Matches in Nanopublications for { ?s <http://purl.org/nanopub/x/asSentence> ?o ?g. }
- assertion asSentence High+hgf+expression+is+associated+with+lung+adenocarcinoma. assertion.
- assertion asSentence Circulating+levels+of+hepatocyte+growth+factor+are+associated+with+increased+risk+of+incident+ischemic+stroke%2C+independent+of+obesity+and+other+cardiovascular+risk+factors%2C+among+postmenopasal+women+aged+50+to+79+years. assertion.
- assertion asSentence Allosteric+peptide+activators+of+pro-hepatocyte+growth+factor+stimulate+Met+signaling. assertion.
- assertion asSentence Intramuscular+injection+of+naked+HGF+plasmid+is+safe+and+feasible+and+can+achieve+successful+improvement+of+ischemic+limbs+as+sole+therapy. assertion.
- assertion asSentence Hepatocyte+growth+factor+gene+therapy+is+safe+and+effective+for+critical+limb+ischemia+in+patients+with+Buerger%27s+disease. assertion.
- assertion asSentence Induction+of+hepatocyte+growth+factor+activator+gene+expression+under+hypoxia+activates+the+hepatocyte+growth+factor%2Fc-Met+system+via+hypoxia+inducible+factor-1+in+pancreatic+cancer. assertion.
- assertion asSentence Failure+to+replicate+the+association+between+NRG1+and+schizophrenia+using+Japanese+large+sample. assertion.
- assertion asSentence NRG1+protein+is+associated+with+schizophrenia+risk. assertion.
- assertion asSentence NRG1+variants+are+specifically+underrepresented+in+subgroups+of+schizophrenic+subjects+with+early+age+of+onset+and+high+positive+symptom+load. assertion.
- assertion asSentence The+ADAM17-NRG-1-HER2+axis+modulates+the+alveolar+epithelial+barrier+and+contributes+to+the+pathophysiology+of+ALI. assertion.
- assertion asSentence Mutations+in+the+NRG1+gene+are+associated+with+Hirschsprung+disease. assertion.
- assertion asSentence The+NRG1+missense+polymorphism+is+not+association+in+schizophrenia+or+bipolar+disorder+in+a+Costa+Rican+population. assertion.
- assertion asSentence Neuronal+overexpression+of+a+NRG1+type+III-variant+transgene%2C+designed+to+mimic+prior+cleavage+in+the+juxtamembrane+stalk+region%2C+induces+hypermyelination+in+vivo+and+is+sufficient+to+restore+myelination+of+NRG1+type+III-deficient+neurons. assertion.
- assertion asSentence HRG-beta1-induced+migration+and+invasion+partly+depend+on+the+upregulation+of+GPR30+expression+through+activation+of+the+ErbB2-ERK+pathway+in+SkBr3+cells. assertion.
- assertion asSentence Tgf-beta+mediated+repression+of+flk-1%2FKDR+and+mediated+repression+of+flk-1%2FKDR+and+VEGF+signaling+involves+the+inducible+formation+of+inhibitory+Hex-GATA+signaling+Hex-GATA+involves+the+formation+of+Hex-GATA+complexes. assertion.
- assertion asSentence Variations+confer+impaired+glucose-+and+tolbutamide-induced+insulin+release+in+middle-aged+and+young+healthy+subjects. assertion.
- assertion asSentence Single-nucleotide+polymorphisms+in+the+HHEX+gene+are+associated+with+susceptibility+to+type+2+diaabetes+across+the+boundary+of+race. assertion.
- assertion asSentence Genetic+variants+of+the+IDE-KIF11-HHEX+region+at+10q23.33+contribute+to+type+2+diabetes+susceptibility. assertion.
- assertion asSentence Promoter+hypermethylation+of+tumor+suppressor+HIC1+is+associated+with+prostate+carcinoma. assertion.
- assertion asSentence Induction+of+leptin+gene+expression+by+hypoxia+and+HIF1. assertion.
