Matches in Nanopublications for { ?s <http://purl.org/nanopub/x/asSentence> ?o ?g. }
- assertion asSentence CD3%2B+T+lymphocytes+co-expressing+CD134+and+CD137+antigens+on+peripheral+blood+revealed+an+increased+percentages+of+OX-40%2FCD137+positive+cells+in+patients+with+Graves%27+disease+%28p%3C0.025%29+compared+to+the+controls. assertion.
- assertion asSentence CD137+ligand+can+also+be+expressed+as+a+transmembrane+protein+on+the+cell+surface+and+transmit+signals+into+the+cells+on+which+it+is+expressed+%28reverse+signaling%29. assertion.
- assertion asSentence NFAT+is+the+crucial+sensor+of+TCR+signaling+in+the+IL-17+promoter. assertion.
- assertion asSentence Two+independent+and+indispensable+signaling+pathways-1%29+JAK1-associated+PI3K+signaling+and+2%29+Act1%2FTRAF6%2FTAK1-mediated+NF-kappaB+activation-are+stimulated+by+IL-17A+to+regulate+gene+induction+in+human+airway+epithelial+cells. assertion.
- assertion asSentence A+failure+of+CD4%2B+T+cells+harboring+heterozygous+STAT3+mutations+to+generate+interleukin+17-secreting+cells+due+to+a+failure+to+express+sufficient+levels+of+the+Th17-specific+transcriptional+regulator+retinoid-related+orphan+receptor+t. assertion.
- assertion asSentence IL-12Rbeta1-+and+STAT-3--dependent+signals+play+a+key+role+in+the+differentiation+and%2For+expansion+of+human+IL-17-producing+T+cell+populations+in+vivo. assertion.
- assertion asSentence Peripheral+blood+mononuclear+cells+from+immunocompetent+Candida-infected+patients+secreted+more+IL-17+and+IL-22+than+those+of+both+chronic+mucocutaneous+candidiasis+patients+and+healthy%2C+non-infected+controls. assertion.
- assertion asSentence Human+IL-17F%2FIL-17A+heterodimer+can+bind+and+signal+through+the+same+receptor+complex+as+homodimeric+cytokines+IL-17F+and+IL-17A. assertion.
- assertion asSentence Fibroblast-like+synoviocytes+are+potently+regulated+by+inflammatory+cytokines+to+specifically+express+IL-23+p19. assertion.
- assertion asSentence The+differentiation+of+IL-17-producing+%28Th17%29+cells+from+naive+T+cells+and+the+amplification+of+Th17+effector+functions+of+memory+T+cells+are+promoted+by+plasmacytoid+dendritic+cells+after+Toll-like+receptor+7+activation. assertion.
- assertion asSentence TLR6+plays+a+pivotal+role+in+the+development+and+severity+of+hypersensitivity+pneumonitis+via+its+role+in+IL-17A+production. assertion.
- assertion asSentence The+onset+of+sepsis+is+related+to+differential+TGFbeta-1+and+IL-17+gene+expression. assertion.
- assertion asSentence IL-17+is+a+potent+activator+of+the+endothelium+in+vivo+leading+to+neutrophil+infiltration+of+the+airways+in+chronic+airway+disease. assertion.
- assertion asSentence The+hallmark+T+helper+cell+type+%28Th%291+cytokine+IFN-gamma+can+also+be+defined+as+a+T+helper+type+%28Th%2917+cytokine%2C+depending+on+the+milieu+and+other+cytokines+produced+by+patients%27+T+cell+subsets+in+peripheral+blood+and+inflamed+tissues. assertion.
- assertion asSentence IL-17-producing+CD8-positive+T+cells+are+generated+by+an+intriguing+mechanism+and+constitute+a+remarkable+portion+of+IL-17-positive+cells+in+human+hepatocellular+carcinomas. assertion.
- assertion asSentence IL-17+is+up-regulated+in+lung+tissues+of+normal+lung+function+smokers+and+COPD+patients. assertion.
