Matches in Nanopublications for { ?s <http://purl.org/nanopub/x/asSentence> ?o ?g. }
- assertion asSentence A+gene+deletion+of+MAPT+at+chromosome+17q21.3+is+associated+with+developmental+delay+and+learning+disability. assertion.
- assertion asSentence Glycogen+synthase+kinase+3+betais+the+missing+link+between+the+amyloid+and+tau-pathology+in+Alzheimer+disease. assertion.
- assertion asSentence FTDP-17T+is+associated+with+symmetric+frontotemporal+atrophy+and+FTDP-17U+with+an+asymmetric+degenerative+process+in+parkinsonism+and+frontotemporal+dementia. assertion.
- assertion asSentence A+caspase-cleaved+NH2-terminal+tau+fragment+of+20-22+kDa%2C+consistent+with+the+size+of+the+N-terminal+26-230+amino-acid+neurotoxic+fragment+of+tau%2C+is+generated+in+vitro+in+differentiated+human+SH-SY5Y+cells. assertion.
- assertion asSentence VQIINK+%28280%29+and+VQIVYK+%28311%29+are+the+major%2C+if+not+sole%2C+critical+regions+that+directly+mediate+intermolecular+contact+between+tau+molecules+during+the+early+phases+of+Tau+aggregation. assertion.
- assertion asSentence MAPT+is+a+susceptibility+gene+for+progressive+supranuclear+palsy. assertion.
- assertion asSentence Pathological+accumulation+of+amyloid-beta+protein+and+hyperphosphorylation+of+tau+develop+concomitantly+within+synaptic+terminals+of+Swedish+mutant+transgenic+mice. assertion.
- assertion asSentence Conformational+diversity+of+wild-type+Tau+fibrils+specified+by+templated+conformation+change. assertion.
- assertion asSentence MAPT+deletion+exacerbates+the+Niemann-Pick+type+C+phenotype. assertion.
- assertion asSentence Activation+of+transgenic+c-Abl+by+amyloid+beta+precursor+proteinbeta+promotes+tau+phosphorylation+through+Tyr15+phosphorylation-mediated+Cdk5+activation. assertion.
- assertion asSentence Baseline+CSF+levels+of+tau+phosphorylated+at+threonine+181+are+independently+associated+with+subsequent+disease+progression%2C+as+reflected+by+hippocampal+atrophy+rate. assertion.
- assertion asSentence At+the+time+of+Alzheimer+disease+diagnosis%2C+a+combination+of+high+CSF+tau+without+proportionally+elevated+p-tau-181+is+associated+with+a+faster+rate+of+cognitive+decline. assertion.
- assertion asSentence Accumulation+of+cytosolic+hyperphosphorylated+forms+of+human+Tau+proteins+correlates+with+human+Tau-mediated+neurodegeneration+in+flies%2C+supporting+the+key+role+of+soluble+cytosolic+hyperphosphorylated+Tau+proteins+as+toxic+species+in+vivo. assertion.
- assertion asSentence In+frontotemporal+lobar+degeneration%2C+cerebrospinal+fluid+tau+levels+are+associated+with+increased+neurodegeneration+and+poor+outcome. assertion.
- assertion asSentence Tau+accumulation+is+present+in+seizure-associated+glioneuronal+lesions+associated+with+abnormal+reconstitution+of+the+cortex. assertion.
- assertion asSentence Elevation+of+NPEPPS+activity+blocks+accumulation+of+hyperphosphorylated+TAU+protein+and+slows+down+the+progression+of+Alzheimer%27s+disease. assertion.
- assertion asSentence Failure+of+proteasomal+and+non-proteasomal+proteolytic+clearance+mechanisms+leads+to+tau+accumulation+and+progressive+neurofibrillary+degeneration+in+Alzheimer%27s+disease. assertion.
- assertion asSentence Subjects+with+FTD+with+GRN+mutations+have+a+faster+rate+of+whole+brain+atrophy+than+subjects+with+FTD+with+MAPT+mutations%2C+with+similar+rates+of+hippocampal+atrophy. assertion.
- assertion asSentence Functional+connectivity+in+the+default+mode+network+is+altered+in+MAPT+subjects+before+the+occurrence+of+both+atrophy+and+clinical+symptoms+in+behavioral+variant+frontotemporal+dementia. assertion.
- assertion asSentence Ubiquitin+targeting+of+tau+protein+occurs+at+neurofibrillary+tangles+in+the+early+and+intermediate+maturation+stages. assertion.
- assertion asSentence Intramolecular+disulfide+bonds+retard+tau+aggregation+by+stabilizing+conformations+that+lack+beta-strand+content+in+subsequences+that+are+aggregation-prone. assertion.
