Matches in Nanopublications for { ?s <http://purl.org/nanopub/x/asSentence> ?o ?g. }
- assertion asSentence CELSR1+is+a+risk+factor+for+neural+tube+defects+or+caudal+agenesis+via+pathogenic+role+of+planar+cell+polarity+signaling+in+these+malformations. assertion.
- assertion asSentence Synphilin-1+inhibits+alpha-synuclein+degradation+by+the+proteasome. assertion.
- assertion asSentence hCLCA2+Is+a+p53-Inducible+Inhibitor+of+Breast+Cancer+Cell+Proliferation. assertion.
- assertion asSentence The+functional+single-nucleotide+polymorphism+of+ARHGEF10+confers+the+susceptibility+to+atherothrombotic+stroke. assertion.
- assertion asSentence Plasma+membrane+protein+SCARA5+can+contribute+to+human+hepatocellular+carcinoma+%28HCC%29+tumorigenesis+and+metastasis+via+activation+of+the+FAK+signaling+pathway. assertion.
- assertion asSentence IKKi%2FIKKepsilon+plays+a+key+role+in+integrating+signals+induced+by+pro-inflammatory+stimuli. assertion.
- assertion asSentence IKBKE+protein+activates+Akt+independent+of+phosphatidylinositol+3-kinase%2FPDK1%2FmTORC2+and+the+pleckstrin+homology+domain+to+sustain+malignant+transformation. assertion.
- assertion asSentence IKKepsilon+regulated+Sendai+virus-induced+apoptosis+via+the+phosphorylation-dependent+turnover+of+XIAP. assertion.
- assertion asSentence Rab+and+Arl+GTPase+family+members+cooperate+in+the+localization+of+GCC2. assertion.
- assertion asSentence The+reduction+in+EGFR+levels+and+EGF-induced+signaling+in+SOCS5-expressing+cells+requires+both+the+Src+homology-2+and+SOCS+box+domains+of+SOCS5. assertion.
- assertion asSentence MDC1+functions+in+Rad51-mediated+homologous+recombination+by+retaining+Rad51+in+chromatin. assertion.
- assertion asSentence NFBD1%2C+53BP1+and+BRCA1+have+both+unique+and+redundant+functions+in+radiation-induced+phosphorylation+and+localization+events+in+the+ATM-Chk2+pathway. assertion.
- assertion asSentence By+monoubiquitination+of+H2A+at+lysine+119%2C+2A-HUB+mediates+a+selective+repression+of+a+specific+set+of+chemokine+genes+in+macrophages%2C+critically+modulating+migratory+responses+to+TLR+activation. assertion.
- assertion asSentence Estrogen+receptors+are+recruited+at+several+proximal+and+distal+estrogen+response+elements+upstream+of+the+GREB1+transcription+unit. assertion.
- assertion asSentence Haplotypes+in+KIAA0391+and+PSMA6+genes+is+a+genetic+link+for+myocardial+infarction+and+coronary+artery+disease. assertion.
- assertion asSentence SMC3+and+separase+are+upregulated+and+securin+is+downregulated+in+malignant+transformation+of+BEAS-2B+cells+induced+by+coal+tar+pitch+smoke+extracts. assertion.
- assertion asSentence The+minor+alleles+of+both+NOS1AP+single+nucleotide+polymorphisms+significantly+potentiate+the+QTc+prolonging+effect+of+verapamil. assertion.
- assertion asSentence Common+variations+in+the+NOS1AP+gene+are+associated+with+a+significant+increase+in+the+risk+of+drug-induced+long+QT+syndrome. assertion.
- assertion asSentence Necessary+for+the+structural+integrity+of+the+pericentrosomal+endosomal+recycling+compartment. assertion.
- assertion asSentence Vpr+acts+to+enhance+constitutive+DCAF1-dependent+UNG2+turnover. assertion.
- assertion asSentence HDAC+suppresses+the+activation+of+PPARgamma+in+the+gastric+carcinoma+cell+line+SGC-7901. assertion.
- assertion asSentence Aurora+B+kinase+activity+is+required+for+the+accumulation+of+tension-sensitive+mitotic-checkpoint+components%2C+such+as+ZW10+and+ROD%2C+in+order+to+maintain+mitotic-checkpoint+arrest. assertion.
- assertion asSentence CP110+suppresses+a+cilia+assembly+program. assertion.
- assertion asSentence The+transition+from+centrioles+to+basal+bodies+is+negatively+regulated+by+CP11+protein. assertion.
- assertion asSentence hOCT2+interacts+with+LAPTM4A+in+lysosomes+and+late+endosomes+and+regulates+endocytotic+recruitment. assertion.
- assertion asSentence The+PX-RICS-14-3-3zeta%2Ftheta+complex+couples+N-cadherin-beta-catenin+with+dynein-dynactin+to+mediate+its+export+from+the+endoplasmic+reticulum. assertion.
