Matches in Nanopublications for { ?s <http://purl.org/nanopub/x/asSentence> ?o ?g. }
- assertion asSentence L1CAM+loss-of-function+mutations+cause+a+severe+form+of+L1+syndrome. assertion.
- assertion asSentence Mechanisms+of+tumoral+L1CAM+induction+and+how+pancreatic+myofibroblasts+contribute+to+malignant+transformation+of+pancreatic+duct+cells+early+in+pancreatic+ductal+adenocarcinoma+tumorigenesis. assertion.
- assertion asSentence L1CAM+downstream+signaling+that+is+fundamental+for+the+development+of+anti-L1CAM+antibody-mediated+therapeutics+in+human+tumor+cells. assertion.
- assertion asSentence Soluble+human+recombinant+fusion+protein+%28hLAG-3Ig%29+used+in+vitro+as+a+single+maturation+agent+induces+phenotypic+maturation+of+monocyte-derived+dendritic+cells+and+promotes+the+production+of+chemokines+and+TNF-alpha+inflammatory+cytokine. assertion.
- assertion asSentence Collagens+are+functional+ligands+for+LAIR-1+and+directly+inhibit+immune+cell+activation+in+vitro. assertion.
- assertion asSentence LAIR-2%2FFc+has+the+capacity+to+interfere+with+platelet-collagen+interactions+mediated+by+Glycoprotein+VI+and+the+VWF%2FGlycoprotein+Ib+axis. assertion.
- assertion asSentence Ku70+is+a+regulator+of+Bax-mediated+pathogenesis+in+laminin-alpha2-deficiency+muscle+cells. assertion.
- assertion asSentence A+single+base+deletion+at+position+8005+in+the+LAMA2+gene+is+associated+with+a+severe+form+of+classical+congenital+muscular+dystrophy+and+partial+merosin+deficiency+in+congenital+muscular+dystrophy+type+1A. assertion.
- assertion asSentence Cell+surface+COL17+can+interact+with+laminin+332+and%2C+together%2C+participate+in+the+adherence+of+a+cell+to+the+extracellular+matrix. assertion.
- assertion asSentence Role+for+laminin-5+during+human+embryogenesis%2C+for+example%2C+for+epithelial+cell+development%2C+beyond+its+involvement+in+hemidesmosome+formation+and+cell+adhesion. assertion.
- assertion asSentence Laminin+beta1+and+integrin+alpha2+expression+is+elevated+in+the+anterior+temporal+neocortex+tissue+from+patients+with+intractable+epilepsy. assertion.
- assertion asSentence Multiple+second-site+mutations%2C+all+correcting+the+germline+mutation+LAMB3+%28628G--%3EA%3BGlu210Lys%29%2C+are+present+in+2+unrelated+non-Herlitz+junctional+epidermolysis+bullosa+patients+with+revertant+mosaicism. assertion.
- assertion asSentence Laminin+gamma+2+chain+exhibits+aberrant+expression+in+a+stepwise+manner+through+different+aggressive+stages+of+tumor+progression. assertion.
- assertion asSentence In+squamous+cell+carcinoma+of+the+tongue+and+colorectal+carcinoma%2C+laminin+5+gamma2+chain+is+important+in+the+invasiveness+of+cancer+cells. assertion.
- assertion asSentence Higher+laminin+332+levels+are+associated+with+aggressive+features+in+breast+cancers. assertion.
- assertion asSentence The+ability+of+LAMR+to+regulate+viability+is+associated+with+its+C-terminal+75+residues. assertion.
- assertion asSentence The+rs182455+polymorphism+of+stathmin+does+not+influence+multiple+sclerosis+susceptibility+or+clinical+disease+course. assertion.
- assertion asSentence LMP1+regulates+Op18%2Fstathmin+signaling+by+cdc2+mediation. assertion.
- assertion asSentence Stathmin+and+interfacial+microtubule+inhibitors+recognize+a+naturally+curved+conformation+of+tubulin+dimers. assertion.
- assertion asSentence Carboxyl-terminal+domain+of+these+closely+related+endotoxin-binding+proteins+dictates+the+route+and+host+responses+to+complexes+they+form+with+endotoxin. assertion.
- assertion asSentence Single+nucleotide+polymorphism+of+the+LBP+gene+is+not+assciated+with+complicated+sepsis+after+trauma. assertion.
- assertion asSentence The+LBR+knockdown+cells+retain+an+ovoid+shaped+nucleus+with+reduced+levels+of+lamin+A%2FC+during+in+vitro+granulopoiesis+induced+with+retinoic+acid. assertion.
