Matches in Nanopublications for { ?s <http://purl.org/nanopub/x/asSentence> ?o ?g. }
- assertion asSentence The+phenotype+in+enhanced+S-cone+syndrome+is+variable%2C+both+in+fundus+appearance+and+in+the+severity+of+the+electrophysiological+abnormalities. assertion.
- assertion asSentence By+activating+the+Abi1+pathway%2C+Bcr-Abl+induces+a+translocation+of+MT1-MMP+to+a+membrane-associated+structural+complex+enriched+with+F-actin+and+adhesion+molecules. assertion.
- assertion asSentence Abi1+isoforms+differentially+regulate+macropinocytosis+as+a+consequence+of+their+different+relative+affinities+for+activated+Rac1+in+Wave+2+complex. assertion.
- assertion asSentence KCNE+variants+reveal+a+critical+role+of+the+beta+subunit+carboxyl+terminus+in+PKA-dependent+regulation+of+the+IKs+potassium+channel%2C+KCNQ1. assertion.
- assertion asSentence Selective+activation+of+p120ctn-Kaiso+signaling+to+unlock+contact+inhibition+of+ARPE-19+cells+without+epithelial-mesenchymal+transition. assertion.
- assertion asSentence Expression+of+TRF2+and+TANK1+increased+in+monoclonal+gammopathy+of+undetermined+significance+and+multiple+myeloma. assertion.
- assertion asSentence Parkin-mediated+K63-linked+polyubiquitination+targets+misfolded+DJ-1+to+aggresomes+via+binding+to+HDAC6. assertion.
- assertion asSentence Lower+HDAC6+levels+combined+with+decreased+microtubule+binding+lead+to+increased+tubulin+acetylation+in+ethanol-treated+cells. assertion.
- assertion asSentence HDAC6+modulates+Hsp90+chaperone+activity+and+regulates+activation+of+aryl+hydrocarbon+receptor+signaling. assertion.
- assertion asSentence Carbamazepine+promotes+Her-2+protein+degradation+in+breast+cancer+cells+by+modulating+HDAC6+activity+and+acetylation+of+Hsp90. assertion.
- assertion asSentence AMP-activated+protein+kinase+%28AMPK%29+regulates+GLUT4+transcription+through+the+histone+deacetylase+%28HDAC%295+transcriptional+repressor. assertion.
- assertion asSentence Alix+is+negatively+regulated+by+Src%2C+via+direct+interaction+and+phosphorylation. assertion.
- assertion asSentence Alix+fragment+364-716+is+a+potent%2C+Alix+binding+site-specific+inhibitor+of+HIV-1+assembly+and+release. assertion.
- assertion asSentence BCL2L10+methylation+is+associated+with+myelodysplastic+syndromes. assertion.
- assertion asSentence The+proapoptotic+effect+of+BIM+%28through+transcriptional+induction+of+two+of+its+isoforms%29is+inhibited+by+the+activation+of+Raf%2FERK+signalling+which+prevents+BIM+up-regulation+and+leads+to+phosphorylation+of+the+BimEL+isoform. assertion.
- assertion asSentence Cleavage+of+Mcl-1+by+caspases+modifies+its+subcellular+localization%2C+increases+its+association+with+Bim+and+inhibits+its+antiapoptotic+function. assertion.
- assertion asSentence TLR+stimulation+of+macrophages+can+regulate+Bim+levels+in+opposing+ways%2C+namely+by+transcriptional+induction+and+by+phosphorylation-dependent+degradation+of+the+protein. assertion.
- assertion asSentence Bim+is+an+essential+mediator+of+amyloid-beta-induced+neurotoxicity. assertion.
- assertion asSentence Bim+mediates+particulate+matter-induced+apoptosis+via+mitochondrial+pathway. assertion.
- assertion asSentence Bad+and+Bim+are+major+B-RAF+responsive+proteins+regulating+apoptosis+in+melanoma+cells. assertion.
- assertion asSentence Treatment+of+B-RAF+mutant+tumor+cells+with+a+MEK+inhibitor+requires+BIM+and+is+enhanced+by+a+BH3+mimetic. assertion.
- assertion asSentence betaTrCP+promotes+cell+survival+in+cooperation+with+the+ERK-RSK+pathway+by+targeting+BimEL+for+degradation. assertion.
- assertion asSentence TGFbeta+stimulates+Bim+transcription+by+up-regulating+the+expression+of+the+transcription+factor+Runx1+through+an+internal+ribosome+entry+site+-dependent+mechanism. assertion.
- assertion asSentence Up-regulation+of+BIM+is+associated+with+increased+sensitivity+to+Imatinib+in+gastrointestinal+stromal+tumor. assertion.
