Matches in Nanopublications for { ?s <http://purl.org/nanopub/x/asSentence> ?o ?g. }
- assertion asSentence Both+MAPKAPK2+and+HSP27+are+necessary+for+TGFbeta-mediated+increases+in+MMP-2+and+cell+invasion+in+human+prostate+cancer. assertion.
- assertion asSentence Arno+behaves+as+a+bistable+switch%2C+having+an+absolute+requirement+for+activation+by+an+Arf+protein+but%2C+once+triggered%2C+becoming+highly+active+through+the+positive+feedback+effect+of+Arf1-GTP. assertion.
- assertion asSentence Involvement+of+cytohesin-1+in+the+regulation+of+the+functional+responses+of+human+PMNs%2C+linked%2C+in+part+at+least%2C+to+the+activation+of+Arf6. assertion.
- assertion asSentence The+human+piwi-like+1+PAZ+domain+is+a+typical+OB+fold+and+specifically+recognizes+the+2nt+3+0+-OH+end+of+the+single-stranded+RNA+and+buries+the+two+3+0+-terminal+nucleotides+in+the+hydrophobic+cleft. assertion.
- assertion asSentence Coactivator+that+enhances+estrogen+receptor+alpha-+and+specificity+protein+%28SP%29-1-mediated+transactivation+in+breast+cancer+cells. assertion.
- assertion asSentence The+N+terminus+of+the+adhesion+G+protein-coupled+receptor+GPR56+controls+receptor+signaling+activity. assertion.
- assertion asSentence Establish+GPR55+as+a+cannabinoid+receptor+with+signaling+distinct+from+CB%281%29+and+CB%282%29. assertion.
- assertion asSentence KLF4+is+both+necessary+and+sufficient+in+preventing+centrosome+amplification+following+gamma-radiation-induced+DNA+damage. assertion.
- assertion asSentence KLF4+is+a+critical+regulator+in+the+transcriptional+network+controlling+monocyte+differentiation. assertion.
- assertion asSentence Dopamine+acting+through+its+D%282%29+receptor%2C+inhibits+IGF-I-induced+proliferation+of+gastric+adenocarcinoma+cells+by+up-regulating+KLF4%2C+a+negative+regulator+of+the+cell+cycle+through+down+regulation+of+IGF-IR+and+AKT+phosphorylation. assertion.
- assertion asSentence Loss+of+nuclear+expression+of+KLF4+is+associated+with+in+situ+and+invasive+breast+carcinomas. assertion.
- assertion asSentence ZNF750+directly+links+a+tissue-specifying+factor%2C+p63%2C+to+an+effector+of+terminal+differentiation%2C+KLF4. assertion.
- assertion asSentence Alien+inhibits+E2F1+gene+expression+and+cell+proliferation. assertion.
- assertion asSentence AM-3K%2C+an+anti-macrophage+antibody%2C+recognizes+CD163%2C+a+molecule+associated+with+an+anti-inflammatory+macrophage+phenotype. assertion.
- assertion asSentence Individuals+with+diabetes+mellitus+and+a+haptoglobin+2.2+genotype+demonstrate+lower+CD163+scavenger+receptor+levels+and+an+impaired+hemoglobin+clearance+capacity%2C+with+increased+incidence+of+myocardial+infarction. assertion.
- assertion asSentence Antibodies+from+a+patient+with+type+1+diabetes+and+celiac+disease+bind+to+macrophages+that+express+the+scavenger+receptor+CD163. assertion.
- assertion asSentence Transglutaminase+5+is+expressed+during+hair+follicle+homeostasis. assertion.
- assertion asSentence Treatment+with+active+matabolite+of+vitamin+D+%281alpha%2C25-dihydroxyvitamin+D3%29+up-regulates+mRNA+expression+of+p21. assertion.
- assertion asSentence VAMP-3+and+VAMP-8+are+present+in+human+platelets+and+are+required+for+granule+secretion. assertion.
- assertion asSentence Na%28%2B%29%2FH%28%2B+%29+exchanger+regulatory+factor+2+directs+parathyroid+hormone+1+receptor+signalling. assertion.
- assertion asSentence A2BR+binds+to+E3KARP+upon+agonist+stimulation. assertion.
- assertion asSentence When+the+second+PDZ+domain+of+E3KARP+is+bound+to+down+regulated+in+adenoma+%28dra%29+gene+product%2C+a+structural+link+is+built+between+the+functionally+coupled+Na%2B%2FH%2B+and+Cl-%2FHCO3-+exchangers+in+the+proximal+colon. assertion.
