Matches in Nanopublications for { ?s <http://purl.org/nanopub/x/asSentence> ?o ?g. }
- assertion asSentence The+RG-rich+and+RGG+box+of+SERBP1+is+asymmetrically+dimethylated+by+PRMT1+and+the+modification+affects+protein+interaction+and+intracellular+localization+of+the+protein. assertion.
- assertion asSentence Notch-mediated+Hes1+expression+contributes+to+the+maintenance+of+the+proliferative+crypt+compartment+of+the+small+intestine+by+transcriptionally+repressing+two+CDK+inhibitors. assertion.
- assertion asSentence Regulates+brain+development+process. assertion.
- assertion asSentence Hyperactivation+of+BRAF-MEK+signaling+activates+MAP2+expression+in+melanoma+cells+by+two+independent+mechanisms%2C+promoter+demethylation+or+down-regulation+of+neuronal+transcription+repressor+HES1. assertion.
- assertion asSentence Human+adrenal+cortex+and+aldosterone+secreting+adenomas+express+both+11beta-hydroxysteroid+dehydrogenase+type+1+and+type+2+genes. assertion.
- assertion asSentence 11beta-Hydroxysteroid+dehydrogenase+types+1+and+2+are+up-+and+downregulated+in+cortisol-secreting+adrenal+adenomas. assertion.
- assertion asSentence Higher+adipose+11-HSD1+activity+is+associated+with+features+of+metabolic+syndrome. assertion.
- assertion asSentence Disease+activity+exerts+a+significant+impact+on+11beta-hydroxysteroid+dehydrogenase+activity+in+acromegalic+patients. assertion.
- assertion asSentence A+relatively+higher+11+beta-HSD1+activity+in+Omentum+vs.+sc+adipose+tissue+is+associated+with+preferential+visceral+fat+accumulation+and+concomitant+metabolic+alterations. assertion.
- assertion asSentence Short-small-for-Gestational-Age+condition+is+associated+with+enhanced+glucocorticoid-stimulated+11beta-HSD-1+activity. assertion.
- assertion asSentence The+overexpression+of+11beta-hydroxysteroid+dehydrogenase+type+1+in+visceral+adipose+tissue+is+associated+with+hyperinsulinemia+in+morbidly+obese+patients. assertion.
- assertion asSentence 11beta-HSD1+visceral+adipose+tissue+expression+is+associated+with+the+presence+of+non-alcoholic+fatty+liver+disease. assertion.
- assertion asSentence Weak+associations+between+the+HSD11B2+gene%2C+type+1+diabetes+mellitus+and+nephropathy. assertion.
- assertion asSentence 11beta-Hydroxysteroid+dehydrogenase+types+1+and+2+are+up-+and+downregulated+in+cortisol-secreting+adrenal+adenomas. assertion.
- assertion asSentence Acute+exposure+of+a+low+dose+of+cadmium+to+choriocarcinoma+cells+decreased+corisol+production+associated+with+increased+11beta-hydroxysteroid+dehydrogenase+2+expression. assertion.
- assertion asSentence The+underexpression+of+11beta-HSD2+after+the+33rd+week+in+impending+intrauterine+fetal+asphyxia+in+IUGR+points+to+an+increased+sensitivity+to+hypoxia+when+impending+asphyxia+is+present+in+the+late+phase+of+IUGR+pregnancies. assertion.
- assertion asSentence HSD17B1+is+a+multispecific+enzyme. assertion.
- assertion asSentence HSD17B1+polymorphism+is+not+associated+with+the+risk+of+breast+cancer+or+fibrocystic+breast+disease+in+Chinese+women. assertion.
- assertion asSentence HSD17B1+upregulation+by+sodium+butyrate+is+associated+with+increased+conversion+of+E1+to+E2+in+colorectal+cancer+cells. assertion.
- assertion asSentence Reduced+HSD17B1+expression+can+be+associated+with+DNA+methylation+in+the+5%27+flanking+region+of+HSD17B1+in+CRC+from+the+proximal+colon. assertion.
- assertion asSentence Higher+mRNA+levels+of+enzymes+synthesizing+and+inactivating+androgens+are+found+in+differentiated+adipocytes%2C+consistent+with+higher+androgen-processing+rates+in+these+cells. assertion.
- assertion asSentence Retrovirus-mediated+transfer+of+dominant-negative+mutant+HSF1+leads+to+massive+cell+death+of+breast+cancer+cells+after+hyperthermia+treatment. assertion.
- assertion asSentence HSF1+can+activate+MDR-1+expression+in+a+stress-independent+manner+that+differs+from+the+canonical+heat+shock-activated+mechanism+involved+in+HSP+induction. assertion.
- assertion asSentence Dominant-positive+HSF1+plays+an+important+role+in+suppressing+alpha-synuclein+aggregation+and+toxicity+in+SH-SY5Y+cells. assertion.