- assertion asSentence The+COX-2%2FPGE%282%29+pathway+as+an+important+negative+regulator+of+Bim+expression+in+colorectal+tumours. assertion.
- assertion asSentence In+rheumatoid+arthritis%2C+the+DNA-PKcs-JNK-Bim%2FBmf+axis+transmits+genotoxic+stress+into+shortened+survival+of+naive+resting+T+cells%2C+imposing+chronic+proliferative+turnover+of+the+immune+system+and+premature+immunosenescence. assertion.
- assertion asSentence Bim+is+required+for+the+combretastatin-A4+induced+cell+death+in+the+H460+lung+cancer+cell+line+via+activation+of+the+mitochondrial+signalling+pathway. assertion.
- assertion asSentence A+stapled+BIM+peptide+overcomes+apoptotic+resistance+in+hematologic+cancers. assertion.
- assertion asSentence Bim+inhibits+autophagy+by+interacting+with+autophagy+regulator+Beclin+1%2C+an+interaction+facilitated+by+LC8. assertion.
- assertion asSentence A+nonsynonymous+SNP+at+12q24%2C+in+SH2B3%2C+associated+significantly+with+myocardial+infarction+in+six+different+populations. assertion.
- assertion asSentence LNK+mutation+is+associated+with+blast-phase+myeloproliferative+neoplasms. assertion.
- assertion asSentence Lnk+adaptor+is+an+effective+regulator+of+the+integrin-mediated+signaling+pathway+that+affects+endothelial+cell+adhesion+and+migration+processes. assertion.
- assertion asSentence Native+I%28f%29+channels+in+atrial+myocardium+are+heteromeric+complexes+composed+of+HCN4+and%2For+HCN2. assertion.
- assertion asSentence MRJ+has+a+relevant+functional+role+in+neurons. assertion.
- assertion asSentence Early+regulatory+GTPase-like+function+of+dynamin+precedes+late%2C+assembly-dependent+steps+during+which+GTP+hydrolysis+is+required+for+vesicle+release. assertion.
- assertion asSentence Endophilin+and+dynamin+colocalize+at+the+base+of+the+clathrin+coat. assertion.
- assertion asSentence In+patients+with+AD%2C+increased+production+of+Abeta+and+the+interaction+of+Abeta+with+Drp1+are+crucial+factors+in+mitochondrial+fragmentation%2C+abnormal+mitochondrial+dynamics+and+synaptic+damage. assertion.
- assertion asSentence DRP-1-mediated+mitotic+fission+is+a+cell-cycle+checkpoint+that+can+be+therapeutically+targeted+in+hyperproliferative+disorders+such+as+pulmonary+arterial+hypertension. assertion.
- assertion asSentence SHP+is+able+to+interact+with+LXR+and+to+modulate+its+transcriptional+activity. assertion.
- assertion asSentence LXRalpha+and+LXRbeta+are+expresed+in+the+majority+of+the+cell+types+in+human+skin. assertion.
- assertion asSentence LXR+%28as+a+heterodimer+with+the+retinoid+X+receptor%29+is+able+to+bind+the+ENG+promoter+on+an+LXR+response+element+and+mediates+the+activation+of+ENG+gene+expression+by+LXRalpha+in+JAR+cells. assertion.
- assertion asSentence 25-Hydroxycholesterol-3-sulfate+regulates+macrophage+lipid+metabolism+via+the+LXR%2FSREBP-1+signaling+pathway. assertion.
- assertion asSentence LXR-activating+oxysterols+induce+the+expression+of+inflammatory+markers+in+endothelial+cells+through+LXR-independent+mechanisms. assertion.
- assertion asSentence LXRalpha+and+LXRbeta+control+cholesterol+homeostasis. assertion.
- assertion asSentence Liver+X+Receptor+activation+downregulates+AKT+survival+signaling+in+lipid+rafts+and+induces+apoptosis+of+prostate+cancer+cells. assertion.
- assertion asSentence LXR+activation+inhibits+chemokine-induced+migration+of+CD4-positive+lymphocytes+by+reducing+PI-3+kinase+activity+and+activation+of+Rac-1+with+subsequent+inhibition+of+MLC+phosphorylation%2C+f-actin+formation+and+ICAM3+translocation. assertion.
- assertion asSentence CIDEA+binds+to+liver+X+receptors+and+regulates+their+activity+in+vitro. assertion.
- assertion asSentence Genetic+polymorphisms+in+NR1H3+and+its+target+genes+ABCA1%2C+APOE%2C+CETP+and+LPL+contribute+to+the+genetic+variance+for+HDL-cholesterol+concentrations+in+adolescence. assertion.
- assertion asSentence The+binding+of+copper+to+Cox17+is+needed+to+activate+cytochrome+c+oxidase+by+Cox17. assertion.
