Matches in Nanopublications for { ?s <http://purl.org/nanopub/x/asSentence> ?o ?g. }
- assertion asSentence Endocrine+disrupting+chemicals+suppressed+CCL22+and+IP-10+levels+in+cultured+monocytes+via%2C+at+least+in+part%2C+the+MKK1%2F2-ERK+MAPK+pathway+and+histone+H4+acetylation. assertion.
- assertion asSentence Autophagic+responses+play+a+role+in+influenza+virus-induced+CXCL10+and+interferon-alpha+expression+in+primary+human+blood+macrophages. assertion.
- assertion asSentence microRNA-155+negatively+regulates+the+expression+of+transforming+growth+factor-beta-activated+kinase-1-binding+protein+2+and+downstream+IFN-gamma-inducible+protein+of+10+kDa+as+a+negative+feedback+system+%28IP-10%29. assertion.
- assertion asSentence Staphylococcal+alpha-toxin+contributes+to+Th1+polarization+by+induction+of+CXCL10+in+macrophages. assertion.
- assertion asSentence Tumor+necrosis+factor-alpha+pathway+plays+a+critical+role+in+regulating+interferon-gamma+induced+protein-10+production+in+initial+allogeneic+human+monocyte-endothelial+cell+interactions. assertion.
- assertion asSentence IL-27+primes+for+CXCL10+production+by+antigen-presenting+cells. assertion.
- assertion asSentence IDDM2+maps+to+one+or+more+of+three+common+variants+in+the+insulin+gene+in+an+approximately+2-kb+region+of+chromosome+11p15. assertion.
- assertion asSentence Class+I+alleles+of+the+insulin+gene+INS-VNTR+locus+are+strongly+associated+with+T1DM+in+the+Romanian+population. assertion.
- assertion asSentence Insulin-dependent+processes+such+as+gene+expression+in+the+human+placenta+will+change+from+mother+to+foetus+throughout+gestation. assertion.
- assertion asSentence Insulin+and+noradrenaline+cooperate+independently+to+the+development+of+the+metabolic+syndrome. assertion.
- assertion asSentence Insulin+stimulates+hepatic+low+density+lipoprotein+receptor-related+protein+1+%28LRP1%29+to+increase+postprandial+lipoprotein+clearance. assertion.
- assertion asSentence Impaired+insulin-mediated+vasorelaxation+in+diabetic+Goto-Kakizaki+rats+is+caused+by+impaired+Akt+phosphorylation. assertion.
- assertion asSentence The+activity+of+insulin+is+enhanced+by+stereospecific+unfolding+of+a+conserved+structural+element. assertion.
- assertion asSentence The+phosphorylation+of+tyrosine+19-caveolin-2+is+required+for+actin+cytoskeleton-dependent+ERK+nuclear+import. assertion.
- assertion asSentence Inflammatory+response+after+percutanous+coronary+interventions+does+not+persist+for+1+month+and+insulin+sensitivity+remains+unaffected. assertion.
- assertion asSentence HCV+infection+of+human+hepatocytes+impaired+insulin-induced+FoxO1+translocation+from+the+nucleus+to+the+cytoplasm+and+reduced+accumulation+of+FoxA2+in+the+nucleus. assertion.
- assertion asSentence The+Wide-angle+X-ray+scattering+peak+at+a+d-spacing+about+10+A+is+sensitive+towards+the+alpha-helix+content+of+insulin. assertion.
- assertion asSentence Insulin-activated+extracellular+signal-regulated+kinase+%28ERK%29+is+translocated+to+the+nuclear+envelope+by+caveolin-2. assertion.
- assertion asSentence Hyperproinsulinaemia+is+associated+with+defects+in+insulin+secretion+rather+than+a+reduction+in+beta-cell+area. assertion.
- assertion asSentence The+formation+of+insulin+adducts+with+the+lipid+peroxidation+byproducts+4-hydroxy-2-nonenal+and+4-hydroxy-2-hexenal+significantly+disrupts+the+biological+activity+of+insulin. assertion.
