Matches in Nanopublications for { ?s <http://purl.org/nanopub/x/asSentence> ?o ?g. }
- assertion asSentence Single+nucleotide+polymorphisms+in+IGF-1+is+associated+with+myocardial+infarction. assertion.
- assertion asSentence High+serum+IGF-1+is+associated+with+non-small-cell+lung+cancer. assertion.
- assertion asSentence Low+IGF-1+is+associated+with+sex+differences+in+statural+growth+impairment+in+Crohn%27s+disease. assertion.
- assertion asSentence IGF-I+enhances+the+migration+of+chondrosarcoma+cells+by+increasing+alpha5beta1+integrin+expression+through+the+IGF-I+receptor%2FPI3K%2FAkt%2FNF-kappaB+signal+transduction+pathway. assertion.
- assertion asSentence Levels+of+circulating+IGF1+are+not+associated+with+increased+mortality+in+Australian+men. assertion.
- assertion asSentence Low+IGF-1+is+associated+with+recurrence+in+breast+cancer. assertion.
- assertion asSentence Associations+between+higher+levels+of+IGF-I+and+adrenal+androgens+at+age+8+yr+with+earlier+menarche%2C+independent+of+body+size%2C+support+functional+roles+of+these+hormones+in+regulating+puberty+timing+in+girls. assertion.
- assertion asSentence Insulin-like+growth+factor+receptor+I+mediates+resistance+to+anti-epidermal+growth+factor+receptor+therapy+in+primary+human+glioblastoma+cells+through+continued+activation+of+phosphoinositide+3-kinase+signaling. assertion.
- assertion asSentence IGF+I+receptor+is+involved+in+apoptosis+protection+in+human+preadipocytes+and+adipocytes. assertion.
- assertion asSentence Expression+in+breast+cancer+correlates+with+estrogen+receptors+alpha+ansd+beta. assertion.
- assertion asSentence Human+micro-+and+macrovascular+endothelial+cells+express+more+IGF-IR+than+insulin+receptor. assertion.
- assertion asSentence Existence+of+unidirectional+IGF-IR%2FEGFR+cross-talk+mechanism+whereby+IGF-II%2C+acting+through+IGF-IR%2C+regulates+basal+and+ligand-activated+EGFR+signaling+and+cell+proliferation+in+a+c-SRC-dependent+manner+in+tamoxifen-resistant+breast+cancer. assertion.
- assertion asSentence EGFR+depletion+induced+enhancement+of+IGF1R+ubiquitylation+and+degradation. assertion.
- assertion asSentence Upregulation+of+IGF-1+receptor+expression+is+associated+with+oral+cancer. assertion.
- assertion asSentence The+ubiquitin+ligase+Nedd4+mediates+oxidized+low-density+lipoprotein-induced+downregulation+of+insulin-like+growth+factor-1+receptor. assertion.
- assertion asSentence Co-targeting+the+EGFR+and+IGF-IR+with+anti-EGFR+monoclonal+antibody+ICR62+and+the+IGF-IR+tyrosine+kinase+inhibitor+NVP-AEW541+in+colorectal+cancer+cells. assertion.
- assertion asSentence Overexpression+for+IGF-1R+is+associated+with+adenocarcinoma+of+the+esophagus. assertion.
- assertion asSentence The+IGF-1R+gene+is+neither+associated+with+the+occurrence+nor+the+curve+severity+of+adolescent+idiopathic+scoliosis. assertion.
- assertion asSentence Rhabdomyosarcoma+pathogenesis+involves+increased+IGF1R+expression+that+enhances+AKT+and+Bcl-x%28L%29-mediated+cell+survival. assertion.
- assertion asSentence IGF-1R+activation+represents+a+previously+unrecognized+key+pathway+involved+in+the+mechanisms+by+which+NT+and+NTR1+modulate+colonic+inflammation+and+inflammatory+bowel+disease. assertion.
- assertion asSentence IGF-IR+is+up-regulated+and+frequently+activated+in+mantle+cell+lymphoma. assertion.
- assertion asSentence IGF-1R+is+an+independent+prognostic+marker+for+osteosarcoma+patients+and+increased+expression+of+this+molecular+is+correlated+with+metastasis+of+osteosarcoma. assertion.
- assertion asSentence GRK2+and+GRK6+coimmunoprecipitate+with+IGF-1R+and+increase+IGF-1R+serine+phosphorylation%2C+promoting+beta-arrestin+1+association. assertion.
- assertion asSentence IGF2+gene+is+imprinted%2C+with+expression+from+only+the+paternal+allele. assertion.
- assertion asSentence Brain+tumor+invasiveness+in+degrees+from+respect+of+the+arachnoid+membrane+progressing+to+frank+brain+invasion+correlated+with+increases+in+IGF-II+and+IGFBP-6+expression. assertion.
