assertion asSentence CYP3A5+genotype+is+a+significant+genetic+factor+whose+algorithm+can+predict+tacrolimus+dose+in+renal+transplant+recipients. assertion.
- assertion asSentence Association+between+renal+function+and+CYP3A5+genotype+in+heart+transplant+recipients+treated+with+calcineurin+inhibitors. assertion.
- assertion asSentence CYP3A5+6986A%3EG+polymorphism+is+associated+with+the+interindividual+variability+of+the+pharmacokinetics+of+Tacrolimus+in+renal+transplantation+patients. assertion.
- assertion asSentence CYP3A5+polymorphisms+are+associated+with+the+severity+and+degree+of+hypertension+in+kidney+transplant+recipients+receiving+calcineurin+inhibitors. assertion.
- assertion asSentence In+patients+with+established+and+stable+coronary+artery+disease+the+434SS+variant+of+CYP4A11+F434+is+associated+with+pronounced+coronary+vasoconstriction. assertion.
- assertion asSentence The+loss-of-function+CYP4A11+8590C+allele+is+associated+with+a+diagnosis+of+hypertension+and%2C+in+normotensive+individuals%2C+with+higher+blood+pressure+regardless+of+salt+intake. assertion.
- assertion asSentence Liver+receptor+homolog+1+%28LRH-1%29+is+a+key+transcriptional+factor+required+for+the+hepatic+expression+of+CYP7A1. assertion.
- assertion asSentence CYP7A1+promoter+polymorphism+is+not+a+valuable+marker+of+gallstone+disease+susceptibility+in+a+Polish+population. assertion.
- assertion asSentence CYP7A1+polymorphisms+are+associated+with+colorectal+adenoma. assertion.
- assertion asSentence SNP+rs3732860+of+CYP8B1+gene+is+associated+with+gallstone+disease+in+this+Chinese+population. assertion.
- assertion asSentence CYP11A+should+be+considered+as+a+candidate+breast+cancer+susceptibility+gene+in+men+and+women. assertion.
- assertion asSentence Repeat+polymorphism+in+CYP11A1+is+associated+with+Prostate+Cancer. assertion.
- assertion asSentence Micro-satellite+polymorphism+%28tttta%29n+of+gene+CYP11+alpha+exists+in+Chinese+women+and+the+polymorphism+does+not+relate+to+the+pathogenesis+of+hyperandrogenism+in+women+with+polycystic+ovary+syndrome. assertion.
- assertion asSentence CYP11B1+gene+is+associated+wth+autistic+traits%2C+empathy+and+Asperger+syndrome. assertion.
- assertion asSentence Inactivating+mutations+cause+aldosterone+synthase+deficiency. assertion.
- assertion asSentence The+C-344T+polymorphism+of+aldosterone+synthase+gene+plays+a+role+in+controlling+systolic+blood+pressure+and+the+age-related+increase+in+systolic+blood+pressure+in+response+to+age+and+to+body+fat. assertion.
- assertion asSentence The+regulatory+role+of+the+-344C%2FT+polymorphism+of+CYP11B2+is+associated+with+Age-+and+gender-related+blood+pressure. assertion.
- assertion asSentence CYP11B2+T-344C+promoter+polymorphism+predisposes+to+clinical+AF+in+patients+with+HF. assertion.
- assertion asSentence CYP11B2+gene+-344C%2FT+polymorphism+affects+the+risk+of+hypertension+in+Japanese+men+and+high-salt+intake+levels+strengthen+this+association. assertion.
- assertion asSentence CN+mediates+the+Ang+II-induced+aldosterone+synthesis+through+up-regulation+of+the+CYP11B2+transcription. assertion.
- assertion asSentence C-344T+polymorphism+is+a+risk+factor+for+accelerated+progression+in+Caucasian+patients+with+IgA+nephropathy. assertion.
- assertion asSentence CYP17+promoter+is+more+active+in+polycystic+ovary+syndrome+theca+cells+than+in+normal+theca+cells. assertion.
