Matches in Nanopublications for { ?s <http://purl.org/nanopub/x/asSentence> ?o ?g. }
- assertion asSentence Regulation+of+human+apolipoprotein+m+gene+expression+by+orphan+and+ligand-dependent+nuclear+receptors. assertion.
- assertion asSentence ApoM+can+bind+oxidized+phospholipids%2C+increasing+the+antioxidant+effect+of+HDL. assertion.
- assertion asSentence The+prosurvival%2C+anti-apoptotic+effect+of+SULF2+in+hepatocellular+carcinoma+is+mediated+through+activation+of+the+PI3K%2FAkt+pathway. assertion.
- assertion asSentence SULF1+and+SULF2+are+overexpressed+in+various+human+cancer+types+and+can+be+associated+to+progression+and+prognosis. assertion.
- assertion asSentence Platelet-derived+growth+factor-C+%28PDGF-C%29+activation+by+serine+proteases. assertion.
- assertion asSentence Autosomal+dominant+familial+calcium+pyrophosphate+dihydrate+deposition+disease+is+caused+by+mutation+in+the+transmembrane+protein+ANKH. assertion.
- assertion asSentence CRTAM+expression+is+driven+by+the+JNK-AP-1+signaling+pathway. assertion.
- assertion asSentence In+humans%2C+the+600+kDa+RNF20%2F40+complex+is+the+E3+ligase. assertion.
- assertion asSentence The+Bre1+protein+specifically+increases+the+global+level+of+H2B+ubiquitylation+at+lysine+120+and+enhances+activator-dependent+transcription. assertion.
- assertion asSentence hBre1+inhibits+Ebp1%27s+tumor+suppressive+activity+through+mediating+its+polyubiquitination+and+degradation. assertion.
- assertion asSentence Capping+enzyme+can+play+a+direct+role+in+transcription+by+modulating+displacement+of+nascent+RNA+during+transcription. assertion.
- assertion asSentence Pard-3+and+AS3+genes+are+mutationally+inactivated+in+prostate+cancer+cells. assertion.
- assertion asSentence Changes+in+cell+polarity+proteins+Par-3+and+PP-1+are+associated+with+altered+expression+and+assembly+of+tight+junction+proteins+claudin-2%2C+-3%2C+-5+and+-7+and+ZO-1%2C+causing+paracellular+leakage+in+active+coeliac+disease. assertion.
- assertion asSentence Functional+properties+of+the+epithelial+Ca2%2B+channel%2C+ECaC. assertion.
- assertion asSentence Four+variants+of+the+gene+SLC2A9+achieved+genome-wide+significance+for+association+with+serum+uric+acid. assertion.
- assertion asSentence The+SNP+rs1014290+within+the+SLC2A9+gene+is+associated+with+type+2+DM+in+Han+Chinese. assertion.
- assertion asSentence GLUT9+mutations+cause+renal+hypouricemia+type+2+%28RHUC2%29+by+their+decreased+urate+reabsorption+on+both+sides+of+the+renal+proximal+tubule+cells. assertion.
- assertion asSentence Apoptosis+induced+by+bufalin+is+related+to+mitochondrial+release+of+Smac%2FDIABLO. assertion.
- assertion asSentence TRAF3+interacts+with+Smac%2FDIABLO+via+TRAF+domain%2C+leading+to+an+increased+proapoptotic+effect+of+Smac%2FDIABLO+in+cytoplasm. assertion.
- assertion asSentence An+obligatory+role+for+Smac%2FDIABLO+in+these+tumor+cells+during+several+pathways+of+apoptosis+induction. assertion.
- assertion asSentence Mitochondrial+survivin+associates+with+Smac%2FDIABLO%2C+delaying+its+release. assertion.
- assertion asSentence XIAP+homotrimerizes+via+its+C-terminal+Ring+domain%2C+making+its+inhibitory+activity+toward+caspase-3+more+susceptible+to+Smac. assertion.
- assertion asSentence Smac%2FDIABLO+protein+expression+is+associated+with+higher+sensitivity+to+standard+chemotherapy+and+a+longer+overall+survival+in+AML+patients. assertion.
- assertion asSentence The+release+of+Smac%2FDIABLO+proved+to+be+crucial+for+full+effector+caspase+activity+and+clonogenic+execution. assertion.
- assertion asSentence GPR91+is+a+receptor+for+succinate+and+mediates+succinate-induced+hypertension. assertion.
- assertion asSentence The+intracellular+trafficking+of+hCaR+from+the+endoplasmic+reticulum+is+Sar1-dependent+via+coat+protein+complex-II+vesicles. assertion.
- assertion asSentence Lipid-directed+and+tether-assisted+Sar1+organization+controls+membrane+constriction+to+regulate+ER+export. assertion.
- assertion asSentence Resistin+induces+HASMC+proliferation+through+both+ERK+1%2F2+and+Akt+signaling+pathways. assertion.
