Matches in Nanopublications for { ?s <http://purl.org/nanopub/x/asSentence> ?o ?g. }
- assertion asSentence Prostaglandin+E2+enhances+the+migration+of+chondrosarcoma+cells+by+increasing+alpha2beta1+integrin+expression+through+the+EP1%2FPLC%2FPKCalpha%2Fc-Src%2FNF-kappaB+signal+transduction+pathway. assertion.
- assertion asSentence The+syndecan-+and+alpha2beta1+integrin-binding+peptides+synergistically+affect+cells+and+accelerate+cell+adhesion. assertion.
- assertion asSentence GPIIb-IIIa+complexes+are+not+in+an+activated+conformational+state+after+dissociation+of+abciximab+unless+there+is+an+additional+source+of+activation. assertion.
- assertion asSentence ERK+promotes+megakaryocyte+differentiation+by+coordinate+regulation+of+nuclear+factors+that+synergize+in+GPIIb+promoter+regulation. assertion.
- assertion asSentence Arginine-methylated+RUNX1+regulates+CD41+gene+expression. assertion.
- assertion asSentence The+alphaIIb+G236E+mutation+causes+Glanzmann%27s+thrombasthenia+by+impairing+the+association+with+beta3+during+biogenesis+of+the+receptor. assertion.
- assertion asSentence Glutathione+regulates+integrin+alpha%28IIb%29beta%283%29-mediated+cell+adhesion+under+flow+conditions. assertion.
- assertion asSentence GPIIb%2FIIIa+and+alphavbeta3+integrins+are+important+mediators+in+the+pathology+of+cervical+cancer. assertion.
- assertion asSentence Disease+duration+of+atopic+myelitis+is+reflected+in+significantly+higher+GP+IIb%2FIIIa+values+than+in+controls+and+involves+the+sensory+system%2C+with+increased+platelet+aggregative+function. assertion.
- assertion asSentence Integrin-alpha+3+sub-unit+participates+the+process+of+regulating+growth+of+meningiomas. assertion.
- assertion asSentence Signaling+through+both+constitutively+expressed+alpha2+integrin+and+Matrigel-induced+alpha3+integrin+expression+is+required+to+acquire+a+differentiated+phenotype+in+Caco-2+cells. assertion.
- assertion asSentence Alpha+3+beta+1+integrin+is+necessary+and+sufficient+for+maximal+keratinocyte+survival+on+laminin-5. assertion.
- assertion asSentence With+increased+tension+cytoskeletal+stress+fibers+develop+that+contain+alphaSMA+and+alphavbeta3+integrin+that+replaces+alpha2beta1+integrin%2C+consistent+with+cell+switching+from+collagen+to+non-collagen+proteins+interactions. assertion.
- assertion asSentence ITGA4+mediates+engraftment+of+GCSF-mobilized+stem+cells. assertion.
- assertion asSentence Distinct+structural+requirements+for+the+VLA-4+integrin+alpha+4+subunit+reflect+different+roles+played+by+VLA-4+under+static+adhesion+and+shear+flow+conditions. assertion.
- assertion asSentence The+VCAM-1%2Fvery+late+activation+antigen+4+adhesive+system+critically+mediates+endothelial+progenitor+cell+adhesion+to+cultured+rheumatoid+arthritis+fibroblasts+and+to+rheumatoid+arthritis+synovial+tissue. assertion.
- assertion asSentence Activation+of+VLA-4+subunit+of+integrin+alpha4beta1+localizes+to+the+lamellipodium+of+polarized+human+T+cells+and+is+critical+for+T+cell+migration+on+VCAM-1. assertion.
- assertion asSentence FLT3%2F+ITD%28internal+tandem+duplication%29+regulates+leukaemia+cell+adhesion+through+alpha4beta1+integrin+and+Pyk2+signalling. assertion.
- assertion asSentence An+association+between+the+cytoplasmic+tail+of+alpha+4+integrin+and+non-muscle+myosin+IIA+%28MIIA%29was+demonstrated+by+co-immunoprecipitation. assertion.
- assertion asSentence Alpha5beta1-mediated+adhesion+of+Ntera2+neuronal+cells+to+fibronectin+decreased+apoptosis+in+response+to+serum+withdrawal. assertion.