- assertion asSentence In+the+Australian+GWAS%2C+the+SNP+rs7530302+near+MARK1+on+chromosome+1+%28p%3D1.90+x+10%28-9%29+achieved+genomewide+significance+for+comorbid+AD%2FND. assertion.
- assertion asSentence The+C-TAK1%2Fp78+constitutively+associates+with+and+phosphorylates+KSR1+generating+a+14-3-3+binding+site. assertion.
- assertion asSentence 14-3-3+binding+to+MARK3+is+dependent+on+phosphorylation. assertion.
- assertion asSentence Lower+expression+of+both+MAT2A+and+MAT2beta+and+interfere+with+leptin+signaling+in+liver+cancer+cells. assertion.
- assertion asSentence There+is+an+association+between+matrilin-1+levels+and+curve+progression+in+adolescent+idiopathic+scoliosis. assertion.
- assertion asSentence High+Ubiquitin-specific+protease+14+expression+associated+with+intrahepatic+cholangiocarcinoma+cell+differentiation. assertion.
- assertion asSentence De-ubiquitinating+protease+USP2a+targets+RIP1+and+TRAF2+to+mediate+cell+death+by+TNF. assertion.
- assertion asSentence USP10+mediates+the+deubiquitination+of+p53%2C+regulating+deubiquitination+activity+of+USP10+and+USP13+by+Beclin1+provides+a+mechanism+for+Beclin1+to+control+the+levels+of+p53. assertion.
- assertion asSentence Activation+of+PKCdelta+in+response+to+Camptothecin+treatment+requires+Myc+and+is+important+in+CPT-mediated+apoptosis+signaling. assertion.
- assertion asSentence Overexpression+of+the+MTA1+gene+correlates+with+lymph+node+metastasis+of+carcinomas+of+the+larynx. assertion.
- assertion asSentence Metastasis-associated+gene+1+expression+is+significantly+associated+with+malignant+behavior+in+pancreatic+endocrine+tumors. assertion.
- assertion asSentence K75+expression+is+closely+associated+with+the+process+of+desquamation+of+the+inner+root+sheath+of+hair+follicles. assertion.
- assertion asSentence In+corneal+epithelium+and+cell+lines+human+monocarboxylic+acid+transporter+4+is+expressed+at+mRNA+and+protein+levels. assertion.
- assertion asSentence Cornelia+de+Lange+syndrome+mutations+in+SMC1A+or+SMC3+bind+to+DNA+with+higher+affinity+and+display+genomic+instability. assertion.
- assertion asSentence Mutations+in+HPRP3%2C+a+third+member+of+pre-mRNA+splicing+factor+genes%2C+implicated+in+autosomal+dominant+retinitis+pigmentosa. assertion.
- assertion asSentence A+mutation+in+the+PRPF3+gene+is+rare+compared+to+other+genes+causing+autosomal+dominant+retinitis+pigmentosa. assertion.
- assertion asSentence Hibiscus+syriacus+extract+exhibits+a+cytotoxic+effect+on+lung+cancer+cells+by+activation+p53+and+AIF. assertion.
- assertion asSentence Different+mechanisms+preserve+translation+of+programmed+cell+death+8+and+JunB+in+poliovirus-infected+endothelial+cells. assertion.
- assertion asSentence Mammalian+and+yeast+U3+snoRNPs+are+matured+in+specific+and+related+nuclear+compartments. assertion.
- assertion asSentence Upon+beta%282%29AR+activation%2C+both+betaArrestin2+and+p115RhoGEF+translocate+to+the+plasma+membrane%2C+with+concomitant+activation+of+RhoA+and+formation+of+focal+adhesions+and+stress+fibers. assertion.
- assertion asSentence Activation+of+p115-RhoGEF+requires+direct+association+of+Galpha13+and+the+Dbl+homology+domain. assertion.
- assertion asSentence Calpain1+plays+an+important+role+in+controlling+the+levels+of+autophagy+in+normal+living+cells+by+regulating+the+levels+of+a+key+signaling+molecule%2C+ATG12-ATG5+conjugate. assertion.
- assertion asSentence PDCD5+expression+in+bone+marrow+nucleated+cells+in+untreated+acute+myeloid+leukemia+patients+is+lower+than+in+normal+controls. assertion.
- assertion asSentence The+kinase+Mirk+is+essential+for+the+growth+and+survival+of+osteosarcoma+cells. assertion.
- assertion asSentence A+functional+EXO1+promoter+variant+is+associated+with+prolonged+life+expectancy+in+centenarians. assertion.
- assertion asSentence WRN+helicase+operates+in+an+EXO1-dependent+pathway+to+help+cells+survive+replicational+stress. assertion.
- assertion asSentence Proprotein+convertase+PC7+enhances+the+activation+of+the+EGF+receptor+pathway+through+processing+of+the+EGF+precursor. assertion.
