Matches in Nanopublications for { ?s <http://purl.org/nanopub/x/asSentence> ?o ?g. }
- assertion asSentence LTA+252+genotype+is+associated+with+noncardia+gastric+cancer+of+diffuse+type+in+Japan. assertion.
- assertion asSentence Patients+with+TNFbeta+%2B+252+AA+genotype+have+protection+against+the+risk+of+grade+II-IV+aGVHD. assertion.
- assertion asSentence The+LTA+%2B252+A%2FG+polymorphism+is+associated+with+both+susceptibility+to+and+mortality+from+sepsis. assertion.
- assertion asSentence LTA+%2B252G+allele+is+associated+with+increased+risk+for+the+presence+of+gastric+cancer+in+a+Helicobacter+pylori+infection+positive+subgroup. assertion.
- assertion asSentence MT1-MMP-mediated+proteolytic+processing+of+ECM-bound+LTBP-1+is+a+mechanism+to+release+latent+TGF-beta+from+the+subendothelial+matrix. assertion.
- assertion asSentence TGF-beta%281%29+augmented+Tumor+necrosis+factor-like+weak+inducer+of+apoptosis+%28TWEAK%29-induced+production+of+IL-8+and+MCP-1+by+retinal+pigment+epithelial+cells. assertion.
- assertion asSentence Latent+transforming+growth+factor+beta-binding+proteins-2+and+-3+inhibit+the+proprotein+convertase+5%2F6A. assertion.
- assertion asSentence Kidney-Tonifying+plus+Blood-Promoting+Recipe+regulates+CD11b%2FCD18+and+Bcl-2%2FBax+expression+in+blood+leukocytes+and+improves+microcirculatory+status+in+aged+patients+with+kidney+deficiency+and+blood+stasis+syndrome. assertion.
- assertion asSentence Expression+of+LTC%284%29S+during+normal+and+leukemic+myelopoiesis+and+correlation+with+the+activity+of+the+disease-specific+tyrosine+kinase+p210+BCR-ABL+in+CML+myeloid+cells. assertion.
- assertion asSentence LTC4S+plays+a+key+role+in+the+process+of+inflammation+as+the+rate+limiting+enzyme+in+the+conversion+of+arachidonic+acid+to+cysteinyl-leukotrienes%2C+important+mediators+of+inflammatory+responses. assertion.
- assertion asSentence The+catalytic+architecture+of+leukotriene+C4+synthase+with+two+arginine+residues. assertion.
- assertion asSentence Bacteriostatic+activity+of+human+lactoferrin+against+Staphylococcus+aureus+is+a+function+of+its+iron-binding+properties+and+is+not+influenced+by+antibiotic+resistance. assertion.
- assertion asSentence The+context+of+the+lactoferrin+gene+influences+the+ERalpha-mediated+transcriptional+activity. assertion.
- assertion asSentence High+lactoferrin+concentrations+in+the+milk+of+transgenic+cows+do+not+protect+them+from+intramammary+Escherichia+coli+infection. assertion.
- assertion asSentence Lactoferrin+sequestration+of+iron+by+human+neutrophils+is+important+for+host+defense+against+the+common+mold+Aspergillus+fumigatus. assertion.
- assertion asSentence This+secondary+granule+protein+is+present+in+cells+from+the+myelocyte+stage+and+throughout+neutrophil+differentiation. assertion.
- assertion asSentence Lactoferrin+exploits+the+control+mechanism+of+E2F1-regulated+target+genes+or+Bcl-2+family+gene+networks+involved+in+the+apoptotic+process+in+Jurkat+human+leukemia+T+lymphocytes. assertion.
- assertion asSentence Lactoferrin+is+internalized+mainly+by+the+clathrin-dependent+pathway+in+THP-1+cells+and+targets+the+endoplasmic+reticulum. assertion.
- assertion asSentence The+Laminin+511%2F521-binding+site+on+the+Lutheran+blood+group+glycoprotein+is+located+at+the+flexible+junction+of+Ig+domains+2+and+3. assertion.
- assertion asSentence Lumican+induces+cell+migration+by+activating+ERK+1%2F2+signaling+and+ERK+1%2F2+stimulates+expression+of+integrin+beta1. assertion.
- assertion asSentence Homologous+sequence+in+lumican+and+fibromodulin+leucine-rich+repeat+5-7+competes+for+collagen+binding. assertion.
- assertion asSentence Expression+and+roles+of+lumican+in+lung+adenocarcinoma+and+squamous+cell+carcinoma. assertion.
- assertion asSentence Genetic+variation+in+lumican+gene+is+associated+with+breast+cancer. assertion.
- assertion asSentence The+LYN+is+present+in+the+majority+of+mediastinal+B+cell+lymphomas. assertion.
