Matches in Nanopublications for { ?s <http://purl.org/nanopub/x/asSentence> ?o ?g. }
- assertion asSentence Mutations+in+OTOF+cause+both+profound+hearing+loss+and+a+type+of+hearing+loss+where+otoacoustic+emissions+are+spared+called+auditory+neuropathy. assertion.
- assertion asSentence Suppression+of+either+LPL+or+EL+decreases+proinflammatory+cytokine+expression+and+influences+the+lipid+composition+of+THP-1+macrophages. assertion.
- assertion asSentence Disruption+of+the+gene+for+NMT2+by+a+t%288%3B10%29+translocation+in+a+male+with+hypogonadism. assertion.
- assertion asSentence RECQ5+is+a+protein+with+DNA+helicase+and+strand-annealing+activities+in+a+single+polypeptide. assertion.
- assertion asSentence RECQL5beta+dramatically+stimulates+the+rate+of+FEN1+cleavage+of+flap+DNA+substrates. assertion.
- assertion asSentence RECQL4+polymorphisms+and+mutations+are+associated+with+Rothmund-Thomson+Syndrome. assertion.
- assertion asSentence p300-mediated+acetylation+of+the+Rothmund-Thomson-syndrome+gene+product+RECQL4+regulates+its+subcellular+localization. assertion.
- assertion asSentence MCM10+interacts+directly+with+RECQ4+and+regulates+its+DNA+unwinding+activity. assertion.
- assertion asSentence Genetic+variation+in+the+FADS1+FADS2+gene+cluster+affects+n-6+polyunsaturated+fatty+acid+profiles+in+erythrocytes+reflecting+altered+delta-5-desaturase+activity. assertion.
- assertion asSentence Strong+associations+of+two+FADS2+SNPs+with+levels+of+polyunsaturated+fatty+acids. assertion.
- assertion asSentence Single+polymorphism+in+the+CYP7B1+gene+is+associated+with+phenotypic+differences+in+an+expression+system+and+a+widely+different+allele+frequency+in+two+ethnic+populations%2C+with+great+differences+in+the+incidence+of+prostate+cancer. assertion.
- assertion asSentence Both+deleted+in+colorectal+cancer+%28DCC%29+and+neogenin+become+tyrosine+phosphorylated+in+cortical+neurons+in+response+to+netrin-1. assertion.
- assertion asSentence Netrin+1%2C+through+its+receptor+DCC%2C+inhibits+RhoA+in+embryonic+spinal+commissural+neurons. assertion.
- assertion asSentence The+transcriptionally+active+TAp73alpha+tumor+suppressor+is+implicated+in+the+apoptosis+induced+by+netrin-1+in+a+p53-independent+and+DCC%2Fubiquitin-proteasome+dependent+manner. assertion.
- assertion asSentence As+a+method+of+circumventing+ABCG2-associated+drug+resistance%2C+low-polarity+camptothecin+analogues+are+considered+to+be+potent+lead+compounds. assertion.
- assertion asSentence Cyclosporin+A+is+neither+a+substrate+nor+an+inhibitor+of+the+human+ABCG2+transporter. assertion.
- assertion asSentence Chemoresistance+of+melanomas+and+neuroendocrine+carcinomas+of+the+skin+cannot+be+explained+by+expression+of+the+ABCG2-chemoresistance+gene. assertion.
- assertion asSentence ABCG2+expression+is+up-regulated+in+gastric+carcinoma. assertion.
- assertion asSentence P-gp%2C+rather+than+BCRP+or+OCT1%2C+is+partially+responsible+for+the+development+of+imatinib-resistance+due+to+constitutive+and+functional+overexpression%2C+leading+to+reduced+intracellular+accumulation+of+imatinib+in+resistant+K562+cells. assertion.
- assertion asSentence Commonly+occurring+SNPs+in+BCRP+linked+with+significantly+increased+oral+sulfasalazine+plasma+exposure+in+humans. assertion.
- assertion asSentence ABCG2+plays+key+role+in+chemoresistance+%28i.e.%2C+multi-drug+chemoresistance%29+in+cancer+stem+cells. assertion.