- assertion asSentence A+common+polymorphism+of+the+human+resistin+promoter+is+critical+for+the+binding+of+stimulaty+protein+1+and+modulates+the+transcriptional+activity+of+the+resistin+gene. assertion.
- assertion asSentence Resistin+promotes+lipid+accumulation+in+human+macrophages+through+its+upregulating+CD36+cell+surface+expression. assertion.
- assertion asSentence Anorexia+nervosa+is+associated+with+decreased+plasma+resistin+levels. assertion.
- assertion asSentence Plasma+resistin+levels+are+increased+in+presence+of+the+metabolic+syndrome+and+are+associated+with+increased+cardiovascular+risk. assertion.
- assertion asSentence RST+polymorphisms+are+associated+with+adiposity+and+with+bone+and+skeletal+muscle+phenotypes. assertion.
- assertion asSentence Exercise+training%2C+without+weight+loss%2C+decreases+resistin+and+inflammatory+cytokines+in+patients+with+type+2+diabetes. assertion.
- assertion asSentence Correlated+with+tumor+necrosis+factor+alpha+in+type+2+diabetes. assertion.
- assertion asSentence In+OSAHS+patients%2C+serum+resistin+level+is+enhanced+and+accompanied+by+disorders+of+blood+pressure+and+serum+lipids. assertion.
- assertion asSentence Resistin+is+more+abundant+in+liver+than+adipose+tissue+and+is+not+up-regulated+by+lipopolysaccharide. assertion.
- assertion asSentence Resistin%2C+at+concentrations+found+in+obese+individuals%2C+significantly+decreases+eNOS+expression+and+NO+production+through+oxidative+stress+and+p38+and+JNK+MAPK+activation+in+coronary+endothelial+cells. assertion.
- assertion asSentence Resistin+induces+expansion+of+functional+regulatory+T+cells+only+when+co-cultured+with+dendritic+cells. assertion.
- assertion asSentence Resistin+greatly+increased+hepatocyte+VLDL+apoB+and+lipid+secretion+because+of+microsomal+triglyceride+transfer+protein+activation+and+induction+of+hepatocyte+insulin+resistance. assertion.
- assertion asSentence Resistin+gene+expression+in+mononuclear+cells+and+monocyte-derived+macrophages+in+PCOS+and+insulin+resistance+is+the+same+as+controls. assertion.
- assertion asSentence The+viral+E6+and+E7+oncogenes+are+sufficient+for+interferon-kappa+repression%2C+with+E6+being+mainly+responsible. assertion.
- assertion asSentence Higher-eukaryotic+cells+separately+employ+PARP1+and+Rad18+to+suppress+the+toxic+effects+of+NHEJ+during+the+HR+reaction+at+stalled+replication+forks. assertion.
- assertion asSentence RAD18+signals+DNA+polymerase+IOTA+to+stalled+replication+forks+in+cells+entering+S+phase+with+DNA+damage. assertion.
- assertion asSentence RAD18-mediated+PCNA+monoubiquitination+is+a+central+hub+for+the+mobilization+of+the+Fanconi+anemia+DNA+repair+network+pathway. assertion.
- assertion asSentence E2F3+controls+the+ubiquitination+of+PCNA+through+the+transcriptional+regulation+of+Rad18. assertion.
- assertion asSentence Gene+induces+transformed+phenotype+when+overexpressed+in+a+cancer+breast+cell+line. assertion.
- assertion asSentence The+basic+nuclear+import+signal+for+AIDA-1+is+buried+at+the+interface+between+the+two+sterile+alpha+motif+domains. assertion.
- assertion asSentence The+ciliary+protein+IFT46+has+a+specific+function+in+chondrocytes+and+is+also+essential+for+normal+development+of+vertebrates. assertion.
- assertion asSentence Single+nucleotide+polymorphisms+in+C16orf61+gene+is+associated+with+breast+cancer. assertion.
- assertion asSentence The+remarkable+clinical+overlap+between+sporadic+EMSY+amplification+and+familial+BRCA2+deletion+implicates+a+BRCA2+pathway+in+sporadic+breast+and+ovarian+cancer. assertion.
- assertion asSentence H%282%29O%282%29+prolongs+NF-kappaB+activation+in+co-stimulated+cells+by+suppressing+the+negative+regulatory+functions+of+Cezanne+and+IkappaBalpha. assertion.
- assertion asSentence PRDM9+variation+strongly+influences+recombination+hot-spot+activity+and+meiotic+instability. assertion.
- assertion asSentence Play+an+important+role+in+mediating+p53-inducible+apoptosis+through+the+mitochondrial+pathway. assertion.
- assertion asSentence High+beta-catenin+is+associated+with+glioma+progression. assertion.
