Matches in Nanopublications for { ?s <http://purl.org/nanopub/x/asSentence> ?o ?g. }
- assertion asSentence Blockage+of+beta4+integrin+activity+by+antagonizing+antibody+abrogated+ATV-induced+endothelial+death. assertion.
- assertion asSentence Deletion+of+the+first+pair+of+fibronectin+type+III+repeats+of+the+integrin+beta-4+gene+is+associated+with+epidermolysis+bullosa%2C+pyloric+atresia+and+aplasia+cutis+congenita+in+the+original+Carmi+syndrome+patients. assertion.
- assertion asSentence Itgb4+protein+remains+expressed+in+the+early+stages+of+peripheral+regeneration+and+subsequent+myelination. assertion.
- assertion asSentence Integrin+alpha6beta4+and+NET1+coexpression+is+independently+associated+with+the+development+of+distant+metastasis+in+breast+cancer. assertion.
- assertion asSentence Mechanical+force+applied+to+filamin+can+expose+cryptic+integrin+binding+sites. assertion.
- assertion asSentence The+specific+affinity+of+gp120+for+alpha%284%29beta%287%29+provides+a+mechanism+for+HIV-1+to+target+activated+cells+that+are+critical+for+efficient+virus+propagation+and+dissemination+following+sexual+transmission. assertion.
- assertion asSentence The+entry+of+recently+activated+CD4-expressing+T+cells+into+the+bone+marrow+can+occur+in+a+transgenic+beta1-+and+beta7-integrin-independent+manner+following+Listeria+monocytogenes+infection. assertion.
- assertion asSentence Itk+catalytic+activity+is+inhibited+by+the+peptidyl+prolyl+isomerase+activity+of+cyclophilin+A+%28CypA%29. assertion.
- assertion asSentence Active+signals+from+transgenic+Tec+kinase+%28ITK%29+regulate+the+development+of+memory-like+CD8%2B+T+cells+with+innate+function. assertion.
- assertion asSentence The+Tec+family+kinase+Itk+exists+as+a+folded+monomer+in+vivo. assertion.
- assertion asSentence Expression+of+patient-derived+ITK+in+mice+induces+highly+malignant+peripheral+T+cell+lymphomas. assertion.
- assertion asSentence The+STT3A+OST+isoform+is+primarily+responsible+for+cotranslational+glycosylation+of+the+nascent+polypeptide+as+it+enters+the+lumen+of+the+endoplasmic+reticulum. assertion.
- assertion asSentence Antibodies+in+Sjogren%27s+syndrome+recognized+residues+224-604+of+the+core+protein+IP%283%29R1. assertion.
- assertion asSentence Functional+cross-talk+between+Ras%2Fextracellular+signal-regulated+kinase+%28Erk%29+and+IL-4%2FJanus+kinase+1+%28JAK1%29%2FSTAT6+contributes+to+the+regulation+of+IL-4+transcription+in+T+cells. assertion.
- assertion asSentence In+T-cell+acute+lymphoblastic+leukemia%2C+PHF6+mutations+are+a+recurrent+genetic+abnormality+associated+with+mutations+of+NOTCH1%2C+JAK1+and+rearrangement+of+SET-NUP214. assertion.
- assertion asSentence Janus+kinase+A+is+involved+in+the+activation+of+STAT6+induced+by+IL-13+in+bronchial+smooth+muscle+cells. assertion.
- assertion asSentence Jak2+activation+is+sufficient+for+GTPCH+I+upregulation+in+response+to+IFN-gamma+and+its+synergy+with+TNF-alpha. assertion.
- assertion asSentence The+JAK2+mutation+can+be+acquired+during+disease+progression+of+myelodysplastic+syndrome+JMML. assertion.
- assertion asSentence Curcumin+treatment+inhibited+Jak2+mRNA+expression+in+K562+chronic+leukaemia+cells. assertion.