- assertion asSentence The+binding+of+pVHL+to+HIF+is+governed+by+the+enzymatic+hydroxylation+of+conserved+prolyl+residues+within+peptidic+motifs+present+in+the+HIFalpha+family+members. assertion.
- assertion asSentence The+role+of+HIF-1+alpha+in+transcriptional+regulation+of+the+proximal+tubular+epithelial+cell+response+to+hypoxia. assertion.
- assertion asSentence HIF+prolyl+hydroxylase+2+is+the+key+oxygen+sensor+setting+low+steady-state+levels+of+HIF-1alpha+in+normoxia. assertion.
- assertion asSentence Noxa+promoter+responds+directly+to+hypoxia+via+hypoxia-inducible+factor+%28HIF%29-1alpha. assertion.
- assertion asSentence PI3K%2FAkt+contributes+to+HIF-1alpha+stabilization+by+provoking+expression+of+heat+shock+proteins. assertion.
- assertion asSentence The+hypoxia-inducible+factor+1+is+a+key+regulator+of+oxygen+homeostasis+in+the+cell. assertion.
- assertion asSentence Enhanced+expression+of+HIF1A+suppressed+HIF2A+and+vice-versa. assertion.
- assertion asSentence Accumulated+EGLN1+in+hypoxia+acts+as+a+negative-feedback+mechanism+to+modulate+HIF-1alpha+target+gene+expression. assertion.
- assertion asSentence Calpain+plays+an+active+role+in+degradation+of+HIF-1alpha. assertion.
- assertion asSentence A+significantly+greater+proportion+of+HP75+cells+transfected+with+siRNA+targeting+HIF+1-alpha+mRNA+sequences+and+exposed+to+hypoxia+demonstrated+apoptosis+to+a+large+extent+when+compared+with+non-transfected+cells. assertion.
- assertion asSentence The+HIF-1alpha+immunopositivity+increased+through+the+tumor+development+with+highest+expression+in+the+late+nodular+stages. assertion.
- assertion asSentence Activity+of+the+alpha-subunit+of+the+hypoxia-inducible+transcription+factor+%28HIF-alpha%29+are+regulated+by+its+post-translation+hydroxylation+as+catalyzed+by+iron-+and+2-oxoglutarate+%282OG%29-dependent+prolyl+and+asparaginyl+hydroxylases+%28PHD1-3%29. assertion.
- assertion asSentence The+upregulated+expression+of+HIF-1alpha+and+VEGF+in+breast+carcinoma+has+a+close+relationship+with+tumor+angiogenesis%2C+tumor+cell+proliferation%2C+lymph+node+metastasis%2C+ER+status+and+stages+of+histology. assertion.
- assertion asSentence Hemin+induces+a+serum+protein-sensitive+pro-inflammatory+phenotype+in+microvascular+endothelial+cells+via+an+oxidant-sensitive+mechanism+that+is+powerfully+regulated+by+HIF-1. assertion.
- assertion asSentence In+papillary+thyroid+carcinoma%2C+HIF-1+alpha%2C+VEGF+and+VEGF-C+expressions+are+significantly+increased. assertion.
- assertion asSentence Eradication+of+HIF-1-active%2Fhypoxic+cells+in+the+xenografts+during+irradiation+exhibited+significant+suppression+in+angiogenesis+and+strong+enhancement+in+a+long-term+growth+suppression+of+tumor+xenografts. assertion.
- assertion asSentence Polymorphisms+in+the+HIF-1alpha+are+not+directly+associated+with+prostate+neoplasms. assertion.
- assertion asSentence HIF-1alpha+increased+DNA-binding+ability+and+transcriptional+activity+of+Runx1+protein. assertion.
- assertion asSentence High+levels+of+the+hypoxia+regulated+proteins+HIF1alpha+and+CA9+in+HNC+predict+resistance+to+platinum+based+radio-chemotherapy. assertion.
