Matches in Nanopublications for { ?s <http://purl.org/nanopub/x/asSentence> ?o ?g. }
- assertion asSentence Monocyte-derived+dendritic+cells+can+modulate+their+sensitivity+to+two+IFN+subtypes+by+differential+regulation+of+the+IFNAR+subunits. assertion.
- assertion asSentence The+antiviral+cytokine+interferon+beta+breaks+peripheral+tolerance+to+pancreatic+beta+cells%2C+influences+insulitis+progression+and+contributes+to+autoimmunity+in+diabetes+and+nondiabetes-prone+mice. assertion.
- assertion asSentence Human+recombinant+IFN-beta+induces+interleukin+%28IL%29-6+production+by+U251+astrocytoma+cells+without+induction+of+IL-1+beta%2C+tumor+necrosis+factor-alpha+and+nitric+oxide. assertion.
- assertion asSentence IFN-beta+transgene+protects+against+ocular+herpes+simplex+virus+type+1+infection+in+vivo+and+in+vitro+via+selective+up-regulation+of+the+oligoadenylate+synthetase+%28OAS%29-1a+pathway+and+by+altering+protein+phosphorylation+in+antiviral+signaling+cascades. assertion.
- assertion asSentence The+NS1+of+influenza+A+virus+binds+to+RIG-I+and+inhibits+downstream+activation+of+IRF-3%2C+preventing+the+transcriptional+induction+of+IFN-beta. assertion.
- assertion asSentence IFNB1+mRNA+levels+in+virus-infected+dendritic+cells+exhibit+cell-to-cell+variation. assertion.
- assertion asSentence Retinal+pigment+epithelial+cell+induction+of+IFN-beta+during+Toll-like+receptor+signaling+in+the+retina+is+an+immunosuppressive+mechanism+that+limits+immunopathologic+damage+by+inhibiting+ICAM-1+adhesion+molecule+synthesis+and+stopping+CXCL9+production. assertion.
- assertion asSentence Respiratory+Syncytial+Virus+G+protein+inhibits+TLR3%2F4+mediated+interferon+beta+induction. assertion.
- assertion asSentence Aberrant+splicing+of+IRF3+in+HCC+contributes+to+the+defect+in+IFN-mediated+antiviral+defenses. assertion.
- assertion asSentence DDX3+helped+IPS-1+up-regulate+IFN-beta+promoter+activation. assertion.
- assertion asSentence Influenza+virus+A+PB2+protein+interacts+with+MAVS+and+inhibits+MAVS-mediated+beta+interferon+expression. assertion.
- assertion asSentence IFN-beta+stimulates+interleukin+%28IL%29-10+production+by+activating+the+Janus+kinase+%28JAK%291-+and+phosphatidylinositol+%28PI%293-kinase-signaling+pathways. assertion.
- assertion asSentence pp32+interacted+with+STAT1+and+STAT2+in+an+IFNB-dependent+manner. assertion.
- assertion asSentence Only+IFN-beta%2C+not+IFN-alpha+%2810-1%2C000+IU%2FmL%29%2C+has+an+inhibitory+activity+on+endothelial+cell+proliferation. assertion.
- assertion asSentence IFN-beta+induces+microRNA-195+expression+and+inhibits+cell+proliferation+by+delaying+G1+to+S+phase+cell+cycle+progression+in+human+hepatic+stellate+cell+line+LX-2. assertion.
- assertion asSentence Human+neural+stem%2Fprogenitor+cells+respond+to+IFN+beta-1b+treatment+via+sustained+proliferation+and+differentiation. assertion.
- assertion asSentence Measles+virus+C+protein+interferes+with+Beta+interferon+transcription+in+the+nucleus. assertion.
- assertion asSentence IFN-beta-induced+upregulation+of+glucocorticoid-induced+tumor+necrosis+factor+receptor+ligand+%28GITRL%29+on+dendritic+cells+and+downregulation+of+CTLA-4+on+regulatory+T+cells+%28Tregs%29+facilitates+proliferation+of+anergic+Tregs+in+treatment+of+multiple+sclerosis. assertion.
