Matches in Nanopublications for { ?s <http://purl.org/nanopub/x/asSentence> ?o ?g. }
- assertion asSentence The+extracellular+flank+of+the+transmembrane+helix+of+E1+is+located+between+S1+and+S6+on+different+subunits+of+Q1+%28Q1+TM+helics%29. assertion.
- assertion asSentence Single+nucleotide+polymorphism+of+KCNE1+is+associated+with+heart+failure. assertion.
- assertion asSentence KCNE1+binds+to+the+outer+face+of+the+KCNQ1+channel+pore+domain%2C+modifies+interactions+between+voltage+sensor%2C+S4-S5+linker+and+the+pore+domain%2C+leading+to+structural+modifications+of+the+selectivity+filter+and+voltage+sensor+domain. assertion.
- assertion asSentence When+coexpressed+with+KCNE1%2C+both+mutants+deactivate+significantly+slower+than+wild-type+KCNQ1%2FKCNE1+channels. assertion.
- assertion asSentence Regulation+of+an+ERG+K%2B+current+by+Src+tyrosine+kinase. assertion.
- assertion asSentence Eag1+and+Best1+improve+intracellular+Ca%282%2B%29+signaling+and+cell+volume+regulation. assertion.
- assertion asSentence hEag1+expression+levels+in+acute+myeloid+leukemia+as+an+independent+predictive+factor+for+reduced+disease-free+and+overall+survival. assertion.
- assertion asSentence HERG+channels+are+selectively+involved+in+proliferation+of+distinct+uterine+cancer+cells. assertion.
- assertion asSentence Two+common+genetic+variants+of+KCNH2+protein+are+associated+with+continuous+QT+interval+duration+in+a+community+sample. assertion.
- assertion asSentence PD-307243+causes+instantaneous+current+through+HERG. assertion.
- assertion asSentence Physical+and+functional+interaction+between+integrins+and+hERG1+channels+in+cancer+cells. assertion.
- assertion asSentence Substitution+of+G546+with+residues+possessing+different+physicochemical+properties+shifted+activation+gating+by+approximately+-50+mV+%28with+the+exception+of+G546C%29. assertion.
- assertion asSentence Closure+of+the+selectivity+filter+gate+in+the+human+K%28v%2911.1+K%28%2B%29+channel+is+initiated+by+K%28%2B%29+exit%2C+followed+in+sequence+by+conformational+rearrangements+of+the+pore+domain. assertion.
- assertion asSentence Monoubiquitin+dynamically+mediates+endocytic+degradation+of+mature+hERG+channels+under+low+K%28%2B%29+conditions. assertion.
- assertion asSentence The+phenotypic+expression+of+KCNH2+mutations+and+the+effect+of+IKr-inhibitory+drug+on+the+surface+electrocardiogram+are+specific. assertion.
- assertion asSentence Antidepressant-induced+ubiquitination+and+degradation+of+the+cardiac+potassium+channel+hERG. assertion.
- assertion asSentence One+disease-causing+mutation+in+the+ROMK+channel+truncates+the+extreme+COOH-terminus+and+induces+a+closed+gating+conformation. assertion.
- assertion asSentence In+a+heterozgous+Bartter+syndrome+patient%2C+AA+exchanges+Arg338Stop+%26+Met357Thr+in+ROMK+exon+5+alter+the+C-terminus+of+the+ROMK+protein+%26+can+affect+channel+function. assertion.
- assertion asSentence KCNJ1+mutations+are+associated+with+Bartter+syndrome. assertion.
- assertion asSentence The+small+GTPase%2C+Rho%2C+transduces+the+m1+muscarinic+receptor-induced+inhibition+of+Kir2.1+via+an+unidentified+mechanism. assertion.
- assertion asSentence KIr2.1+and+Kir2.2+are+directly+activated+by+membrane+phosphatidylinositol+4%2C5-bisphosphate. assertion.
- assertion asSentence AMPK+is+a+potent+regulator+of+Kir2.1. assertion.
- assertion asSentence hKir2.1+channels+are+down-regulated+by+protein+tyrosine+kinase+inhibition. assertion.
- assertion asSentence Kir3.1+channel+is+involved+in+the+TLR4-mediated+signal+at+an+early+event+by+facilitating+the+recruitment+of+TLR4+into+lipid+raft. assertion.
- assertion asSentence KCNJ5+mutations+are+prevalent+in+aldosterone+producing+adenomas+%28APA%29. assertion.
- assertion asSentence GIRK+channels+are+important+functional+effectors+of+the+P2Y%2812%29+receptor+in+human+platelets. assertion.
- assertion asSentence The+effect+of+nicotine+on+Kir6.1+channels+is+mediated+by+the+production+of+superoxides. assertion.