- assertion asSentence Activation+of+Lyn+and+its+interaction+with+rafts+and+toll-like+receptor+2+play+an+important+role+in+the+initial+stages+of+Pseudomonas+aeruginosa+interaction+with+host+lung+cells. assertion.
- assertion asSentence SAP+forms+a+ternary+complex+with+the+kinase+Lyn+and+the+inhibitory+IgG+Fc+receptor+FcgammaRIIB+to+regulate+B+cell+proliferation+and+survival. assertion.
- assertion asSentence Mutations+in+the+gene+SH2D1A+is+associated+with+X-linked+lymphoproliferative+syndrome+type+1. assertion.
- assertion asSentence TROP2+overexpression+is+an+independent+prognostic+marker+in+patients+with+oral+squamous+cell+carcinoma. assertion.
- assertion asSentence The+expression+of+Trop-2+is+correlated+with+the+development+and+malignancy+of+pancreatic+cancer. assertion.
- assertion asSentence Trop-2+is+overexpressed+in+a+proportion+of+human+uterine+%28UMMT%29+and+ovarian+%28OMMT%29+carcinosarcoma. assertion.
- assertion asSentence Prognostic+impact+of+this+and+other+cancer+stem+cell+markers+expression+in+colorectal+cancer. assertion.
- assertion asSentence High+EpCAM+expression+is+associated+with+cervical+adenosquamous+carcinomas. assertion.
- assertion asSentence In+Lyncho+syndrome+EPCAM+expression+in+tumors+from+EPCAM+deletion+carriers+depends+on+the+localization+of+the+second+somatic+hit+that+inactivates+MSH2. assertion.
- assertion asSentence MiR-16+negatively+regulate+HMGA1+and+caprin-1+which+are+involved+in+cell+proliferation. assertion.
- assertion asSentence NBR1+together+with+p62+promotes+autophagic+degradation+of+ubiquitinated+targets+and+simultaneously+regulates+their+aggregation+when+autophagy+becomes+limited. assertion.
- assertion asSentence Breast+and+ovarian+cancer+risk+are+high+in+Jewish+women+with+BRCA1+genetic+mutation. assertion.
- assertion asSentence MARCKS+proteolysis+is+necessary+for+the+fusion+of+myoblasts. assertion.
- assertion asSentence PKC+delta+plays+an+important+role+in+mucin+secretion+by+airway+epithelium+via+regulation+of+MARCKS+phosphorylation. assertion.
- assertion asSentence BK+promotes+neurite+outgrowth+through+transient+MARCKS+phosphorylation+involving+the+PKC-dependent+RhoA%2FROCK+pathway+and+PP2A+in+a+neuroblastoma+cell+line. assertion.
- assertion asSentence The+PTEN+tumor+suppressor+gene+is+a+target+of+MAD1. assertion.
- assertion asSentence Existence+of+a+symmetric+Mad2+dimer+with+Mad1-assisted+conformational+activation+in+the+spindle+checkpoint. assertion.
- assertion asSentence Tpr+regulates+Mad1-Mad2+proteins+are+regulated+during+the+cell+cycle+and+mitotic+spindle+checkpoint+signaling. assertion.
- assertion asSentence Smad1+directly+regulated+transcription+for+Col4+through+the+binding+of+Smad1+to+the+promoter+of+Col4. assertion.
- assertion asSentence BMP-9+induced+endothelial+cell+tubule+formation+and+inhibition+of+migration+involves+Smad1+driven+endothelin-1+production. assertion.
- assertion asSentence Smurf1+is+a+negative+feedback+regulator+for+IFN-gamma+signaling+by+targeting+STAT1+for+ubiquitination+and+proteasomal+degradation. assertion.
- assertion asSentence Levels+of+phosphorylated+Smad2%2F3+are+sensors+of+the+interplay+between+effects+of+retinoic+acid+and+TGF-beta+or+vitamin+D3+on+monocytic+and+granulocytic+differentiation+of+HL-60+cells. assertion.
- assertion asSentence mRNA+expressed+in+human+granulosa-luteal+cells+at+oocyte+retrieval. assertion.
- assertion asSentence High+D-glucose+increases+L-arginine+transport+and+eNOS+expression+following+TbetaRII+activation+by+TGF-beta1+involving+p42%2F44%28mapk%29+and+Smad2+in+HUVEC. assertion.
- assertion asSentence Single+nucleotide+polymorphism+in+SMAD2+gene+is+associated+with+acute+lymphoblastic+leukemia. assertion.
- assertion asSentence TGFbeta1-induced+Smad2+nuclear+translocation+is+negatively+regulated+by+intracellular+Ca%282%2B%29+in+OLI-neu+cells+and+increased+intracellular+Ca%282%2B%29+concentrations+block+Smad2-mediated+transcription+of+TGFbeta+target+genes. assertion.
