Matches in Nanopublications for { ?s <http://purl.org/nanopub/x/asSentence> ?o ?g. }
- assertion asSentence Serum+alpha-defensin+%28-1%2C+-2+and+-3%29+concentrations+are+increased+in+type+1+diabetic+patients+with+diabetic+nephropathy. assertion.
- assertion asSentence Alpha-defensin+human+neutrophil+protein+1+%28HNP1%29+and+human+alpha-defensin+5+%28HD5%29+inhibit+BKV+infection+by+targeting+an+early+event+in+the+viral+lifecycle. assertion.
- assertion asSentence Defensins+5+and+6+enhance+HIV-1+infectivity+through+promoting+HIV+attachment. assertion.
- assertion asSentence DEFB1+is+down-regulated+in+human+prostatic+and+renal+carcinomas. assertion.
- assertion asSentence Expression+of+mRNA+is+upregulated+during+differentation+of+keratinocyte+immortalized+cell+lines. assertion.
- assertion asSentence Variation+in+DEFB1+contributes+to+asthma+diagnosis%2C+with+apparent+gender-specific+effects. assertion.
- assertion asSentence Francisella+tularensis+LVS+infection+has+a+moderate+effect+on+the+level+of+hBD-1+in+airway+epithelial+cells. assertion.
- assertion asSentence The+DEFB1+gene+has+a+main+effect+on+the+skin+inflammation+and%2For+skin+responsiveness+to+any+kind+of+allergic+reaction. assertion.
- assertion asSentence Under+the+condition+of+bisphosphonate-associated+osteonecrosis+of+the+jaws+an+increased+expression+of+hBD-1%2C-2%2C-3+is+detectable. assertion.
- assertion asSentence Functional+single-nucleotide+polymorphisms+in+the+DEFB1+gene+are+associated+with+systemic+lupus+erythematosus+in+Southern+Brazilians. assertion.
- assertion asSentence Nontypeable+Haemophilus+influenzae+%28NTHI%29+lipooligosaccharide+htrB+mutants+exhibited+greater+than+45-fold-increased+sensitivity+to+human+beta-defensin+2+%28HBD-2%29+compared+to+the+wild+type. assertion.
- assertion asSentence In+human+epidermis%2C+HBD-2+protein+is+packaged+in+lamellar+bodies. assertion.
- assertion asSentence Beta-defensins+are+integral+components+of+innate+host+defenses+playing+an+essential+part+in+the+resistance+of+the+human+skin+surfaces+against+M.+furfur+uptake+and+other+microbial+invasion. assertion.
- assertion asSentence DEFB4+gene+is+duplicated+on+human+chromosome+8p. assertion.
- assertion asSentence Activation+of+NF-kappaB+%28p50-p65%29+and+AP-1+are+crucial+events+for+induction+of+hBD-2+in+keratinocytes+upon+IL-1beta+and+Pseudomonas+aeruginosa+stimulation. assertion.
- assertion asSentence Induced+by+flagellin+of+probiotic+Escherichia+coli+Nissle+1917. assertion.
- assertion asSentence Histamine+stimulates+H1+receptor+and+potentiates+TNF-alpha-+or+IFN-gamma-induced+hBD-2+production+dependent+on+NF-kappaB%2C+AP-1%2C+or+STAT1+in+human+keratinocytes. assertion.
- assertion asSentence Beta+defensin+2+induction+by+NTHi+takes+place+through+the+TLR2+dependent+MyD88-IRAK1-TRAF6-p38+MAPK+pathway+in+airway+mucosa. assertion.
- assertion asSentence Prolonged+exposure+to+IL-4%2F13+during+mucociliary+differentiation+contributes+to+antimicrobial+defence+by+increasing+the+expression+and+release+of+hBD-2+and+mucus. assertion.
- assertion asSentence Removal+of+antibodies+by+immunoadsorption+modulates+myocardial+gene+expression+of+desmin+in+dilated+cardiomyopathy+patients. assertion.