- assertion asSentence LPA2+is+the+major+LPA+receptor+in+colon+cancer+cells+and+cellular+signals+by+LPA2+are+largely+mediated+through+its+ability+to+interact+with+NHERF2. assertion.
- assertion asSentence Txnl1+is+the+first+example+of+a+direct+connection+between+protein+reduction+and+proteolysis%2C+two+major+intracellular+protein+quality+control+mechanisms. assertion.
- assertion asSentence Solution+structure+of+the+C-terminal+DUF1000+domain+of+the+human+thioredoxin-like+1+protein. assertion.
- assertion asSentence SLIT2+mRNA+decreases+with+vascular+function+decline+in+pulmonary+fibrosis. assertion.
- assertion asSentence Downregulation+of+Slit2+expression+is+associated+with+gliomas. assertion.
- assertion asSentence Mutations+in+LHX2+do+not+represent+a+frequent+cause+of+micro%2Fanophthalmia. assertion.
- assertion asSentence The+level+of+human+OAT1+mRNA+is+significantly+lower+in+the+kidney+of+patients+with+renal+diseases+than+in+the+normal+controls. assertion.
- assertion asSentence High+urine+OAT1+and+OAT3+and+low+OAT4+is+associated+with+early+reversible+proximal+tubular+damage. assertion.
- assertion asSentence Association+of+human+aging+with+a+functional+variant+of+klotho. assertion.
- assertion asSentence Klotho+gene+polymorphism+is+associated+with+bone+density+and+spondylosis+of+the+lumbar+spine+in+Japanese+postmenopausal+women. assertion.
- assertion asSentence Depressed+expression+of+the+Klotho-FGFR1+complex+in+hyperplastic+glands+underlies+the+pathogenesis+of+secondary+hyperparathyroidism+and+its+resistance+to+extremely+high+FGF23+levels+in+uremic+patients. assertion.
- assertion asSentence Klotho+deficiency+causes+vascular+calcification+in+chronic+kidney+disease. assertion.
- assertion asSentence Klotho+regulates+tumor+invasion+through+the+epithelial+mesenchymal+transition+process. assertion.
- assertion asSentence Modulation+of+the+expression+of+CFTR+%28cystic+fibrosis+transmembrane+conductance+regulator%29+protein+partners%2C+like+NHE-RF1%2C+can+rescue+sequence-deleted+CFTR+activity. assertion.
- assertion asSentence Beta-oestradiol-dependent+up-regulation+of+NHERF1+significantly+increases+F508CFTR+functional+expression+in+CFBE41o%28-%29+cells. assertion.
- assertion asSentence The+down-regulation+of+hOAT4+activity+by+activation+of+protein+kinase+C+and+the+up-regulation+of+hOAT4+activity+by+NHERF-1+are+mediated+through+alteration+of+hOAT4+internalization. assertion.
- assertion asSentence Association+of+a+polymorphism+in+the+NRXN3+gene+with+the+degree+of+smoking+in+schizophrenia. assertion.
- assertion asSentence Genetic+variation+in+the+gene+encoding+adiponectin+is+associated+with+an+increased+risk+of+type+2+diabetes+in+the+Japanese+population. assertion.
- assertion asSentence Decreased+serum+adiponectin+level+is+an+independent+risk+factor+for+progression+to+type+2+diabetes+in+the+Japanese+population. assertion.
- assertion asSentence Hypoadiponectinemia+in+youth+is+a+strong+and+independent+correlate+of+insulin+resistance. assertion.
- assertion asSentence Low+levels+associated+with+type+2+diabetes+in+Mexican+children. assertion.
- assertion asSentence Increases+in+plasma+levels+of+adiponectin+or+reductions+in+TNF-alpha+are+not+required+for+marked+improvements+in+glucose%2Finsulin+and+lipid+metabolism+with+acute+weight+loss. assertion.
- assertion asSentence Increased+adiponectin+levels+are+associated+with+a+moderately+decreased+coronary+heart+disease+risk+in+diabetic+men. assertion.
- assertion asSentence Reduced+activation+of+AMPkinase+by+globular+adiponectin+in+obese+and+obese+type+2+diabetic+subjects+is+not+caused+by+reduced+adiponectin+receptor+expression. assertion.
- assertion asSentence Low+adiponectin+levels+occur+in+very+young+obese+children%2C+correlating+with+a+range+of+variables+of+metabolic+syndrome. assertion.
- assertion asSentence Plasma+adiponectin+levels+are+associated+with+increased+hepatic+lipase+activity+in+Japanese+hyperlipidemic+men. assertion.