- assertion asSentence BCRP+plays+a+minor+role+in+the+elimination+of+sulfate+conjugates+4-nitrophenyl+sulfate+and+acetaminophen+sulfate+across+the+apical+membrane+of+placental+trophoblast+%28BeWo%29cells. assertion.
- assertion asSentence In+Chinese+patients+with+hypercholesterolemia+treated+with+rosuvastatin%2C+the+c.421C%3EA+variant+allele+single+nucleotide+polymorphism+of+ABCG2+is+significantly+associated+with+a+greater+reduction+in+low-density+lipoprotein+cholesterol+level. assertion.
- assertion asSentence ABCG2+messenger+RNA+levels+increased+more+than+three-fold+in+side+population+dental+pulp+cells+after+exposure+to+ischemic+culture+conditions+for+48+hours. assertion.
- assertion asSentence Nuclear+translocation+of+epidermal+growth+factor+receptor+by+Akt-dependent+phosphorylation+enhances+breast+cancer-resistant+protein+expression+in+gefitinib-resistant+cells. assertion.
- assertion asSentence Role+of+runt-related+transcription+factor+3+%28RUNX3%29+in+transcription+regulation+of+natural+cytotoxicity+receptor+1+%28NCR1%2FNKp46%29%2C+an+activating+natural+killer+%28NK%29+cell+receptor. assertion.
- assertion asSentence MED26+can+function+as+a+molecular+switch+that+interacts+first+with+TFIID+in+the+Pol+II+initiation+complex+and+then+exchanges+TFIID+for+complexes+containing+ELL%2FEAF+and+P-TEFb+to+facilitate+transition+of+Pol+II+into+the+elongation+stage+of+transcription. assertion.
- assertion asSentence The+QKI+RNA-binding+proteins+regulate+oligodendrocyte+differentiation+by+modulating+the+expression+of+AIP-1. assertion.
- assertion asSentence QKI-7+regulates+expression+of+interferon-related+genes+in+human+astrocyte+glioma+cells. assertion.
- assertion asSentence Decreased+cerebrospinal+fluid+levels+of+Bri2-23%2C+a+peptide+cleaved+from+Bri2%2C+significantly+associates+with+multiple+scleerosis+patients+with+cerebellar+dysfunction+and+cognition+impairment. assertion.
- assertion asSentence BRI2+protein+regulates+beta-amyloid+degradation+by+increasing+levels+of+secreted+insulin-degrading+enzyme+%28IDE%29. assertion.
- assertion asSentence Glutathione+S-transferase+omega+is+abundant+in+alveolar+macrophages+and+airway+secretions%2C+with+the+levels+decreased+in+patients+with+chronic+obstructive+pulmonary+disease. assertion.
- assertion asSentence PERK+activates+glycogen+synthase+kinase+3+to+promote+the+proteasomal+degradation+of+p53. assertion.
- assertion asSentence The+growth-inhibitory+function+of+PERK+is+preserved+in+tumors+and+upon+proper+reactivation+can+severely+inhibit+tumor+growth+through+induction+of+quiescence. assertion.
- assertion asSentence Transcriptional+profiling+by+cDNA+microarray+combined+with+reverse+genetics+revealed+phosphorylation+of+the+eukaryotic+initiation+factor+2-alpha+%28EIF2A%29+through+the+eukaryotic+translation+initiation+factor+2-alpha+kinase+3+%28EIF2AK3%2FPERK%29. assertion.
- assertion asSentence HOMER1+plays+a+role+in+the+etiology+of+major+depression+and+genetic+variation+affects+depression+via+the+dysregulation+of+cognitive+and+motivational+processes. assertion.
- assertion asSentence The+PICK1+mRNA+is+elevated+in+patient+with+schizophrenia. assertion.
- assertion asSentence Hand2+plays+a+pivotal+role+in+regulating+both+cell-autonomous+and+-nonautonomous+functions+of+the+cardiac+neural+crest. assertion.
- assertion asSentence Doxorubicin+switches+protective+autophagy+in+SPP1-depleted+cells+to+apoptosis+by+calpain-mediated+Atg5+cleavage. assertion.