- assertion asSentence Paramyxovirus+5+V+proteins+interact+with+the+RNA+Helicase+LGP2+to+inhibit+RIG-I-dependent+interferon+beta+induction. assertion.
- assertion asSentence P.+gingivalis+membrane+vesicles+apparently+inhibited+IFN-gamma-induced+MHC+class+II+by+disrupting+the+IFN-gamma+signaling+transduction+pathway. assertion.
- assertion asSentence Production+of+matrix+metalloproteinase-9+in+early+stage+B-CLL+is+suppressed+by+interferons+alpha+and+gamma. assertion.
- assertion asSentence IFN-gamma+plays+a+critical+role+in+the+protection+of+Schistosoma+mansoni-infected+patients+against+periportal+fibrosis. assertion.
- assertion asSentence Lipid+microdomains+are+required+sites+for+the+selective+endocytosis+and+nuclear+translocation+of+IFN-gamma. assertion.
- assertion asSentence Association+between+a+high-expressing+interferon-gamma+allele+and+a+lower+frequency+of+kidney+angiomyolipomas+in+TSC2+patients. assertion.
- assertion asSentence When+transfected+into+hepatocytes%2C+ameliorates+hepatic+fibrosis+in+rats+and+modifies+intrasplenic+transplantation+of+syngenic+hepatocytes. assertion.
- assertion asSentence Downregulation+of+waf1+mediates+apoptosis+of+human+hepatocellular+carcinoma+cells+in+response+to+interferon-gamma. assertion.
- assertion asSentence Measles+virus+V+protein+does+not+block+IFNG+signaling. assertion.
- assertion asSentence In+pre+eclampsia+IFN-gamma+expression+mimicked+that+in+early+placental+development. assertion.
- assertion asSentence Among+host+genetic+factors+contributing+to+H.+pylori+disease+outcome%2C+IFN-G+%2B874+AA+genotype+favors+cagA+positive+infections. assertion.
- assertion asSentence IFN-gamma+sensitizes+KB+cells+for+apoptosis+induction+by+facilitating+death-inducing+signaling+complex+%28DISC%29-mediated+caspase+8+processing. assertion.
- assertion asSentence No+association+is+found+for+IFNgamma+single+nucleotide+polymorphisms+in+patients+with+increased+susceptibility+to+bronchiectasis. assertion.
- assertion asSentence In+a+Turkish+population%2C+the+interferon-gamma+874T-A+polymorphism+is+associated+with+tuberculosis+disease+and+affects+the+magnitude+of+the+interferon-gamma+response. assertion.
- assertion asSentence Parkinson%27s+disease+patients+express+significantly+elevated+levels+of+IFN-gamma+in+their+blood+plasma. assertion.
- assertion asSentence In+human+mesenchymal+stem+cells%2C+interferon-+gamma-induced+major+histocompatibility+complex+%28MHC%29+class+II+expression+occurs+at+highest+levels+in+low-density+cultures%2C+via+effects+on+class+II+transactivator+CIITA+expression. assertion.
- assertion asSentence IFN-gamma-induced+MIC+molecules+participated+in+monocyte%2FNK+cell+interaction+and+this+interaction+also+involved+mIL-15. assertion.
- assertion asSentence Deficiency+of+interferon+gamma+in+cytotoxic+T-lymphocyte+precursors+predicts+donor-specific+cytotoxicity+after+clinical+kidney+transplantation. assertion.
- assertion asSentence Synergistic+induction+of+endothelin-1+by+tumor+necrosis+factor+alpha+and+interferon+gamma+is+due+to+enhanced+NF-kappaB+binding+and+histone+acetylation+at+specific+kappaB+sites. assertion.
- assertion asSentence TNFA+and+INFG+are+the+most+consistently+upregulated+cytokines+in+large+abdominal+aortic+aneurysms. assertion.