- assertion asSentence ErbB2+promotes+glycolysis+at+least+partially+through+the+HSF1-mediated+upregulation+of+LDH-A. assertion.
- assertion asSentence KRIBB11+inhibits+HSP70+synthesis+through+inhibition+of+heat+shock+factor+1+function+by+impairing+the+recruitment+of+positive+transcription+elongation+factor+b+to+the+hsp70+promoter. assertion.
- assertion asSentence HSF1+plays+a+prosurvival+role+in+the+pathogenesis+of+pancreatobiliary+tumors. assertion.
- assertion asSentence MEL-18+bound+to+HSF2+inhibits+its+sumoylation+by+binding+to+and+inhibiting+the+activity+of+UBC9+enzymes+in+the+vicinity+of+HSF2. assertion.
- assertion asSentence K562+cells+transfected+with+the+vector+exhibited+slower+proliferation%2C+increased+apoptosis+and+increased+G%280%29%2FG%281%29+arrest. assertion.
- assertion asSentence Upon+heat+shock%2C+the+Hsp70.1+promoter-bound+PARP-1+is+released+to+activate+transcription+through+ADP-ribosylation+of+other+Hsp70.1+promoter-bound+proteins. assertion.
- assertion asSentence Hsp72+plays+a+role+in+protecting+cells+from+DNA+damage+induced+by+coke+oven+emissions. assertion.
- assertion asSentence GRP-induced+up-regulation+of+Hsp72+promotes+CD16%2B%2F94%2B+natural+killer+cell+binding+to+colon+cancer+cells+causing+tumor+cell+cytolysis. assertion.
- assertion asSentence Mild+electrical+stimulation+increases+ubiquitinated+proteins+and+Hsp72+in+A549+cells+via+attenuation+of+proteasomal+degradation. assertion.
- assertion asSentence Filamentous+keratins+and+Hsp70+are+required+for+the+rescue+rephosphorylation+of+mature+atypical+PKC%2C+regulating+the+subcellular+distribution+and+steady-state+levels+of+active+PKC+iota. assertion.
- assertion asSentence Hsp72+is+involved+in+HCV+RNA+replication. assertion.
- assertion asSentence HSP70-2+polymorphism+does+not+play+a+major+role+in+the+development+of+alcoholic+chronic+pancreatits+in+Koreans. assertion.
- assertion asSentence HSP70-2+down-regulation+induces+apoptosis+of+HCC+cells+through+the+mitochondrial+apoptotic+pathway. assertion.
- assertion asSentence HSP70-2+expression+is+up-regulated+in+response+to+hypoxia. assertion.
- assertion asSentence Significantly+higher+frequency+of+HSP+70-2+gene+mutant+allele+%28G+allele%29+in+patients+with+acute+pancreatitis+and+pancreatic+carcinoma+as+compared+to+control+population. assertion.
- assertion asSentence APG-2+has+a+chaperone-like+activity+similar+to+Hsp110+and+is+overexpressed+in+human+hepatocellular+carcinoma. assertion.
- assertion asSentence Human+keratinocyte-derived+cells+release+Hsp70+in+the+extracellular+medium+through+a+pathway+involving+secretory-like+granules. assertion.
- assertion asSentence Both+heat+and+BPDE+can+induce+the+expressions+of+Hsp27+and+Hsp70+in+A549+cells. assertion.
- assertion asSentence Heat+shock+and+ADM+chemotherapy+both+induce+over+expression+of+HSP70+and+MDR1. assertion.
- assertion asSentence HSP70+gene+expression+tended+to+be+induced+in+the+group+administered+Healing+and+Wound+Emulsion+following+gamma-ray+irradiation. assertion.
- assertion asSentence Hsp70+interaction+with+membranes+acts+as+a+platform+for+its+release+into+the+extracellular+environment+during+its+recovery+from+stress. assertion.
- assertion asSentence Sequential+measurement+intraoperatively+of+the+levels+of+the+heat+shock+proteins+HSP70+and+HSP27+in+the+cerebrospinal+fluid+can+predict+those+patients+who+are+at+greatest+risk+for+paralysis+during+thoracic+aneurysm+surgery. assertion.
- assertion asSentence A+reliable+marker+for+the+detection+of+hepatocellular+carcinoma+in+liver+biopsies. assertion.
- assertion asSentence HSF1+and+major+HSP%27s+are+expressed+strongly+in+classical+Hodgkin+lymphoma. assertion.
- assertion asSentence Differential+expression+of+Hsp40+and+Hsp70+reciprocally+regulates+viral+gene+expression+and+replication+in+HIV-1+infection. assertion.