- assertion asSentence Deficiency+is+manifested+by+fish+eye+disease. assertion.
- assertion asSentence Functional+LCAT+is+not+required+for+macrophage+cholesterol+efflux+to+human+serum. assertion.
- assertion asSentence Low+LCAT+plasma+levels+are+not+associated+with+increased+atherosclerosis+in+the+general+population. assertion.
- assertion asSentence Sensitivity+to+apoptosis+is+regulated+through+quantitative+changes+in+the+stoichiometry+of+DISC+components+triggered+by+p56%28Lck%29+activation+and+localization. assertion.
- assertion asSentence A+role+of+Galphaq+in+the+fine-tuning+of+proximal+TCR+signals+at+the+level+of+Lck+and+a+negative+regulatory+role+of+Galphaq+in+transcriptional+activation+of+cytokine+responses. assertion.
- assertion asSentence Lck+protects+cells+from+glucocorticoid-induced+apoptosis+and+its+inhibition+enhances+sensitivity+to+dexamethasone. assertion.
- assertion asSentence Tear+lipocalin+is+the+principal+endonuclease+in+human+tear+fluid. assertion.
- assertion asSentence NGAL+in+complex+with+activated+MMP-9+is+present+in+AAA+wall+and+thrombus. assertion.
- assertion asSentence NGAL+is+an+early+predictive+biomarker+of+contrast-induced+nephropathy+in+children. assertion.
- assertion asSentence Hypertension+is+associated+with+kidney+injury+as+reflected+by+elevated+serum+NGAL+and+cystatin+C. assertion.
- assertion asSentence Urine+NGAL+is+an+early+predictive+biomarker+of+acute+kidney+injury+severity+after+cardiopulmonary+bypass. assertion.
- assertion asSentence In+patients+with+chronic+kidney+disease%2C+NGAL+closely+reflects+the+entity+of+renal+impairment+and+represents+a+strong+and+independent+risk+marker+for+disease+progression. assertion.
- assertion asSentence Protein+expression+levels+of+lipocalin-2+are+upregulated+in+visceral+adipose+tissue+of+obese+subjects+along+with+increased+activity+of+matrix+metalloproteinase-2+and+matrix+metalloproteinase-9%2F+lipocalin-2+complex. assertion.
- assertion asSentence In+adult+cardiac+surgery+patients%2C+the+predictive+value+of+NGAL+increases+with+grade+of+acute+kidney+injury+%28AKI%29. assertion.
- assertion asSentence Neutrophil+gelatinase-associated+lipocalin+%28NGAL%29+reflects+iron+status+in+haemodialysis+patients. assertion.
- assertion asSentence NGAL+represents+an+early+biomarker+of+renal+failure+in+patients+undergoing+cardiac+surgery. assertion.
- assertion asSentence High+NGAL+is+associated+with+impaired+kidney+function+in+renal+allograft+recipients. assertion.
- assertion asSentence Both+serum+and+urinary+concentrations+of+NGAL+change+during+the+course+of+cyclosporine+A+treatment. assertion.
- assertion asSentence The+presence+of+elevated+admission+serum+NGAL+levels+is+associated+with+heightened+risk+of+subsequent+worsening+of+renal+function+in+patients+admitted+with+acute+decompensated+heart+failure. assertion.
- assertion asSentence Measurement+of+plasma+NGAL+in+patients+in+the+first+few+hours+after+cardiopulmonary+bypass+is+predictive+of+acute+kidney+injury. assertion.
- assertion asSentence %5Breview%5D+role+of+hepcidin+and+NGAL+in+iron+metabolism+and+its+regulation%2C+particularly+in+kidney+disease. assertion.
- assertion asSentence High+NGAL+is+associated+with+HIV-associated+nephropathy. assertion.
- assertion asSentence NGAL+is+up-regulated+in+patients+with+endometrial+hyperplasia+to+prevent+the+transition+from+hyperplasia+to+carcinoma. assertion.
- assertion asSentence Imatinib+mesylate+therapy+induces+reduction+in+neutrophil+gelatinase-associated+lipocalin+serum+levels+and+increase+in+leptin+concentrations+in+chronic+myeloid+leukemia+patients+in+molecular+remission. assertion.
- assertion asSentence In+abdominal+aortic+aneurysms+NGAL+is+released+by+neutrophils+and+by+the+luminal+part+of+AAA+thrombus. assertion.
- assertion asSentence In+T+cells+all+SLP-76+proteins+are+in+a+approximately+400+kDa+complex+with+the+small+adaptor+protein+Grb2-like+adaptor+protein+Gads. assertion.