- assertion asSentence Insulin+efficiently+inhibits+Toll-like+receptor+%28TLR%293-induced+human+bronchial+epithelial+cell+apoptosis+via+phosphatidylinositol+3-kinase%2FAkt+and+ERK-MAP+kinase+pathways%2C+at+least+in+part%2C+via+protein+synthesis-independent+mechanisms. assertion.
- assertion asSentence NaCl+enhances+insulin+fibrillation+mainly+due+to+subtle+structural+changes+and+is+not+a+mere+salt+effect. assertion.
- assertion asSentence Assessment+of+C-peptide+levels+is+a+useful+tool+to+monitor+progress+of+metabolic+syndrome+among+patients+suffering+from+type-2+diabetes+mellitus+and+Alzheimer%27s+disease. assertion.
- assertion asSentence SHIP2+plays+a+distinct+role+in+signaling+pathways+mediated+by+integrins+and+growth+factor+receptors. assertion.
- assertion asSentence High+expression+of+obesity-linked+phosphatase+SHIP2+is+associated+with+invasive+breast+cancer. assertion.
- assertion asSentence RhoA+associates+with+SHIP2+to+regulate+cell+polarization+and+migration. assertion.
- assertion asSentence Even+testosterone+and+INSL3+are+both+dependent+on+lutropin%2C+thesse+two+Leydig+cell+hormones+are+regulated+differently. assertion.
- assertion asSentence Via+comparison+of+the+solution+structure+of+a+fully+active+carboxy-terminal+cross-linked+RLF+analogue+with+the+native+synthetic+human+RLF%2C+it+becomes+clear+that+the+cross-linked+analogue+largely+retains+the+essential+folding+of+the+native+protein. assertion.
- assertion asSentence High+INSL3+is+associated+with+testicular+Leydig+cell+tumors. assertion.
- assertion asSentence A+C%2FT+single+nucleotide+polymorphism+at+the+tyrosine+kinase+domain+of+the+insulin+receptor+gene+is+associated+with+polycystic+ovary+syndrome. assertion.
- assertion asSentence Human+micro-+and+macrovascular+endothelial+cells+express+more+IGF-I+receptor+than+insulin+receptor. assertion.
- assertion asSentence Transcriptional+repression+of+the+human+insulin+receptor+gene+mediated+by+estrogen+receptor+beta+in+U-937+cells. assertion.
- assertion asSentence High+levels+of+insulin+receptor+expression+in+early+stage+breast+cancers+is+independently+and+significantly+associated+with+more+favorable+clinical+outcomes. assertion.
- assertion asSentence The+autophosphorylation+of+insulin+receptors+decreases+in+polycystic+ovary+syndrome+patients. assertion.
- assertion asSentence Association+of+insulin+receptor+genetic+variants+with+polycystic+ovary+syndrome+in+european+women. assertion.
- assertion asSentence Met+stimulates+hepatocyte+glucose+uptake+through+crosstalk+with+insulin+receptor. assertion.
- assertion asSentence The+IRR+gene+is+expressed+in+the+same+ovarian+compartment%2C+IRR+mRNA+content+increases+strikingly+in+these+cells+in+the+afternoon+of+the+first+proestrus. assertion.
- assertion asSentence INT6+stabilizes+chromatin-bound+MCM7+and+alteration+of+this+effect+is+associated+with+replication+deficiency. assertion.
- assertion asSentence Int6+depletion+blocks+ubiquitin-dependent+proteolysis+by+decreasing+both+ubiquitin+levels+and+the+assembly+of+functional+proteasome+machinery%2C+leading+to+accumulation+of+oncoproteins%2C+such+as+SRC3. assertion.
- assertion asSentence Under+diabetic+conditions%2C+expression+and%2For+activities+of+PDX-1+and+MafA+in+beta-cells+are+reduced+%5BREVIEW%5D. assertion.