- assertion asSentence In+BRCA1+germline+mutation+related+breast+cancer%2C+functional+HIF-1alpha+overexpression+is+seen+at+a+much+higher+frequency+than+in+sporadic+breast+cancer. assertion.
- assertion asSentence Hypoxic+preconditioning+of+cisplatin-treated+proximal+tubular+cells+in+culture+reduced+apoptosis+in+an+HIF-1alpha-dependent+fashion. assertion.
- assertion asSentence Nasal+epithelial+cells+actively+produce+HIF-1alpha+and+VEGF+when+stimulated+by+LPS%2C+IL-1beta+or+hypoxia. assertion.
- assertion asSentence UBXD7+links+p97+to+the+ubiquitin+ligase+CUL2%2FVHL+and+its+substrate+hypoxia-inducible+factor+1alpha+%28HIF1alpha%29. assertion.
- assertion asSentence Stem+cell+factor+-induced+accumulation+of+HIF-1alpha+is+dependent+on+both+the+PI-3-kinase+and+Ras%2FMEK%2FErk+pathways. assertion.
- assertion asSentence Stabilization+of+HGF+mRNA+by+hypoxia+is+mediated%2C+at+least+in+part%2C+by+HIF-1. assertion.
- assertion asSentence Antisense+HIF1A+gene+therapy+enhances+the+therapeutic+efficacy+of+doxorubicin+to+combat+hepatocellular+cacinoma. assertion.
- assertion asSentence Cardioprotection+by+hypoxia-inducible+factor+1+alpha+transfection+in+skeletal+muscle+is+dependent+on+haem+oxygenase+activity+in+mice. assertion.
- assertion asSentence SMG-1+negatively+regulated+HIF-1alpha+activity+in+hypoxia%2C+in+part+through+blocking+MAPK+activation. assertion.
- assertion asSentence Endotoxin+tolerance+impairs+HIF-1alpha+induction+which+reduces+the+ability+of+monocytic+cells+to+survive+and+function+under+hypoxic+conditions. assertion.
- assertion asSentence The+supernatant+of+apoptotic+cells+causes+transcriptional+activation+of+hypoxia-inducible+factor-1alpha+in+macrophages+via+sphingosine-1-phosphate+and+transforming+growth+factor-beta. assertion.
- assertion asSentence KLF5+is+overexpressed+in+pancreatic+cancer+cells+and+exceeds+KLF5+expression+of+KRAS-mutated+colon+cancer+cells. assertion.
- assertion asSentence Importins+4+and+7+accomplish+nuclear+import+of+HIF-1alpha+more+efficiently+than+the+classical+importin+alpha%2Fbeta+NLS+receptor. assertion.
- assertion asSentence Expression+of+HIF1A+and+VEGF+revealed+divergent+pH+dependencies. assertion.
- assertion asSentence Increased+HIF-1alpha+expression+under+normoxic+conditions+contributes+to+some+of+the+malignant+phenotypes+exhibited+by+human+melanoma+cells. assertion.
- assertion asSentence HIF1A+gene+in+HMC-1+immature+hematopoietic+cells+is+suppressed+by+a+process+dependent+on+DNA+methylation. assertion.
- assertion asSentence Overexpression+of+HIF-1alpha+is+associated+with+relapse+in+gastric+cancer+patients+who+underwent+curative+surgery+followed+by+adjuvant+5-fluorouracil+chemotherapy. assertion.
- assertion asSentence Hypoxia+enhances+BMP-2+expression+in+osteoblasts+by+an+HIF-1alpha-dependent+mechanism+involving+the+activation+of+ILK%2FAkt+and+mTOR+pathways. assertion.
- assertion asSentence Nrf2-dependent+Trx1+induction+turned+out+to+enhance+HIF-1+alpha+signaling+in+intermittent+hypoxia. assertion.
- assertion asSentence Hypoxia-inducible+factor+signaling+provides+protection+in+Clostridium+difficile-induced+intestinal+injury. assertion.
- assertion asSentence Low-dose+fractioned+irradiation+can+lower+MDR1+and+HIF1alpha+expressions+in+esophageal+cancer+cells. assertion.