- assertion asSentence Arg271Cys+missense+variation+in+KCNJ10+%28or+a+nearby+variation%29+is+related+to+general+seizure+susceptibility+in+humans. assertion.
- assertion asSentence Gain-of-function+defects+in+Kir4.1+causes+dysfunction+in+astrocytic-dependent+potassium+buffering+and+contributes+to+autism%2Fepilepsy+phenotype+by+altering+neuronal+excitability+and+synaptic+function. assertion.
- assertion asSentence The+prevalent+Glu23Lys+polymorphism+in+the+potassium+inward+rectifier+6.2+%28KIR6.2%29+gene+is+associated+with+impaired+glucagon+suppression+in+response+to+hyperglycemia. assertion.
- assertion asSentence Amino+acid+substituion+polymorphism+increases+the+risk+of+type+2+diabetes. assertion.
- assertion asSentence R201H+mutation+pf+the+kir6.2+channel+is+able+to+cause+neonatal+diabetes+in+patients. assertion.
- assertion asSentence Kir6.2+E23K+polymorphism+is+an+independent+genetic+risk+factor+for+diabetes+in+the+general+Japanese+population. assertion.
- assertion asSentence Meta-analysis+verified+that+single+nucleotide+polymorphisms+of+KCNJ11+gene+are+significantly+associated+with+the+risk+of+type+2+diabetes+mellitus+in+East+Asian+populations. assertion.
- assertion asSentence KIr2.1+and+Kir2.2+are+directly+activated+by+membrane+phosphatidylinositol+4%2C5-bisphosphate. assertion.
- assertion asSentence Kir2.1+and+Kir2.2+have+two+distinct+lipid+requirements+for+activity. assertion.
- assertion asSentence The+important+role+of+selectivity+filter+gating+in+the+regulation+of+TREK-1+by+the+extracellular+K%28%2B%29+and+proton. assertion.
- assertion asSentence Host+TASK-1+protein+and+HIV-1+Vpu+undergo+mutual+functional+destruction. assertion.
- assertion asSentence ET-1+inhibited+TASK1-mediated+I%28KN%29+currents+in+hPASMC. assertion.
- assertion asSentence Carbon+monoxide+acts+as+a+partial+agonist+for+the+high-affinity+divalent+cation+sensor+in+the+RCK1+domain+of+the+Slo1+BK+channel. assertion.
- assertion asSentence Dominant-negative+regulation+of+cell+surface+expression+by+a+pentapeptide+motif+at+the+extreme+COOH+terminus+of+an+Slo1+calcium-activated+potassium+channel+splice+variant. assertion.
- assertion asSentence Membrane+cholesterol+influences+ethanol%27s+modulation+of+BK. assertion.
- assertion asSentence Cloned+BK%28Ca%29+channel+directly+regulated+apoptosis+and+proliferation+of+HEK293+cell+under+hyperglycemia+condition. assertion.
- assertion asSentence Kit-negative+fibroblast-like+cells+express+this+channel+in+smooth+gut+muscle+in+health+and+dissease. assertion.
- assertion asSentence The+longer+polyglutamine+stretches+are+associated+with+reduced+conductance+of+KCNN3+channel. assertion.
- assertion asSentence KCa3.1+channels+are+a+part+of+the+signaling+complex+that+forms+at+the+IS+upon+antigen+presentation. assertion.
- assertion asSentence KCNN4+activity+decines+sharply+throughout+the+lifespan+of+human+red+blood+cells. assertion.
- assertion asSentence IK1+channels+are+present+in+biliary+epithelial+cells+and+contribute+to+ATP-stimulated+secretion+through+a+P2Y-IP3+receptor+pathway. assertion.
- assertion asSentence Despite+the+high+degree+of+homology+of+the+pore+region+among+the+various+K%28%2B%29+channels%2C+KCNQ1+channels+display+significant+structural+and+functional+uniqueness. assertion.
- assertion asSentence LQT1+patients+with+transmembrane+mutations+are+at+higher+risk+of+congenital+LQTS-related+cardiac+events+and+have+greater+sensitivity+to+sympathetic+stimulation%2C+as+compared+with+patients+with+C-terminal+mutations. assertion.
- assertion asSentence The+unmethylated+Kcnq1+imprinting+control+region+harbors+bidirectional+silencer+activity+and+drives+expression+of+an+antisense+RNA. assertion.
- assertion asSentence A+variant+in+intron+1+of+the+KCNQ1+gene+%28rs757092%2C+%2B1.7+ms%2Fallele%29+is+associated+with+QT+interval+length. assertion.
- assertion asSentence The+researchers+found+an+association+between+gene+deletions+and+duplications+in+the+KCNQ1+gene+and+the+risk+of+long+QT+syndrome. assertion.
- assertion asSentence MinK+is+an+endocytic+chaperone+for+KCNQ1. assertion.