- assertion asSentence Recapitulation+of+pancreatic+neuroendocrine+tumors+in+human+multiple+endocrine+neoplasia+type+I+syndrome+via+Pdx1-directed+inactivation+of+Men1. assertion.
- assertion asSentence Pdx-1+functions+as+a+%22pancreas-permitting+gene%22. assertion.
- assertion asSentence Leishmania+can+exploit+a+host+protein+tyrosine+phosphatase%2C+namely+SHP-1%2C+to+directly+inactivate+IRAK-1. assertion.
- assertion asSentence Over-expression+of+interleukin-1+receptor-associated+kinase-1+led+to+increased+constitutive+and+cytokine+induced+production+of+Chemokines%2C+CC. assertion.
- assertion asSentence Reduced+IRAK-1+protein+expression+is+an+important+mechanism+in+the+development+of+bacterial+lipoprotein-induced+tolerance. assertion.
- assertion asSentence Leptin+increases+the+expression+of+IRAK-1+in+human+monocytes. assertion.
- assertion asSentence Glioblastoma+stem+cell+express+high+levels+of+integrin+alpha6. assertion.
- assertion asSentence High+Integrin+alpha6beta4+is+associated+with+anaplastic+thyroid+carcinoma. assertion.
- assertion asSentence P-cadherin+is+coexpressed+with+CD44+and+CD49f+and+mediates+stem+cell+properties+in+basal-like+breast+cancer. assertion.
- assertion asSentence IRF1+represses+CDK2+gene+expression+by+interfering+with+SP1-dependent+transcriptional+activation. assertion.
- assertion asSentence Expression+of+IRF-1+is+altered+in+human+endometrioid+adenocarcinoma+compared+with+normal+endometrium+and+postmenopausal+endometrium. assertion.
- assertion asSentence IRF-1+is+one+of+the+key+host+factors+that+regulate+intracellular+HCV+replication+through+modulation+of+interferon-stimulated-gene-mediated+antiviral+responses. assertion.
- assertion asSentence The+role+of+the+Mf1+domain+of+IRF-1+in+orchestrating+the+recruitment+of+regulatory+factors+that+can+impact+on+both+its+turnover+and+transcriptional+activity. assertion.
- assertion asSentence Direct+involvement+of+CREB-binding+protein%2Fp300+in+sequence-specific+DNA+binding+of+virus-activated+interferon+regulatory+factor-3+holocomplex. assertion.
- assertion asSentence Transduction+of+active+forms+of+IRF-3+or+IRF-7+differentially+modulate+the+apoptotic+and+antitumor+properties+of+primary+macrophages. assertion.
- assertion asSentence MspTL%2C+the+major+outer+protein+of+Treponema+lecithinolyticum%2C+induces+interferon-stimulated+genes+in+monocytes+via+TANK-binding+kinase+1%2FIRF-3+signaling+secondary+to+lipid+raft+activation. assertion.
- assertion asSentence The+transcription+factor+E2F1+negatively+regulates+the+basal+transcriptional+activity+of+IRF-3+and+deregulates+IRF-3+expression+at+the+mRNA+level. assertion.
- assertion asSentence Caspase-8-mediated+cleavage+of+IRF-3+helps+to+modulate+dsRNA-dependent+gene+induction. assertion.
- assertion asSentence Bocavirus+nonstructural+protein+%28NP%291+interacts+with+the+DNA-binding+domain+of+human+IRF-3+and+blocks+its+association+with+interferon+%28IFN%29beta+promoter. assertion.
- assertion asSentence Chronic+IRF4+expression+in+human+T+cell+leukemia+virus-I-infected+T+lymphocytes+is+associated+with+a+leukemic+phenotype%2C+driven+through+activation+of+the+NF-kappa+B+and+NF-AT+pathways. assertion.
