Matches in Nanopublications for { ?s <http://purl.org/nanopub/x/asSentence> ?o ?g. }
- assertion asSentence In+Caucasian+men+and+especially+in+women+between+50+and+75+years+of+age+who+are+without+diabetes%2C+high+HbA1c+levels+are+associated+with+increased+risk+of+future+non-fatal+cardiovascular+disease. assertion.
- assertion asSentence Mediterranean+diet+lowered+HbA1c+in+type+2+diabetes. assertion.
- assertion asSentence HbA2+level+a+reliable+diagnostic+measurement+for+beta-thalassemia+trait+in+people+with+iron+deficiency. assertion.
- assertion asSentence Assembly+of+human+hemoglobin+%28Hb%29+beta-+and+gamma-globin+chains+expressed+in+a+cell-free+system+with+alpha-globin+chains+to+form+Hb+A+and+Hb+F. assertion.
- assertion asSentence BP1%2C+a+homeodomain-containing+isoform+of+DLX4%2C+represses+the+beta-globin+gene. assertion.
- assertion asSentence Hb+G-San+Jose+variant+levels+correlate+with+alpha-thalassemia+genotypes. assertion.
- assertion asSentence The+SB-Tn+system+is+a+promising+nonviral+vector+for+efficient+genomic+insertion+conferring+stable%2C+persistent+erythroid-specific+expression+of+beta-globin. assertion.
- assertion asSentence The+correlation+between+soluble+P-selectin+and+VEGF+in+sickle+cell+disease+and+HbSC+disease+is+consistent+with+the+view+that+VEGF+is+released+from+platelets+during+in+vivo+activation. assertion.
- assertion asSentence The+splicing+mutation+in+intron+1+of+beta-globin+gene+is+the+most+common+mutation+in+Egyptian+thalassemics+that+causes+aberrant+splicing+of+pre-mRNA+and+deficient+beta-globin. assertion.
- assertion asSentence Unstable+hemoglobin+Rush+%5Bbeta+101%28G3%29+Glu%3EGln%2C+HBB%3Ac.304G%3EC%5D+in+a+Brazilian+family+with+moderate+hemolytic+anemia. assertion.
- assertion asSentence The+HbA%2FHbE+polymorphism+would+not+be+a+major+genetic+factor+influencing+the+onset+of+cerebral+malaria+in+Thailand. assertion.
- assertion asSentence KLF1+controls+globin+gene+switching+by+directly+activating+beta-globin+and+indirectly+repressing+gamma-globin+gene+expression. assertion.
- assertion asSentence The+HBZ+protein+is+localized+to+heterochromatin+and+capable+of+repressing+JUN+activity+and+viral+transcription. assertion.
- assertion asSentence Altered+expression+is+associated+with+therapy+failure+and+death+in+patients+with+multiple+types+of+cancer. assertion.
- assertion asSentence During+the+G1-to-S+phase+transition%2C+HCF-1+recruits+the+mixed-lineage+leukemia+%28MLL%29+and+Set-1+histone+H3+lysine+4+methyltransferases+to+E2F-responsive+promoters+and+induces+histone+methylation+and+transcriptional+activation. assertion.
- assertion asSentence HCK+and+BIN1+plays+critical+roles+in+AHI-1-mediated+leukemic+transformation+of+cutaneous+T-Cell+Lymphoma. assertion.
- assertion asSentence Loss+of+HCK+is+associated+with+acute+promyelocytic+leukemia. assertion.
- assertion asSentence HS1+is+a+central+regulator+of+cytoskeleton+remodeling+that+controls+lymphocyte+trafficking+and+homing+and+significantly+influences+the+tissue+invasion+and+infiltration+in+chronic+lymphocytic+leukemia. assertion.
- assertion asSentence High+HS1+expression+predicts+poor+survival+of+chronic+lymphocytic+leukemia+patients. assertion.
- assertion asSentence Orexin+stimulates+HIF-1+activity. assertion.
- assertion asSentence OXA+levels+in+untreated+anorexia+nervosa+patients+differ+significantly+from+healthy+subjects+and+decrease+during+realimentation. assertion.
- assertion asSentence Heteromultimerization+of+cannabinoid+CB%281%29+receptor+and+orexin+OX%281%29+receptor+generates+a+unique+complex+in+which+both+protomers+are+regulated+by+orexin+A. assertion.
- assertion asSentence In+differentiated+IMR-32+neuroblastoma+cells+orexin%2Fhypocretin+and+bradykinin+receptors+activate+TRPC3%2F6+channels. assertion.
- assertion asSentence Mutant+huntingtin+containing+an+expanded+polyglutamine+stretch+induces+neuronal+death. assertion.
- assertion asSentence Regulated+expression+of+huntingtin+%28Huntington+disease%29+induced+reversible+striatal+neuropathology+typical+for+Huntington+disease. assertion.