- assertion asSentence Colocalization+of+CytB5+and+P450c17+strongly+supports+the+view+that+CytB5+plays+an+important+role+in+the+regulation+of+the+androgen+biosynthetic+pathway+in+the+fetal+and+adult+human. assertion.
- assertion asSentence Sphingosine+is+a+bonafide+endogenous+ligand+for+SF1+and+a+negative+regulator+of+CYP17+gene+expression. assertion.
- assertion asSentence Genetic+polymorphisms+of+CYP17+are+associated+with+breast+cancer. assertion.
- assertion asSentence CYP17+gene+polymorphism+in+women+affected+with+endometriosis. assertion.
- assertion asSentence No+association+between+CYP17+polymorphisms+and+risk+for+hepatocellular+carcinoma. assertion.
- assertion asSentence Single+nucleotide+polymorphisms+in+the+CYP17+is+Associated+with+premenopausal+breast+cancer+women. assertion.
- assertion asSentence CYP17+gene+polymorphism+is+associated+with+prostate+cancer+susceptibility. assertion.
- assertion asSentence Anderogen+receptor+activity+in+castration-resistant+VCaP+tumor+xenografts+can+be+restored+through+CYP17A1-dependent+de+novo+androgen+synthesis. assertion.
- assertion asSentence The+syndrome+of+17%2C20+lyase+deficiency. assertion.
- assertion asSentence Modulation+of+aromatase+expression+in+human+breast+tissue. assertion.
- assertion asSentence 17alpha-methyl+testosterone+is+a+competitive+inhibitor+of+aromatase+activity+in+Jar+choriocarcinoma+cells+and+macrophage-like+THP-1+cells+in+culture. assertion.
- assertion asSentence Phosphorylation+processes+mediate+rapid+changes+of+brain+aromatase+activity. assertion.
- assertion asSentence Polymorphisms+in+the+CYP19+gene+are+associated+with+bone+gain+in+response+to+hormone+replacement+therapy. assertion.
- assertion asSentence Regulation+of+cytochrome+P450+gene+expression+in+gonadial+cells. assertion.
- assertion asSentence CYP19+gene+polymorphism+increases+the+risk+of+breast+cancer+in+premenopausal+japanese+women. assertion.
- assertion asSentence Three+CYP19A1+polymorphisms+%28rs1065779%2C+rs752760%2C+rs1870050%29+are+related+to+risk+of+endometrial+cancer%2C+effects+modified+by+tea+consumption. assertion.
- assertion asSentence Adrenal+cortical+carcinomas+are+character-+ized+by+an+imbalance+between+estrogen+receptor+alpha+and+estrogen+receptor+beta+levels+and+increased+aromatase+expression. assertion.
- assertion asSentence No+association+between+CYP19+polymorphisms+and+risk+for+hepatocellular+carcinoma. assertion.
- assertion asSentence Common+variants+in+CYP19A1+%28the+A+alleles+of+rs749292+and+rs727479%29+influences+susceptibility+to+endometrial+cancer%2C+particularly+among+older+and+obese+women. assertion.
- assertion asSentence High+confluency+of+human+adipose+stromal+cells+cultured+in+vitro+can+significantly+stimulate+aromatase+gene+expression+and+reduce+the+expression+of+breast+tumor+suppressor+BRCA1+and+members+of+the+NR4A+orphan+nuclear+family. assertion.
- assertion asSentence FXR+is+able+to+compete+with+steroidogenic+factor+1+in+binding+to+a+common+sequence+present+in+the+aromatase+promoter+region+interfering+negatively+with+its+activity. assertion.
- assertion asSentence Boundaries+within+AR+and+CYP19A1+that+are+associated+with+endometrial+cancer+risk. assertion.
- assertion asSentence Frequency+of+CYP21+heterozygosity+is+high+among+Turkish+women+with+hirsutism+and+hyperandrogenism. assertion.
- assertion asSentence In+21-hydroxylase+dficiency%2C+level+of+in+vitro+enzymatic+function+allows+for+classification+of+mutation+groups+and+prediction+of+disease+severity. assertion.