- assertion asSentence Three+SNPs+%28G%2FC-14010%2C+T%2FG-13915+and+C%2FG-13907%29+are+associated+with+lactase+persistence+in+African+groups. assertion.
- assertion asSentence In+the+Italian+population+the+LCT-13910C%3ET+polymorphism+is+not+associated+to+the+risk+for+colorectal+cancer+or+polyps. assertion.
- assertion asSentence LDL-M+is+released+into+blood+fo+patients+exposed+to+myocardial+ischemia+reperfusion. assertion.
- assertion asSentence LDH5+is+highly+expressed+in+squamous+cell+head+and+neck+cancer+and+is+linked+with+local+relapse%2C+survival+and+distant+metastasis. assertion.
- assertion asSentence High+LDH+is+associated+with+M1b+prostate+cancer. assertion.
- assertion asSentence Critical+role+of+diacylglycerol-+and+phospholipid-regulated+protein+kinase+C+epsilon+in+induction+of+low-density+lipoprotein+receptor+transcription+in+response+to+depletion+of+cholesterol. assertion.
- assertion asSentence apoE+binds+to+the+LDL+receptor+by+interacting+with+more+than+one+of+the+receptor+ligand-binding+repeats. assertion.
- assertion asSentence LDLR+is+involved+at+an+early+stage+in+infection+of+normal+human+hepatocytes+by+serum-derived+HCV+virions. assertion.
- assertion asSentence The+mRNA+level+of+LDLR+is+downregulated+in+a+tumor+cell+line+by+thymomoquine. assertion.
- assertion asSentence The+LDLR+mutation+p.W556R+is+a+frequent+and+severe+defect+for+familial+hypercholesterolemia%2C+influencing+LDL+lipoprotein+synthesis%2Fcatabolism. assertion.
- assertion asSentence Apolipoprotein+E4+does+not+increase+coronary+heart+disease+risk+in+carriers+of+LDLR+mutations. assertion.
- assertion asSentence LECT2+participates+in+liver+regeneration+and+injury+following+hepatectomy. assertion.
- assertion asSentence Leptin+gene+polymorphism+is+associated+with+hypertension+independent+of+obesity. assertion.
- assertion asSentence Serum+leptin+and+leptin+binding+activity+in+children+and+adolescents+with+hypothalamic+dysfunction. assertion.
- assertion asSentence Skillful+mechanism+where+a+change+in+the+serum+SLEPR+level+regulates%2C+in+part%2C+the+biological+activity+of+leptin+in+the+circulation. assertion.
- assertion asSentence Not+expressed+or+secreted+by+human+luteinized+granulosa+cells. assertion.
- assertion asSentence The+blood+Leptin+level+of+0+-+14+years+old+children+is+consistent+with+the+level+of+growth+of+adiposity+tissue+and+the+degree+of+adiposity+rebound. assertion.
- assertion asSentence There+is+a+developmental+increase+in+leptin+mRNA+expression+in+adipose+tissue+during+childhood%2C+reaching+maximal+capacity+in+adulthood. assertion.
- assertion asSentence Leptin+corrects+plasma+adiponectin%28ApN%29+in+obese+mice+by+restoring+adipose+tissue+ApN+concentrations+and+secretion+via+direct+stimulation+of+ApN+gene+expression. assertion.
- assertion asSentence Leptin+production+is+enhanced+in+Helicobacter+pylori-infected+gastric+mucosa. assertion.
- assertion asSentence Leptin+resistance+is+both+a+consequence+and+cause+of+obesity. assertion.
- assertion asSentence Elevated+blood+levels+correlate+with+insulin+sensitivity+in+pregnancy. assertion.
- assertion asSentence LEP+down-regulates+PPAR+gamma+mRNA+levels+in+primary+monocyte-derived+macrophages. assertion.
- assertion asSentence Leptin+and+the+molar+excess+of+leptin+receptor+are+better+biomarkers+of+nutritional+status+than+IGF-I+in+protein+malnutrition+children+during+nutritional+recovery. assertion.
- assertion asSentence Leptin%2C+rather+than+insulin%2C+is+the+major+regulator+of+hepatic+monounsaturated+fatty+acid+synthesis+in+obesity-linked+diabetes. assertion.
- assertion asSentence Leptin+is+a+trophic+and+mitogenic+factor+for+trophoblastic+cells+by+virtue+of+its+inhibiting+apoptosis+and+promoting+proliferation. assertion.