- assertion asSentence Smad2+loss+causes+HGF+upregulation+via+loss+of+Smad2-mediated+transcriptional+repression+and+enhanced+Smad3%2F4-mediated+transactivation. assertion.
- assertion asSentence Smad2%2F3+and+p38+MAPK+differentially+regulate+TGFB1-induced+epithelial-mesenchymal+transition+in+pulmonary+epithelial+cells. assertion.
- assertion asSentence L+type-specific+target+selection+by+combinatorial+binding+of+Smad2%2F3+proteins+and+hepatocyte+nuclear+factor+4alpha+in+HepG2+cells. assertion.
- assertion asSentence Tuberin+%28TSC2%29+interact+with+smad2%2Fsmad3+during+TGF-beta1+growth+regulation. assertion.
- assertion asSentence HCV+viral+proteins+interact+with+the+TGF-beta+signaling+mediator+Smad3+and+differentially+impair+TGF-beta%2FSmad3-mediated+transactivation+and+growth+inhibition. assertion.
- assertion asSentence mRNA+expressed+in+human+granulosa-luteal+cells+at+oocyte+retrieval. assertion.
- assertion asSentence SMAD3+dependent+inactivation+of+CYP17+promoter+activity+and+repression+of+SF-1+expression. assertion.
- assertion asSentence Ligand-dependent+ubiquitination+of+Smad3+is+regulated+by+CK1g2%2C+an+inhibitor+of+TGF-beta+signaling. assertion.
- assertion asSentence Protein+phosphatase+PPM1A+regulates+the+nuclear+export+of+Smad2%2F3+through+targeting+nuclear+exporter+RanBP3. assertion.
- assertion asSentence Low+Smad3+is+associated+with+lung+cancer. assertion.
- assertion asSentence Cancer+cell+lines+harboring+Smad4+point+mutations+exhibited+rapid+Smad4+protein+degradation+due+to+the+effect+of+SCF%28beta-TrCP1%29. assertion.
- assertion asSentence There+are+two+populations+of+TGF-beta+target+genes+that+are+distinguished+by+their+dependency+on+Smad4. assertion.
- assertion asSentence Smad4+plays+the+role+in+the+transcriptional+activation+of+NF-kappaB. assertion.
- assertion asSentence In+MSI+CRC+this+is+associated+predominantly+with+impaired+BMPR2+expression+and+in+MSS+CRC+with+impaired+SMAD4+expression. assertion.
- assertion asSentence Inhibition+of+pancreatic+carcinoma+cell+growth+in+vitro+by+DPC4+gene+transfection. assertion.
- assertion asSentence Smad4+is+dispensable+for+enhanced+invasiveness+of+human+colorectal+cancer+cells+due+to+BMP-4+overexpression. assertion.
- assertion asSentence TGFbeta1+down-regulated+expression+of+prolactin+and+IGFBP-1+in+endometrial+stromal+cells+in+SMAD4-dependent+and+SMAD4-independent+manners. assertion.
- assertion asSentence Smad6+bound+to+Pellino-1+promoted+TGF-beta-mediated+anti-inflammatory+effects. assertion.
- assertion asSentence Splice+variant+Smad6B%2C+in+human+prostatic+and+rodent+testicular+cell+lines%2C+exhibits+a+truncated+C-terminus+lacking+the+entire+MH-2+domain+and+most+parts+of+the+linker+region. assertion.
- assertion asSentence Loss+of+SMAD6+is+associated+with+lung+adenocarcinoma. assertion.
- assertion asSentence Smad6+indirectly+maintains+stemness+by+preventing+spontaneous+erythropoiesis+in+hematopoietic+stem+cells. assertion.
- assertion asSentence Axin+and+Arkadia+cooperate+with+each+other+in+promoting+Smad7+ubiquitination. assertion.
- assertion asSentence TGFbeta+rapidly+induces+nuclear+translocation+of+Smad+proteins+and+subsequently+stimulates+Smad-Sp1+complex+formation+which+increases+Sp1+binding+to+promoter+boxes+in+a+pancreatic+cancer+cell+line. assertion.
- assertion asSentence Genetic+variants+of+SMAD7+are+markers+predisposing+to+colon+cancer%2C+specifically+in+women. assertion.
- assertion asSentence Both+ZEB1+downregulation+and+Smad7+overexpression+contribute+to+resistance+to+TGF-beta1-mediated+growth+suppression+in+adult+T-cell+leukemia%2Flymphoma. assertion.
- assertion asSentence Smad7+overexpression+is+effective+in+blocking+gingival+myofibroblast+transformation+and+activation. assertion.