- assertion asSentence Causes+huntingti0n+disase+when+transfected+into+mice. assertion.
- assertion asSentence Mutant+huntingtin+protein+effects+disease-related+transcription+in+the+brain. assertion.
- assertion asSentence Wild-type+huntingtin+is+a+component+of+the+DNA+damage+response+signal+in+neurons. assertion.
- assertion asSentence An+altered+association+between+membrane-associated+guanylate+kinases+%28such+as+PSD-95%29+and+NMDA+receptors+in+mutant+huntingtin-expressing+cells+contributes+to+increased+susceptibility+to+excitotoxicity. assertion.
- assertion asSentence Mutant+huntingtin+in+glial+cells+exacerbates+neurological+symptoms+of+Huntington+disease+mice. assertion.
- assertion asSentence Mutant+htt+rescues+cell+death+upon+microtubule+depolymerization+via+the+GEF-H1-RhoA-ERK+pathway. assertion.
- assertion asSentence Hsp70+and+Hsp40+functionally+interact+with+soluble+mutant+huntingtin+oligomers+in+a+classic+ATP-dependent+reaction+cycle. assertion.
- assertion asSentence An+important+role+for+a+compact+beta+structure+in+mutant+huntingtin-induced+cell+toxicity. assertion.
- assertion asSentence Preferential+accumulation+of+N-terminal+mutant+huntingtin+in+the+nuclei+of+striatal+neurons+is+regulated+by+phosphorylation. assertion.
- assertion asSentence Tumor+necrosis+factor+receptor-associated+factor+6+%28TRAF6%29+associates+with+huntingtin+protein+and+promotes+its+atypical+ubiquitination+to+enhance+aggregate+formation. assertion.
- assertion asSentence Interaction+with+polyglutamine-expanded+huntingtin+alters+cellular+distribution+and+RNA+processing+of+huntingtin+yeast+two-hybrid+protein+A+%28HYPA%29. assertion.
- assertion asSentence Only+huntingtinNT+QN+peptides+with+N%3D8+or+more+underwent+conversion+into+polyQ+beta-sheet+aggregates. assertion.
- assertion asSentence Inhibition+of+lipid+signaling+enzyme+diacylglycerol+kinase+epsilon+attenuates+mutant+huntingtin+toxicity. assertion.
- assertion asSentence Histone+deacetylase+1+overexpression+is+associated+with+advanced+stage+esophageal+squamous+cell+carcinoma. assertion.
- assertion asSentence The+MLL+repression+domain+specifically+interacts+with+HDAC1. assertion.
- assertion asSentence ZBP-89+functions+as+a+repressor+by+recruiting+HDAC1+to+the+vimentin+promoter. assertion.
- assertion asSentence HDAC1+is+found+to+be+the+major+enzyme+regulating+Nur77+protein+levels+and+turnover. assertion.
- assertion asSentence In+hepatocellular+carcinoma+cells%2C+up-regulation+of+HDAC1-3+reduces+expression+of+miR-449%2C+activating+hepatocyte+growth+factor+and+altering+tumor+growth. assertion.
- assertion asSentence A+rationale+for+targeting+HIF-1+alpha+with+histone+dacetylase+inhibitors+against+class+II+isozymes+as+anticancer+agents+in+renal+carcinoma+cells. assertion.
- assertion asSentence Nitration+of+distinct+tyrosine+residues+modifies+both+the+expression+and+activity+of+HDAC2%2C+having+an+impact+on+epigenetic+regulation. assertion.
- assertion asSentence The+cell-autonomous+function+of+transgenic+HDAC2+exclusively+in+adult+neurogenesis+reveals+clear+differences+in+the+molecular+mechanisms+regulating+neurogenesis+during+development+and+in+adulthood. assertion.
- assertion asSentence Defective+levels+found+in+normal+placenta+compared+with+pre-eclampsia+labor. assertion.
- assertion asSentence High+HDGF+is+associated+with+hilar+cholangiocarcinoma. assertion.
- assertion asSentence Plasma+beta-hexosaminidase+and+beta-galactosidase%29+levels+are+higher+in+patients+with+Alzheimer%27s+disease-type+2+diabetes+mellitus+%28T2DM%29+compared+to+those+with+T2DM+alone. assertion.
- assertion asSentence Three+SIBLINGs+%28small+integrin-binding+ligand%2C+N-linked+glycoproteins%29+enhance+factor+H%27s+cofactor+activity+enabling+MCP-like+cellular+evasion+of+complement-mediated+attack. assertion.
- assertion asSentence When+bound+to+Neisseria+meningitidis%2C+factor+H+retains+its+activity+as+cofactor+of+alternative+complement+pathway+factor+I+and+contributes+to+the+ability+of+N.+meningitidis+to+avoid+complement-mediated+killing+in+the+presence+of+human+serum. assertion.