- assertion asSentence OPN+plays+a+crucial+role+for+tumor+growth+and+angiogenesis+of+human+lung+cancer+cells+in+vivo+by+interacting+with+alphavbeta3+integrin. assertion.
- assertion asSentence An+N-glycosylation+site+on+the+beta-propeller+domain+of+the+integrin+alpha5+subunit+plays+key+roles+in+both+its+function+and+site-specific+modification+by+beta1%2C4-N-acetylglucosaminyltransferase+III. assertion.
- assertion asSentence VAMP2+mediates+the+trafficking+of+alpha5beta1+integrin+to+the+plasma+membrane+and+VAMP2-dependent+integrin+trafficking+is+critical+in+cell+adhesion%2C+migration+and+survival. assertion.
- assertion asSentence TMPRSS4+induces+invasion+and+epithelial-mesenchymal+transition+through+upregulation+of+integrin+alpha5. assertion.
- assertion asSentence The+interplay+between+alpha5-integrin+and+sFn+contributes+significantly+to+tissue+cohesion+and%2C+depending+on+their+level+of+expression%2C+can+mediate+a+shift+from+liquid+to+elastic+behavior. assertion.
- assertion asSentence Tumor-cell+expressions+of+alpha9+and+beta1+integrins+in+combination+with+extracellular+tenascin+are+necessary+for+medulloblastoma+adhesion+to+the+leptomeninges. assertion.
- assertion asSentence Integrin%2Factivation+marker+CD103+%28alphaEbeta7%29+is+expressed+on+Epstein-Barr+virus-specific+tonsil-resident+%28but+not+peripheral+blood+mononuclear+leukocyte-derived%29+cytotoxic+T+lymphocytes. assertion.
- assertion asSentence TNF-alpha+acts+as+a+potent+stimulator+of+Actinobacillus+actinomycetemcomitans+leukotoxin-induced+HL-60+cell+apoptosis+via+TNF+receptor+1-mediated+upregulation+of+LFA-1+expression. assertion.
- assertion asSentence LFA-1+delivers+a+distinct+signal+essential+for+directing+released+cytolytic+granules+to+the+surface+of+antigen-bearing+target+cells+to+mediate+the+effective+destruction+of+these+cells+by+cytotoxic+T+lymphocytes. assertion.
- assertion asSentence The+high-affinity+state+of+LFA-1+on+T+cells+is+critical+to+induce+targeted+movements+of+both+ICAM-1+and+MHC+class+II+to+the+immunological+synapse+on+APCs. assertion.
- assertion asSentence Regulator+of+G+protein+signaling+%28RGS%29+represses+Galpha-dependent+signaling+during+chemokine-activated+integrin+alphaLbeta2-+and+alpha4beta1-+dependent+T+cell+adhesion. assertion.
- assertion asSentence DNA+hypermethylation+at+the+CD11a+locus+contributes+to+the+lowered+expression+of+CD11a+in+biliary+atresia+CD4%2B+T+cells. assertion.
- assertion asSentence CD11b-mediated+adhesion+of+myeloid+leukemia+cells+in+the+course+of+induced+monocytic+differentiation+is+crucial+for+cell+attachment%2C+development+of+a+monocytic+phenotype+and+subsequent+survival. assertion.
- assertion asSentence Mac-1+%28CD11b%29+is+required+for+neutrophil-Fc+alpha+RI+binding+of+secretory+IgA+and+subsequent+neutrophil+activation. assertion.
- assertion asSentence Stabilizing+the+integrin+alpha+M+inserted+domain+in+alternative+conformations+with+a+range+of+engineered+disulfide+bonds. assertion.
- assertion asSentence A+nonsynonymous+functional+variant+in+integrin-alpha%28M%29%28encoded+by+ITGAM%29+is+associated+with+systemic+luopus+erythematosus. assertion.
- assertion asSentence Diabetic+microangiopathy+is+accompanied+by+increase+in+CD11b+expression+and+decrease+in+CD62L+expression+on+peripheral+blood+neutrophils. assertion.