- assertion asSentence The+expression+of+Tbeta10+in+the+human+kidney+during+the+initial+phases+of+its+physiological+development%2C+mainly+restricted+in+the+proximal+and+the+distal+tubuli. assertion.
- assertion asSentence Thymosin+beta10+expression+driven+by+the+human+TERT+promoter+induces+ovarian+cancer-specific+apoptosis+through+ROS+production. assertion.
- assertion asSentence Percent+change+in+ST2+biomarker+concentrations+during+acute+heart+failure+treatment+is+predictive+of+90-day+mortality+and+is+independent+of+B-type+natriuretic+peptide+%28BNP%29+or+amino-terminal+brain+natriuretic+peptide+precursor+%28NT-proBNP%29+levels. assertion.
- assertion asSentence ST2+is+a+potent+marker+of+risk+in+chronic+heart+failure+and+when+used+in+combination+with+NT-proBNP+offers+moderate+improvement+in+assessing+prognosis+beyond+clinical+risk+scores. assertion.
- assertion asSentence sST2+is+a+strong+predictor+of+mortality+in+patients+presenting+with+acute+dyspnea%2C+particularly+those+with+preserved+LVEF. assertion.
- assertion asSentence Epigenetic+silencing+and+DNA+methylation+of+OSMR+is+associated+with+colorectal+cancers. assertion.
- assertion asSentence Heparin+inhibits+pulmonary+artery+smooth+muscle+cell+proliferation+through+GEF-H1%2FRhoA%2FROCK%2Fp27+signaling+pathway. assertion.
- assertion asSentence Accumulation+of+ZW10+at+tensionless+kinetochores+stems+from+a+4-fold+reduction+of+kinetochore+turnover+rate+and+requires+aurora+B+kinase+activity. assertion.
- assertion asSentence Gamma-hydroxybutyric+acid+%28GHB%29+is+a+substrate+for+both+MCT2+and+MCT4. assertion.
- assertion asSentence A+missense+mutation+in+SLC33A1+causes+autosomal-dominant+spastic+paraplegia. assertion.
- assertion asSentence High+DCAMKL1+is+associated+with+HCV-induced+hepatocarcinogenesis. assertion.
- assertion asSentence Hypergonadotropic+ovarian+failure+is+associated+with+an+inherited+mutation+of+human+bone+morphogenetic+protein-15+gene. assertion.
- assertion asSentence BMP15+is+associated+with+high+response+to+ovarian+stimulation. assertion.
- assertion asSentence The+target+antigen+of+antibodies+in+patients+with+limbic+encephalitis+previously+attributed+to+voltage-gated+potassium+channels+is+in+fact+LGI1%2C+a+secreted+neuronal+protein+that+functions+as+a+ligand+for+two+epilepsy-related+proteins%2C+ADAM22+and+ADAM23. assertion.
- assertion asSentence Antibodies+bind+to+proteins+complexed+with+voltage-gated+potassium+channel+%28VGKC%29+complex+in+two+patients+with+LG11-antibody+encephalitis. assertion.
- assertion asSentence Multinucleated+giant+tumor+cells+remain+in+the+early+mitotic+phase+because+of+aurora-B+dysfunction%2C+effecting+aberrations+in+cytoplasmic+cleavage+without+affecting+nuclear+division. assertion.
- assertion asSentence Aurora+B+is+responsible+for+mitotic+arrest+in+the+absence+of+aurora+A. assertion.
- assertion asSentence Anti-proliferative+effect+of+p53+tumor+suppressor+is+activated+by+aurora+B+in+normal+and+glioblastoma+cells+containing+intact+p53. assertion.
- assertion asSentence The+specific+inhibition+of+Aurora-B+kinase+activity+by+PARP-1+contributes+to+the+physiological+response+to+DNA+damage. assertion.
- assertion asSentence Sgo1+is+phosphorylated+by+both+AurB+and+Plk1+in+vitro. assertion.
- assertion asSentence Aurora+kinases+A+and+B+overexpression+is+a+relatively+early+phenomenon+in+the+genesis+of+malignant+epithelial+neoplasm+tumorigenesis. assertion.
- assertion asSentence Levels+of+Aurora+B+correlated+with+histological+grade+in+B-cell+non-Hodgkin+lymphoma. assertion.
- assertion asSentence Widespread+genomic+instability+mediated+by+a+pathway+involving+glycoprotein+Ib+alpha+and+Aurora+B+kinase. assertion.
- assertion asSentence Aurora+B+kinase+activation+requires+survivin+priming+phosphorylation+at+Ser20+which+is+catalyzed+by+polo-like+kinase+1. assertion.
- assertion asSentence Aurora+B+potentiates+Mps1+activation+to+ensure+rapid+checkpoint+at+the+onset+of+mitosis. assertion.