- assertion asSentence The+high-molecular-weight+complex+of+adiponectin+is+associated+with+renal+insufficiency+in+type+2+diabetic+patients. assertion.
- assertion asSentence Circulating+adiponectin+is+associated+with+insulin+resistance+and+HDL-C+levels+independent+from+body+mass+index+in+overweight+subjects. assertion.
- assertion asSentence Adiponectin+levels+do+not+contribute+to+the+prediction+of+type+1+diabetes+in+islet+cell+antibody-polisitive+relatives. assertion.
- assertion asSentence Common+single-nucleotide+polymorphisms+in+the+adiponectin+gene+do+not+play+an+important+role+in+the+development+of+cardiovascular+disease+in+humans. assertion.
- assertion asSentence Metabolic+disturbances+related+to+metabolic+syndrome+or+diabetes+affect+the+ability+to+detect+early-stage+prostate+cancer. assertion.
- assertion asSentence Role+of+adiponectin+in+mediating+the+insulin-sensitizing+action+of+exercise+by+investigating+changes+in+plasma+adiponectin+levels+and+tissue-specific+adiponectin+receptor+expression. assertion.
- assertion asSentence Adiponectin+protects+the+endothelial+monolayer+from+Ang+II+or+TNF-alpha-induced+hyperpermeability+by+modulating+microtubule+and+cytoskeleton+stability+via+a+cAMP%2F+PKA+signaling+cascade. assertion.
- assertion asSentence High+adiponectin+plasma+levels+in+severe+insulin+resistance+have+a+97%25+positive+predictive+value+for+insulin+receptor+dysfunction. assertion.
- assertion asSentence High+rather+than+low+adiponectin+independently+predict+total+mortality+in+hemodialysis+patients. assertion.
- assertion asSentence Combination+of+CRP+and+HMW-adiponectin+reflects+further+metabolic+abnormalities+compared+with+each+of+them+in+type+2+diabetic+subjects. assertion.
- assertion asSentence Chronic+pancreatitis+in+humans+does+not+affect+serum+adiponectin+levels. assertion.
- assertion asSentence Stimulates+osteoblast+proliferation%2C+differentiation+and+maintains+bone+mineral+density. assertion.
- assertion asSentence Relationship+between+excess+adiposity+and+adiponectin+levels+is+inconsistent+in+Turkish+adults. assertion.
- assertion asSentence Intracoronary+adiponectin+levels+reflect+systemic+adiponectin+levels+in+epicardial+adipose+tissue+in+coronary+artery+disease. assertion.
- assertion asSentence Adiponectin+protected+HepG2+cells+from+free+faty+acids-triggered+CD95%2FFas+expression+and+induction+of+apoptosis. assertion.
- assertion asSentence The+SNP+rs182052+in+intron+1+of+the+adiponectin+gene+is+associated+with+type+2+diabetes+in+African+Americans. assertion.
- assertion asSentence Promoter+variants+associated+with+hypoadiponectinemia+in+humans+substantially+affect+adiponectin+promoter+activity+in+adipocytes. assertion.
- assertion asSentence The+ratio+of+high-molecular+weight+adiponectin+and+total+adiponectin+differs+in+preterm+and+term+infants. assertion.
- assertion asSentence The+adiponectin+gene+polymorphisms+are+associated+with+type+2+diabetes+in+Polish+Caucasians. assertion.
- assertion asSentence Adiponectin+levels+predict+mixed+and+non-calcified+coronary+atherosclerotic+plaque+burden. assertion.
- assertion asSentence Measured+serum+adiponectin+levels+in+prostate+cancer+patients. assertion.
- assertion asSentence Decreased+adiponectin+levels+are+associated+with+impaired+coronary+flow+reserve+in+women+with+normal+epicardial+coronary+arteries. assertion.
- assertion asSentence Zinc-alpha2-glycoprotein+enhances+adiponectin+production+by+human+adipocytes. assertion.
- assertion asSentence Participation+of+adiponectin+multimer+in+preterm+parturition. assertion.
- assertion asSentence An+association+of+ADIPOQ+genetic+polymorphism+with+coronary+artery+disease+risk+is+modified+by+traditional+risk+factors%2C+such+as+blood+pressure+and+plasma+cholesterol+level. assertion.
- assertion asSentence Changes+in+high-molecular+weight+adiponectin+concentration+are+not+involved+in+the+acute+exercise-induced+enhancement+of+insulin+action. assertion.
- assertion asSentence Low+adiponectin+levels+are+asssociated+with+heavy+smoking. assertion.