- assertion asSentence JAK2+exon+12+mutations+define+a+distinctive+myeloproliferative+syndrome+that+affects+patients+who+currently+receive+a+diagnosis+of+polycythemia+vera+or+idiopathic+erythrocytosis. assertion.
- assertion asSentence Unlike+the+risk+of+thrombosis+in+essential+thrombocythemia%2C+the+risk+in+polycythemia+vera+is+not+linked+to+JAK2V617F+mutational+status. assertion.
- assertion asSentence V617F+mutation+does+not+affect+hematopoietic+progenitor+cells+in+myeloproliferative+disorders. assertion.
- assertion asSentence The+JAK2V617F+mutation+is+found+in+chronic+non-cirrhotic+portal+vein+thrombosis+%28PVT%29+patients%2C+irrespective+of+the+presence+or+absence+of+myeloproliferative+diseases+%28MPDs%29. assertion.
- assertion asSentence Atypical+chronic+myeloid+leukemia+should+be+considered+as+a+JAK2+negative+chronic+myeloid+neoplasm. assertion.
- assertion asSentence Most+chronic+myeloproliferative+disorder+patients%2C+especially+those+with+polycythemia+vera%2C+carry+the+JAK2+V617F+mutation%2C+except+CML+patients. assertion.
- assertion asSentence Extent+of+JAK2%28V617F%29+CD34%28%2B%29+cell+clonal+dominance+is+associated+with+disease+phenotype+within+the+myeloproliferative+disorders. assertion.
- assertion asSentence Effect+of+hydroxyurea+on+the+JAK2V617F+allelic+ratio+of+patients+with+polycythemia+vera+and+essential+thrombocythemia. assertion.
- assertion asSentence JAK2%28V617F%29+should+be+considered+as+a+hyperactive+kinase+rather+than+a+constitutively+active+kinase. assertion.
- assertion asSentence The+occurrence+of+JAK2+mutations+is+frequent+in+acquired+sideroblastic+anemia+with+dysplasia. assertion.
- assertion asSentence JAK2V617F+mutation+screening+in+patients+with+retinal+vein+thrombosis+or+recurrent+fetal+loss. assertion.
- assertion asSentence In+patients+with+polycythemia+vera%2C+the+JAK2V617F+point+mutation+is+correlated+with+age+and+higher+leukocyte+counts. assertion.
- assertion asSentence The+decrease+of+JAK2+V617F+allele+burden+in+leukemia+transformation+of+an+elderly+patient+with+myelofibrosis. assertion.
- assertion asSentence High+frequency+of+JAK2+mutations+are+associated+with+refractory+anemia+with+ring+sideroblasts+and+thrombocytosis. assertion.
- assertion asSentence There+is+a+correlation+between+JAK2V617F+mutation+in+myeloproliferative+neoplasms+and+advanced+age%2C+higher+leukocyte+counts%2C+hemoglobin+level+and+vascular+events. assertion.
- assertion asSentence Myeloproliferative+disorders+patients+with+the+JAK2+V617F+mutation+are+predisposed+to+thrombosis. assertion.
- assertion asSentence JAK2+phosphorylates+histone+H3Y41+and+excludes+HP1alpha+from+chromatin+in+leukemogenesis. assertion.
- assertion asSentence A+double+L611V%2FV617F+in+cis+mutation+of+JAK2+is+associated+with+isolated+erythrocytosis+and+increased+activation+of+AKT+and+ERK1%2F2+rather+than+STAT5. assertion.
- assertion asSentence The+JAK2+46%2F1+haplotype+predisposes+to+MPL-mutated+myeloproliferative+neoplasms. assertion.
- assertion asSentence JAK2%2FSTAT3%2Fvimentin+signaling+pathway+participates+in+regulating+the+proliferation+and+migration+of+human+colon+cancer+cells. assertion.
- assertion asSentence The+JAK2%2FSTAT3+signaling+pathway+plays+an+important+role+in+the+angiogenesis+of+non-small+cell+lung+cancer. assertion.