- assertion asSentence The+IL-23+induced+cytokines+allow+for+the+subsequent+production+of+IL-12+and+amplify+the+IFN-gamma+production+in+the+type-1+cytokine+pathway. assertion.
- assertion asSentence Systematic+mutation+screening+of+IFNG+by+the+LightCycler%28%28R%29%29-based+procedure+of+high-resolution+melting+%28HRM%29+revealed+additional+rare+mutations. assertion.
- assertion asSentence Activation+of+signal+transducer+and+activator+of+transcription-1+%28STAT-1%29+and+differential+expression+of+interferon-gamma+and+anti-inflammatory+proteins+in+pelvic+ileal+pouches+for+ulcerative+colitis+and+familial+adenomatous+polyposis. assertion.
- assertion asSentence IL-27+induced+by+mycobacterium+tuberculosis+infection+in+human+macrophages+opposed+IFN-gamma+production+by+antagonizing+IL-18+activity. assertion.
- assertion asSentence Cigarette+smoke+extract+inhibits+the+antiviral+effects+of+IFN-gamma+in+airway+epithelial+cells. assertion.
- assertion asSentence The+hallmark+T+helper+cell+type+%28Th%291+cytokine+IFN-gamma+can+also+be+defined+as+a+T+helper+type+%28Th%2917+cytokine%2C+depending+on+the+milieu+and+other+cytokines+produced+by+patients%27+T+cell+subsets+in+peripheral+blood+and+inflamed+tissues. assertion.
- assertion asSentence Interferon+gamma+synthesis+is+crucial+for+the+ability+of+dendritic+cells+to+activate+CD8%2B+T+cells. assertion.
- assertion asSentence IFNG+methylation+is+associated+with+ulcerative+colitis+patients+based+on+reactivity+to+microbial+antigens. assertion.
- assertion asSentence In+lines+of+intestinal+epithelial+cells+from+inflammatory+bowel+disease+patients%2C+interferon-gamma+selectively+up-regulated+IL-18+binding+protein. assertion.
- assertion asSentence Polymorphisms+in+IFNG+genes+can+affect+susceptibility+to+tubal+factor+infertility+or+disease+severity+by+contributing+to+the+cytokine+profile+and+host+immune+responses+during+C+trachomatis+infection. assertion.
- assertion asSentence IFN-gamma-expressing+regulatory+T+cells+%28Tregs%29are+selectively+enriched+in+patients+with+type+1+diabetes. assertion.
- assertion asSentence ESAT-6+inhibits+T+cell+IFN-gamma+production+in+a+p38+MAPK-dependent+manner. assertion.
- assertion asSentence IFN-gamma+gene+expression+is+decreased+in+response+to+lipopolysaccharide+and+increased+in+response+to+CD3+antibody+with+sepsis. assertion.
- assertion asSentence High+IL-7+concentration+can+prime+resting+B+cells+to+CD95-mediated+apoptosis+via+an+indirect+mechanism. assertion.
- assertion asSentence The+IFNgamma+expression+levels+are+increased+in+spinal+cords+of+patients+with+sporadic+amyotrophic+lateral+sclerosis. assertion.
- assertion asSentence Nucleocapsid+protein+of+measles+virus+blocks+host+IFN-alpha%2Fbeta+and+gamma-+responses. assertion.
- assertion asSentence Tim-3+is+an+inducible+human+natural+killer+cell+receptor+that+enhances+interferon+gamma+production+in+response+to+galectin-9. assertion.
- assertion asSentence Monocyte-derived+CD40+expression+is+regulated+by+interferon-gamma%2Finterferon-gamma+receptor-1+pathway+when+acting+as+a+bridge+during+their+interaction+with+T+cells+and+allogeneic+endothelial+cells. assertion.
- assertion asSentence Expression+downregulated+by+Mycobacterium+tuberculosis+in+human+cells+as+immune+evasion+mechanism. assertion.