- assertion asSentence The+heparan+sulfate+proteoglycan+form+of+epithelial+CD44v3+plays+a+critical+role+in+facilitating+PMN+recruitment+during+inflammatory+episodes+via+directly+binding+to+CD11b%2FCD18. assertion.
- assertion asSentence Epidermal+growth+factor+receptor+and+alphavbeta3+work+together+as+coreceptors+for+Human+cytomegalovirus+entry+and+signaling. assertion.
- assertion asSentence Binding+of+resveratrol+to+integrin+alphaVbeta3%2C+principally+to+the+beta3+monomer%2C+is+essential+for+transduction+of+the+stilbene+signal+into+p53-dependent+apoptosis+of+breast+cancer+cells. assertion.
- assertion asSentence The+apo%28a%29+component+of+Lp%28a%29+signals+through+integrin+alphaVbeta3+to+activate+endothelial+cells. assertion.
- assertion asSentence OPN+enhances+the+migration+of+chondrosarcoma+cells+by+increasing+MMP-9+expression+through+the+alphavbeta3+integrin%2C+FAK%2C+MEK%2C+ERK+and+NF-kappaB+signal+transduction+pathway. assertion.
- assertion asSentence Oscillatory+shear+stress+induces+osteoblast-like+cell+proliferation+through+activation+of+alpha%28v%29beta%283%29+and+beta%281%29+integrins+and+synergistic+interactions+of+FAK+and+Shc+with+PI3K%2C+leading+to+the+modulation+of+ERK+and+Akt%2FmTOR%2Fp70S6K+pathways. assertion.
- assertion asSentence Integrin+alphavbeta5+is+a+primary+receptor+for+adenovirus. assertion.
- assertion asSentence PAK4+is+activated+by+cell+attachment+to+vitronectin+as+mediated+by+PAK4+binding+partner+integrin+alphavbeta5. assertion.
- assertion asSentence PET+of+alphavbeta3-integrin+and+alphavbeta5-integrin+expression+with+18F-fluciclatide+for+assessment+of+response+to+targeted+therapy. assertion.
- assertion asSentence With+increased+tension+cytoskeletal+stress+fibers+develop+that+contain+alphaSMA+and+alphavbeta3+integrin+that+replaces+alpha2beta1+integrin%2C+consistent+with+cell+switching+from+collagen+to+non-collagen+proteins+interactions. assertion.
- assertion asSentence CD56%28bright%29CD11c%28positive%29+cells+play+a+key+role+in+the+interleukin+%28IL%29-18-mediated+proliferation+of+gammadelta+T+cells. assertion.
- assertion asSentence beta1+and+beta2+integrins+activate+different+signalling+pathways+in+monocytes. assertion.
- assertion asSentence Expression+of+focal+adhesion+kinase+and+alpha5+and+beta1+integrins+in+carcinomas+and+its+clinical+significance. assertion.
- assertion asSentence Decidual+beta1+integrin+and+FAK+participate+in+this+final+step+of+implantation. assertion.
- assertion asSentence Hox+D3+coordinately+regulates+the+expression+of+integrin+alpha5beta1+and+integrin+alphavbeta3+during+angiogenesis+in+vivo. assertion.
- assertion asSentence Alpha4beta1+is+an+important+endothelial+cell+receptor+for+mediating+motility+and+proliferative+responses+to+thrombospondins+and+for+modulation+of+angiogenesis. assertion.
- assertion asSentence Alpha5beta1-mediated+adhesion+of+Ntera2+neuronal+cells+to+fibronectin+decreased+apoptosis+in+response+to+serum+withdrawal. assertion.
- assertion asSentence RACK1+enhances+IGF-I-mediated+cell+migration+through+its+ability+to+exclusively+associate+with+either+beta1+integrin+or+PP2A+in+a+complex+at+the+IGF-IR. assertion.
- assertion asSentence Salivary+progenitor+epithelial+cell+survival+is+beta+1+integrin-dependent. assertion.
- assertion asSentence Talin+1+is+a+versatile+VLA-4+affinity+regulator+implicated+in+both+spontaneous+and+chemokine-triggered+rapid+adhesions+to+VCAM-1. assertion.