- assertion asSentence MiR-146a+is+associated+with+IL-17+expression+in+peripheral+blood+mononuclear+cells+and+synovium+in+rheumatoid+arthritis+patients. assertion.
- assertion asSentence The+downregulation+of+the+level+of+interleukin-17+contributes+to+the+therapeutic+effects+of+IFN-beta+in+Multiple+sclerosis%28MS%29. assertion.
- assertion asSentence Microbiota+are+required+for+the+generation+of+both+IL-17-positive+and+Foxp3-positive%2C+retinoic+acid-related+orphan+receptor+gamma-positive+transgenic+T+cell+subsets+in+the+intestinal+lamina+propria. assertion.
- assertion asSentence Alpha-toxin+induced+IL-17A+directly+in+T+cells. assertion.
- assertion asSentence Human+IL-17-positive+Foxp3-positive+T+cells+induce+proinflammatory+cytokines+and+suppress+T+cell+function%2C+promoting+active+inflammation+and+tumor+development+through+multiple+modes+of+action+in+the+local+environment. assertion.
- assertion asSentence Delivery+of+Notch1+small-interfering+%28si%29RNA+to+human+naive+CD4+T+cells+leads+to+decreased+interleukin+%28IL%29-17+secretion. assertion.
- assertion asSentence Higher+infiltration+by+Th17+cells+compared+with+regulatory+T+cells+is+associated+with+severe+acute+T-cell-mediated+graft+rejection. assertion.
- assertion asSentence Expression+IL-7+and+IL-15+genes+in+prostate+tissues+and+corresponding+serum+titres+are+significantly+increased+in+patients+with+early+stage+prostate+cancer+as+compared+with+patients+with+benign+prostatic+hyperplasia. assertion.
- assertion asSentence IL-17+specifically+enhances+the+proinflammatory+response+in+cells+infected+with+respiratory+syncytial+virus+A2+strain. assertion.
- assertion asSentence Interleukin-17-positive+mast+cells+contribute+to+synovial+inflammation+in+spondylarthritis. assertion.
- assertion asSentence Patients+with+esophageal+cancer+have+an+increased+number+of+il-17+producting+t4+cells. assertion.
- assertion asSentence IL-17+specifically+when+combined+with+TNFalpha+has+major+pro-coagulant+and+pro-thrombotic+effects+on+vessels. assertion.
- assertion asSentence Higher+levels+of+IL-17+is+associated+with+the+formation+of+an+M2-macrophage-dominant+tumor+microenvironment+in+lung+cancer. assertion.
- assertion asSentence MiR-23b+suppresses+IL-17-%2C+tumor+necrosis+factor+alpha+%28TNF-alpha%29-+or+IL-1beta-induced+NF-kappaB+activation+and+inflammatory+cytokine+expression+by+targeting+TAB2%2C+TAB3+and+IKK-alpha. assertion.
- assertion asSentence Bioactive+IL-18+exhibiting+IFN-gamma-inducing+activity+is+detected+in+the+supernatant+of+cultured+gingival+epithelial+cells+on+costimulation+with+neutrophil+proteinase+3+and+LPS+after+IFN-gamma-priming. assertion.
- assertion asSentence Physiological+levels+of+interleukin-18+stimulate+multiple+neutrophil+functions+through+p38+MAP+kinase+activation. assertion.
- assertion asSentence Neutrophils+from+both+rheumatoid+arthritis+patients+and+healthy+donors+produce+significant+amounts+of+leukotriene+B4+in+response+to+recombinant+human+IL-18. assertion.
- assertion asSentence IL-15+alone%2C+similarly+to+IL-18%2C+has+no+significant+ability+for+regulation+of+both+soluble+IL-6+receptors%2C+sIL-6R+and+sgp130%2C+released+by+human+neutrophils. assertion.
- assertion asSentence IL-18+stimulation+induces+the+production+of+activated+forms+of+matrix+metalloproteinase-2+in+natural+killer+cells. assertion.