- assertion asSentence Follicular+fluid+levels+of+leptin+are+a+better+predictor+of+oocyte+fertilization+success+rates+than+follicular+diameter+in+women+undergoing+controlled+ovarian+stimulation. assertion.
- assertion asSentence Blood+leptin+is+reduced+by+glucose+uptake+in+insulin-sensitive+normal+adults. assertion.
- assertion asSentence Leptin%27s+gene+expression+regulation+in+breast+cancer+is+dependent+on+HIF-1alpha. assertion.
- assertion asSentence In+children%2C+leptin+levels+worsen+throughout+the+continuum+of+obesity+and+especially+in+the+presence+of+components+of+the+metabolic+syndrome. assertion.
- assertion asSentence Circulating+LEP+level+affects+insulin+resistance+in+healthy+premenopausal+obese+women. assertion.
- assertion asSentence Chronic+pancreatitis+in+humans+is+associated+with+decreases+in+serum+leptin+and+insulin+concentrations. assertion.
- assertion asSentence Rosiglitazone+improves+the+insulin+sensitivity+with+increased+serum+leptin+levels+in+patients+with+type+2+diabetes. assertion.
- assertion asSentence Ghrelin+and+leptin+interact+in+the+central+nervous+system+and+affect+energy+metabolism. assertion.
- assertion asSentence Leptin-receptor+play+a+role+in+the+development+of+obesity+through+leptin+resistance+and+blunted+leptin-mediated+sympathetic+nerve+activity. assertion.
- assertion asSentence Leptin+amplifies+the+pro-atheromatic+properties+of+human+monocytes+through+a+complex+signaling+net. assertion.
- assertion asSentence PTP-1B+constitutes+a+key+divergent+element+between+leptin%2Finsulin+and+CNTF+signaling+pathways+at+the+neuronal+level. assertion.
- assertion asSentence Increased+leptin+expression+is+associated+with+colorectal+adenocarcinoma. assertion.
- assertion asSentence In+patients+with+moderate-to-severe+obstructive+sleep+apnea%2C+compliant+CPAP+usage+reduced+leptin+levels. assertion.
- assertion asSentence Leptin+exerts+an+anti-apoptotic+effect+on+human+dendritic+cells+via+the+PI3K-Akt+signaling+pathway. assertion.
- assertion asSentence The+angiogenic+effects+of+leptin+are+mediated+by+circulating+angiogenic+cells+and+involve+src+kinase+dependent+phosphorylation+of+integrin+alphavbeta5. assertion.
- assertion asSentence Leptin+does+not+independently+predict+the+risk+of+diabetes+and+impaired+fasting+glucose+in+older+Chinese+adults. assertion.
- assertion asSentence The+adiponectin-leptin+ratio+is+associated+with+insulin+resistance%2C+measured+with+the+euglycemic+hyperinsulinemic+clamp%2C+in+Caucasians+with+T2D. assertion.
- assertion asSentence 17beta-estradiol+induces+leptin+expression+in+trophoblastic+cells+via+crosstalk+between+estrogen+receptor+1+and+MAPK+and+PI3K+signal+transduction+pathways. assertion.
- assertion asSentence Spa+therapy+can+modify+plasma+levels+of+the+adipocytokines+leptin+and+adiponectin%2C+important+mediators+of+cartilage+metabolism. assertion.
- assertion asSentence In+older+adults+leptin+in+both+sexes+are+positively+associated+with+hip+joint+space+narrowing%28JSN%29.Association+between+body+composition+and+hip+JSN+in+women+are+mediated+by+leptin. assertion.
- assertion asSentence Leptin+up-regulates+MUC5B+expression+in+human+airway+epithelial+cells+via+activation+of+ERK1%2F2+or+p38+MAPK. assertion.
- assertion asSentence Estrogen+receptor+alpha+pathway+is+involved+in+leptin-induced+ovarian+cancer+cell+growth. assertion.
- assertion asSentence Sprint+exercise+performed+under+fasting+conditions+is+a+leptin+signaling+mimetic+in+human+skeletal+muscle. assertion.
- assertion asSentence In+women+with+morbid+obesity%2C+subcutaneous+adipose+tissue+in+forearm+releases+increased+leptin+%28and+interleukin-6%29+as+compared+to+control. assertion.
- assertion asSentence High+leptin+is+associated+with+higher+hypertension%2C+inflammation+and+insulin+resistance+independently+of+BMI+and+fat+distribution+among+overweight+men. assertion.
- assertion asSentence Cultured+human+articular+chondrocytes+express+functional+leptin+receptor+Ob-R%2C+a+receptor+present+on+chondrocytes+in+native+human+cartilage. assertion.