- assertion asSentence Knock+down+of+HIF-1alpha+in+human+and+murine+glioma+cells+impairs+their+migration+in+vitro+and+their+invasion+in+vivo. assertion.
- assertion asSentence p70S6K1+is+required+for+tumor+growth+and+angiogenesis+through+HIF-1alpha+and+VEGF+expression%2C+providing+a+molecular+mechanism+of+human+ovarian+cancer+mediated+by+p70S6K1+signaling. assertion.
- assertion asSentence HIF1A1+C1772T+and+G1790A+polymorphisms+are+not+involved+in+the+progression+or+metastasis+of+colorectal+cancer. assertion.
- assertion asSentence RNA+interference+of+HIF-1alpha+prevents+hypoxia-induced+increase+in+vascular+endothelial+cell+permeability. assertion.
- assertion asSentence Overexpression+of+HIF1A+is+associated+with+gastric+adenocarcinoma. assertion.
- assertion asSentence miR-210+regulates+mitochondrial+function+by+targeting+key+electron+transport+chain+component+genes+with+important+consequences+on+cell+metabolism%2C+survival+and+modulation+of+HIF-1+activity. assertion.
- assertion asSentence HIF-1+plays+a+role+in+Hyperthermia-induced+tumor+reoxygenation+by+transactivating+its+downstream+targets. assertion.
- assertion asSentence Silencing+HIF1a+increases+the+apoptosis+ratio+in+human+gastric+cancer+cell+in+a+high+pressure+environment. assertion.
- assertion asSentence HIF1-mediated+ALAS2+upregulation+promotes+erythropoiesis+to+satisfy+the+needs+of+an+organism+under+hypoxic+conditions. assertion.
- assertion asSentence Microtubule+integrity+and+dynamics+are+intricately+involved+in+orchestrating+HIF-1alpha+translation. assertion.
- assertion asSentence Hypoxia+upregulates+low-density+lipoprotein+receptor-related+protein-1+expression+and+aggregated+low-density+lipoprotein-derived+intracellular+cholesterol+esters+accumulation+in+human+vascular+smooth+muscle+cells+through+HIF-1alpha+induction. assertion.
- assertion asSentence DEC1+expression+is+correlated+with+HIF-1alpha+protein+in+gastric+cancer+cell+line. assertion.
- assertion asSentence Hypoxia-induced+migration+of+HSC%2FMFs+involves+an+early%2C+mitochondrial-dependent+ROS-mediated+activation+of+ERK+and+JNK%2C+followed+by+a+delayed-+and+HIF-1alpha-dependent+up-regulation+and+release+of+VEGF. assertion.
- assertion asSentence High+HIF1-alpha+is+associated+with+small+cell+lung+cancer. assertion.
- assertion asSentence HCV+core+protein+enhances+the+expression+of+HIF-1alpha+and+VEGF+in+Huh7.5.1.+cells. assertion.
- assertion asSentence HIP1+is+a+nucleocytoplasmic+protein+capable+of+associating+with+membranes+and+DNA+response+elements+and+regulating+transcription. assertion.
- assertion asSentence Crystal+structure+at+2.8+A+of+HIP1+coiled-coil+domain+reveals+a+charged+surface+suitable+for+HIP1+protein+interactor+%28HIPPI%29. assertion.
- assertion asSentence HINT1+is+differentially+expressed+in+schizophrenia+brain. assertion.
- assertion asSentence Glycated+hemoglobin+levels+are+associated+with+genetic+variation+of+HK1. assertion.
- assertion asSentence An+association+is+noted+between+the+rs7072268+T-allele+in+HK1+and+an+increased+blood+glucose+in+non-diabetic+individuals+and+a+nominal+association+with+type+2+diabetes+prior+to+Bonferroni+correction. assertion.
- assertion asSentence Soluble+HLA-A+serum+level+is+significantly+increased+in+allergic+rhinitis+patients+with+pollen+allergy. assertion.