- assertion asSentence The+Smad7-APC+complex+links+the+TGFbeta+type+I+receptor+to+the+microtubule+system+to+regulate+directed+cellular+extension+and+migratory+responses+evoked+by+TGFbeta. assertion.
- assertion asSentence CD13+transcription+is+regulatd+by+MAF+via+an+atypical+response+element. assertion.
- assertion asSentence RNF10+is+a+trans-acting+protein+regulating+MAG+expression+and+is+required+for+myelin+formation. assertion.
- assertion asSentence MAGE-A3+gene+mRNA+is+expressed+at+the+mRNA+level+in+a+proportion+of+human+leukemias. assertion.
- assertion asSentence In+stage+III+melanomas+the+expression+of+MAGE-3%2C+either+alone+or+in+association+with+the+expression+of+other+tumour-specific+antigens+at+a+transcriptional+level%2C+is+a+good+prognostic+factor+for+higher+disease-free+survival. assertion.
- assertion asSentence MAGE3+expression+mediated+by+demethylation+of+MAGE3+promoter+induce+progression+of+non-small+cell+lung+cancer. assertion.
- assertion asSentence Expressed+in+a+large+part+of+epithelial+skin+tumors+with+predominantly+scattered+immunoexpression+pattern+in+organ-transplant+recipients. assertion.
- assertion asSentence High+MAGE-A10+is+associated+with+lung%2C+skin+and+urothelial+malignancies. assertion.
- assertion asSentence The+Mal-Toll%2Finterleukin-1+receptor+%28TIR%29+domains+AB+loop+is+capable+of+mediating+direct+binding+to+the+TIR+domains+of+TLR4+and+MyD88+simultaneously. assertion.
- assertion asSentence MAO-A+promoter+polymorphism+is+associated+with+Moclobemide+response+in+depressed+patients. assertion.
- assertion asSentence Monoamine+oxidase+A+variant+influences+antidepressant+treatment+response+in+female+patients+with+Major+Depression. assertion.
- assertion asSentence 5-HT2A+and+MAOA+genes%2C+regulating+activity+of+serotonin%2C+influence+on+subjective+time+flow. assertion.
- assertion asSentence Contribution+of+the+MAOA+gene%2C+parenting+style+and+their+interactions+to+variation+in+the+risk+for+early+onset+behavior+disorders+and+liability+to+substance+use+disorders. assertion.
- assertion asSentence MAOA-uVNTR+polymorphism+can+affect+activation+of+limbic+regions%2C+elicited+by+negative+emotional+stimuli. assertion.
- assertion asSentence In+boys+hemizygosity+for+the+short+MAO-A+hemizygosity+for+the+short+MAO-A+Variable+Number+of+Tandem+Repeats%28VNTR%29+allele+is+s+associated+with+disruptive+behavior+allele+is+associated+with+disruptive+behavior. assertion.
- assertion asSentence High-activity+variants+of+the+uMAOA+polymorphism+increase+the+risk+for+depression+in+large+primary+care+sample. assertion.
- assertion asSentence The+adverse+consequences+of+physical+discipline+on+forms+of+externalizing+behavior+are+exacerbated+by+an+underlying+biological+risk+conferred+by+MAOA+genotype. assertion.
- assertion asSentence MAOB+gene+is+associated+with+autistic+traits%2C+empathy+and+Asperger+syndrome. assertion.
- assertion asSentence In+early+stage+Alzheimer+disease%2C+discrete+MAO-B+reduction+reflects+the+capacity+of+the+population+of+MAO-B-positive+progenitor+cells+to+adapt+to+the+neurodegenerative+process. assertion.
- assertion asSentence Amyloid-beta+1-42+binds+to+a+peptide+comprising+the+microtubule+binding+domain+of+the+heavy+chain+of+microtubule-associated+protein+1B+by+the+screening+of+a+human+brain+cDNA+library+expressed+on+M13+phage. assertion.
- assertion asSentence Tat+action+on+MAP2+stability+involved+Tat-mediated+translocation+of+the+proteasome+to+the+site+of+microtubule+filaments. assertion.
- assertion asSentence In+aging+and+sporadic+Alzheimer%27s+disease%2C+severe+tau+pathology+%28stage+7+to+stage+10%29+correlates+well+with+a+huge+and+widespread+Abeta+burden. assertion.
- assertion asSentence Overexpression+of+human+tau+in+Drosophila+larvae+disrupts+axonal+transport+causing+vesicle+aggregation+and+this+is+associated+with+loss+of+locomotor+function. assertion.
- assertion asSentence Both+in+multiple+sclerosis+and+other+inflammatory+neurological+diseases%2C+tau+protein+levels+in+the+cerebrospinal+fluid+%28csf%29+are+significantly+higher+than+in+csf+samples+from+non-inflammatory+neurological+diseases. assertion.