- assertion asSentence Notch1+ligand%2C+Delta-like+ligand-4%2C+stimulates+R-Ras-dependent+alpha+5+beta+1+integrin-mediated+adhesion%2C+demonstrating+the+physiological+relevance+of+this+pathway. assertion.
- assertion asSentence The+integrin+beta1-focal+adhesion+kinase+signal+pathway+plays+a+role+in+the+invasiveness+of+pituitary+adenomas. assertion.
- assertion asSentence uPAR+and+beta1-integrin+interactions+are+essential+to+signals+induced+by+integrin+matrix+ligands+or+uPA+in+lung+cancer+cells. assertion.
- assertion asSentence High+levels+of+VLA-4+is+associated+with+mantle+cell+lymphoma. assertion.
- assertion asSentence TRPV4+channels+mediate+cyclic+strain-induced+endothelial+cell+reorientation+through+integrin-to-integrin+signaling. assertion.
- assertion asSentence A+GPVI-independent+signaling+role+of+alpha2beta1+in+response+to+collagen+stimulation. assertion.
- assertion asSentence Targeting+of+integrin+beta1+and+kinesin+2alpha+by+microRNA+183. assertion.
- assertion asSentence Interleukin-8+%28CXCL8%29+stimulates+trophoblast+cell+migration+and+invasion+by+increasing+levels+of+integrins+alpha5+and+beta1. assertion.
- assertion asSentence Prostaglandin+E2+enhances+the+migration+of+chondrosarcoma+cells+by+increasing+alpha2beta1+integrin+expression+through+the+EP1%2FPLC%2FPKCalpha%2Fc-Src%2FNF-kappaB+signal+transduction+pathway. assertion.
- assertion asSentence WASH+and+Arp2%2F3+regulates+integrin+alpha5beta1-mediated+invasive+cell+migration. assertion.
- assertion asSentence Fibronectin+induces+endothelial+cell+migration+through+beta1+integrin+and+Src-dependent+phosphorylation+of+fibroblast+growth+factor+receptor-1+at+tyrosines+653%2F654+and+766. assertion.
- assertion asSentence uPAR+is+an+essential+component+of+the+network+through+which+VEGF+controls+integrin+redistribution+and+endothelial+cell+migration. assertion.
- assertion asSentence Integrin+beta1+mediates+vaccinia+virus+entry+through+activation+of+PI3K%2FAkt+signaling. assertion.
- assertion asSentence beta1+and+beta2+integrins+activate+different+signalling+pathways+in+monocytes. assertion.
- assertion asSentence Porphyromonas+gingivalis+fimbriae+activate+human+peripheral+blood+monocytes+utilizing+TLR2%2C+CD14+and+CD11a%2FCD18+as+cellular+receptors. assertion.
- assertion asSentence Adhesion+of+dendritic+cells+derived+from+CD34%2B+progenitors+to+resting+human+dermal+microvascular+endothelial+cells+is+down-regulated+upon+maturation+and+partially+depends+on+CD11a-CD18%2C+CD11b-CD18+and+CD36. assertion.
- assertion asSentence ICAM-4+binds+to+the+I+domain+of+this+integrin. assertion.
- assertion asSentence Platelets%2C+by+binding+via+P-selectin+to+PSGL-1+on+monocytes%2C+induce+up-regulation+and+activation+of+beta1+and+beta2integrins+and+increased+adhesion+of+monocytes+to+activated+endothelium. assertion.
- assertion asSentence In+Helicobacter+pylori+infection%2C+cathepsin+X+mediated+activation+of+beta-2+integrin+receptor+Mac-1+suppresses+the+stimulatory+signal+in+the+form+of+cytokines. assertion.
- assertion asSentence Binding+of+integrin+beta+2+to+angiopoietin-2+eliminates+Ang-2%2Fplatelet-derived+growth+factor-BB-mediated+upregulation+of+monocyte+fibrin+invasion. assertion.
- assertion asSentence Structure+of+an+integrin+with+an+alphaI+domain%2C+complement+receptor+type+4. assertion.
- assertion asSentence Thioredoxin+reductase+linked+to+cytoskeleton+by+focal+adhesion+kinase+reverses+actin+S-nitrosylation+and+restores+neutrophil+beta%282%29+integrin+function. assertion.