- assertion asSentence CRH+regulates+IL-18+production+through+the+MAPK+signaling+pathway+in+human+keratinocytes. assertion.
- assertion asSentence Variations+of+the+IL18+gene+consistently+influence+circulating+levels+of+IL-18+and+clinical+outcome+in+patients+with+coronary+artery+disease. assertion.
- assertion asSentence HIV-1+and+its+regulatory+protein%2C+Nef%2C+are+able+to+down-regulate+the+release+of+IL-18%2C+in+vitro. assertion.
- assertion asSentence Serum+levels+do+not+differ+between+men+and+women%2C+nor+do+they+correlate+with+body+weight+and+body+fat+mass. assertion.
- assertion asSentence Through+its+capacity+to+affect+DNA+repair%2C+IL-18+can+restore+an+immune+response+that+is+suppressed+by+ultraviolet+radiation. assertion.
- assertion asSentence IL-18+plays+a+key+role+in+thrombospondin-1+expression+involving+JNK. assertion.
- assertion asSentence Enhanced+induction+of+dendritic+cell+maturation+and+HLA-A%2A0201-restricted+CEA-specific+CD8%28%2B%29+CTL+response+by+exosomes+derived+from+IL-18+gene+modified+CEA-positive+tumor+cells. assertion.
- assertion asSentence Serum+IL-18+levels+are+significantly+higher+in+type+1+diabetic+subjects+compared+with+nondiabetic+subjects. assertion.
- assertion asSentence E.+coli+modulates+S100A15+and+IL-8+expression+of+keratinocytes+by+recognition+through+TLR4. assertion.
- assertion asSentence IL-18+gene+promoter+polymorphisms+are+not+associated+with+susceptibility+or+resistance+to+pulmonary+tuberculosis+in+south+Indian+population+of+Dravidian+descent. assertion.
- assertion asSentence The+guanine%2Fcytosine+%28GC%29+genotype+of+the+interleukin-18+polymorphism+is+associated+with+raised+blood+pressure+and+increased+risk+for+metabolic+syndrome. assertion.
- assertion asSentence IL-18+inhibits+tumorigenesis+in+vivo+by+interdicting+cell+cycle+and+accelerating+apoptosis+of+tumor+cells. assertion.
- assertion asSentence The+TT+genotype+of+the+IL-18+9545+T%2FG+polymorphism+is+associated+with+an+increased+occurence+of+greater+post-surgical+inflammation. assertion.
- assertion asSentence A+role+for+IL-18+in+inflammation%2C+allergy+and+immune+diseases. assertion.
- assertion asSentence Synergy+between+TLR3+and+IL-18+promotes+IFN-gamma+dependent+TRAIL+expression+in+liver+NK+cells. assertion.
- assertion asSentence NF45+is+a+is+a+highly+conserved+transcriptional+activator+of+the+gene+IL-2. assertion.
- assertion asSentence Production+of+HIV+particles+is+regulated+by+altering+sub-cellular+localization+and+dynamics+of+Rev+induced+by+double-strand+RNA+binding+protein. assertion.
- assertion asSentence Strong+expression+of+ILK+in+cancerous+tissues+is+involved+with+aggressive+capability+in+pancreatic+cancer. assertion.
- assertion asSentence PI3K%2FILK%2FAkt%2FNF-kappaB+axis+is+a+promising+target+for+therapeutic+intervention+in+renal+cell+carcinoma. assertion.
- assertion asSentence EphA1+regulates+cell+morphology+and+motility+through+the+ILK-RhoA-ROCK+pathway. assertion.
- assertion asSentence Hypoxia+enhances+BMP-2+expression+in+osteoblasts+by+an+HIF-1alpha-dependent+mechanism+involving+the+activation+of+ILK%2FAkt+and+mTOR+pathways. assertion.
- assertion asSentence Beta-arrestin-1+is+involved+in+a+distinct+signalling+mechanism+linking+the+endothelin-1+%2FET+A+receptor+axis+to+phosphoinositide+3-kinase+%2Fintegrin-linked+kinase+%2FAkt+in+HEY+ovarian+cancer+cells. assertion.