- assertion asSentence Monocyte-derived+CD40+expression+is+regulated+by+interferon-gamma%2Finterferon-gamma+receptor-1+pathway+when+acting+as+a+bridge+during+their+interaction+with+T+cells+and+allogeneic+endothelial+cells. assertion.
- assertion asSentence The+existence+of+abnormalities+in+the+intracellular+processing+and+protein+expression+of+the+IFN-gamma+R2+in+response+to+specific+stimuli+such+as+IFN-gamma+and+M.+leprae+membrane+proteins+in+adherent+cells+of+LL+patients. assertion.
- assertion asSentence JAK2+is+a+critical+factor+that+stabilizes+IFN-gammaR2+surface+expression+in+Th17+cells+from+AMS+patients%2C+making+them+sensitive+to+IFN-gamma. assertion.
- assertion asSentence Single+nucleotide+polymorphism+in+ACO1+gene+is+associated+with+skin+pigmentation. assertion.
- assertion asSentence In+the+absence+of+PC4%2FIFRD1+skeletal+muscle+differentiation+is+defective. assertion.
- assertion asSentence IGF-1+up-regulates+K%2B+channels+via+PI3-kinase%2C+PDK1+and+SGK1. assertion.
- assertion asSentence Reduced+serum+insulin-like+growth+factor-1+%28IGF-1%29+and+IGF-binding+protein-3+levels+in+adults+with+inflammatory+bowel+disease. assertion.
- assertion asSentence IGF1+mediated+AKT+activation+delays+radiation-induced+apoptosis%2C+allowing+the+DNA+repair+mechanism+more+time+to+remove+cyclobutane+thymine+dimers. assertion.
- assertion asSentence Circulating+levels+of+IGF-1+and+IGFBP-1+are+significantly+related+to+the+extent+of+myocardial+injury+in+patients+with+hypertrophic+cardiomyopathy. assertion.
- assertion asSentence The+different+energetic+state+of+the+intra+A-chain%2Fdomain+disulfide+of+insulin+and+insulin-like+growth+factor+1+is+mainly+controlled+by+their+B-chain%2Fdomain. assertion.
- assertion asSentence IGF-I+does+not+affect+the+net+increase+in+GH+release+in+response+to+arginine. assertion.
- assertion asSentence Reduced+IGF+I+secretion+in+normal+elderly+subjects+not+due+to+alteration+of+nutritional+status. assertion.
- assertion asSentence IGF-1+prevents+age-related+decline+in+peak+intracellular+Ca2%2B+and+specific+force+in+a+muscle+that+does+not+exhibit+changes+in+fibre+type+composition+with+senescence. assertion.
- assertion asSentence IGF-I+prevents+apoptosis+by+preventing+downstream+caspase+activation%2C+maintaining+Delta+Psi%28M%29+and+regulating+Bcl+proteins. assertion.
- assertion asSentence Association+between+high+IGF-I+and+IGFBP-3+levels+and+increased+risk+of+breast+cancer+in+premenopausal+women. assertion.
- assertion asSentence The+CA-repeat+promoter+polymorphism+in+the+IGF-I+gene+is+associated+with+the+risk+for+fragility+fracture+at+old+age+in+women+and+with+bone+structure+in+both+genders. assertion.
- assertion asSentence IGF-1-induced+hypertrophy+can+involve+the+recruitment+of+reserve+cells+in+human+skeletal+muscle. assertion.
- assertion asSentence The+IGF1%2870+amino+acids%29+is+single-chain+polypeptides+structurally+similar+to+proinsulin. assertion.
- assertion asSentence Increased+breast+cancer+risk+in+women+with+promoter+polymorphisms+in+IGF1+and+IGFBP3+genes%2C+with+increased+risk+for+individuals+homozygous+for+both+polymorphisms. assertion.
- assertion asSentence IGF-I+can+significantly+stimulate+trophoblast+cells+adhesion+to+fibronectin. assertion.
- assertion asSentence Leptin+and+the+molar+excess+of+leptin+receptor+are+better+biomarkers+of+nutritional+status+than+IGF-I+in+protein+malnutrition+children+during+nutritional+recovery. assertion.