- assertion asSentence The+Uruguayan+family+with+severe+cardiomyopathy+carries+an+unusual+deletion+p.E114del+within+the+1A+rod+domain+of+desmin. assertion.
- assertion asSentence C-terminal+region+of+each+subunit%2C+DFF40+%28RLKRK%29+and+DFF45+%28KRAR%29%2C+is+essential+for+nuclear+accumulation+of+the+DFF+complex. assertion.
- assertion asSentence The+DFF45+level+in+human+endometrium+corresponds+to+the+respective+phase+of+the+menstrual+cycle+and+decreases+significantly+after+menopause. assertion.
- assertion asSentence CAD+is+downregulated+at+the+mRNA+and+protein+level+during+the+erythroid+differentiation+in+TF-1+cells. assertion.
- assertion asSentence Bax%2FBak-dependent+release+of+DDP%2FTIMM8a+promotes+Drp1-mediated+mitochondrial+fission+and+mitoptosis+during+programmed+cell+death. assertion.
- assertion asSentence mRNA+expression+demonstrate+increased+TIMM8A+mRNA+levels+in+cultured+fibroblasts+from+a+patient+with+Mohr-Tranebjaerg+Syndrome. assertion.
- assertion asSentence Cochlin-specific+interferon-gamma-producing+T+cells+are+implicated+in+the+etiopathogenesis+of+autoimmune+sensorineural+hearing+loss. assertion.
- assertion asSentence Deoxyguanosine+kinase+gene+mutations+combined+with+impaired+glucose+homeostasis+and+iron+overload+features+are+associated+with+severe+progressive+liver+failure. assertion.
- assertion asSentence DHCR7+mutation+is+a+rapid+and+reliable+method+for+prenatal+diagnosis+of+Smith-Lemli-Opitz+syndrome. assertion.
- assertion asSentence GC+and+NADSYN1%2FDHCR7+loci+individually+and+collectively+contribute+to+variation+in+plasma+vitamin+D+levels+in+Chinese+Hans. assertion.
- assertion asSentence DHCR24+protects+neuroblastoma+cells+against+Abeta+toxicity+by+increasing+membrane+cholesterol+content. assertion.
- assertion asSentence The+tea+polyphenol%2C+epigallocatechin-3-gallate%2C+is+an+efficient+inhibitor+of+human+dihydrofolate+reductase. assertion.
- assertion asSentence A+19-base+pair+deletion+polymorphism+in+dihydrofolate+reductase+is+a+functional+polymorphism%2C+because+it+limits+assimilation+of+folic+acid+into+cellular+folate+stores+at+high+and+low+folic+acid+intakes. assertion.
- assertion asSentence Interaction+of+the+molecular+chaperone+Hsp70+with+human+NAD%28P%29H%3Aquinone+oxidoreductase+1. assertion.
- assertion asSentence Activation+of+NAD%28P%29H%3Aquinone+oxidoreductase+1+prevents+arterial+restenosis+by+suppressing+vascular+smooth+muscle+cell+proliferation. assertion.
- assertion asSentence Genetic+polymorphisms+in+the+NQO1+gene+are+associated+with+susceptibility+to+asthma+in+adults+among+those+exposed+to+traffic-related+air+pollution. assertion.
- assertion asSentence Indolequinones+inhibit+NQO2+activity+in+K562+leukemia+cells+at+nanomolar+concentrations+that+do+not+inhibit+NQO1+and+are+nontoxic+to+cells. assertion.
- assertion asSentence C609T+polymorphism+of+NAD%28P%29H+quinone+oxidoreductase+1+is+associated+with+response+to+amrubicin+therapy+in+lung+cancer. assertion.
- assertion asSentence Type+2+iodothyronine+deiodinase+expression+is+upregulated+by+the+protein+kinase+A-dependent+pathway+and+is+downregulated+by+the+protein+kinase+C-dependent+pathway+in+cultured+human+thyroid+cells. assertion.