- assertion asSentence Common+genetic+variation+in+KCNQ1+is+associated+with+insulin+secretion+upon+oral+glucose+load+in+a+German+population+at+increased+risk+of+type+2+diabetes. assertion.
- assertion asSentence 2+of+the+8+MiRP2+extracellular+domain+acidic+residues+%28D54+and+D55%29+are+important+for+KCNQ1-MiRP2+constitutive+activation. assertion.
- assertion asSentence CNVs+in+KCNQ1+and+KCNH2+explain+around+3%25+of+LQTS+in+patients+with+no+point+mutation+in+these+genes. assertion.
- assertion asSentence KCNQ1+gene+variants+is+associated+with+new-onset+diabetes+in+tacrolimus-treated+renal-transplanted+patients. assertion.
- assertion asSentence Variation+in+KCNQ1+is+associated+with+therapeutic+response+to+sulphonylureas+in+diabetes+mellitus+type+2. assertion.
- assertion asSentence Surface-expressed+Kv7.1+channels+are+endocytosed+and+sent+for+degradation+in+lysosomes+by+an+AMPK-mediated+activation+of+Nedd4-2+during+the+initial+phase+of+the+MDCK+cell+polarization+process. assertion.
- assertion asSentence KCNQ2+mutation+exists+in+patients+with+benign+familial+infantile+convulsions. assertion.
- assertion asSentence Trafficking+of+KCNQ2%28potassium+voltage-gated+channel%2C+KQT-like+subfamily%2C+member+2+protein%29+potassium+channels+by+calmodulin. assertion.
- assertion asSentence A+cytoplasmic+carboxy-terminal+subunit+interaction+domain+%28sid%29+suffices+to+transfer+assembly+properties+between+KCNQ3+and+KCNQ1. assertion.
- assertion asSentence KDR+plays+a+key+role+in+regulating+the+proliferation+of+HGCC+and+HVEC. assertion.
- assertion asSentence Tgf-beta+mediated+repression+of+flk-1%2FKDR+and+mediated+repression+of+flk-1%2FKDR+and+VEGF+signaling+involves+the+inducible+formation+of+inhibitory+Hex-GATA+signaling+Hex-GATA+involves+the+formation+of+Hex-GATA+complexes. assertion.
- assertion asSentence Vascularization+and+VEGF+and+Flk-1+expression+are+significantly+higher+in+deeply+infiltrating+endometriosis+affecting+the+rectum. assertion.
- assertion asSentence The+expression+of+VEGF-C+and+VEGF+receptors+is+regulated+specifically+in+HL-60+cells+during+macrophage+differentiation. assertion.
- assertion asSentence Surveillance+of+VEGFR-2+levels+to+predict+chemotherapy+response+is+not+useful. assertion.
- assertion asSentence In+malignant+pleural+mesothelioma+cells%2C+plexin-A1+and+VEGF-receptor+2+%28VEGF-R2%29+are+associated+in+a+complex+which+are+involved+in+survival+pathways. assertion.
- assertion asSentence 271+G%3EA+polymorphism+of+the+KDR+gene+is+related+to+transcriptional+regulation+in+patients+with+non-small+cell+lung+cancer. assertion.
- assertion asSentence Repression+of+the+small+Rho+GTPase+Rac1+in+human+endothelial+cellsseems+to+be+an+additional+critical+molecular+mechanism+in+the+regulation+of+VEGFR2+expression. assertion.
- assertion asSentence A+dysregulation+of+the+placental+expression+of+the+VEGFR-2+related+to+the+different+degrees+of+the+gestational+periods. assertion.
- assertion asSentence Ginsenosides+Rg3+can+down-regulate+the+expressions+of+KDR+and+VEGF+in+human+lung+squamous+cancer+SK-MES-1+cells. assertion.
- assertion asSentence Inhibition+of+VEGFR2+augments+cigarette+smoke-induced+oxidative+stress+and+inflammatory+responses+leading+to+endothelial+dysfunction. assertion.
- assertion asSentence Importance+of+syntaxin+6+in+the+maintenance+of+cellular+VEGFR2+levels. assertion.
- assertion asSentence The+immediate+micromechanical+stiffening+is+dependent+on+activation+of+the+vascular+endothelial+growth+factor+receptor+%28VEGFR%29-2%2C+because+inhibition+of+the+receptor+abrogates+the+micromechanical+response. assertion.
- assertion asSentence VEGFR1%3AVEGFR2+ratio+is+substantially+increased+during+hypoxia+to+block+VEGF-A-stimulated+and+VEGFR2-regulated+endothelial+responses+to+maximize+cell+viability+and+recovery. assertion.
- assertion asSentence High+articular+levels+of+the+angiogenetic+factors+VEGF+and+VEGF-receptor+2+as+tissue+healing+biomarkers+after+single+bundle+anterior+cruciate+ligament+reconstruction. assertion.