- assertion asSentence The+C+and+D+domains+of+IGF-II+promote+higher+affinity+binding+to+the+IR-A+than+the+equivalent+domains+of+IGF-I. assertion.
- assertion asSentence IGF-II+plays+a+role+in+colonic+carcinogenesis+from+ulcerative+colitis+by+interacting+with+interleukin+5. assertion.
- assertion asSentence SYT-SSX1+induces+insulin-like+growth+factor+II+expression+in+fibroblast+cells. assertion.
- assertion asSentence Implication+of+IGF2+duplication+in+overgrowth+and+Wilms%27tumorigenesis. assertion.
- assertion asSentence Different+members+of+Rho+GTPase+family+regulate+IGF-II-mediated+EVT+cell+migration+differentially%2C+depending+upon+whether+it+signals+through+IGF1R+or+in+an+IGF1R-independent+manner. assertion.
- assertion asSentence Endometrial+IGF-I+and+-II+are+differentially+regulated+during+decidualization+and+by+human+chorionic+gonadotropin. assertion.
- assertion asSentence IGF2+helps+predict+disease+outcome+in+GIST+patients. assertion.
- assertion asSentence Significantly+higher+IGF2+expression+is+associated+with+adrenocortical+carcinomas+compared+to+adrenocortical+adenomas. assertion.
- assertion asSentence IGF2+loss+of+imprinting+is+present+in+high+frequency+in+Chinese+gastric+cancer+patients%2C+especially+those+with+gastric+corpus+cancer. assertion.
- assertion asSentence Cohesin+has+a+critical+role+in+maintaining+CTCF-mediated+chromatin+conformation+at+the+at+the+IGF2-H19+locus+locus+and+disruption+of+this+conformation+coincides+with+changes+in+IGF2+expression. assertion.
- assertion asSentence The+high+morbility+of+the+FGR+with+hypertentive+disorder+complicating+pregnancy+has+no+relationshipswith+the+imprinting+status+of+IGF-II+and+H19+genes. assertion.
- assertion asSentence Low+doses+of+IGF-II+induce+hepatoprotective%2C+neuroprotective+and+metabolic+effects%2C+improving+mitochondrial+function%2C+without+affecting+testosterone+and+IGF-I+levels. assertion.
- assertion asSentence High+IGF2+mrna+is+associated+with+rabdomyosarcoma. assertion.
- assertion asSentence The+cytoprotective+effects+of+IGF-II+are+related+to+mitochondrial+protection+leading+to+increased+ATP+production+reducing+free+radical+generation%2C+oxidative+damage+and+apoptosis. assertion.
- assertion asSentence The+placental+lectins+have+no+effect+on+the+binding+of+IGF-II+to+IGF+II+Receptor. assertion.
- assertion asSentence DNA+methylation%2C+particularly+in+the+vicinity+of+a+key+CTCF-binding+site+%28CTCF3%29+in+the+imprinting+control+region+%28ICR%29+upstream+of+H19%2C+is+strongly+correlated+with+cerebellum+weight. assertion.
- assertion asSentence The+levels+of+protein+products+of+IGFR2+arwe+correlated+with+paramateres+of+birth+size. assertion.
- assertion asSentence M6P%2FIGF2R+controls+cell+invasion+by+regulating+alphaV+integrin+expression+and+by+accelerating+uPAR+cleavage%2C+leading+to+the+loss+of+the+urokinase%2Fvitronectin%2Fintegrin-binding+site+on+uPAR. assertion.
- assertion asSentence Leu%2827%29IGF2+promoted+mitogenesis+and+survival+only+in+explants+with+intact+IGF2R+expression. assertion.
- assertion asSentence Key+role+of+ALS+in+regulating+transendothelial+IGF+transport. assertion.
- assertion asSentence IGF-binding+protein+1+%28IGFBP1%29+gene+variant+is+associated+with+overfeeding-induced+metabolic+changes.+accumulation+of+abdominal+visceral+fat+and+the+early+symptoms+of+the+metabolic+syndrome. assertion.
- assertion asSentence Conditioned+medium+of+decidualized+ESC+cultured+with+cyclic+stretch+increased+IGFBP-1+secretion+from+decidualized+ESC+cultured+under+stationary+conditions. assertion.
- assertion asSentence Cadmium+cation+increases+the+production+of+IGFBP1. assertion.
- assertion asSentence The+recombinant+proteins+of+IGFBP1+%28IGFBP-rP1%29induce+senescence-like+growth+arrest+in+colorectal+cancer+cells. assertion.