- assertion asSentence Increased+thyroidal+D2+activity+in+the+thyroid+gland+is+responsible+for+the+higher+serum-free+levels+in+patients+with+defective+thyroglobin+transport. assertion.
- assertion asSentence DIO2+modifies+inflammatory+responses+in+chondrocytes. assertion.
- assertion asSentence The+SeC+residue+in+the+catalytic+center+of+D3+is+essential+for+efficient+inner-ring+deiodination+of+T%283%29+and+in+particular+T%284%29+at+physiological+substrate+concentrations. assertion.
- assertion asSentence Deiodinase+D3+exists+as+homo-+or+heterodimer+in+living+intact+cells%2C+a+feature+that+is+critical+for+their+catalytic+activities. assertion.
- assertion asSentence Impaired+interaction+between+NAP57+and+SHQ1+is+a+molecular+basis+for+dyskeratosis+congenita. assertion.
- assertion asSentence MPP7+targets+to+the+lateral+surface+of+epithelial+cells+via+its+L27N+domain%2C+through+an+interaction+with+Dlg1. assertion.
- assertion asSentence The+different+hDlg+isoforms+play+distinct+roles+at+various+stages+of+epithelial+differentiation. assertion.
- assertion asSentence SAP97+is+a+major+partner+for+surface+expression+and+CaMKII-dependent+regulation+of+cardiac+Kv4.2+and+kv4.3+channels. assertion.
- assertion asSentence Muscarinic-induced+recruitment+of+plasma+membrane+Ca2%2B-ATPase+involves+PSD-95%2FDlg%2FZo-1-mediated+interactions. assertion.
- assertion asSentence Provides+the+sequence+of+human+DLX2+and+compares+it+to+the+murine+gene. assertion.
- assertion asSentence MDA-MB-231+breast+neoplasms+expressed+DLX2. assertion.
- assertion asSentence A+RING+finger+protein+Praja1+regulates+Dlx5-dependent+transcription+through+its+ubiquitin+ligase+activity+for+the+Dlx%2FMsx-interacting+MAGE%2FNecdin+family+protein%2C+Dlxin-1. assertion.
- assertion asSentence p63+binds+to+an+enhancer+element+in+the+SHFM1+locus+and+this+element+controls+expression+of+DLX6+and+DLX5+which+are+important+for+limb+development. assertion.
- assertion asSentence Two+patients+that+have+in+common+a+p63-Dlx5%2FDlx6+pathway+dysregulation. assertion.
- assertion asSentence The+repetitive+scavenger+receptor+cysteine-rich+%28SRCR%29+domains+and+SRCR-interspersed+domains+%28SID%29+of+DMBT1+define+a+complex+multi-allele+system+that+represents+the+major+basis+for+the+variability+of+DMBT1+in+cancer. assertion.
- assertion asSentence The+applicability+of+the+vector+system+by+expression+of+the+largest+DMBT1+variant+in+a+tetracycline-inducible+mammalian+expression+system+using+the+Chinese+hamster+ovary+cell+line. assertion.
- assertion asSentence DMBT1+and+its+glycosylation+in+the+adenoma-carcinoma+sequence+leading+to+the+adenocarcinoma+phenotype. assertion.
- assertion asSentence Since+Dp71+lacks+the+actin+binding+domain%2C+it+cannot+form+the+essential+linkage+between+the+dystrophin+associated+proteins+complex+and+the+cytoskeleton. assertion.
- assertion asSentence Patients+with+double+deletion+mutations+within+the+dystrophin+gene+have+a+milder+phenotype+than+patients+harboring+single+deletions+at+either+major+or+minor+hot+spots+of+the+gene. assertion.
- assertion asSentence Disruption+of+DMD+and+the+absence+of+ACSL4+in+a+patient+are+responsible+for+neuromuscular+disease+and+cognitive+impairment. assertion.
- assertion asSentence Deletions+within+the+dystrophin+gene+account+for+%3E70%25+of+mutations+leading+to+Duchenne+and+Becker+muscular+dystrophies. assertion.