- assertion asSentence ACAP1+has+robust%2C+constitutive+Arf6+GAP+activity+in+vivo%2C+with+little+activity+toward+Arf1. assertion.
- assertion asSentence HDAC4+as+a+specific+downstream+substrate+of+CaMKIIdeltaB+in+cardiac+cells+and+have+broad+applications+for+the+signaling+pathways+leading+to+cardiac+hypertrophy+and+heart+failure. assertion.
- assertion asSentence P%2FCAF+deacetylation+by+HDAC3+and+in+a+minor+degree+by+HDAC1%2C+HDAC2%2C+or+HDAC4+leads+to+cytoplasmic+accumulation+of+P%2FCAF. assertion.
- assertion asSentence mTORC1+suppresses+autophagy+through+direct+regulation+of+the+approximately+3-MDa+ULK1-Atg13-FIP200+complex. assertion.
- assertion asSentence MATR3+binds+viral+RNA+and+is+required+for+the+Rev%2FRRE+mediated+nuclear+export+of+unspliced+HIV-1+RNAs. assertion.
- assertion asSentence Hepatocellular+carcinoma+patients+can+be+separated+into+three+prognosis-distinguishable+groups+by+use+of+a+risk+score+that+is+based+upon+HURP+expression. assertion.
- assertion asSentence MAML1+recruits+CycC%3ACDK8+to+phosphorylate+the+Notch+ICD+and+coordinate+activation+with+turnover. assertion.
- assertion asSentence The+RBP-Jkappa-associated+domain+of+Notch+increases+the+effective+concentration+of+the+ankyrin+domain+for+its+binding+site+on+CSL%2C+enabling+docking+of+the+ankyrin+domain+and+subsequent+recruitment+of+the+Mastermind-like+coactivator. assertion.
- assertion asSentence In+response+to+CSNO+Keap1+accumulates+in+the+nucleus+with+a+time+course+similar+to+that+of+Nrf2. assertion.
- assertion asSentence ap1-dependent+signaling+pathway+for+the+induction+of+the+constitutive+GST+A1+expression+during+epithelial+cell+differentiati+in+Caco-2+cells. assertion.
- assertion asSentence Activating+Nrf2+pathways+in+tissue-specific+Keap1+knockout+mice+and+human+epithelial+cells+represents+an+important+genetic+approach+against+oxidant-induced+lung+damage. assertion.
- assertion asSentence Regulation+of+KEAP1+expression+by+promoter+methylation+in+malignant+gliomas+and+association+with+patient%27s+outcome. assertion.
- assertion asSentence In+a+proteomic+screen+for+p53+interactors+the+cullin+protein+Cul7+efficiently+associates+with+p53. assertion.
- assertion asSentence RB1CC1+insufficiency+causes+neuronal+atrophy+through+mTOR+signaling+alteration+and+involved+in+the+pathology+of+Alzheimer%27s+diseases. assertion.
- assertion asSentence Nuclear+RB1CC1+directly+activates+the+RB1+promoter+to+enhance+RB1+expression+in+cancer+cells. assertion.
- assertion asSentence Mowat-Wilson+syndrome+is+a+genetic+condition+caused+by+heterozygous+mutations+or+deletions+of+the+ZEB2+gene. assertion.
- assertion asSentence ZEB2+and+CTNNB1+are+the+functional+downstream+targets+of+miR-200a+and+they+play+distinct+roles+in+regulating+nasopharyngeal+carcinoma+development. assertion.
- assertion asSentence Dock180+ELMO+complex+functions+as+an+unconventional+two-part+exchange+factor+for+Rac. assertion.
- assertion asSentence ARNO+and+ARF6+coordinate+with+the+Dock180%2FElmo+complex+to+promote+Rac+activation+at+the+leading+edge+of+migrating+cells. assertion.
- assertion asSentence Serine+residue+623+of+Gab2+is+a+phosphorylation+target+for+MAP+kinase+%28ERK%29%2C+with+demonstrated+biochemical+consequences+on+activation+of+ERK+itself+and+on+activation+of+STAT5. assertion.
- assertion asSentence Gab2+regulates+cytoskeletal+organization+and+cell+motility+by+regulating+RhoA+activation+and+binding+to+Shp2. assertion.
- assertion asSentence KIAA0319+protein+is+associated+with+dyslexia. assertion.
- assertion asSentence Mutations+in+cilia+co-expressed+DCDC2%2C+DYX1C1+and+KIAA0319+genes+are+associated+with+a+cognitive+neurological+disorder%2C+dyslexia. assertion.
- assertion asSentence Cep170+interacts+with+Polo-like+kinase+1+in+mature+centrioles. assertion.