- assertion asSentence High+endogenous+levels+of+IL-18BP+in+trangenic+mice+effectively+neutralize+IL-18+and+are+protective+in+response+to+different+inflammatory+stimuli. assertion.
- assertion asSentence In+lines+of+intestinal+epithelial+cells+from+inflammatory+bowel+disease+patients%2C+interferon-gamma+selectively+up-regulated+IL-18+binding+protein. assertion.
- assertion asSentence In+malignant+neoplasms+of+the+ovary+DPP+III+activity+increased+with+growing+histologic+grade. assertion.
- assertion asSentence Ets-1%2FElk-1+is+a+critical+mediator+of+DPP3+transcription+in+human+glioblastoma+cells. assertion.
- assertion asSentence Mule+%28HUWE1%29+poly-ubiquitinates+anti-apoptotic+gene+Mcl-1. assertion.
- assertion asSentence LASU1+is+an+E3+ligase+that+ubiquitinates+Mcl-1+in+vitro+and+is+required+for+its+proteasome-dependent+degradation%2C+the+BH3+domain+of+LASU1+interactes+with+Mcl-1. assertion.
- assertion asSentence HectH9-mediated+ubiquitination+of+Myc+is+required+for+transactivation+of+multiple+target+genes. assertion.
- assertion asSentence Miz1+and+Myc+affect+the+activity+of+the+Atr+checkpoint+through+their+effect+on+TopBP1+chromatin+association+and+stability. assertion.
- assertion asSentence Mitochondrion-dependent+N-terminal+processing+of+outer+membrane+Mcl-1+protein+removes+an+essential+Mule%2FLasu1+protein-binding+site. assertion.
- assertion asSentence Increased+dosage+of+HUWE1+causes+nonsyndromic+intellectual+disability. assertion.
- assertion asSentence Gene+expression+of+GLEPP-1+is+decreased+in+podocytes+from+women+with+preeclampsia. assertion.
- assertion asSentence GPBP+regulates+GBM+collagen+organization+and+its+elevated+expression+causes+dissociation+and+subsequent+accumulation+of+IgA+on+the+GBM. assertion.
- assertion asSentence Arp2%2F3+complex+is+required+for+actin+polymerization+during+platelet+shape+change. assertion.
- assertion asSentence ARP3-mediated+actin+polymerization+is+regulated+by+phosphorylation+of+the+WASP+protein. assertion.
- assertion asSentence ASF1+cellular+levels+are+tightly+controlled+by+distinct+pathways+and+provide+a+molecular+mechanism+for+post-translational+regulation+of+dASF1+and+hASF1a+by+TLK+kinases. assertion.
- assertion asSentence Asf1b%2C+the+necessary+Asf1+isoform+for+proliferation%2C+is+predictive+of+outcome+in+breast+cancer. assertion.
- assertion asSentence Membrane+recruitment+of+the+cargo-selective+retromer+subcomplex+VPS35%2F29%2F26+is+catalysed+by+the+small+GTPase+Rab7+and+inhibited+by+the+Rab-GAP+TBC1D5. assertion.
- assertion asSentence Only+a+single+heterozygous+variant+in+the+VPS35+gene+caused+late-onset+Parkinson+disease+in+this+family. assertion.
- assertion asSentence The+small+GTPases+of+the+Ras+superfamily+mediate+numerous+biological+processes+through+their+ability+to+cycle+between+an+inactive+GDP-bound+and+an+active+GTP-bound+form. assertion.
- assertion asSentence Phosphorylation+of+actopaxin+regulates+cell+spreading+and+migration. assertion.
- assertion asSentence Frequent+hypermethylation+of+the+5%27+CpG+island+of+the+mitotic+stress+checkpoint+gene+Chfr+in+colorectal+and+non-small+cell+lung+cancer. assertion.
- assertion asSentence Aberrant+promoter+hypermethylation+of+the+CHFR+gene+is+associated+with+oral+squamous+cell+carcinomas. assertion.
- assertion asSentence Hypermethylation+of+CHFR+gene+promoter+is+associated+with+loss+or+lower+expression+of+CHFR+mRNA+in+laryngeal+squamous+cell+carcinoma. assertion.
- assertion asSentence Hypermethylation+of+CHFR+gene+is+associated+with+advanced+gastric+cancer. assertion.
- assertion asSentence Common+variants+in+CNDP1+and+CNDP2+play+a+role+in+susceptibility+to+kidney+disease+in+patients+with+type+2+diabetes. assertion.
- assertion asSentence High+CACNA2D3+gene+expression+is+assiciated+with+glioblastoma+multiforme. assertion.
- assertion asSentence Expression+of+CACNA2D3+mRNA+is+regulated+in+breast+cancer+cell+lines+by+methylation+in+the+CpG+island+located+in+the+5%27+regulatory+region+of+the+gene. assertion.