- assertion asSentence Distinct+domains+of+alphaIIbbeta3+support+different+aspects+of+outside-in+signal+transduction+and+platelet+activation+induced+by+LSARLAF. assertion.
- assertion asSentence Factor+XIII+mediates+adhesion+of+platelets+to+endothelial+cells+through+alpha%28v%29beta%283%29+and+glycoprotein+IIb%2FIIIa+integrins. assertion.
- assertion asSentence Alpha%28v%29beta%283%29+integrin+engagement+enhances+cell+invasiveness+in+human+multiple+myeloma. assertion.
- assertion asSentence Role+for+beta3+integrins+in+human+melanoma+growth+and+survival. assertion.
- assertion asSentence Individuals+homozygous+for+the+Leu33Pro+polymorphism+of+the+beta3+integrin+subunit+have+an+increased+cancer+risk. assertion.
- assertion asSentence The+177-184+sequence+of+beta3+is+necessary+for+vitronectin+binding+to+alphaVbeta3. assertion.
- assertion asSentence Cells+overexpressing+beta3+integrin+can+bind+human+ADAM12+via+beta3+integrin. assertion.
- assertion asSentence The+endometrial+expression+of+beta3+integrin+subunit+is+reduced+in+the+presence+of+tubal+phimosis+or+hydrosalpinx%2C+during+the+window+of+implantation. assertion.
- assertion asSentence Glycoprotein+IIIa+%28GPIIIa%2C+platelet+antigen+A1+and+A2%29+polymorphisms+that+contribute+to+resistance+or+augmented+response+to+aspirin+are+rare+in+the+Chinese+population. assertion.
- assertion asSentence RN181+associates+with+the+platelet-specific+integrin+alphaIIbbeta3+in+human+platelets+through+the+conserved+alphaIIb+cytoplasmic+KVGFFKR+motif. assertion.
- assertion asSentence CRP+at+levels+found+during+episodes+of+inflammation+directly+binds+to+the+activated+form+of+alphaIIbbeta3+and+inhibits+platelet+aggregation. assertion.
- assertion asSentence Talin+recruitment+to+alphaIIbbeta3+by+RIAM+mediates+agonist-induced+alphaIIbbeta3+activation%2C+with+implications+for+hemostasis+and+thrombosis. assertion.
- assertion asSentence SDF-1alpha+enhances+the+invasiveness+of+chondrosarcoma+cells+by+increasing+alphavbeta3+integrin+expression+through+the+CXCR4%2FERK%2FNF-kappaB+signal+transduction+pathway. assertion.
- assertion asSentence Rationally+designed+integrin+beta3+mutants+stabilized+in+the+high+affinity+conformation. assertion.
- assertion asSentence The+regulation+of+EC+junctional+integrity+involves+the+coordinated+and+dynamic+modification+of+localization+and+activity+of+junctional+stabilizers+such+as+the+integrin+beta%283%29+and+the+destabilizer%2C+JAM-C. assertion.
- assertion asSentence PAI-1-mediated+regulation+of+alphavbeta3+integrin+is+critical+for+the+control+of+TGFbeta+signaling+and+the+prevention+of+fibrotic+disease. assertion.
- assertion asSentence GPIIb%2FIIIa+and+alphavbeta3+integrins+are+important+mediators+in+the+pathology+of+cervical+cancer. assertion.
- assertion asSentence Variant+type+Glanzmann+thrombasthenia+caused+by+homozygous+p.724R%3EX+mutation+in+beta3+integrin. assertion.
- assertion asSentence Platelet+glycoprotein+IIb%2FIIIa+polymorphism+HPA-3+b%2Fb+is+associated+with+increased+risk+of+ischemic+stroke+in+patients+under+60+years+of+age. assertion.
- assertion asSentence Expression+of+ITGB3+and+leukemia+inhibitory+factor+%28LIF%29+in+the+peri-implantation+endometrium+does+not+change+in+women+with+unexplained+recurrent+pregnancy+loss. assertion.
- assertion asSentence Link+between+the+ligation+of+the+beta%284%29+integrin+and+beta%281%29+integrin-mediated+cell+adhesion+in+carcinoma+and+pre-carcinoma+cells. assertion.