- assertion asSentence Pharmacologic+inhibition+of+Rho+kinase+2+signaling+blocked+LPA-induced+p65+phosphorylation+and+suppressed+ICAM-1+and+VCAM-1+expression. assertion.
- assertion asSentence ROCK1+has+a+role+in+regulating+myometrial+contractility. assertion.
- assertion asSentence ROCK1+and+ROCK2+have+distinct+and+separate+roles+in+adhesion+complex+assembly+and+turnover+in+human+epidermal+keratinocytes. assertion.
- assertion asSentence Diagnostic+utility+of+PAX8%2C+TTF-1+and+napsin+A+for+discriminating+metastatic+carcinoma+from+primary+adenocarcinoma+of+the+lung. assertion.
- assertion asSentence OC2+transcription+factor+is+a+direct+target+of+T-bet+in+type-1+T-helper+cells. assertion.
- assertion asSentence Dimeric+AKAP79+concentrates+pockets+of+second+messenger+responsive+enzyme+activities+at+the+plasma+membrane. assertion.
- assertion asSentence Mutations+within+the+MYOT+gene+are+not+a+cause+for+Vocal+Cord+and+Pharyngeal+Weakness+with+Distal+Myopathy+%28VCPDM%29. assertion.
- assertion asSentence The+C-terminal+domains+of+ADAMTS-4+and+ADAMTS-5+affect+the+structure+around+the+active+site%2C+favouring+interaction+with+TIMP-3. assertion.
- assertion asSentence ADAMTS-4+is+present+in+human+coronary+atherosclerotic+plaques. assertion.
- assertion asSentence ADAMTS1+significantly+blocks+VEGFR2+phosphorylation+due+to+direct+binding+and+sequestration+of+VEGF165%2C+with+consequent+suppression+of+endothelial+cell+proliferation. assertion.
- assertion asSentence Itch+protein+re-localization+is+dependent+upon+the+interaction+with+the+PPXY+sequences+of+LITAF%2C+since+disruption+of+these+binding+motifs+completely+abrogates+Itch+re-localization. assertion.
- assertion asSentence Mutations+in+the+SPTLC2+subunit+of+serine+palmitoyltransferase+cause+hereditary+sensory+and+autonomic+neuropathy+type+I. assertion.
- assertion asSentence TAp63-dependent+induction+of+growth+differentiation+factor+15+%28GDF15%29+plays+a+critical+role+in+the+regulation+of+keratinocyte+differentiation. assertion.
- assertion asSentence Two+in-and-out+modulation+strategies+for+endoplasmic+reticulum+stress-linked+gene+expression+of+pro-apoptotic+macrophage-inhibitory+cytokine+1. assertion.
- assertion asSentence TLF+is+a+functional+regulator+of+transcription+with+targets+distinct+from+those+of+TBP. assertion.
- assertion asSentence BAG5+directly+interacts+with+Parkin+and+stabilizes+Parkin+via+the+ubiquitin-mediated+proteasomal+pathway. assertion.
- assertion asSentence Vincristine+induces+Jurkat+cell+apoptosis+by+downregulating+expression+of+SODD+protein+and+priming+the+death+receptor+pathway. assertion.
- assertion asSentence A+requirement+for+BAG3+to+augment+virus+gene+expression+and+demonstrate+that+the+co-chaperone+acts+independently+of+promyelocytic+leukemia+to+increase+herpes+simplex+virus+replication. assertion.
- assertion asSentence BAG3+gene+expression+is+controlled+by+its+own+product. assertion.
- assertion asSentence BAG3+is+cleaved+during+apoptosis+of+pancreatic+cancer+cells%2C+disrupting+its+anti-apoptotic+properties. assertion.
- assertion asSentence Treatment+of+Ca9-22+cells+and+HOK+with+oxLDL+induced+an+up-regulation+of+IL-8+and+the+PGE%282%29-producing+enzymes%2C+cyclooxygenase-2+and+microsomal+PGE%282%29+synthase-1. assertion.