- assertion asSentence The+sodium+channel+%7Bbeta%7D3-subunit+induces+multiphasic+gating+in+NaV1.3+and+affects+fast+inactivation+via+distinct+intracellular+regions. assertion.
- assertion asSentence Hairless+protein+functions+as+a+corepressor+of+vitamin+D+receptor+to+block+calcitriol+action+on+keratinocytes. assertion.
- assertion asSentence The+stable+transfection+of+MDA-MB-231+with+an+expression+vector+encoding+ST6GalNAc+I+induces+the+expression+of+STn+antigen+at+the+cell+surface. assertion.
- assertion asSentence TReP-132+is+a+trans-acting+factor+of+genes+involved+in+adrenal+glucocorticoid%2C+C%2819%29+steroid+and+estrogen+production. assertion.
- assertion asSentence Selenoprotein+S+-105%28adenosine%29+allele+is+a+non-significant+risk+factor+in+young+stroke+patients+from+Italy+and+Germany. assertion.
- assertion asSentence COMMD1+%28copper+metabolism+MURR1+domain-containing+protein+1%29+regulates+Cullin+RING+ligases+by+preventing+CAND1+%28Cullin-associated+Nedd8-dissociated+protein+1%29+binding. assertion.
- assertion asSentence Crystal+structure+of+mitoNEET+reveals+distinct+groups+of+iron+sulfur+proteins. assertion.
- assertion asSentence The+presenilin-subunit+stabilizing+function+of+PEN-2+depends+on+length+and+overall+sequence+of+its+carboxyl-terminal+domain. assertion.
- assertion asSentence Transactivation+of+the+Pen2+promoter+by+presenilin+1%2F2+is+p53-dependent. assertion.
- assertion asSentence Mutations+in+the+coding+regions+of+the+RNF146+and+ECHDC1+genes+do+not+contribute+to+the+burden+of+inherited+predisposition+of+breast+cancer+in+Ashkenazi+high+risk+women. assertion.
- assertion asSentence hOAT4+is+the+long-postulated%2C+low-affinity+apical+urate+anion+exchanger+that+facilitates+hydrochlorothiazide-associated+hyperuricemia. assertion.
- assertion asSentence The+down-regulation+of+hOAT4+activity+by+activation+of+protein+kinase+C+and+the+up-regulation+of+hOAT4+activity+by+NHERF-1+are+mediated+through+alteration+of+hOAT4+internalization. assertion.
- assertion asSentence PKA-mediated+phosphorylation+of+HDAC8+plays+a+central+role+in+the+overall+acetylation+status+of+histones. assertion.
- assertion asSentence ASH1+and+MLL1+synergize+in+activation+of+Hox+genes. assertion.
- assertion asSentence The+GSDMA+%28rs7212938%29+and+GSDMB+%28rs7216389%29+polymorphisms+are+associated+with+asthma+susceptibility+and+intermediate+asthma+phenotypes. assertion.
- assertion asSentence Expression+of+mRNA+is+upregulated+during+differentation+of+keratinocyte+immortalized+cell+lines. assertion.
- assertion asSentence Increased+expression+of+beta-defensin+3+is+associated+with+oral+squamous+cell+carcinomas. assertion.
- assertion asSentence In+periodontally+healthy+subjects%2C+HBD-2+and+HBD-3+levels+are+not+influenced+by+stress. assertion.
- assertion asSentence Transcription+factors+ETS2+and+MESP1+transdifferentiate+human+dermal+fibroblasts+into+cardiac+progenitors. assertion.
- assertion asSentence Ritonavir+%28at+100+mg+once+daily+and+100+mg+twice+daily+significantly+down-regulated+acyl-CoA+synthetase+short-chain+family+member+2+in+20+healthy+individuals. assertion.
- assertion asSentence Lanthionine+synthetase+components+C-like+2+increases+cellular+sensitivity+to+adriamycin+by+decreasing+the+expression+of+P-glycoprotein+through+a+transcription-mediated+mechanism. assertion.
- assertion asSentence Human+recombinant+LANCL2+binds+abscisic+acid+%28ABA%29+directly+and+provide+the+first+demonstration+of+ABA+binding+to+a+mammalian+ABA+receptor. assertion.
- assertion asSentence Induction+of+MMP-9+gene+expression+is+regulated+by+oscillatory%2Fcumulative+activation+of+NFkappaB+in+a+colon+cancer+cell+line. assertion.
- assertion asSentence In+the+setting+of+low+density+lipoprotein+receptor+deficiency%2C+apoM-Tg+mice+with+approximately+2-fold+increased+plasma+apoM+concentrations+developed+smaller+atherosclerotic+lesions+than+controls. assertion.