- assertion asSentence Adiponectin+decreases+the+receptor+dimerization+in+a+concentration-dependent+manner. assertion.
- assertion asSentence HMW+adiponectin+didn%27t+have+a+superior+predictive+value+for+insulin+resistance+compared+to+adiponectin. assertion.
- assertion asSentence Adeponectin+does+not+substantially+affect+insulin+resitance+either+in+end-sttage+renal+disease+or+kidney+tranplantation+patients. assertion.
- assertion asSentence Adiponectin+levels+remained+independently+predictive+when+controlling+for+well-established+predictors+of+mortality%2Fmorbidity+in+congestive+heart+failure. assertion.
- assertion asSentence Adiponectin+decreases+with+increasing+adiposity+and+insulin+resistance+in+type+2+diabetic+Trinidadians. assertion.
- assertion asSentence Adiponectin+gene+polymorphism+is+associated+with+reduced+proportion+of+long-chain+omega-3+fatty+acids+in+serum+phospholipids+in+nondiabetic+Koreans. assertion.
- assertion asSentence Serum+adiponectin+levels+inversely+correlates+with+the+grade+of+steatosis%2C+histological+activity+index+and+the+stage+of+fibrosis. assertion.
- assertion asSentence Adiponectin+enhances+IL-6+synthesis+and+release+in+adult+rat+cardiac+fibroblasts+through+AdipoR1. assertion.
- assertion asSentence Adiponectin+and+inflammatory+markers+can+predict+the+course+of+metabolic+syndrome. assertion.
- assertion asSentence Hyperadiponectinemia+enhances+bone+formation+in+male+transgenic+mice. assertion.
- assertion asSentence 5+ADIPOQ+4-single+nucleotide+polymorphisms+%28SNPs%29+haplotypes+and+1+ADIPOR1+2-SNP+haplotype+tightly+associated+with+prostate+cancer+risk. assertion.
- assertion asSentence High-intensity+endurance+training+caused+an+increase+adiponectin+mRNA+in+obese+middle-aged+men. assertion.
- assertion asSentence Early+intensive+insulin+therapy+can+increase+serum+adiponectin+and+NO+concentrations+and+improve+endothelial+function+in+patients+with+newly+diagnosed+type+2+diabetes. assertion.
- assertion asSentence Globular+adiponectin+possesses+both+AdipoR1-dependent+ability+to+stimulate+COX-2+expression+and+AdipoR1-independent+effects+related+to+expression+of+VCAM-1+and+adhesion+of+monocytes+to+endothelium. assertion.
- assertion asSentence ApN+also+exerts+a+pivotal+role+in+vascular+protection+through+activation+of+multiple+intracellular+signaling+cascades. assertion.
- assertion asSentence Maternal+multimeric+forms+of+adiponectin+are+independent+predictors+of+the+concentrations+of+cbAdiponectin+and+its+multimeric+forms+at+delivery. assertion.
- assertion asSentence Adiponectin+levels+are+lower+in+patients+with+colorectal+carcinoma+or+colorectal+adenoma+compared+with+those+in+healthy+controls. assertion.
- assertion asSentence ACRP30+and+its+high+molecular+weight+oligomers+are+involved+in+the+metabolic+phenotype+of+type+1+myotonic+dystrophy+patients. assertion.
- assertion asSentence The+SNP+of+adiponectin+locus+%2B45T%2FG+is+associated+with+male+premature+coronary+heart+disease+in+the+Han+ethnic+group. assertion.
- assertion asSentence Low+plasma+adiponectin+predicts+progression+of+kidney+disease+in+type+2+diabetes+mellitus+patients. assertion.
- assertion asSentence Pre-diagnostic+plasma+adiponectin+levels+are+associated+with+decreased+colorectal+cancer+risk. assertion.
- assertion asSentence Protein-protein+and+protein-lipid+interactions+organized+by+SARA+regulate+the+vesicular+targeting+of+rhodopsin-bearing+axonemal+vesicles+to+nascent+discs+at+the+base+of+the+rod+outer+segment. assertion.
- assertion asSentence Both+hOAT1+and+hOAT3+are+responsible+for+the+basolateral+uptake+of+edaravone+sulfate+in+the+kidney. assertion.
- assertion asSentence The+renal+expression+of+OAT1+and+OAT3+should+be+taken+into+account+in+order+to+improve+pharmacotherapeutic+efficacy+and+to+prevent+drug+toxicity+during+the+onset+of+this+hepatic+disease. assertion.
- assertion asSentence The+mutational+testing+found+a+heterozygous+deletion+in+NRXN1+in+one+patient. assertion.