- assertion asSentence Decreased+placental+expression+of+hPGH%2C+IGF-I+and+IGFBP-1+in+pregnancies+complicated+by+fetal+growth+restriction. assertion.
- assertion asSentence Increased+circulating+levels+of+IGFBP1+predict+increased+all-cause+mortality+in+Australian+men. assertion.
- assertion asSentence Insulin-like+growth+factor-binding+protein-1+%28IGFBP-1%29+regulates+human+schwannoma+proliferation%2C+adhesion+and+survival. assertion.
- assertion asSentence Regions+upstream+and+downstream+of+the+CWCV+motif+in+IGFBP2+participate+in+IGF-1+binding. assertion.
- assertion asSentence Variations+confer+impaired+glucose-+and+tolbutamide-induced+insulin+release+in+middle-aged+and+young+healthy+subjects. assertion.
- assertion asSentence Preoperative+plasma+IGFBP-2+levels+are+significantly+higher+in+high-grade+glioma+patients+than+in+low-grade+glioma+and+are+significantly+correlated+with+recurrence+and+disease-free+survival+in+patients+with+glioblastoma+multiforme. assertion.
- assertion asSentence The+metal-binding+domain+of+IGFBP3+mediate+cellular+uptake+and+modulates+apoptosis. assertion.
- assertion asSentence Actions+of+IGFBP-3+are+mediated+by+internalization+via+distinct+endocytic+pathways. assertion.
- assertion asSentence IGFBP-3+mRna+expression+is+increased+in+endometriosis%2C+compared+to+normal+endomatrium. assertion.
- assertion asSentence Endogenous+IGFBP-3+directly+inhibits+proliferation+of+human+intestinal+smooth+muscle+cells+by+activation+of+TGF-betaRI+and+Smad2%2C+an+effect+that+is+independent+of+its+effect+on+IGF-I-stimulated+growth. assertion.
- assertion asSentence Serum+IGFBP-3+levels+differed+significantly+between+pubertal+developmental+stages. assertion.
- assertion asSentence Loss+of+insulin-like+growth+factor-binding+protein-3+expression+is+associated+with+head+and+neck+carcinogenesis. assertion.
- assertion asSentence Both+addition+of+IGFBP-3+protein+to+cell+cultures+or+enforced+expression+of+IGFBP-3+in+the+HT29+colon+carcinoma+cell+line+inhibited+nuclear+factor+kappa+B+%28NF-kappaB%29+activation+in+response+to+the+induction+of+apoptosis+by+TRAIL. assertion.
- assertion asSentence Common+genetic+variation+in+the+IGFBP3+gene+does+not+substantially+influence+prostate+and+breast+cancer+susceptibility. assertion.
- assertion asSentence IGFBP-3+and+Nur77+associate+in+the+cytoplasmic+compartment+in+22RV1+human+prostate+cancer+cells. assertion.
- assertion asSentence Severely+deficient+in+a+case+of+insulin-resistance+syndrome+%28Rabson-Mendenhall+type%29. assertion.
- assertion asSentence Serum+levvels+amd+a+single+nucleotide+polymorphism+are+indiative+of+prostate+carcinogenesis. assertion.
- assertion asSentence No+major+role+of+the+assessed+genetic+variation+within+the+IGF1+and+the+IGFBP3+genes+in+CRC+risk. assertion.
- assertion asSentence Increased+myocardial+IGFBP-3+expression+in+23+failing+hearts+from+patients+undergoing+cardiac+transplantation+for+end-stage+dilated+or+ischemic+cardiomyopathy. assertion.
- assertion asSentence Circulating+levels+of+intact+IGFBP3+measured+after+diagnosis+is+associated+with+increased+risk+of+prostate+cancer-specific+death. assertion.
- assertion asSentence Adjusting+for+IGF-II%2C+the+inverse+association+of+IGFBP-3+with+cancer+mortality+shifted+from+significance+into+non-significance+when+adjusting+for+IGF-II+levels. assertion.
- assertion asSentence Upregulated+endogenous+IGFBP-3+and+TGF-beta1+expression+regulates+excess+collagen+IalphaI+production+and+contributes+to+fibrosis+and+stricture+formation+in+Crohn%27s+disease. assertion.
- assertion asSentence Host+genetic+variants+in+IGBFP3+impact+on+survival+of+patients+with+advanced+gastric+cancer+treated+with+palliative+chemotherapy. assertion.
- assertion asSentence Polymorphisms+in+the+IGFBP3+gene+on+chromosome+7p12.3+are+associated+with+circulating+IGF-I+and+IGFBP-3. assertion.
- assertion asSentence IGFBP-3+positively+and+negatively+impacts+on+IGF1-induced+lung+cancer+development. assertion.