- assertion asSentence Aurora+B+both+regulates+and+is+regulated+by+chromosome+attachment+to+the+spindle. assertion.
- assertion asSentence Aurora+B+spatially+control+the+dynamics+of+non-kinetochore+microtubules+during+spindle+assembly. assertion.
- assertion asSentence Luteolin+inhibits+Aurora+B+kinase+activity+and+blocks+proliferation+of+cancer+cells. assertion.
- assertion asSentence Cyclin-dependent+kinase%2Faurora+kinase+inhibitor+JNJ-7706621+is+a+unique+regulator+of+tumor+cell+cycle+progression+at+multiple+points. assertion.
- assertion asSentence Overexpression+of+TOSO+gene+is+associated+with+chronic+lymphocytic+leukemia. assertion.
- assertion asSentence Adeno-associated+viral-mediated+over-expression+of+both+wild-type+and+mutated+form+of+human+VAPB+selectively+induces+death+of+primary+mouse+motor+neurons%2C+albeit+with+different+kinetics. assertion.
- assertion asSentence VAP-A+is+an+important+regulator+both+of+the+subcellular+localization+of+protrudin+and+of+its+ability+to+stimulate+neurite+outgrowth. assertion.
- assertion asSentence Evolutionarily+conserved+multisubunit+protein+complex+that+contains+p130+and+E2F4+mediates+the+repression+of+cell+cycle-dependent+genes+in+quiescence. assertion.
- assertion asSentence Both+NOLC1+and+tumor+protein+53+work+together+synergistically+to+activate+the+MDM2+promoter+in+NPC+cells. assertion.
- assertion asSentence Increased+expression+of+discs+large+homolog+5+gene+is+associated+with+ulcerative+colitis. assertion.
- assertion asSentence Demonstration+of+the+importance+of+PTTG1+in+human+tumorigenesis. assertion.
- assertion asSentence PTTG1+overexpression+promotes+cell+motility+and+lymph+node+metastasis+in+esophageal+squamous+cell+carcinoma+patients%2C+leading+to+poorer+survival. assertion.
- assertion asSentence PTTG1+regulates+aurora+kinase+activity. assertion.
- assertion asSentence PTTG+expression+and+its+correlation+with+clinicopathologic+parameters+in+patients+with+neoplasms%2C+particularly+of+endocrine+organs. assertion.
- assertion asSentence Oveexpression+of+p300+upregulated+hPTTG+at+the+levels+of+promoter+activity%2C+mRNA+and+protein+expression. assertion.
- assertion asSentence Influenza+A+virus+infection+activates+IL-32+and+iNOS+expression+by+a+heretofore+unrecognized+complex+mechanism%2C+in+which+the+two+pro-inflammatory+factors+regulate+each+other%2C+involving+positive+and+negative+feedback+regulatory+loops. assertion.
- assertion asSentence IL-32+plays+a+host+defense+role+against+M.+tuberculosis+in+differentiated+THP-1+human+macrophages. assertion.
- assertion asSentence Antagonism+of+bone+morphogenetic+protein+signaling+by+transgenic+Noggin+plays+a+critical+role+in+ensuring+proper+levels+of+cell+proliferation+and+epithelial-to-mesenchymal+transformation+during+cardiac+morphogenesis. assertion.
- assertion asSentence Frequently+downregulated+in+colorectal+cancer+and+suppresses+colon+cancer+cell+growth. assertion.
- assertion asSentence One+function+of+Gcm2+is+to+maintain+high+levels+of+CaR+expression+in+parathyroid+cells. assertion.
- assertion asSentence Gcm2+is+a+useful+adjunct+marker+for+the+diagnosis+of+parathyroid+lesions. assertion.
- assertion asSentence p53-Inducible+DHRS3+is+an+endoplasmic+reticulum+protein+associated+with+lipid+droplet+accumulation. assertion.
- assertion asSentence The+MSK1+can+be+phosphorylated+and+activated+in+cells+by+both+ERK1%2F2+and+p38alpha. assertion.
- assertion asSentence Three-dimensional+structure+is+projected+from+amino+acid+sequence. assertion.
- assertion asSentence MFHAS1+regulates+Toll-like+receptor+%28TLR%29-dependent+signaling. assertion.
- assertion asSentence LMP1+mediates+serine+256+phosphorylation+and+nuclear+entry+of+Annexin+A2+via+PLC-PKCalpha%2FPKCbeta+pathway. assertion.
- assertion asSentence The+30-amino+acid+docking+domain+peptide+of+MAPKAPK2+isoform+a+%28MK2a%29+is+required+for+the+formation+of+a+tight%2C+functional+p38alpha-MK2a+signaling+complex. assertion.