- assertion asSentence Interferon+regulatory+factor+4+is+involved+in+Epstein-Barr+virus-mediated+transformation+of+human+B+lymphocytes. assertion.
- assertion asSentence IRF4%2C+another+member+in+the+IRF+family+of+transcription+factors+overexpressed+in+a+Tax-independent+manner%2C+negatively+regulated+TAK1-dependent+IRF3+transcriptional+activity. assertion.
- assertion asSentence Support+the+clinical+utility+of+FISH+for+IRF4+in+the+differential+diagnosis+of+T-cell+lymphoproliferative+disorders+in+skin+biopsies%2C+with+detection+of+a+translocation+favoring+cutaneous+anaplastic+large+cell+lymphoma. assertion.
- assertion asSentence A+structural+insertion%2Fdeletion+in+the+IRF5+gene+leads+to+expression+of+specific+isoforms+in+the+risk+haplotype+associated+with+system+lupus+erythematosus. assertion.
- assertion asSentence Epstein-Barr+virus+initially+uses+TLR7+signaling+to+enhance+B-cell+proliferation+and+subsequently+modifies+the+pathway+to+regulate+IRF-5+activity. assertion.
- assertion asSentence IRF5+mRNA+is+expressed+in+cells+in+atherosclerotic+tissue+and+its+expression+is+modified+by+single+nucleotide+polymorphisms+in+the+IRF5+gene. assertion.
- assertion asSentence The+cellular+IRF5+and+vIRF3+interact%2C+leading+to+the+functional+modulation+of+IRF5-mediated+type+I+IFN+expression+and+cell+cycle+regulation. assertion.
- assertion asSentence Interferon+regulatory+factor+5+gene+polymorphism+confers+risk+to+several+rheumatic+diseases+and+correlates+with+expression+of+alternative+thymic+transcripts. assertion.
- assertion asSentence A+broad+spectrum+of+IRF6+mutations+is+found+in+the+Van+der+Woude+and+popliteal+pterygium+syndrome+phenotypes+originating+in+17+kindreds+from+Finland%2C+Sweden%2C+Norway%2C+Thailand+and+Singapore. assertion.
- assertion asSentence The+Van+der+Woude+syndrome+is+a+mendelian+CL%2FP%2C+accounting+for+about+2%25+of+all+cases+and+caused+by+mutations+in+the+interferon+regulatory+factor+6+%28IRF6%29+gene%2C+located+on+1q32.2+chromosome. assertion.
- assertion asSentence IRF6+and+the+10q25+and+8q24+loci+confer+a+risk+for+the+development+of+Nonsyndromic+cleft+lip+with+or+without+cleft+palate%2C+in+persons+of+Mayan+origin. assertion.
- assertion asSentence IRF6+gene+im+implicated+in+the+Van+der+Woude+and+popliteal+pterygium+syndromes. assertion.
- assertion asSentence Interferon+regulatory+factor-7+synergizes+with+other+transcription+factors+through+multiple+interactions+with+p300%2FCBP+coactivators. assertion.
- assertion asSentence LPS-TLR4+signaling+to+IRF-3%2F7+and+NF-kappaB+involves+the+toll+adapters+TRAM+and+TRIF. assertion.
- assertion asSentence Herpes+simplex+type+1+infection+triggered+an+IRF-3+and+IRF-7-dependent+antiviral+response. assertion.
- assertion asSentence A20+negatively+regulates+LMP1-stimulated+IRF7+ubiquitination+and+activity+in+EBV+latency. assertion.
- assertion asSentence The+ubiquitin+E3+ligase+activity+of+tripartite+motif-containing+%28TRIM%2928+protein+is+specific+to+IRF7. assertion.
- assertion asSentence TRAF6+can+regulate+HIV-1+production+and+expression+of+IRF7+promotes+HIV-1+replication. assertion.