- assertion asSentence Heterozygous+R1215Q+mutation+is+found+in+atypical+hemolytic+uremic+syndrome%2C+with+incomplete+penetrance+of+the+disease. assertion.
- assertion asSentence The+R1210C+mutation+is+a+prototypical+atypical+hemolytic+uremic+syndrome+mutation+that+is+present+as+a+rare+polymorphism+in+geographically+separated+human+populations. assertion.
- assertion asSentence The+FH+Y402H+polymorphism+associated+with+AMD+%28age-related+macular+degeneration%29+causes+a+reduction+in+binding+of+FH+%28factor+H%29and+FHL-1+to+CRP+%28c-reactive+protein%29+and+%28atreptococcal+M+protein%29+M+protein. assertion.
- assertion asSentence Kallikrein+is+responsible+for+the+cleavage+of+factor+H. assertion.
- assertion asSentence The+SNPs+rs3753394+and+rs800292+of+CFH+and+rs11200638+of+HTRA1+are+significantly+associated+with+the+risk+of+PCV+%28polypoidal+choroidal+vasculopathy%29+in+Chinese+patients. assertion.
- assertion asSentence CFH+Y402H+polymorphism+is+associated+with+early-onset+CAD+in+Chinese. assertion.
- assertion asSentence Peripheral+retinal+drusen+and+reticular+pigment+are+associated+with+CFHY402H+and+CFHrs1410996+genotypes%2C+adjusting+for+age-related+macular+degeneration+grade. assertion.
- assertion asSentence Protein+overload+reduces+the+ability+of+the+tubule+cell+to+bind+factor+H+and+counteract+complement+activation%2C+effects+instrumental+to+renal+disease+progression. assertion.
- assertion asSentence AM%2FAMBP-1+elevates+cAMP+levels%2C+followed+by+activating+PKA%2C+to+protect+neural+cells+from+the+injury+caused+by+hypoxia. assertion.
- assertion asSentence Protective+effect+of+the+fH-Ile%2862%29+variant+is+due+to+its+better+capacity+to+bind+C3b%2C+inhibit+proconvertase+formation+and+catalyze+inactivation+of+fluid-phase+and+surface-bound+C3b. assertion.
- assertion asSentence Binding+of+the+human+complement+regulators+CFHR1+and+factor+H+by+streptococcal+collagen-like+protein+1+%28Scl1%29+via+their+conserved+C+termini+allows+control+of+the+complement+cascade+at+multiple+levels. assertion.
- assertion asSentence A+mutant+factor+H+binding+protein+%28fHbp%29+with+a+single+amino+acid+substitution+%28Arg41Ser%29+does+not+bind+human+complement+factor+H%2C+demonstrating+greater+complement-mediated+serum+bactericidal+activity. assertion.
- assertion asSentence Factor+H+regulates+the+classical+complement+pathway. assertion.
- assertion asSentence NC4+Domain+of+cartilage-specific+collagen+IX+inhibits+complement+directly+due+to+attenuation+of+membrane+attack+formation+and+indirectly+through+binding+and+enhancing+activity+of+complement+inhibitors+C4B-binding+protein+and+factor+H. assertion.
- assertion asSentence Photo-oxidative+stress+reduces+the+ability+of+IFN-gamma+to+increase+CFH+expression+in+RPE. assertion.
- assertion asSentence Copy+number+variation+of+CFH+is+associated+with+age-related+macular+degeneration. assertion.
- assertion asSentence Genotyping+of+the+C282Y+and+H63D+substitutions+in+the+HFE+gene+provides+a+satisfactory+marker+since+these+genotypes+are+associated+with+~90%25+of+herditary+hemochromatosis. assertion.
- assertion asSentence The+presence+of+HFE+mutations+is+independently+associated+with+iron+loading+and+advanced+fibrosis+in+patients+with+compensated+liver+disease+from+chronic+hepatitis+C%2C+especially+after+controlling+for+duration+of+disease. assertion.
- assertion asSentence Role+of+HFE+mutations+as+primary+risk+factors+for+fibrogenesis+and+disease+progression+in+chronic+hepatitis+C. assertion.
- assertion asSentence Feasibility+of+screening+for+an+amino+acid+substitution+at+birth. assertion.
- assertion asSentence A+significant+role+of+the+HFE+gene+C282Y+mutation+in+the+pathogenesis+of+porphyria+cutanea+tarda. assertion.
- assertion asSentence 9+out+of+every+100%2C000+African-Americans+have+a+hemochromatosis+phenotype+and+2+common+HFE+mutations. assertion.
- assertion asSentence The+HFE+C282Y+heterozygous+mutation+is+associated+with+advanced+fibrosis+among+Caucasians+with+nonalcoholic+steatohepatitis. assertion.
