Matches in Nanopublications for { ?s <http://purl.org/nanopub/x/asSentence> ?o ?g. }
- assertion asSentence HMGA1B+mediates+PIT1+over+expression+in+pituitary+neoplasms. assertion.
- assertion asSentence The+combined+phenotype+of+RHAMM+and+p21+expression+is+an+invaluable+independent+prognostic+immunohistochemical+profile+in+microsatellite+instability-high+colorectal+cancer. assertion.
- assertion asSentence Heme+oxygenase-1+expression+attenuates+glucose-mediated+cell+growth+arrest+and+apoptosis+in+vascular+endothelium. assertion.
- assertion asSentence Regulation+of+HO+expression+in+the+human+placenta+is+a+complex+process+that+depends%2C+at+least+in+part%2C+on+local+glucose+and+oxygen+concentrations. assertion.
- assertion asSentence Short+GT+repeats+in+the+HO-1+gene+promoter+region+confer+a+reduced+risk+for+cerebrovascular+events+in+individuals+with+normal+plasma+lipid+levels. assertion.
- assertion asSentence The+functional+promoter+repeat+polymorphism+%28GT%29%28n%29has+no+influence+of+on+the+development+of+heart+failure%2C+graft+survival%2C+acute+rejection%2C+or+transplant+atherosclerosis. assertion.
- assertion asSentence Increased+HO-1+expression%2C+mainly+in+Leydig+cells%2C+is+considered+to+protect+the+cells+against+oxidative+stresses+in+varicocele+testes. assertion.
- assertion asSentence Heme+oxygenase-1+plays+a+vital+role+in+the+inhibition+of+vaso-occlusion+in+transgenic+sickle+mice. assertion.
- assertion asSentence Key+role+of+down-regulation+of+Bach1+and+up-regulation+of+heme+oxygenase+1+in+diminishing+cytotoxic+effects+of+hepatitis+C+virus+proteins+in+human+hepatocytes. assertion.
- assertion asSentence HO-1+and+Akt+exert+codependent+cytoprotective+effects+against+oxidative+stress-induced+apoptosis+in+human+aortic+smooth+muscle+cells. assertion.
- assertion asSentence Sulforaphane+transcriptionally+activates+the+upstream+ARE-rich+enhancer+region%2C+located+at+-9.0+kb+upstream+human+HO-1+promoter. assertion.
- assertion asSentence Micro-RNA-122+%28miR-122%29+plays+an+important+role+in+the+regulation+of+hepacvirus+replication+and+heme+oxygenase-1%2FBach1+expression+in+hepatocytes. assertion.
- assertion asSentence The+expression+level+of+HO-1+gene+is+a+marker+for+Cr%28VI%29-induced+cell+stress+leading+to+cytotoxicity. assertion.
- assertion asSentence Inhibition+of+plasminogen+activator+inhibitor-1+expression+in+vascular+smooth+muscle+cells+by+protoporphyrins+through+a+heme+oxygenase-independent+mechanism. assertion.
- assertion asSentence Polymorphism+in+the+HO-1+gene+promoter+is+correlated+with+susceptibility+to+coronary+artery+disease+in+diabetic+patients. assertion.
- assertion asSentence HO-1+is+a+negative+regulator+of+trophoblast+motility+acting+via+up-regulation+of+PPARgamma. assertion.
- assertion asSentence Zinc+protoporphyrin+regulates+cyclin+D1+expression+independent+of+heme+oxygenase+inhibition. assertion.
- assertion asSentence The+overexpression+of+HO-1+in+hypoxic+HepG2+cells+is+HIF-1alpha-dependent. assertion.
- assertion asSentence Alpha-Zearalanol+has+a+potent+inhibitory+effect+on+the+HO-1+expression+and+cytosolic+free+calcium+level+in+HUVECs. assertion.
- assertion asSentence In+the+United+States%2C+among+Caucasian+or+African-American+subjects+with+advanced+chronic+hepatitis+C%2C+genetic+variations+in+the+HMOX1+gene+promoter+are+not+predictive+of+responsiveness+to+antiviral+therapy+or+risks+of+outcomes+of+HCV+infection. assertion.
- assertion asSentence Taurocholic+acid+downregulates+heme+oxygenase+activity+and+expression+in+human+hepatoblastoma+cell+line+%28HepG2%29+stably+transfected+with+the+transporter+for+conjugated+bile+acids+%28Ntcp%29. assertion.
- assertion asSentence BAY+11-7082+induces+protein+expression+of+HO-1+by+activating+ARE-dependent+gene+expression+through+Nrf2+nuclear+translocation. assertion.