- assertion asSentence A+molecular+pathway+links+integrin-linked+kinase+signaling+to+the+contractile+vascular+smooth+muscle+cell+gene+program. assertion.
- assertion asSentence Promoter+is+polymorphic+in+bipolar+disorder. assertion.
- assertion asSentence Single+nucleotide+polymorphism+in+IMPA2+gene+is+associated+with+acute+lymphoblastic+leukemia. assertion.
- assertion asSentence A+missense+mutation+in+this+isozyme+causes+human+autosomal+retinitis+pigmentosa. assertion.
- assertion asSentence If+IMPDH+genetic+variability+contributes+to+azathioprine+resistance+in+inflammatory+bowel+disease+it+does+so+infrequently. assertion.
- assertion asSentence IMPDH1+mutation+is+associated+with+retinitis+pigmentosa. assertion.
- assertion asSentence IMPDH+has+a+function+in+the+retina%2C+apparently+independent+of+its+enzymatic+activity%2C+mediated+by+retina-specific+variants. assertion.
- assertion asSentence INCENP+phosphorylation+by+Cdk1+is+necessary+for+the+recruitment+of+Plk1+to+the+kinetochore. assertion.
- assertion asSentence Dephosphorylation+of+INCENP+at+anaphase+and+the+concomitant+relocation+of+the+chromosomal+passenger+protein+complex+prevents+kinetochore+recruitment+of+mitotic+checkpoint+proteins. assertion.
- assertion asSentence Induction+of+IDO+in+airway+epithelial-like+tumor+cells+by+exposure+to+IFN-gamma+for+24+hr+markedly+amplifies+IL-6+and+IL-8+responses+via+depletion+of+tryptophan+from+the+culture+medium. assertion.
- assertion asSentence Indoleamine+2%2C3-dioxygenase+is+necessary+for+cytolytic+activity+of+natural+killer+cells. assertion.
- assertion asSentence Human+acute+monocyte+leukemia+and+acute+lymphocyte+leukemia+express+indoleamine+2%2C+3-dioxygenase. assertion.
- assertion asSentence IDO+pathway+is+essential+for+PDC-driven+Treg+generation+from+CD4%28%2B%29CD25%28-%29+T+cells+and+implicate+the+generation+of+kynurenine+pathway+metabolites+as+the+critical+mediator+of+this+process. assertion.
- assertion asSentence Dendritic+cells+polarizing+culture+conditions+increased+expression+of+IDO+protein+and+IDO+enzyme+activity. assertion.
- assertion asSentence Human+IDO+transfected+into+composite+three-dimensional+islet+grafts+in+mice%2C+prolongs+the+islet+allograft. assertion.
- assertion asSentence ING1+mutations+abrogate+its+enhancement+in+nucleotide+excision+repair+in+melanoma. assertion.
- assertion asSentence Subcellular+targeting+of+ING1+by+phosphorylation-dependent+14-3-3+binding+regulates+P21+expression. assertion.
- assertion asSentence ING1+proteins+regulate+the+expression+of+proteins+that+are+critical+for+angiogenesis+in+glioblastoma+multiforme+%28GBM%29+such+as+the+angiopoietins. assertion.
- assertion asSentence Loss+of+ING1+is+associated+with+non-small+cell+lung+cancer. assertion.
- assertion asSentence ING1+stabilizes+p53+by+inhibiting+polyubiquitination+of+multimonoubiquitinated+forms+via+interaction+with+and+colocalization+of+the+HAUSP-deubiquitinase+with+p53. assertion.
- assertion asSentence P33ING2+cooperates+with+p53+to+regulate+apoptosis+via+activation+of+both+the+mitochondrial%2Fintrinsic+and+death-receptor%2Fextrinsic+apoptotic+pathways. assertion.
- assertion asSentence Expressed+in+Sertoli+cells+in+oligozoospermia. assertion.