- assertion asSentence In+MCCRCC+patients+treated+with+sunitinib%2C+VEGF+SNP+-634+is+associated+with+hypertension+and+a+combination+of+VEGF+SNP+936+and+VEGFR2+SNP+889+genotypes+is+associated+with+overall+survival. assertion.
- assertion asSentence VEGFR2+is+critically+involved+in+adhesion+molecule+induction+and+monocytic+cell+recruitment+to+endothelium+in+response+to+non-uniform+shear+stress+and+TNF-alpha. assertion.
- assertion asSentence Thermodynamic+and+structural+description+of+allosterically+regulated+VEGFR-2+dimerization. assertion.
- assertion asSentence The+concentrations+of+VEGF+and+VEGFR2+differed+more+significantly+in+primary+and+recurrent+forms+of+arteriovenous+angiodysplasias+%28as+compared+to+venous+angiodysplasias%29. assertion.
- assertion asSentence Single+nucleotide+polymorphisms+in+VEGFR2+gene+is+associated+with+lymphedema+after+breast+cancer. assertion.
- assertion asSentence DDA3+interacts+with+the+MT+depolymerase+Kif2a+in+an+microtubule-dependent+manner+and+recruits+Kif2a+to+the+mitotic+spindle+and+spindle+poles. assertion.
- assertion asSentence Targeting+of+integrin+beta1+and+kinesin+2alpha+by+microRNA+183. assertion.
- assertion asSentence The+kinesin-2+deficiency+weakened+intercellular+adhesion%2C+despite+the+maintenance+of+adherens+junctions+and+other+desmosome+components+at+the+plasma+membrane. assertion.
- assertion asSentence The+KIR2DL1+gene+polymorphism+and+KIR%2FHLA-C+gene+compatibility+are+associated+with+type+1+diabetes. assertion.
- assertion asSentence KIR2DL2+is+positively+associated+with+diabetes+mellitus%2C+type+1. assertion.
- assertion asSentence In+two+unrelated+viral+infections%2C+hepatitis+C+virus+and+human+T+lymphotropic+virus+type+1%2C+possession+of+the+KIR2DL2+gene+enhanced+both+protective+and+detrimental+HLA+class+I-restricted+anti-viral+immunity. assertion.
- assertion asSentence The+modulated+expression+of+KIR+by+IL-2+and+TGF-beta+can+be+associated+with+the+changed+NK-cytotoxic+target-discriminating+ability+of+NK+cells+upon+their+exposure+to+IL-2+and+TGF-beta. assertion.
- assertion asSentence Despite+its+particular+monoclonal+antibody+reactivity%2C+the+specificity+of+KIR2DL3%2A005+for+HLA-C+molecules+does+not+differ+from+that+of+other+KIR2DL2%2FL3+alleles. assertion.
- assertion asSentence The+single+tyrosine-based+inhibitory+motif+%28ITIM%29in+the+cytoplasmic+domain+of+KIR2DL4+efficiently+inhibits+natural+cytotoxicity+responses+and+recruits+SHP-2+protein+tyrosine+phosphatase+%28but+not+SHP-1%29+to+the+2DL4+cytoplasmic+domain+in+NK+cells. assertion.
- assertion asSentence Signaling+pathways+are+specifically+activated+by+engagement+of+killer+receptor+KIR2DL4+transmembrane+association+with+the+FcepsilonRI-gamma+%28FCER1G%29+receptor+in+natural+killer+%28NK%29+cells. assertion.
- assertion asSentence Differential+transcription+factor+use+by+the+KIR2DL4+promoter+under+constitutive+and+IL-2%2F15-treated+conditions. assertion.
- assertion asSentence Genomic+and+mRNA+sequences+support+the+KIR2DS3%2A002+gene+being+a+hybrid+of+KIR2DS3%2A00103+and+KIR2DS5. assertion.
- assertion asSentence KIR2DS5+gene+codes+for+a+surface+receptor+triggering+natural+killer+cell+function. assertion.
- assertion asSentence KIR+donor-recipient+genotype+is+not+predictive+for+the+outcome+of+unrelated-donor+hematopoietic+stem+cell+tranplantation+in+patients+with+beta-Thalassemia. assertion.
- assertion asSentence kir3dl1+expression+in+K562+cells+is+regulated+by+DNA+methylation. assertion.
- assertion asSentence Polymorphism+at+sites+throughout+the+human+leukocyte+antigen+%28HLA%29+class+I+molecule+can+influence+the+interaction+of+the+HLA+Bw4+epitope+with+KIR3DL1. assertion.
- assertion asSentence The+frequency+of+KIR3DL1%2FS1+subtype+expression+on+NK+cells+contribute+to+the+phenotypic+variation+across+allotypes+with+respect+to+disease+resistance. assertion.