- assertion asSentence Helicobacter+Pylori+CagA+protein+activates+the+gastrin+promoter+to+up-regulate+gastrin+mRNA+expression+through+the+JAK2-signaling+pathway+in+gastric+cancer+cells. assertion.
- assertion asSentence Coexistence+of+JAK2V617F+mutation+and+BCR-ABL1+transcript+in+two+Chinese+patients+with+chronic+myelogenous+leukemia. assertion.
- assertion asSentence Inhibition+of+JAK3+signaling+in+colon+carcinoma+tumors+and+cell+lines+induces+apoptosis+and+cell+cycle+arrest+of+colon+carcinoma+cells. assertion.
- assertion asSentence WHI-P154%2C+an+inhibitor+of+Janus+protein+tyrosine+kinase+%28JAK3%29%2C+Hck+and+Syk%2C+prevented+PDGF-induced+neurite+outgrowth. assertion.
- assertion asSentence Lyn+coimmunoprecipitates+with+the+interleukin-2+beta+receptor+and+JAK3+proteins+in+human+T-cell+leukemia+virus+type+1-infected+T-cells. assertion.
- assertion asSentence JAK3+mutations+are+associated+with+response+to+therapy+in+T-cell+acute+lymphoblastic+leukemia. assertion.
- assertion asSentence Tumor+promoter+arsenite+stimulates+histone+H3+phosphoacetylation+of+c-fos+and+this+proto-oncogene+chromatin+in+diploid+fibroblasts. assertion.
- assertion asSentence Critical+role+of+the+transcription+factor+AP-1+for+the+constitutive+and+interferon-induced+expression+of+IFI+16. assertion.
- assertion asSentence C-Jun+plays+an+important+role+in+epidermal+differentiation+by+negatively+regulating+the+human+involucrin+gene. assertion.
- assertion asSentence SMAP2+functions+in+the+retrograde%2C+early+endosome-to-trans+golig+network+pathway+in+a+clathrin-+and+AP-1-dependent+manner. assertion.
- assertion asSentence Tacrolimus+or+cyclosporine+A+act+on+human+osteoclast+precursors+in+rheumatoid+arthritis+patients+by+targeting+the+calcineurin-dependent+NFAT+pathway+and+activation+pathway+for+c-Jun+or+MITF. assertion.
- assertion asSentence Elafin+inhibits+the+lipopolysaccharide-induced+production+of+monocyte+chemoattractant+protein-1+in+monocytes+by+inhibiting+AP-1+and+NF-kappaB+activation. assertion.
- assertion asSentence MCJ+is+required+in+these+cells+to+prevent+c-Jun-mediated+expression+of+ABCB1+and+maintain+drug+response. assertion.
- assertion asSentence FasL-induced+activator+protein+%28AP%29-1+activation+is+required+for+optimal+IL-8+production. assertion.
- assertion asSentence Absence+of+CFTR+at+the+cell+membrane+leads+to+an+intrinsic+AP1+activity. assertion.
- assertion asSentence Amino+acid+residues+required+for+physical+and+cooperative+transcriptional+interaction+of+STAT3+and+API-1+proteins+c-Jun+and+c-Fos. assertion.
- assertion asSentence Increased+intracellular+ROS+generation+in+peripheral+blood+monocytes+of+diabetic+patients+is+involved+in+the+pathogenesis+of+diabetic+nephropathy+via+activation+of+AP-1. assertion.
- assertion asSentence Nuclear+c-Abl+kinase+can+activate+CSF-1+gene+transcription+by+regulating+AP-1+activity+in+the+signaling+events+induced+by+L-selectin+ligation. assertion.
- assertion asSentence The+SAF-1.c-Fos.c-Jun+ternary+complex+efficiently+promotes+transcription+from+both+SAF-1+and+AP-1+sites+of+human+MMP-1+promoter. assertion.
- assertion asSentence Differential+expression+and+activation+of+AP-1+super-family+proteins+in+relation+to+severity+of+lesion+and+their+crucial+role+in+human+oral+carcinogenesis. assertion.