- assertion asSentence Immunohistochemistry+detected+inhibin-alpha%2C+-betaA+and+-betaB%2C+Ki67%2C+p53+and+glycodelin+A+in+invasive+trophoblastic+mole. assertion.
- assertion asSentence Inhibin+alpha-subunit+N+terminus+interacts+with+activin+type+IB+receptor+to+disrupt+activin+signaling. assertion.
- assertion asSentence Expression+of+transcription+factors+controlling+alpha+inhibin+gene+expression+in+placental+tissues+from+pregnancies+affected+by+fetal+Down+syndrome. assertion.
- assertion asSentence Activin+has+autocrine+roles+in+tumor+growth+of+ovarian+clear+cell+adenocarcinoma+cells. assertion.
- assertion asSentence Elevated+plasma+activin+A+levels+are+associated+with+the+presence+of+carcinoid+heart+disease. assertion.
- assertion asSentence Human+amniotic+fluid+activin-A+and+inhibin-A+are+involved+in+biological+processes+linked+to+intra-amniotic+infection%2Finflammation-induced+preterm+birth. assertion.
- assertion asSentence Activin+and+estrogen+crosstalk+regulates+transcription+in+human+breast+cancer+cells. assertion.
- assertion asSentence Bone+morphogenetic+protein-6+stimulates+gene+expression+of+inhibin%2Factivin+beta+subunits+in+human+granulosa+cells. assertion.
- assertion asSentence A+variant+in+the+fibrillin-3+gene+is+associated+with+TGF-beta+and+inhibin+B+levels+in+women+with+polycystic+ovary+syndrome. assertion.
- assertion asSentence Gene+expression+is+predictive+for+the+individual+response+of+children+with+chronic+allograft+nephropathy+to+mycophenolate+mofetil. assertion.
- assertion asSentence A+higher+amount+of+IP-10+mRNA+is+expressed+after+exposure+of+keratinocytes+to+interferon-gamma%2C+leading+to+migration+of+T+cells+from+the+dermis+to+the+epidermis+and+representing+a+second+step+of+chemotaxis+following+T+cell+recruitment+from+blood. assertion.
- assertion asSentence CCR3+functional+responses+are+regulated+by+both+CXCR3+and+its+ligands+CXCL9%2C+CXCL10+and+CXCL11. assertion.
- assertion asSentence IP-10%2FCXCR3+signaling+is+associated+with+the+pathogenesis+of+human+myasthenia+gravis. assertion.
- assertion asSentence IP10+inhibits+viral+replication+through+the+induction+of+host+cell+death+via+a+p53-mediated+apoptotic+pathway. assertion.
- assertion asSentence This+CXCR3+ligand+has+the+ability+to+activate+biochemical+%28e.g.%2C+PtdIns+3-kinase+and+MAP+kinase+activation%29+and+functional+events+in+intestinal+myofibroblasts. assertion.
- assertion asSentence The+histone+H4+deacetylation+at+the+ISRE+site+is+related+to+the+activation+of+IP-10+by+IFN-gamma. assertion.
- assertion asSentence Low+serum+and+peritoneal+fluid+concentration+of+interferon-gamma-induced+protein-10+%28CXCL10%29+in+women+with+endometriosis. assertion.
- assertion asSentence The+functional+association+between+PI3K%2FAkt+and+NF-kB+demonstrates+another+mechanism+in+the+regulation+of+M.+bovis+BCG-induced+CXCL10+in+A549+cells. assertion.
- assertion asSentence Pretreatment+IP-10+levels+correlated+with+HCV+viral+load%2C+ALT+levels%2C+hepatic+inflammation+and+fibrosis. assertion.
- assertion asSentence SpeB+destroys+most+of+the+signaling+and+antibacterial+properties+of+chemokines+expressed+by+an+inflamed+epithelium. assertion.
- assertion asSentence Enterovirus+infection+of+the+pancreas+initiates+coexpression+of+interferon-gamma+and+CXCL10+in+beta-cells+in+type+1+diabetes. assertion.