- assertion asSentence The+regulatory+regions+are+tightly+linked+with+exons+in+most+of+HLA-A+alleles+excluding+A%2A24020101. assertion.
- assertion asSentence Bw4+motifs+can+increase+the+CD4+cell+count+and+decrease+the+viral+load+of+patients+with+primary+HIV+infection. assertion.
- assertion asSentence Abundant+HLA-A%2A02+self-peptides+protect+vascular+endothelium+from+cytotoxic+T+cell+%28CTL%29-mediated+lysis+by+competing+for+HLA-A%2A02+binding+sites+with+immunodominant+scarcely+expressed+antigenic+peptides. assertion.
- assertion asSentence Sequencing-based+typing+of+HLA-B%2A51+alleles+and+the+significant+association+of+HLA-B%2A5101+and+-B%2A5108+with+Behcet%27s+disease+in+Greek+patients. assertion.
- assertion asSentence Distribution+of+HLA-B+alleles+in+nasopharyngeal+carcinoma+patients+and+normal+controls+in+Thailand. assertion.
- assertion asSentence Polymorphisms+in+some+alleles+of+B+and+C+in+HLA+class+I+genes+are+associated+with+Kawasaki+disease+in+Korean+children. assertion.
- assertion asSentence HLA-B%2A27%2FHLA-B%2A07+in+combination+with+D6S273-134+allele+is+associated+with+increased+susceptibility+to+juvenile+spondylarthropathies+in+Croatian+children. assertion.
- assertion asSentence The+gene+frequency+of+HLA-B%2A13+in+CML+patients+is+significantly+higher+than+normal+people+in+Guangdong. assertion.
- assertion asSentence HLA-B27+heavy-chain+homodimer+formation+can+be+induced+by+dendritic+cell+activation. assertion.
- assertion asSentence Homozygosity+for+HLA-B27+does+not+affect+the+clinical+manifestations+of+ankylosing+spondylitis+in+Korean+patients. assertion.
- assertion asSentence Despite+its+ability+to+license+NK+cells%2C+KIR3DL1%2A004%2FHLA-Bw4+is+not+associated+with+a+reduced+risk+of+HIV+infection. assertion.
- assertion asSentence Bw4+motifs+can+increase+the+CD4+cell+count+and+decrease+the+viral+load+of+patients+with+primary+HIV+infection. assertion.
- assertion asSentence Frequency+of+HLA-A%2C+-B+and+-DRB1+specificities+and+haplotypic+associations+in+the+population+of+Castilla+y+Leon+%28northwest-central+Spain%29. assertion.
- assertion asSentence Three+amino+acid+positions+%2811%2C+71+and+74%29+in+HLA-DRbeta1+and+single-amino-acid+polymorphisms+in+HLA-B+%28position+9%29+and+HLA-DPbeta1+%28position+9%29%2C+all+located+in+peptide-binding+grooves%2C+almost+completely+explain+MHC+association+to+rheumatoid+arthritis+risk. assertion.
- assertion asSentence HLA-B%2A07+is+an+allele+associated+with+a+very+high+risk+of+familial+cervical+cancer+in+a+Chinese+population. assertion.
- assertion asSentence Activating+KIR+and+HLA+Bw4+ligands+are+associated+to+decreased+susceptibility+to+pemphigus+foliaceus%2C+an+autoimmune+blistering+skin+disease. assertion.
- assertion asSentence CTGGAC+haplotype+is+a+single-point+score+haplotypes+telomeric+to+HLA-C+and+gives+a+1+df%2C+chi2+of+50.27+%28p%3C0.0001%29. assertion.
- assertion asSentence HLA-Cw+mismatched+in+donor+and+recipient+of+hematopoietic+stem+cell+transplantation+is+beneficial+for+reducing+II-IV+aGVHD. assertion.
- assertion asSentence Tissue+donor+HLA-C+genotype+has+a+profound+impact+on+the+clinical+outcome+following+liver+transplantation. assertion.