- assertion asSentence Inhibition+of+the+nitric+oxide-dependent+induction+of+HO-1+in+gastric+epithelial+cells+is+mediated+by+Helicobacter+pylori+virulence+factor+cagA. assertion.
- assertion asSentence The+thiol%2Fdisulfide+switch+in+HO-2+responds+to+cellular+oxidative+stress+and+reductive+conditions%2C+representing+a+paradigm+for+how+heme+regulatory+motifs+can+integrate+heme+homeostasis+with+carbon+monoxide+signaling+and+redox+regulation. assertion.
- assertion asSentence For+the+first+time%2C+copy+number+variations+in+the+HMOX2+gene+and+an+association+of+the+SNP+rs2270363+with+Parkinson%27s+disease+risk. assertion.
- assertion asSentence TR3+is+a+modulator+of+vascular+endothelial+cell+proliferation+and+arrests+endothelial+cells+in+the+G1+phase+of+the+cell+cycle+by+influencing+cell+cycle+protein+levels. assertion.
- assertion asSentence The+repressive+effect+of+Nur77+on+IL-2+promoter+activation+is+mediated+through+inhibition+of+the+transcription+factor+complex+nuclear+factor-kappaB. assertion.
- assertion asSentence TR3+is+an+important+apoptosis+inducing+factor+in+melanoma+cells. assertion.
- assertion asSentence Plays+an+important+role+in+the+apoptotic+actions+of+IGFBP-3. assertion.
- assertion asSentence Loss+of+NR4A1+is+associated+with+thyroid+follicular+neoplasia. assertion.
- assertion asSentence Foxa1+reduces+lipid+accumulation+in+human+hepatocytes+and+is+down-regulated+in+nonalcoholic+fatty+liver. assertion.
- assertion asSentence Foxa2+regulates+the+expression+of+genes+important+for+glucose+sensing+in+pancreatic+beta-cells. assertion.
- assertion asSentence HNF4A+gene+mutation+is+rare+in+Chinese+pedigrees+with+early+and%2For+multiplex-onset+diabetes. assertion.
- assertion asSentence Cooperative+interaction+between+HNF4A+and+GATA4+and+GATA6+regulates+ABCG5+and+ABCG8. assertion.
- assertion asSentence Macrosomic+infants+with+transient+or+persistent+hyperinsulinemic+hypoglycemia+should+be+screened+for+HNF4A+mutations+if+there+is+a+family+history+of+youth-onset+diabetes. assertion.
- assertion asSentence TCF+and+beta-catenin+binding+plays+important+roles+in+HCCR-1+oncogene+expression. assertion.
- assertion asSentence Congenital+hyperinsulinism+due+to+mutations+in+HNF4A+and+HADH. assertion.
- assertion asSentence L+type-specific+target+selection+by+combinatorial+binding+of+Smad2%2F3+proteins+and+hepatocyte+nuclear+factor+4alpha+in+HepG2+cells. assertion.
- assertion asSentence Control+network+for+Egr-1+expression+through+a+feedback+loop+between+SHP+and+HNF4alpha. assertion.
- assertion asSentence The+-60+T--%3EC+mutation+in+the+factor+VII+strongly+diminishes+functional+interaction+between+the+FVII+promoter+and+transcription+factor+HNF4alpha+contributing+to+severe+factor+VII+deficiency+in+homozygous+twins. assertion.
- assertion asSentence miR-34a+and+miR-21+cooperate+in+downregulation+of+the+HNF4A+mRNA. assertion.
- assertion asSentence HNF4alpha+regulates+human+hepatic+ABCA1+expression+in+response+to+cholesterol+depletion. assertion.
- assertion asSentence HNF4-specific+DNA+recognition+and+transactivation+are+mediated+by+residues+Asp69+and+Arg76+in+the+DNA-binding+domain. assertion.
- assertion asSentence hENT1+and+hENT2+on+the+basolateral+membrane+function+with+concentrative+nucleoside+transporters+on+the+apical+membrane+to+mediate+active+reabsorption+of+nucleosides+within+the+kidney. assertion.
- assertion asSentence Equilibrative+nucleoside+transporters+%28hENT1%2C+hENT2%29+together+with+adenosine+kinase+and+5%27-nucleotidase+play+a+crucial+role+in+the+regulation+of+CFTR+through+an+adenosine-dependent+pathway+in+human+airway+epithelia. assertion.
- assertion asSentence Human+cardiac+microvascular+endothelial+cells+rely+on+ENT1+for+nucleoside+transport+with+little+contribution+from+ENT2. assertion.
- assertion asSentence Interactions+between+different+hnRNP+proteins+bound+to+distinct+locations+on+a+pre-mRNA+can+change+its+conformation+to+affect+splicing+decisions. assertion.