- assertion asSentence Interaction+of+Rpn7+with+DNA+damage+response+foci+in+situ+mediates+the+protection+of+DNA+damage+foci+from+premature+resolution. assertion.
- assertion asSentence Interstitial+deletions+that+include+the+MAGI2+gene+on+chromosome+7q11.23-q.21.11+are+associated+with+IS+cases. assertion.
- assertion asSentence ASF1+cellular+levels+are+tightly+controlled+by+distinct+pathways+and+provide+a+molecular+mechanism+for+post-translational+regulation+of+dASF1+and+hASF1a+by+TLK+kinases. assertion.
- assertion asSentence Adenoviral+delivery+of+Tousled+kinase+protects+salivary+glands+against+ionizing+radiation+damage. assertion.
- assertion asSentence ARK5+suppresses+the+apoptosis+induced+by+nutrient+starvation+and+death+receptors+via+inhibition+of+caspase+8+activation. assertion.
- assertion asSentence ARK5+negatively+regulates+procaspase-6+by+phosphorylation+at+Ser257%2C+leading+to+resistance+to+the+FasL%2FFas+system. assertion.
- assertion asSentence The+expression+of+KIAA0196+at+chromosomal+region+8q24+is+significantly+higher+in+prostate+carcinomas+with+gene+amplification+than+in+those+without+it. assertion.
- assertion asSentence Mannose+receptor+activity+is+up-regulated+by+surfactant+protein+A+on+monocyte-derived+macrophages. assertion.
- assertion asSentence Approximately+60%25+of+the+initial+association+of+HIV+with+macrophages+that+lack+expression+of+DC-SIGN+%28a+dendritic+cell-specific+ICAM-3+receptor%2FHIV-1-binding+protein%29+is+mediated+by+the+macrophage+mannose+receptor. assertion.
- assertion asSentence KIAA0471+mRNA+expression+is+reduced+in+Alzheimer+patients. assertion.
- assertion asSentence ATP2C2+modulates+phonological+short-term+memory+in+language+impairment. assertion.
- assertion asSentence There+is+no+association+of+ARNT2+gene+with+cleft+palate+only+%28n+%3D+45%29+and+cleft+lip%2Fpalate+%28n+%3D+37%29. assertion.
- assertion asSentence GEP100%2FArf6+is+required+for+epidermal+growth+factor-induced+ERK%2FRac1+signaling+and+cell+migration+in+human+hepatoma+HepG2+cells. assertion.
- assertion asSentence Mitofusin+degradation+by+mitochondria-associated+Parkin+inhibits+the+fusion+of+damaged+mitochondria+with+healthy+mitochondria+to+facilitate+the+selective+elimination+of+the+former+by+autophagy. assertion.
- assertion asSentence RNA+interference-mediated+silencing+of+KIF14+disrupts+cell+cycle+progression+and+induces+cytokinesis+failure. assertion.
- assertion asSentence The+stable+association+of+multiprotein+exon+junction+complex+core+with+RNA+is+maintained+by+inhibition+of+eIF4AIII+ATPase+activity+by+MAGOH-Y14. assertion.
- assertion asSentence Y14+interacts+with+STAT3+and+regulates+the+transcriptional+activation+of+STAT3+by+influencing+the+tyrosine-phosphorylation+of+STAT3. assertion.
- assertion asSentence Golgin-84+on+coat+protein+I+vesicles+interacts+with+the+conserved+oligomeric+Golgi+complex+before+SNARE+assembly. assertion.
- assertion asSentence The+3OST-2+and+-4+are+specifically+expressed+in+brain. assertion.
- assertion asSentence Genetic+variants+of+HS3ST3A1+and+HS3ST3B1+are+associated+with+Plasmodium+falciparum+parasitaemia. assertion.
- assertion asSentence Genetic+variants+of+HS3ST3A1+and+HS3ST3B1+are+associated+with+Plasmodium+falciparum+parasitaemia. assertion.
- assertion asSentence A+functional+Zn+finger+of+USP15+is+needed+to+maintain+a+conformation+essential+for+disassembling+poly-Ub+chains%2C+a+prerequisite+for+rescuing+the+E3+ligase+Rbx1. assertion.
- assertion asSentence Tumor+Suppressor+Protein+p53+contributes+to+the+major+vault+protein+-facilitated+resistance+to+apoptosis+by+senescent+human+diploid+fibroblasts+by+transcriptionally+activating+MVP+gene+in+these+cells. assertion.
- assertion asSentence The+liver+expresses+FGF19+under+conditions+of+extrahepatic+cholestasis. assertion.
- assertion asSentence The+inhibitory+effect+of+FGF-19+on+insulin+activation+of+hepatic+fatty+acid+synthesis+constitutes+a+mechanism+that+would+explain+the+beneficial+effect+of+FGF-19+on+metabolic+syndrome. assertion.