- assertion asSentence Lipid+rafts+play+a+critical+role+in+the+early+stage+of+JEV+infection+by+concentrating+the+JEV+E+protein+and+HSP70+in+membrane+microdomains. assertion.
- assertion asSentence Mononuclear+leukocytes+responded+to+BiP+with+secretion+of+an+antiinflammatory+profile+of+cytokines. assertion.
- assertion asSentence Disturbed+SIL1-HSPA5+interaction+and+protein+folding+is+the+primary+pathology+in+Marinesco-Sjogren+syndrome. assertion.
- assertion asSentence N-methyl-N%27-nitro-N-nitrosoguanidine+%28MNNG%29+can+induce+the+clustering+of+epidermal+growth+factor+receptor+%28EGFR%29+with+GRP78+in+human+amnion+FL+cells. assertion.
- assertion asSentence BiP%2FGRP78+is+a+defined+intracellular+target+of+action+and+presents+an+unparalleled+opportunity+to+develop+improved+therapeutic+versions+of+this+cancer-specific+apoptosis-inducing+cytokine. assertion.
- assertion asSentence Acquisition+of+the+oncogenic+function+of+Gp96+or+Grp78+contribute+to+aggressive+cancers. assertion.
- assertion asSentence The+ER+chaperone+GRP78+is+crucial+for+synoviocyte+proliferation+and+angiogenesis%2C+the+pathological+hallmark+of+rheumatoid+arthritis. assertion.
- assertion asSentence Hsp70B%27+and+Hsp72+play+cooperative+roles+in+cell+survival+of+proteotoxic+stress. assertion.
- assertion asSentence Both+Hsp70B%27+and+Hsp72+are+important+for+maintaining+viability+under+conditions+that+increase+the+accumulation+of+damaged+proteins+in+HT-29+cells. assertion.
- assertion asSentence Sequestered+in+discrete+foci+in+the+nucleus+of+the+infected+cell+in+herpes+simplex+virus+type+1+infection. assertion.
- assertion asSentence Histidine+89+is+an+essential+residue+for+Hsp70+in+the+phosphate+transfer+reaction. assertion.
- assertion asSentence Nef%27s+interaction+with+cellular+mortalin+is+required+for+Nef+secretion. assertion.
- assertion asSentence DNLZ%2FHEP+zinc-binding+subdomain+is+critical+for+regulation+of+the+mitochondrial+chaperone+HSPA9. assertion.
- assertion asSentence A+tumor+marker+for+hepatocellular+hepatoma. assertion.
- assertion asSentence Acidic+pH+exposure+protects+HEMEC+through+induction+of+Hsps+and+activation+of+MAPK+and+PI3+kinase+pathway. assertion.
- assertion asSentence Overexpression+of+HSP27+in+Hep-2+cells+confers+chemoresistance+which+is+associated+with+the+delay+in+cell+growth. assertion.
- assertion asSentence Hsp27+expression+is+increased+in+the+normal-appearing+vessel+adjacent+to+carotid+atherosclerotic+plaque. assertion.
- assertion asSentence Hsp27+is+a+mediator+of+repression+of+androgen+receptor+function+by+PKD1+in+prostate+cancer+cells. assertion.
- assertion asSentence HSP27+expressed+higher+in+the+right+sided+colon+cancer+than+in+the+left+sided+colon+cancer. assertion.
- assertion asSentence Hsp27+inhibits+cisplatin-+induced+hepatocellular+carcinoma+cell+death+through+autophagy+activation. assertion.
- assertion asSentence Higher+concentration+of+HSP+27+in+adjacent+distal+normal+mucosa+can+be+a+response+to+stress+factors+related+with+metabolic+changes+of+colorectal+adenocarcinoma+tissues+or+can+be+a+protective+function+to+stress+factors+of+the+tumour. assertion.
- assertion asSentence The+key+contribution+of+HSPB1-VEGF+interactions+in+the+balance+between+physiological+and+pathological+angiogenesis. assertion.
- assertion asSentence Both+heat+and+BPDE+can+induce+the+expressions+of+Hsp27+and+Hsp70+in+A549+cells. assertion.
- assertion asSentence HSP27+phosphorylation+is+correlated+with+ADP-induced+platelet+granule+secretion. assertion.
- assertion asSentence HSP27+and+HSP60+are+predictors+of+biochemical+recurrence+of+prostate+cancer+after+radical+prostatectomy. assertion.
- assertion asSentence Overexpression+of+huHSP27+protects+against+hepatic+injury+and+acute+kidney+injury+associated+with+liver+ischemia-reperfusion+injury+in+mice. assertion.
- assertion asSentence HSP27+and+p53+protein+levels+play+a+key+role%28s%29+in+heat+shock-mediated+switch+of+glucose+depreivation-induced+necrosis+to+apoptosis. assertion.