- assertion asSentence Up-regulation+of+TRPM6+transcriptional+activity+by+AP-1+in+renal+epithelial+cells. assertion.
- assertion asSentence Stability+and+DNA-binding+ability+of+the+bZIP+dimers+formed+by+the+ATF-2+and+c-Jun. assertion.
- assertion asSentence Inhibition+of+AP-1+by+SARI+negatively+regulates+transformation+progression+mediated+by+CCN1. assertion.
- assertion asSentence Intracellular+CMTM2+can+negatively+regulate+HIV-1+transcription%2C+at+least+in+part%2C+by+targeting+the+AP-1+and+CREB+pathways. assertion.
- assertion asSentence Alcohol+induces+RNA+polymerase+III-dependent+transcription+through+c-Jun+by+co-regulating+TATA-binding+protein+%28TBP%29+and+Brf1+expression. assertion.
- assertion asSentence Cigarette+smoke+extract+regulates+cytosolic+phospholipase+A2+expression+via+NADPH+oxidase%2FMAPKs%2FAP-1+and+p300+in+human+tracheal+smooth+muscle+cells. assertion.
- assertion asSentence C-Jun%2FAP-1+activity+mediated+by+JNK%2C+PI3K%2FAkt+and+ERK+pathways+is+required+for+laminin-1-induced+neurite+outgrowth+in+human+bone+marrow+mesenchymal+stem+cells. assertion.
- assertion asSentence Dimerumic+acid+inhibits+AP-1-mediated+MMP-7+gene+transcription+in+H2O2-stimulated+SW620+cells. assertion.
- assertion asSentence AP-1+sequences+within+the+c-JUN+gene+can+function+as+transcriptional+amino+acid-response+elements. assertion.
- assertion asSentence Low+molecular+weight+hyaluronan+produced+by+lung+fibroblasts+in+response+to+cyclic+stretch+increases+the+secretion+of+IL-8+in+transformed+bronchial+epithelial+cells+via+AP-1+and+NF-kappaB+signalling+pathways. assertion.
- assertion asSentence FOXK2+can+promote+transcriptional+activation+and+is+required+for+the+efficient+recruitment+of+AP-1+components+to+chromatin. assertion.
- assertion asSentence Cultivated+ginseng+inhibits+UVB-induced+collagenolytic+MMP+production+by+interfering+with+MAPK%2FAP-1+and+NF-kappaB+signaling. assertion.
- assertion asSentence 5%2C6-dichloro-1-beta-D-ribofuranosylbenzimidazole+sensitivity-inducing+factor+%28DSIF%29-+and+NELF-mediated+transcriptional+pausing+has+a+dual+function+in+regulating+immediate-early+expression+of+the+human+junB+gene. assertion.
- assertion asSentence JunB+is+a+critical+target+of+mTOR+and+is+translationally+regulated+in+NPM-ALK-positive+lymphomas. assertion.
- assertion asSentence The+increase+in+JunB+expression+attenuated+nuclear+relocation+of+apoptosis-inducing+factor+and+mitochondrial+Bcl-2+reduction+that+occurred+following+hydrogen+peroxide+exposure. assertion.
- assertion asSentence JunD+activated+by+LHRH+acts+as+a+modulator+of+cell+proliferation+and+cooperates+with+the+anti-apoptotic+and+anti-mitogenic+functions+of+LHRH. assertion.
- assertion asSentence Dimerization+with+the+Jun+proteins+inhibits+c-Fos+nuclear+exit. assertion.
- assertion asSentence Activated+c-Jun+is+dimerized+with+JunD+in+response+to+adrenomedullin. assertion.
- assertion asSentence HTLV-1+bZIP+factor%28hbz%29+requires+cellular+JunD+to+upregulate+HTLV-1+antisense+transcription+from+the+3%27+long+terminal+repeat. assertion.