- assertion asSentence Molecular+genetics+of+21-hydroxylase+deficiency. assertion.
- assertion asSentence It+inactivate+vitamin+D+and+its+expression+is+controlled+by+mechanical+stress+and+mitogen+activated+protein+kinase. assertion.
- assertion asSentence The+presence+of+CYP24A1+mutations+explains+the+increased+sensitivity+to+vitamin+D+in+patients+with+idiopathic+infantile+hypercalcemia+and+is+a+genetic+risk+factor+for+the+development+of+symptomatic+hypercalcemia. assertion.
- assertion asSentence Bioengineering+anabolic+vitamin+D-25-hydroxylase+activity+into+the+human+vitamin+D+catabolic+enzyme%2C+cytochrome+P450+CYP24A1%2C+by+a+V391L+mutation. assertion.
- assertion asSentence Low+CYP24+is+associated+with+breast+cancer. assertion.
- assertion asSentence Levels+of+27-hydroxycholesterol+are+not+of+critical+importance+for+cholesterol+homeostasis+in+mice. assertion.
- assertion asSentence Features+of+the+retinal+environment+which+affect+the+activities+and+product+profile+of+cholesterol-metabolizing+cytochromes+P450+CYP27A1+and+CYP11A1. assertion.
- assertion asSentence 1Alpha-hydroxylase+is+found+in+both+neurons+and+glial+cells+of+the+brain+in+a+regional+and+layer-specific+pattern. assertion.
- assertion asSentence Common+inherited+variation+in+the+vitamin+D+metabolism+such+as+mutation+in+CYP27B1+affect+susceptibility+to+type+1+diabetes. assertion.
- assertion asSentence Association+between+polymorphisms+across+the+entire+vitamin+D+receptor+%28VDR%29+gene+and+genes+encoding+for+vitamin+D+activating+enzyme+1-alpha-hydroxylase+%28CYP27B1%29+and+deactivating+enzyme+24-hyroxylase+%28CYP24A1%29+and+prostate+cancer+risk. assertion.
- assertion asSentence Low+CYP27B1+is+associated+with+invasive+breast+tumours. assertion.
- assertion asSentence A+cAMP-responsive+element+binding+site+is+essential+for+sterol+regulation+of+the+human+lanosterol+14alpha-demethylase+gene. assertion.
- assertion asSentence DAB2+expression+during+megakaryocytic+differentiation+expression+is+regulated+by+platelet-derived+growth+factor. assertion.
- assertion asSentence DOC-2%2FDAB2+can+modulate+androgen+receptor-mediated+cell+growth+in+both+normal+and+malignant+prostatic+epithelial+cells. assertion.
- assertion asSentence Loss+of+Disabled-2+%28DAB2%29+protein+expression+occurs+in+early+pre-neoplastic+stages+of+development+of+esophageal+cancer+and+is+sustained+down+the+tumorigenic+pathway. assertion.
- assertion asSentence DAD1+gene+expression+is+decreased+in+follicular+variant+of+papillary+thyroid+carcinoma. assertion.
- assertion asSentence Single-nucleotide+polymorphisms+in+DAD1+gene+is+associated+with+neuroendocrine+tumor. assertion.
- assertion asSentence In+transgenic+pigs%2C+delays+xenograft+heart+rejection+in+baboons+treated+with+immunosuppressive+agents. assertion.
- assertion asSentence In+transgenic+swine%2C+significantly+increased+survival+time+of+kidney+xenograft+to+baboons. assertion.
- assertion asSentence Transgenic+human+DAF+improves+the+performance+of+pig+hearts+by+reducing+myocardial+damage+and+intravascular+thrombosis+after+heart+translpantation. assertion.
- assertion asSentence CD55+and+CD59+expressions+on+peripheral+blood+leucocytes+are+decreased+in+T2DM+patients+with+macrovascular+diseases. assertion.
- assertion asSentence Human+CD55+expression+blocks+hyperacute+rejection+and+restricts+complement+activation+in+Gal+knockout+cardiac+xenografts. assertion.