- assertion asSentence Hsp90%2C+a+molecular+chaperone+that+is+central+to+the+cellular+stress+response%2C+associates+with+survivin%2C+an+apoptosis+inhibitor+and+essential+regulator+of+mitosis. assertion.
- assertion asSentence Hsp90+inhibition+significantly+inhibited+DC+function. assertion.
- assertion asSentence The+conversion+of+Thr%28566%29+and+Ala%28629%29+of+Hsp90alpha+to+Ala%28558%29+and+Met%28621%29+is+primarily+responsible+for+impeded+dimerization+of+Hsp90beta. assertion.
- assertion asSentence HSP90+inhibition+abrogates+the+topoisomerase+I+poison-induced+G2%2FM+checkpoint+in+p53-null+tumor+cells+by+depleting+CHK1+and+WEE1. assertion.
- assertion asSentence Heat+shock+protein+90+inhibitors+suppress+aryl+hydrocarbon+receptor-mediated+activation+of+CYP1A1+and+CYP1B1+transcription+and+DNA+adduct+formation. assertion.
- assertion asSentence Hsp90+modulates+intermediate+steps+of+amyloid+assembly+of+the+Parkinson-related+protein+alpha-synuclein. assertion.
- assertion asSentence HSP70%2FHSP90+expression+in+nasopharyngeal+carcinoma+cells+up+regulated+promptly+after+thermotherapy. assertion.
- assertion asSentence Decreased+Hsp90+expression+is+associated+with+infiltrative+lobular+carcinoma. assertion.
- assertion asSentence Cdc37-mediated+direct+interaction+between+Hsp90%2FCdc37+and+an+IRE1alpha+cytosolic+motif+is+important+to+maintain+basal+IRE1alpha+activity+and+contributes+to+normal+protein+homeostasis+and+unfolded+protein+response+under+physiological+stimulation. assertion.
- assertion asSentence Protective+role+of+chaperones+%28HSP70+and+90%29+in+preeclampsia. assertion.
- assertion asSentence Hsp90+inhibition+overcomes+HGF-triggering+resistance+to+EGFR-TKIs+in+EGFR-mutant+lung+cancer+by+decreasing+client+protein+expression+and+angiogenesis. assertion.
- assertion asSentence A+regulatory+HSP60+peptide+specifically+recognized+by+the+T+cells+of+DNA-vaccinated+rats+is+successfully+used+as+an+effective+vaccine+to+inhibit+the+development+of+adjuvant+arthritis+in+rats. assertion.
- assertion asSentence Mitochondrial+HSP60+chaperonopathy+causes+an+autosomal-recessive+neurodegenerative+disorder+linked+to+brain+hypomyelination+and+leukodystrophy. assertion.
- assertion asSentence HSP27+and+HSP60+are+predictors+of+biochemical+recurrence+of+prostate+cancer+after+radical+prostatectomy. assertion.
- assertion asSentence Coexpression+of+HSP60+and+nuclear+beta-catenin+predicts+a+worse+prognosis+of+metastatic+head+and+neck+cancer+patients. assertion.
- assertion asSentence Hereditary+spastic+paraplegia+SPG13+is+associated+with+a+mutation+in+the+gene+encoding+the+mitochondrial+chaperonin+Hsp60. assertion.
- assertion asSentence Augmented+synthesis+and+differential+localization+of+heparan+sulfate+proteoglycans+in+Duchenne+muscular+dystrophy. assertion.
- assertion asSentence The+gene+expression+of+perlecan+is+partially+suppressed+by+antiangiogenic+forms+of+antithrombin. assertion.
- assertion asSentence Caspase-3+activation+triggers+extracellular+cathepsin+L+release+and+endorepellin+proteolysis. assertion.
- assertion asSentence Inhibitory+peptides+of+the+sulfotransferase+domain+of+the+heparan+sulfate+enzyme%2C+N-deacetylase-N-sulfotransferase-1. assertion.
- assertion asSentence The+presence+of+the+D2LR-5-HT2AR+heteromer+in+discrete+brain+regions+is+postulated+based+on+the+existence+of+D2LR-5-HT2A+receptor-receptor+interactions+in+living+cells+and+their+codistribution+inter+alia+in+striatal+regions. assertion.
- assertion asSentence Expression+in+cultured+skin+cells. assertion.
- assertion asSentence 2+polymorphisms+in+HTR2C+and+the+5-HTTLPR+in+SLC6A4+to+be+weakly+associated+with+BMI. assertion.
- assertion asSentence HT2C+genetic+variant+and+greater+increase+in+waist+circumference+%28P%3D0.03%29%2C+fasting+glucose+level+%28P%3D0.046%29+and+triglyceride+level+%28P%3D0.045%29+in+blood+after+a+3-month+period+of+using+olanzapine%2Frisperidone+for+schizophrenia. assertion.