- assertion asSentence Stem+cells+from+fetal+blood+differentiate+into+myotubes+and+express+DMD+in+vitro+only+after+exposure+to+in+vivo+muscle+environment. assertion.
- assertion asSentence Mutant+DMD+platelets+have+a+disorganized+cytoskeleton+and+manifest+Gs+hyperactivity+and+reduced+platelet+collagen+reactivity. assertion.
- assertion asSentence Changes+in+transgenic+dystrophin+expression+and+the+formation+of+rings+are+adaptations+to+myotendinous+strain+injury+that+help+to+prevent+muscle+necrosis+and+retain+the+function+of+necessary+muscles+during+injury%2C+aging+and+disease. assertion.
- assertion asSentence Insertion+of+the+IL1RAPL1+gene+into+the+duplication+junction+of+the+dystrophin+gene+is+associated+with+muscular+dystrophy. assertion.
- assertion asSentence Combination+of+traditional+multiplex+PCR+of+hotspot+exons+with+real-time+PCR+quantification+of+only+exons+4%2C+17%2C+47+and+52+positively+diagnosed+59%25+of+Syrian+DMD%2FBMD+patients. assertion.
- assertion asSentence Three+SIBLINGs+%28small+integrin-binding+ligand%2C+N-linked+glycoproteins%29+enhance+factor+H%27s+cofactor+activity+enabling+MCP-like+cellular+evasion+of+complement-mediated+attack. assertion.
- assertion asSentence Simvastatin+plus+all-trans+retinoic+acid+reduces+expression+of+WT1+and+DMP1+in+the+promyelocytic+leukemia+cell+line+NB4. assertion.
- assertion asSentence Crystal+structure+of+human+dynamin+1+in+the+nucleotide-free+state+with+a+four-domain+architecture+comprising+the+GTPase+domain%2C+the+bundle+signalling+element%2C+the+stalk+and+the+pleckstrin+homology+domain. assertion.
- assertion asSentence Myotonic+dystrophy+is+an+autosomal+dominant+disease+caused+by+a+trinucleotide+repeat-expansion%2C+cytosine-thymine-guanine+%28CTG%29n%2C+in+the+3%27+untranslated+region+of+a+gene+encoding+DMPK. assertion.
- assertion asSentence The+Poly%28ADP-ribose%29+polymerase-1-regulated+endonuclease+DNAS1L3+is+required+for+etoposide-induced+internucleosomal+DNA+fragmentation+and+increases+etoposide+cytotoxicity+in+transfected+osteosarcoma+cells. assertion.
- assertion asSentence Four+heterozygous+dynamin+2+%28DNM2%29+mutations+in+five+centronuclear+myopathy+patients+aged+1+to+15+years. assertion.
- assertion asSentence Over-expressed+in+squamous+cell+carcinoma+of+the+mouth. assertion.
- assertion asSentence DNMT1+protein+levels+are+elevated+in+breast+cancer+tissues+and+in+MCF-7+breast+cancer+cells+relative+to+normal+human+mammary+epithelial+cells+without+a+concomitant+increase+in+DNMT1+mRNA+or+proliferative+fraction. assertion.
- assertion asSentence Direct+role+of+Dnmt1+in+the+restoration+of+epigenetic+information+during+DNA+repair. assertion.
- assertion asSentence DNMT1+expression+is+increased+in+schizophrenia+%28SZ%29+and+bipolar+%28BP%29+disorder+brains. assertion.
- assertion asSentence EBV+latent+membrane+protein+2A+%28LMP2A%29+up-regulated+DNMT1%2C+leading+to+an+increase+in+methylation+of+the+PTEN+promoter+in+stomach+cancer. assertion.
- assertion asSentence No+association+between+DNMT1+and+colorectal+cancer+in+Iranian+patients. assertion.
- assertion asSentence The+mRNA+of+DNMT1+%28DNA-methyltransferase+1%29+is+expressed+in+the+endometrium+across+the+menstrual+cycle. assertion.