- assertion asSentence Barrett%27s+esophagus+is+not+associated+with+hemochromatosis+gene+defects. assertion.
- assertion asSentence The+three+variants+in+TF+%28rs3811647%2C+rs1799852+and+rs2280673%29+plus+the+HFE+C282Y+mutation+explained+approximately+40%25+of+genetic+variation+in+serum+transferrin+%28p+%3D+7.8+x+10%28-25%29%29. assertion.
- assertion asSentence HFE+mutations+modulate+the+effect+of+iron+on+serum+hepcidin-25+in+chronic+hemodialysis+patients. assertion.
- assertion asSentence Mutant+His63Asp+HFE+increases+tau+phosphorylation+via+glycogen+synthase+kinase+%28GSK%29-3beta+activity+and+iron-mediated+oxidative+stress. assertion.
- assertion asSentence An+unbiased+estimate+of+the+HFE+C282Y+homozygote+prevalence+in+Norway+is+0.75%25. assertion.
- assertion asSentence Detection+of+soluble+HFE+associated+with+soluble+transferrin+receptor+in+human+serum. assertion.
- assertion asSentence Molecular+diagnosis+of+HFE+mutations+in+routine+laboratories. assertion.
- assertion asSentence Mutations+in+the+HFE+gene+is+associated+with+hemochromatosis. assertion.
- assertion asSentence Human+complement+regulatory+factor+H-like+protein+1+%28FHL-1%29+binds+to+Streptococcal+pyogenes+M18+surface+protein+Emm18. assertion.
- assertion asSentence Combined+deletion+of+CFHR3+and+CFHR1+is+associated+with+a+decreased+risk+of+developing+age-related+macular+degeneration. assertion.
- assertion asSentence The+production+of+this+factor+in+kidney+increases+after+unilateral+nephrectomy. assertion.
- assertion asSentence After+acceleration+of+regenerative+response+by+HGF%2C+subsequent+elevation+of+TGF-beta1+synergistically+controls+graft+size%2C+regulating+uncontrolled+proliferation+of+hepatocytes. assertion.
- assertion asSentence Densisty+of+HGF+in+hepatic+allograft+biopsy+specimens+compared+with+those+from+a+control+group+of+healthy+patients. assertion.
- assertion asSentence HGF%2FMet+system+is+involved+in+the+pathogenesis+of+endometriosis+by+promoting+stromal+cell+proliferation+and+invasion+of+shed+endometria+and+endometrial+lesions+via+autocrine+and+paracrine+pathways. assertion.
- assertion asSentence HGF%2FMET+signalling+protects+Plasmodium+sporozoite-infected+host+cells+from+apoptosis. assertion.
- assertion asSentence The+consistent+expression+of+HGF+and+c-met+during+the+perinatal+period+supports+a+physiological+role+for+HGF+in+human+lung+development. assertion.
- assertion asSentence HGF+secreted+by+subepithelial+fibroblasts+contributes+to+human+bronchial+epithelial+cell+differentiation. assertion.
- assertion asSentence Upregulation+of+hepatocyte+growth+factor+plays+a+role+in+skin+homeostasis+after+UV+irradiation. assertion.
- assertion asSentence ERK+activation+with+some+other+pathway%28s%29%2C+activated+through+the+HGF+receptor%2C+are+required+to+up-regulate+p16+and+p21+expression%2C+that+of+p21+contributes+to+suppression+of+Cdk2+activity+leading+to+inhibition+of+proliferation+of+HGF-treated+HepG2+cells. assertion.
- assertion asSentence In+medulloblastoma%2C+HGF+induces+cell+cycle+progression%2C+cell+proliferation%2C+apoptosis+and+increase+in+cell+size+in+a+c-Myc-dependent+manner. assertion.
- assertion asSentence Induction+of+hepatocyte+growth+factor+activator+gene+expression+under+hypoxia+activates+the+hepatocyte+growth+factor%2Fc-Met+system+via+hypoxia+inducible+factor-1+in+pancreatic+cancer. assertion.
- assertion asSentence Hepatocyte+growth+factor+inhibits+VEGF-FOXO1-dependent+gene+expression+in+endothelial+cells. assertion.
- assertion asSentence High+glucose+concentration+in+cell+culture+medium+does+not+acutely+affect+human+mesenchymal+stem+cell+HGF+production+or+proliferation. assertion.
- assertion asSentence HGF+is+a+potent+inhibitor+of+cell+apoptosis+in+nasopharyngeal+carcinoma+by+upregulating+Bcl-2+through+both+autocrine+and+paracrine+Epstein-Barr+virus-independent+pathways. assertion.
- assertion asSentence HGF+protects+endothelial+cells+against+gamma+ray+irradiation-induced+damage. assertion.
- assertion asSentence HGF+inhibited+TGF-beta1+mRNA+expression+and+reduced+collagen+III+secretion. assertion.