- assertion asSentence Over-expression+of+hnRNP+A1+is+associated+with+non-small+cell+lung+cancer. assertion.
- assertion asSentence Two+mRNA+binding+proteins%2C+HuR+and+AUF1%2C+are+colocalized+and+are+capable+of+functional+interaction+in+both+the+nucleus+and+cytoplasm. assertion.
- assertion asSentence Via+phosphorylating+hnRNPK+Aurora-A+participates+in+regulating+p53+activity+during+DNA+damage. assertion.
- assertion asSentence hnRNP+L+represses+splicing+by+preventing+5%27+splice+site+recognition+of+the+U1+snRNP. assertion.
- assertion asSentence Ash2l+and+Saf-A+are+recruited+to+the+inactive+X+chromosome+at+the+onset+of+stable+X+inactivation. assertion.
- assertion asSentence Single+nucleotide+polymorphism+in+HNRPU+gene+is+associated+with+speech+delay%2C+seizures+and+variable+corpus+callosum+thickness. assertion.
- assertion asSentence NCX-TRPC+channel+interaction+constitutes+an+important+functional+unit+in+receptor-mediated+divalent+calcium+ion+influx+in+neuronal+cells. assertion.
- assertion asSentence Loss+of+HOXA1+is+associated+with+pancreatic+cancer. assertion.
- assertion asSentence Hox+A7-sustained+expression+disturbs+the+regulation+of+cell+adhesive+and+migratory+capacities+on+fibronectin+during+early+differentiation. assertion.
- assertion asSentence HOXA9+participates+in+the+transcriptional+activation+of+SELE+in+endothelial+cells. assertion.
- assertion asSentence HOXA9+is+required+for+TNF-alpha-dependent+binding+of+PRMT5+to+the+E-selectin+promoter+in+endothelial+cells. assertion.
- assertion asSentence The+expression+of+HOXA10+is+restricted+to+primordial+and+early+primary+follicles. assertion.
- assertion asSentence Hoxa10+is+expressed+in+the+developing+uterus. assertion.
- assertion asSentence HOXA10+is+overexpressed+in+human+ovarian+clear+cell+adenocarcinoma. assertion.
- assertion asSentence HOXA10+is+an+essential+mediator+that+regulates+expression+of+endothelin+type+A+receptor+in+endometrium+and+decidua+in+a+manner+similar+to+the+process+seen+in+vascular+smooth+muscle+cells. assertion.
- assertion asSentence Abnormal+endometrial+HOXA10+expression+is+associated+with+infertility+in+endometriosis+patients. assertion.
- assertion asSentence HOXA10+and+HOXA11+expression+increases+during+the+menstrual+cycle%2C+increasing+drastically+in+the+midluteal+phase%2C+at+the+time+of+implantation. assertion.
- assertion asSentence HOXA11+is+critical+for+development+and+maintenance+of+uterosacral+ligaments+and+deficient+in+pelvic+prolapse. assertion.
- assertion asSentence Hippocalcin+is+a+sensitive+Ca2%2B+sensor+capable+of+responding+to+increases+in+intracellular+Ca2%2B+concentration+over+the+narrow+dynamic+range+of+200-800+nM+free+Ca2%2B. assertion.
- assertion asSentence Overexpression+of+HOXA13+mRNA+is+associated+with+hepatocellular+carcinoma. assertion.
- assertion asSentence The+protein+transduction+domain-Hoxb4protein+can+be+used+with+other+recombinant+proteins+to+efficiently+generate+transplantable+hemaat4opoietic+stem+cells+from+human+embryonic+stem+cells. assertion.
- assertion asSentence Cytomegalovirus+infection+markedly+down-regulated+HOXB4+expression+which+affected+proliferation+and+differentiation+of+erythroid+and+lymphocyte+progenitor+cells. assertion.
- assertion asSentence The+homeodomain+contains+most+or+all+of+the+important+structures+required+for+HOXB6+activity+in+blood+cells. assertion.
- assertion asSentence Prox1+and+HoxD8+play+important+roles+in+the+maturation+and+maintenance+of+lymphatic+vessels. assertion.
- assertion asSentence Haptoglobin+expression+by+retrogradely+shed+endometrial+tissues+in+peritoneal+fluid+supports+a+mechanism+whereby+these+purported+precursors+of+endometriotic+lesions+escape+immune+destruction. assertion.
- assertion asSentence Individuals+with+diabetes+mellitus+and+a+haptoglobin+2.2+genotype+demonstrate+lower+CD163+scavenger+receptor+levels+and+an+impaired+hemoglobin+clearance+capacity%2C+with+increased+incidence+of+myocardial+infarction. assertion.
- assertion asSentence Casein+kinase+II+activity+is+increased+by+the+binding+of+haptoglobin+1-1-hemoglobin+to+CD163. assertion.