- assertion asSentence Nitric+oxide+regulates+oestrogen-activated+signalling+pathways+at+multiple+levels+through+cyclic+GMP-dependent+recruitment+of+insulin+receptor+substrate+1+in+human+breast+cancer+cells. assertion.
- assertion asSentence Increased+growth+caused+by+IRS-1+over-expression+is+balanced+by+constitutive+activation+of+pro-death+mechanisms. assertion.
- assertion asSentence Both+of+the+IRS+proteins+modulate+VPF%2FVEGF+expression+in+pancreatic+cancer+cells+by+different+mechanistic+pathways. assertion.
- assertion asSentence G972R+IRS-1+polymorphism+impairs+insulin+regulation+of+endothelial+nitric+oxide+synthase+in+vascular+endothelial+cells. assertion.
- assertion asSentence SH2-B+dramatically+enhanced+leptin-stimulated+tyrosine+phosphorylation+of+IRS1+and+IRS2+in+human+and+mouse+cells. assertion.
- assertion asSentence Phosphorylation+of+Ser1223+dampens+association+of+IRS-1+with+Src+homology+domain+2+%28SH2%29-containing+phosphatase-2+%28SHP-2%29. assertion.
- assertion asSentence Raptor+directly+binds+to+and+serves+as+a+scaffold+for+mTOR-mediated+phosphorylation+of+IRS-1+on+Ser636%2F639. assertion.
- assertion asSentence Ser24+is+a+negative+regulatory+phosphorylation+site+in+IRS-1. assertion.
- assertion asSentence IRS-1+is+selectively+inactivated+in+metastatic+breast+cancer+in+transgenic+mice. assertion.
- assertion asSentence IRS-1+gene+polymorphisms+do+not+associate+with+obesity. assertion.
- assertion asSentence Mir-126%2C+a+cell+growth+suppressor%2C+targets+IRS-1. assertion.
- assertion asSentence S6K1+directly+phosphorylates+IRS-1+on+Ser-270+to+promote+insulin+resistance+in+response+to+TNF-%28alpha%29+signaling+through+IKK2. assertion.
- assertion asSentence The+differential+degradation+of+IRS-1+and+IRS-2+contributes+to+their+distinct+modes+of+action. assertion.
- assertion asSentence IGF-I+induces+a+temporally+regulated+nuclear+or+cytoplasmic+localization+of+IRS-1+that+correlate+with+the+transition+from+proliferation+to+chondrogenic+differentiation. assertion.
- assertion asSentence Only+the+IRS-1+polymorphism+is+associated+with+increased+susceptibility+to+PCOS+in+a+Greek+population. assertion.
- assertion asSentence The+G972R+polymorphism+of+the+IRS-1+gene+is+associated+with+insulin+resistance%2C+salt+sensitivity+and+non-dipper+hypertension. assertion.
- assertion asSentence Genetic+variation+near+IRS1+associates+with+reduced+adiposity+and+an+impaired+metabolic+profile. assertion.
- assertion asSentence ERbeta+affects+integrin+expression+and+clustering+and+consequently+modulates+adhesion+and+migration+of+breast+cancer+cells. assertion.
- assertion asSentence Trimucytin%2C+a+collagen-like+snake+venom+protein%2C+activates+platelets+independent+of+I-domain+within+alpha2+subunit+of+alpha2beta1+integrin. assertion.
- assertion asSentence This+meta-analysis+does+not+support+an+association+between+the+C807T+polymorphism+of+ITAG2+gene+and+stroke. assertion.
- assertion asSentence Nucleotide+substitution+at+position+2235+induces+a+Q716H+amino+acid+change+in+the+GPIa+mature+protein+that+causes+Fetal%2Fneonatal+alloimmune+thrombocytopenia. assertion.
- assertion asSentence TGF-beta-mediated+up-regulation+of+the+expression+of+the+integrin+subunits+alpha%282%29+and+alpha%286%29+is+mainly+mediated+in+MSC+by+Smad2. assertion.