- assertion asSentence Jasmonates+can+circumvent+drug+resistance+induced+by+p53+mutations. assertion.
- assertion asSentence Nrg-2-induced+Acetylcholine+Receptor+transcription+requires+an+N-box+motif+and+is+regulated+by+alternative+splicing. assertion.
- assertion asSentence Gln43+of+NRG2beta+is+both+necessary+and+sufficient+for+NRG2+stimulation+of+ErbB4+coupling+to+IL3+independence. assertion.
- assertion asSentence Membrane+recruitment+of+the+cargo-selective+retromer+subcomplex+VPS35%2F29%2F26+is+catalysed+by+the+small+GTPase+Rab7+and+inhibited+by+the+Rab-GAP+TBC1D5. assertion.
- assertion asSentence Mutations+found+in+beta+thassemia+patients+complicated+by+liver+disease. assertion.
- assertion asSentence Tyrosine+phosphorylation+of+p130CAS+regulates+localization+and+downstream+signaling+with+profound+affects+on+cell+movement. assertion.
- assertion asSentence Requirement+of+the+p130CAS-Crk+coupling+for+metastasis+suppressor+KAI1%2FCD82-mediated+inhibition+of+cell+migration+in+a+metastatic+prostate+cancer+cell+line. assertion.
- assertion asSentence PTP1B+mediates+of+RhoA-dependent+phosphorylation+of+p130Cas. assertion.
- assertion asSentence p130CAS+is+an+important+component+in+the+netrin+signaling+pathway+acting+between+tyrosine+kinases+and+small+GTPase+Rac1+and+is+essential+for+commissural+axon+guidance+in+vivo. assertion.
- assertion asSentence Activation+of+the+FAK-src+molecular+scaffolds+and+p130Cas-JNK+signaling+cascades+by+alpha1-integrins+during+colon+cancer+cell+invasion. assertion.
- assertion asSentence In+hepatocellular+carcinoma+%28HCC%29%2C+there+is+a+negative+correlation+between+the+positive+expression+of+p130Cas+and+the+normal+expression+of+E-cadherin%2Fbeta-catenin.+p130Cas+plays+important+roles+in+the+invasion%2C+metastasis+and+prognosis+of+HCC. assertion.
- assertion asSentence The+lysyl+oxidase+pro-peptide+attenuates+fibronectin-mediated+activation+of+focal+adhesion+kinase+and+p130Cas+in+breast+cancer+cells. assertion.
- assertion asSentence BCAR-1+is+a+physiological+substrate+of+Syk. assertion.
- assertion asSentence p130Cas%2C+Src+and+talin+function+in+both+oral+carcinoma+invasion+and+resistance+to+cisplatin. assertion.
- assertion asSentence CrkI+and+p130%28Cas%29+complex+regulates+the+migration+and+invasion+of+prostate+cancer+cells. assertion.
- assertion asSentence GABA%28B%29+receptor+subunit+GABA%28B%29R2+is+found+on+the+same+neurons+and+follows+the+same+distribution+patterns+in+the+basal+ganglia+as+the+GABABR1+receptor+subunit. assertion.
- assertion asSentence Association+of+the+GABA%28B%29R1+with+the+GABA%28A%29+receptor+gamma2S+subunit+robustly+promotes+cell+surface+expression+of+GABA%28B%29R1+in+the+absence+of+GABA%28B%29R2%2C+that+is+usually+required+for+efficient+trafficking+of+GABA%28B%29R1+to+the+cell+surface. assertion.
- assertion asSentence GABA%28B%29+receptor+subunit+2+levels+are+significantly+decreased+in+the+cingulate+cortex+and+fusiform+gyrus+of+autism+patients+compared+to+controls. assertion.
- assertion asSentence Gamma-aminobutyric+acid+type+B+%28GABA%28B%29%29+receptor+internalization+is+regulated+by+the+R2+subunit. assertion.
- assertion asSentence GTF2IRD1+is+associated+with+Williams+syndrome+facies+and+visual-spatial+construction. assertion.
- assertion asSentence Rev-erbalpha+modulates+the+synthesis+of+its+own+ligand+in+a+negative+feedback+pathway+that+maintains+heme+levels+and+regulates+cellular+energy+metabolism. assertion.