- assertion asSentence FGFR4+activation+mediates+the+induction+of+hepatocyte+proliferation+and+the+suppression+of+bile+acid+biosynthesis+by+FGF19. assertion.
- assertion asSentence Differential+specificity+of+endocrine+FGF19+and+FGF21+to+FGFR1+and+FGFR4+in+complex+with+KLB. assertion.
- assertion asSentence The+TNFSF15+genotype+is+positively+associated+with+isolated+colonic+%28L2%29+Crohn+disease. assertion.
- assertion asSentence The+HOPA12bp+polymorphism+is+a+significant+risk+factor+for+schizophrenia+for+both+men+and+women. assertion.
- assertion asSentence Transcriptional+regulation+of+the+human+CYP3A4+gene+by+the+constitutive+androstane+receptor. assertion.
- assertion asSentence Alternatively+spliced+isoforms+of+the+constitutive+androstane+receptor. assertion.
- assertion asSentence CAR+transactivates+ABCG2+through+the+DR5+motif+located+in+its+distal+promoter+in+hepatocytes+and+the+motif+prefers+CAR+to+pregnane+X+receptor. assertion.
- assertion asSentence The+bile+acid+receptor+FXR+is+significantly+overexpressed+in+Barrett%27s+esophagus+compared+to+normal+mucosa%2C+esophagitis+and+esophageal+adenocarcinoma. assertion.
- assertion asSentence High+farnesoid+X+receptor+is+associated+with+estrogen+receptor-positive+luminal-like+breast+cancer. assertion.
- assertion asSentence In+human+adrenal+cells%2C+FXR+increases+transcription+and+expression+of+HSD3B2. assertion.
- assertion asSentence FXR+promotes+endothelial+cell+motility+through+coordinated+regulation+of+FAK+and+MMP-9. assertion.
- assertion asSentence Bile+salts+control+the+antimicrobial+peptide+cathelicidin+through+nuclear+receptors+%28farnesoid+X+receptor+and+vitamin+D+receptor%29+in+the+human+biliary+epithelium. assertion.
- assertion asSentence FXR+is+able+to+compete+with+steroidogenic+factor+1+in+binding+to+a+common+sequence+present+in+the+aromatase+promoter+region+interfering+negatively+with+its+activity. assertion.
- assertion asSentence FXR+activation+in+the+ileum+is+decreased+in+patients+with+Crohn%27s+colitis. assertion.
- assertion asSentence The+binding+of+STAT-1+to+specific+responsive+elements+in+the+promoter+of+PPARgamma+and+FXR+and+MCP-1+shifts+macrophages+toward+a+pro-atherogenetic+phenotype. assertion.
- assertion asSentence Smad2+nucleocytoplasmic+shuttling+by+nucleoporins+CAN%2FNup214+and+Nup153+feeds+TGFbeta+signaling+complexes+in+the+cytoplasm+and+nucleus. assertion.
- assertion asSentence The+copper+chaperone+CCS+is+responsible+for+copper+insertion+into+apo-superoxide+dismutasse+1. assertion.
- assertion asSentence Loss+of+copper+chaperone+for+superoxide+dismutase+%28CCS%29+increases+amyloid-beta+production+in+both+CCS+knockout+neurons+and+CCS+small-interfering+%28si%29RNA-treated+cultured+tumor+cells. assertion.
- assertion asSentence NKp80+is+expressed+on+a+highly+responsive+subset+of+effector+memory+CD8+T+cells+with+an+inflammatory+NK-like+phenotype+and+promotes+T-cell+responses+toward+AICL-expressing+cells. assertion.
- assertion asSentence KLF5+promotes+breast+cell+survival+partially+through+fibroblast+growth+factor-binding+protein+1-pERK-mediated+dual+specificity+MKP-1+protein+phosphorylation+and+stabilization. assertion.
- assertion asSentence Regulator+of+differentiation+1+%28ROD1%29+binds+to+the+amphipathic+C-terminal+peptide+of+thrombospondin-4+and+is+involved+in+its+mitogenic+activity. assertion.
- assertion asSentence KCNE2+R27C+is+a+gain-of-function+mutation+associated+with+the+initiation+and%2For+maintenance+of+Atrial+Fibrillation. assertion.
- assertion asSentence CD95+signals+are+mediated+by+nucleo-cytoplasmic+translocation+of+FLASH. assertion.
- assertion asSentence Human+FLASH+interacts+with+Lsm11+in+vitro+and+stimulates+3%27+end+processing+of+histone+pre-mRNA+in+mammalian+nuclear+extracts. assertion.
- assertion asSentence Akt3+and+mutant+V600E+B-Raf+cooperate+to+promote+early+melanoma+development. assertion.