- assertion asSentence Mutations+in+DNMT1+cause+autosomal+dominant+cerebellar+ataxia%2C+deafness+and+narcolepsy. assertion.
- assertion asSentence The+human+de+novo+enzymes+hDNMT3a+and+hDNMT3b+form+complexes+with+the+major+maintenance+enzyme+hDNMT1. assertion.
- assertion asSentence DNMT3L+stimulates+de+novo+methylation+by+Dnmt3a. assertion.
- assertion asSentence Over-expressed+in+squamous+cell+carcinoma+of+the+mouth. assertion.
- assertion asSentence Disruption+of+the+N-capping+motif+of+helix+9+alters+the+conformational+dynamics+of+the+C-terminal+region+and%2C+consequently%2C+the+features+of+the+H-site+to+which+hydrophobic+substrates+bind. assertion.
- assertion asSentence Both+Met51+and+Phe52+in+the+intersubunit+lock-and-key+motif+play+important+structural+roles+in+maintaining+the+catalytic+and+ligandin+functions+and+stability+of+the+GST+dimer. assertion.
- assertion asSentence Polymorphisms+of+glutathione+S-transferase+A1+and+O1+and+breast+cancer+among+postmenopausal+Danish+women. assertion.
- assertion asSentence Polymorphisms+in+GSTA1+is+associated+with+lower+busulfan+pharmacokinetics+in+children+with+congenital+hemoglobinopathies+undergoing+hematopoietic+stem+cell+transplantation. assertion.
- assertion asSentence From+the+total+of+117+samples%2C+43.5%25+are+homozygous+for+hGSTA1%2AA+allele%2C+13%25+are+homozygous+for+hGSTA1%2AB+allele+and+43.5%25+are+hGSTA1%2AA%2FB+heterozygotes. assertion.
- assertion asSentence Overexpression+of+GSTA2+by+transient+transfection+protected+Colo+320HSR+cells+against+both+cycle+arrest+and+apoptosis+following+exposure+to+HN2. assertion.
- assertion asSentence Single+nucleotide+polymorphism+in+GSTA2+is+associated+with+low-stage+non-small+cell+lung+cancer. assertion.
- assertion asSentence Different+genotype+combinations+of+p53+and+GSTM1+increase+the+risk+of+developing+specific+histological+subtypes+of+NSCLC. assertion.
- assertion asSentence Polymorphism+is+not+associated+with+laryngeal+cancer+risk+in+Caucasians. assertion.
- assertion asSentence Suppresses+MEKK1-mediated+apoptosis+and+functions+as+a+negative+regulator+of+MEKK1. assertion.
- assertion asSentence There+is+a+significant+association+between+the+GSTM1+null+genotype+and+rosacea. assertion.
- assertion asSentence The+GSTM1+null+genotype%2C+greatly+increases+the+risk+for+colorectal+and+gastric+cancers. assertion.
- assertion asSentence GSTM1+polymorphism+is+not+a+genetic+risk+factor+of+seminal+estradiol+and+testosterone+levels+in+infertile+men. assertion.
- assertion asSentence Association+between+GSTM1+gene+deletion+and+an+increased+risk+of+hereditary+breast+neoplasms+in+a+case-control+population. assertion.
- assertion asSentence Genetic+polymorphisms+of+metabolic+enzymes+CYP1A1%2C+CYP2D6%2C+GSTM1+and+GSTT1+and+leukemia+susceptibility. assertion.
- assertion asSentence Germline+genetic+polymorphisms+in+GSTM1+is+associated+with+breast+cancer. assertion.
- assertion asSentence The+GSTM1+gene+is+a+genetic+contributor+to+overall+COPD+susceptibility+in+non-Asian+populations. assertion.
- assertion asSentence There+are+no+relationship+between+GSTT1+and+GSTM1+gene+deletions+and+hepatic+damage+caused+by+HBV. assertion.