- assertion asSentence Interleukin+6+expressed+in+pancreatic+cancer+is+a+factor+that+induces+the+haptoglobin+production. assertion.
- assertion asSentence Hp+protects+Hemoglobin+%28Hb%29+when+oxidatively+challenged+with+H%282%29O%282%29+preserving+CD163-mediated+Hb+clearance+under+oxidative+stress+conditions. assertion.
- assertion asSentence Cellular+expression+of+haptoglobin+is+closely+related+to+recurrence+rate+in+HNSCC+patients. assertion.
- assertion asSentence 15-PGDH+is+a+direct+downstream+effector+of+HNF3beta+and+acts+as+a+tumor+suppressor+in+lung+cancer. assertion.
- assertion asSentence Hepsin+activates+prostasin+and+cleaves+the+extracellular+domain+of+the+epidermal+growth+factor+receptor. assertion.
- assertion asSentence In+children+with+cancer+there+is+no+significant+increase+in+background+HPRT+mutation+frequency. assertion.
- assertion asSentence Mutations+do+not+confer+a+growth+advantage+to+somatic+heterozygous+clusters+or+maintenance+turnover+units. assertion.
- assertion asSentence Acrylamide+has+a+weak+mutagenic+effect+at+HPRT+gene+locus+in+human+promyelocytic+leukaemia+HL-60+and+NB4+cell+lines. assertion.
- assertion asSentence Ras+gene+alterations+have+a+specific+and+early+role+in+the+development+of+follicular+type+of+thyroid+tumors+in+Taiwan. assertion.
- assertion asSentence Germline+mutations+in+HRAS+perturb+human+development+and+increase+susceptibility+to+tumors. assertion.
- assertion asSentence Ras+induces+ErbB4+receptor+phosphorylation+in+a+non-autocrine+manner+and+this+activation+depends+on+multiple+Ras+effector+pathways+and+on+ErbB4+kinase+activity. assertion.
- assertion asSentence Targeted+activation+of+a+human+oncogenic-ras+transgene+in+rat+pancreas+can+induce+carcinomas+correspondent+to+human+pancreatic+ductal+adenocarcinomas. assertion.
- assertion asSentence The+subcellular+distribution+of+K-Ras+is+driven+by+electrostatic+interaction+of+the+polybasic+region+of+the+protein+with+negatively+charged+membranes. assertion.
- assertion asSentence De+novo+germline+HRAS+%28G12A%29+and+KRAS+%28F156L%29+mutations+in+two+siblings+with+short+stature+and+neuro-cardio-facio-cutaneous+features. assertion.
- assertion asSentence Scribble+is+an+important+mediator+of+MAPK+signalling+and+cooperates+with+H-ras+to+promote+cell+invasion. assertion.
- assertion asSentence Features+of+KRAS+mutations+in+lung+cancer+and+contrast+these+with+the+features+of+EGFR+mutations. assertion.
- assertion asSentence Conformational+states+of+human+rat+sarcoma+%28Ras%29+protein+complexed+with+its+natural+ligand+GTP+and+their+role+for+effector+interaction+and+GTP+hydrolysis. assertion.
- assertion asSentence G-CSF-induced+MMP-2+upregulation+and+invasive+phenotype+is+mediated+by+Rac1. assertion.
- assertion asSentence HRAS+mutations+and+llelic+loss+of+susceptibility+loci+are+associated+with+familial+non-medullary+thyroid+cancer. assertion.
- assertion asSentence NADPH+oxidase+NOX4+is+a+critical+mediator+in+oncogenic+H-RasV12-induced+DNA-damage+response+and+subsequent+senescence. assertion.
- assertion asSentence The+HRAS+G-quadruplexes+behave+as+transcription+repressors. assertion.
- assertion asSentence Reduced+C4ST-1+expression+and+chondroitin+sulfation+imbalance+mediating+the+effects+of+oncogenic+HRAS+signaling+in+the+pathogenesis+of+Costello+syndrome. assertion.
- assertion asSentence High+ERas+is+associated+with+the+tumorigenic+process+of+gastric+carcinomas. assertion.
- assertion asSentence H2r+exposure+to+an+agonist+caused+desensitization+controlled+by+H2r+phosphorylation+via+GRK2+and+GRK3. assertion.
- assertion asSentence Methylates+Ki-1%2F57+and+CGI-55+%28PAI-1+mRNA-binding+protein%29+at+a+conserved+Gly%2FArg-rich+motif+cluster. assertion.
- assertion asSentence PRMT1-+dependent+methylation+of+RUNX1+at+arginine+residues+206+and+210+abrogates+its+association+with+SIN3A. assertion.