- assertion asSentence Plakoglobin+rescues+adhesive+defects+induced+by+ectodomain+truncation+of+the+desmosomal+cadherin+desmoglein+1. assertion.
- assertion asSentence Junction+plakoglobin+%28JUP%29+interacts+with+SOX4+in+both+the+cytosol+and+the+nucleus+and+the+interaction+between+SOX4+and+plakoglobin+is+significantly+increased+when+prostate+and+breast+cancer+cells+are+stimulated+with+WNT3A. assertion.
- assertion asSentence KAL1+gene+expression+plays+an+important+role+in+cancer+metastasis+and+protection+from+apoptosis. assertion.
- assertion asSentence EWI2%2FPGRL+associates+with+the+metastasis+suppressor+KAI1%2FCD82+and+inhibits+the+migration+of+prostate+cancer+cells. assertion.
- assertion asSentence The+abnormal+expression+of+KAI1+participates+in+malignant+progression+of+colorectal+cancer. assertion.
- assertion asSentence KAI1+is+a+tumor+metastasis+suppressor+gene+in+digestive+tract+carcinomas+and+cancer+cells. assertion.
- assertion asSentence Association+of+HTLV-1+Gag+protein+with+tetraspanin-enriched+microdomains+is+mediated+by+the+inner+loops+of+CD82+and+CD81. assertion.
- assertion asSentence Levels+of+CD82+expressed+in+A431+cells+are+much+higher+than+those+expressed+in+KB+cells+and+motility+of+A431+cells+is+also+much+higher+than+that+of+KB+cells. assertion.
- assertion asSentence KAI1+induces+autophagy+through+phosphorylation+of+extracellular+signal-related+kinases+rather+than+that+of+AKT. assertion.
- assertion asSentence Editing+of+K%28V%291.1+channel+mRNAs+disrupts+binding+of+the+N-terminus+tip+at+the+intracellular+cavity. assertion.
- assertion asSentence The+numbers+of+Kv1.2+channels+are+higher+in+DRs+than+VRs. assertion.
- assertion asSentence Cholesterol+depletion+causes+significant%2C+reversible+alterations+in+the+Kv1.3+channel+function+in+Jurkat+cells. assertion.
- assertion asSentence Reduction+in+the+activation+energy+for+the+inactivation+transition+from+the+open+state+underlies+the+inhibition+of+hKv1.5+Na%28%2B%29+current+at+low+pH. assertion.
- assertion asSentence Heterologously+expressed+human+pulmonary+arterial+smooth+muscle+cells+%28PASMC%29+Kv1.5+generated+an+O2-+and+correolide-sensitive+I%28K%29+like+that+in+resistance+PASMCs. assertion.
- assertion asSentence There+is+a+central+role+for+developmentally+regulated+ductus+arteriosus+SMC+O2-sensitive+Kv+channels+in+the+functional+closure+of+the+DA. assertion.
- assertion asSentence A+comparison+of+the+expression+patterns+of+Kv1.3+and+Kv1.5+in+the+human+fetus. assertion.
- assertion asSentence Mutation+of+histidine+105+in+the+T1+domain+of+the+potassium+channel+Kv2.1+disrupts+heteromerization+with+Kv6.3+and+Kv6.4. assertion.
- assertion asSentence Mutations+in+the+voltage-gated+potassium+channel+KCNC3+are+causative+for+spinocerebellar+ataxia+13. assertion.
- assertion asSentence KChIP4a+functions+to+promote+tetrameric+assembly+and+enhance+surface+expression+of+Kv4+channels. assertion.
- assertion asSentence The+%22structurally+minimal%22+isoform+KChIP2d+modulates+recovery+of+K%28v%294.3+N-terminal+deletion+mutant+Delta2-39. assertion.
- assertion asSentence Human+atrial+I%28to%29+and+cloned+hKv4.3+channels+are+modulated+by+EGFR+kinase+via+phosphorylation+of+the+Y136+residue+and+by+Src-family+kinases+via+phosphorylation+of+the+Y108+residue. assertion.