- assertion asSentence Human+IGFBP-3+overexpression+impairs+glucose+regulation+in+mice+via+an+inhibition+of+insulin+secretion. assertion.
- assertion asSentence High+IGFBP-3+is+associated+with+acoustic+neuromas. assertion.
- assertion asSentence Polymorphic+variation+in+the+IGFBP3+gene+is+associated+with+extremely+tall+stature. assertion.
- assertion asSentence Insulin-like+growth+factor-binding+protein+5+%28IGFBP-5%29+interacts+with+a+four+and+a+half+LIM+protein+2+%28FHL2%29. assertion.
- assertion asSentence Promoter+contains+a+CACCC-rich+consensus+sequence+required+for+activation+by+MN1. assertion.
- assertion asSentence PSA+secreted+by+prostate+cancer+cells+degrades+IGFBP-5+and+augments+the+IGF+signal+transduction. assertion.
- assertion asSentence Increased+IGFBP-5+is+associated+with+cervical+intraepithelial+neoplasia+and+cervical+carcinoma. assertion.
- assertion asSentence Insulin-like+growth+factor-binding+protein-5+stimulates+growth+of+human+intestinal+muscle+cells+by+activation+of+Galphai3. assertion.
- assertion asSentence Regulation+of+the+IGFBP-5+and+MMP-13+genes+by+the+microRNAs+miR-140+and+miR-27a+in+human+osteoarthritic+chondrocytes. assertion.
- assertion asSentence The+IGFBP-6+protein+is+synthesized+as+propeptides+with+a+hydrophobic+leader+sequence%2C+removal+of+which+yields+a+mature+protein+composed+of+3+recognizable+domains+of+similar+size. assertion.
- assertion asSentence Similar+to+oncogenic+BRAF-positive+common+naevi+without+atypia%2C+enhanced+expression+of+the+tumour+suppressor+IGFBP7+in+oncogenic+BRAF-positive+atypical+genital+nevi+supports+that+they+are+biologically+inert. assertion.
- assertion asSentence Fascin+regulates+the+proliferation+and+invasiveness+of+ESCC+cells+by+modulating+the+expression+of+CTGF+and+CYR61+via+TGF-beta+pathway. assertion.
- assertion asSentence Expression+of+tumor-promoting+Cyr61+is+regulated+by+hTRA2-beta1+and+acidosis. assertion.
- assertion asSentence The+mechanism+by+which+retinoids+such+as+vitamin+A+improve+aged+skin%2C+through+increased+collagen+production%2C+involves+down-regulation+of+CCN1. assertion.
- assertion asSentence Both+IgE+and+chymase+associate+with+diabetes+status. assertion.
- assertion asSentence Mutations+in+the+IGHMBP2+gene+of+patients+with+more+favorable+outcomes+retained+residual+enzymatic+activity. assertion.
- assertion asSentence IGHV+mutations+is+associated+with+chronic+lymphocytic+leukemia. assertion.
- assertion asSentence In+survivors+of+chronic+kidney+failure%2C+median+serum+levels+of+free+kappa+plus+lambda+immunoglobulin+light+chains+are+significantly+higher+compared+with+nonsurvivors. assertion.
- assertion asSentence The+phosphatase+and+tensin+homolog+%28PTEN%29+gene+is+a+direct+target+of+Notch-1+signal+transduction%2C+through+binding+of+the+Notch-activated+transcription+factor+CBF-1+to+the+PTEN+minimal+promoter. assertion.
- assertion asSentence RBP-J+binds+methylated+DNA+in+the+context+of+a+mutated+RBP-J+consensus+motif. assertion.
- assertion asSentence Unique+mutations+in+RBPJ+lead+to+impaired+DNA+binding+in+cases+of+Adams-Oliver+syndrome. assertion.
- assertion asSentence A+single+smino+acid+deletion+in+IHH+causes+mild+brachdactyly+A1. assertion.
- assertion asSentence Nuclear+and+cytoplasmic+endometrial+expression+of+Indian+hedgehog+is+decreased+in+women+with+endometriosis. assertion.
- assertion asSentence IK+gene+expression+is+decreased+in+follicular+variant+of+papillary+thyroid+carcinoma. assertion.
- assertion asSentence Phosphorylation+of+serine+536%2C+the+main+T-cell-inducible+phosphorylation+site+of+the+NF-kappa+B+p65+subunit%2C+is+mediated+by+IKK+beta+and+occurs+within+the+cytosolic+p50%2Fp65%2FI+kappa+B+alpha+complex. assertion.
- assertion asSentence Protein+kinase+R+is+involved+in+NF-kappaB+mediated+gene+transcription+of+pro-inflammatory+cytokines+via+IkappaB+kinase-beta. assertion.