- assertion asSentence Igf-I+transduction+up-regulated+markers+of+osteoblastic+differentiation+and+in+conjunction+with+recombinant+BMP-2-induced+matrix+mineralization+independently+of+Dex. assertion.
- assertion asSentence IGF-I+and+its+downstream+pathway+is+a+valuable+therapeutic+approach+to+overcome+Ara-C+resistance+in+AML. assertion.
- assertion asSentence The+structures+reveal+the+mechanisms+of+insulin-like+growth+factor+%28IGF%29+signaling+regulation+via+insulin-like+growth+factor-binding+proteins+%28IGFBP%29+binding. assertion.
- assertion asSentence IGF-1+cell+signaling+leading+to+collagen+synthesis+in+fetal+lung+fibroblasts+is+mediated+by+PI3+Kinase+acting+through+NF-%28k%29B+in+HFLF. assertion.
- assertion asSentence In+human+keratinocytes%2C+insulin-like+growth+factor-1+%28IGF-1%29+induces+the+expression+of+LL-37. assertion.
- assertion asSentence No+significant+differences+in+levels+in+fibromyalgia+patients. assertion.
- assertion asSentence MGF+splice+variant+is+sensitive+to+muscle+damage-inducing+exercise+and+is+differentially+regulated+compared+with+IGF-IEa. assertion.
- assertion asSentence IGF-I+regulates+immature+testicular+cell+proliferation%2C+apoptosis+and+steroidogenesis. assertion.
- assertion asSentence Lower+insulin-like+growth+factor+1+is+associated+with+colorectal+cancer. assertion.
- assertion asSentence IGF-I%2C+IGFBP-1+and+IGFBP-3+are+all+inversely+related+to+adiposity+in+Hispanic+children. assertion.
- assertion asSentence IGF-I+is+a+more+important+metabolic+regulator+in+skeletal+muscle+than+previously+estimated. assertion.
- assertion asSentence The+IGF1+gene+alone+or+in+concert+with+diabetes+increases+the+risk+of+pancreatic+cancer. assertion.
- assertion asSentence Normal+IGF-I+bioactivity+in+obese+women+despite+severely+reduced+endogenous+GH+secretion. assertion.
- assertion asSentence Variations+of+the+stress+distribution+in+cancellous+bone+correlate+with+the+variation+of+the+concentrations+of+TGF-beta2+and+IGF-I+in+bone+matrix. assertion.
- assertion asSentence IGF-1+released+from+corneal+epithelial+cells+up-regulates+the+expression+of+N-cadherin+in+corneal+fibroblasts. assertion.
- assertion asSentence Partial+primary+deficiency+of+insulin-like+growth+factor+%28IGF-I%29+activity+associated+with+IGF1+mutation+demonstrates+its+critical+role+in+growth+and+brain+development. assertion.
- assertion asSentence IGFBP-3+and+IGF-1+decreased+significantly+following+regular+physical+activity+in+children+and+adolescents+with+type+1+diabetes. assertion.
- assertion asSentence The+growth+hormone-insulin-like+growth+factor+system+is+impaired+in+motor+neurons+and+degenerating+muscle+fibers+during+amyotrophic+lateral+sclerosis. assertion.
- assertion asSentence Resistance+training+initiated+in+the+acute+post-operative+phase+is+highly+effective+in+increasing+mean+fiber+area+and+in+addition+induces+marked+increases+in+the+expression+of+IGF-I+splice+variants. assertion.
- assertion asSentence High+concentrations+of+IGF-I+mat+play+a+permissive+role+in+progression+of+stent+restenosis+after+stenting+of+a+myocardial+infarct-related+artery. assertion.
- assertion asSentence Exercise+and+fasting+increase+IGF-1+mRNA+expression. assertion.
- assertion asSentence Patients+with+194+bp+genotype+are+the+resistant+patients+with+active+disease+and+they+required+high+dose+medication. assertion.