- assertion asSentence The+difference+between+the+mean+value+for+the+lowest+expression+individual+%28DeltaCT+8.8%29+and+the+highest+expression+individual+%28DeltaCT+3.7%29+revealed+an+approximately+34-fold+difference+in+relative+clock+gene+expression+levels. assertion.
- assertion asSentence Allelic+variants+interaction+of+CLOCK+gene+and+GNB3+subunit+gene+with+diurnal+preference. assertion.
- assertion asSentence No+relationship+between+hCLOCK+T3111C+polymorphism+and+endometriosis%2C+nor+any+effect+of+the+polymorphism+on+the+relationship+of+shift+work+to+endometriosis. assertion.
- assertion asSentence CLOCK+polymorphisms+interact+with+fatty+acids+to+modulate+metabolic+syndrome+X+traits. assertion.
- assertion asSentence REV-ERBalpha+plays+a+dual+role+in+regulation+of+the+activity+of+the+BMAL1%2FCLOCK+heterodimer+by+regulation+of+expression+of+both+the+BMAL1+and+CLOCK+genes. assertion.
- assertion asSentence There+is+an+association+between+CLOCK+gene+T3111C+polymorphism+and+both+attention+deficit+hyperactivity+disorder+and+related+sleep+disturbances+in+children. assertion.
- assertion asSentence p31%28comet%29+negatively+regulates+the+spindle+assembly+checkpoint+by+extracting+Mad2+from+the+MCC. assertion.
- assertion asSentence Protects+HeLa+cells+from+H%282%29O%282%29-induced+cell+death. assertion.
- assertion asSentence In+brain+tissue+of+patients+with+Alzheimer%27s+disease+%2C+many+blood+vessels+exhibited+peroxiredoxin+6+staining+that+appeared+to+be+due+to+the+astrocytic+foot+processes. assertion.
- assertion asSentence Overexpression+of+peroxiredoxin+I+and+is+associated+with+breast+carcinoma. assertion.
- assertion asSentence AKAP250+acts+as+a+scaffold+that+binds+protein+kinase+A+%28PKA%29%2C+protein+kinase+C+and+protein+phosphatases%2C+associating+reversibly+with+the+beta%282%29-adrenergic+receptor. assertion.
- assertion asSentence AKAP12alpha+promoter+methylation+is+associated+with+lung+cancer. assertion.
- assertion asSentence AKAP12+is+involved+in+the+regulation+of+endothelial+cell+migration+through+the+inhibitory+regulation+of+MMP-9+expression+in+tumor+cells. assertion.
- assertion asSentence A+point+mutation+%28S296R%29+in+the+amino-terminal+domain+of+the+androgen+receptor+%28AR%29+can+decrease+the+ligand+specificity+of+the+AR+and+alter+the+interaction+between+serine296arginine+and+the+nuclear+receptor+co-repressor+1+%28N-coR%29. assertion.
- assertion asSentence Aberrant+corepressor+interactions+implicated+in+PML-RAR%28alpha%29+and+PLZF-RAR%28alpha%29+leukemogenesis+reflect+an+altered+recruitment+and+release+of+specific+NCoR+and+SMRT+splice+variants. assertion.
- assertion asSentence SMRT+and+N-CoR+corepressors+are+involved+in+transcriptional+regulation+by+both+agonist-+and+antagonist-bound+AR+and+regulate+the+magnitude+of+hormone+response%2C+at+least+in+part%2C+by+competing+with+coactivators. assertion.
- assertion asSentence miR-16+targets+SMRT+and+modulates+NF-kappaB-regulated+transactivation+of+the+IL-8+gene. assertion.
- assertion asSentence Promotes+hypoxia-inducible+factor+1+alpha+subunit+%28HIF-1+alpha%29+ubiquitination+and+degradation. assertion.
- assertion asSentence There+is+a+functional+variant+in+ABCG1+that+associates+with+increased+risk+of+myocardial+infarction+and+ischemic+heart+disease+in+the+general+population. assertion.