- assertion asSentence Microatellite-stable+cases+exhibited+reduced+membranous+beta+catenin+and+increased+cytoplasmic+and+nuclear+beta+catenin+compared+with+microsatellite-instable+cases. assertion.
- assertion asSentence Higher+expression+of+CXCR7+is+associated+with+Rec-Distant+and+poor+DFS+in+patients+with+p-stage+I+NSCLC. assertion.
- assertion asSentence The+tumor+suppressor+HIC1+is+implicated+in+the+transcriptional+regulation+of+the+chemokine+receptor+CXCR7%2C+a+key+player+in+the+promotion+of+tumorigenesis+in+a+wide+variety+of+cell+types. assertion.
- assertion asSentence The+autocrine%2Fparacrine+macrophage+migration+inhibitory+factor+%28MIF%29%2Fchemokines+CXCR4%2FCXCR7+axis+plays+an+important+pleiotropic+role+in+rhabdomyosarcoma+growth. assertion.
- assertion asSentence High+expression+of+CXCR7+combined+with+Alpha+fetoprotein+in+hepatocellular+carcinoma+correlates+with+extra-hepatic+metastasis+to+lung+after+hepatectomy. assertion.
- assertion asSentence CXCR7%2FCXCR4+heterodimer+constitutively+recruits+beta-arrestin+to+enhance+cell+migration. assertion.
- assertion asSentence High+CXCR7+expression+is+associated+with+cervical+cancer. assertion.
- assertion asSentence Z-2+allele+of+the+aldose+reductase+gene+is+a+risk+factor+for+the+development+of+diabetic+retinopathy+in+a+group+of+Caucasian+participants+with+Type+2+diabetes. assertion.
- assertion asSentence High+AKR1B10+secretion+is+associated+with+neoplasms. assertion.
- assertion asSentence AKR1B10+is+associated+with+smoking+and+smoking-related+non-small-cell+lung+cancer. assertion.
- assertion asSentence Cyclin+L1+amplification+is+associated+with+uterine+cervical+carcinoma. assertion.
- assertion asSentence Low+expression+of+CIAPIN1+is+associated+with+colorectal+cancer. assertion.
- assertion asSentence PLS3+is+a+downstream+effector+of+PKC-delta+in+the+mitochondria. assertion.
- assertion asSentence Nek4+interaction+with+both+RPGRIP1+and+the+RPGRIP1L+is+involved+in+cilium+assembly. assertion.
- assertion asSentence Deficient+in+lipid+storage+diseases. assertion.
- assertion asSentence The+lack+of+the+C-terminal+domain+of+adipose+triglyceride+lipase+causes+neutral+lipid+storage+disease+through+impaired+interactions+with+lipid+droplets. assertion.
- assertion asSentence GBF1+and+ATGL+interact+directly+and+in+cells%2C+through+multiple+contact+sites+on+each+protein. assertion.
- assertion asSentence ATGL+knockdown+increased+monocyte+adhesion+to+the+endothelium+through+enhanced+TNFalpha-induced+ICAM-1+expression+via+activation+of+NFkappaB+and+PKC. assertion.
- assertion asSentence The+synthesis+of+cys-LTs+from+LTA%284%29+by+endothelial+cells+is+directly+associated+with+the+activation+of+the+CysLT%282%29+receptor+in+a+typical+autocrine+fashion. assertion.
- assertion asSentence CAL+retains+CFTR+in+the+cell+and+targets+CFTR+for+degradation. assertion.
- assertion asSentence The+cystic+fibrosis-associated+ligand+%28CAL%29+PDZ+domain+of+the+C-terminus+of+cystic+fibrosis-associated+conductance+regulator+%28CFTR%29+is+competitively+involved+with+PDZ+proteins+Na%2B%2FH%2B+exchanger-3+regulatory+factors+NHERF1+and+NHERF2. assertion.
- assertion asSentence The+SUMO-specific+isopeptidase+SENP2+associates+dynamically+with+nuclear+pore+complexes+through+interactions+with+karyopherins+and+the+Nup107-160+nucleoporin+subcomplex. assertion.
- assertion asSentence Endosialin+is+a+marker+of+stromal+fibroblasts+and+is+not+selectively+expressed+on+tumor+endothelium. assertion.
- assertion asSentence PRV1+overexpression+is+associated+with+Essential+Thrombocythemia+and+Myelofibrosis. assertion.
- assertion asSentence CHMP1B+is+bound+by+the+VPS4A+microtubule+interacting+and+transport+%28MIT%29+domain. assertion.
- assertion asSentence The+2.5-A+structure+of+the+C-terminal+tail+of+CHMP1B+with+the+MIT+domain+of+spastin+reveals+a+specific%2C+high-affinity+complex+involving+a+noncanonical+binding+site+between+the+first+and+third+helices+of+the+MIT+domain. assertion.
- assertion asSentence Inhibition+of+integrin+signaling+by+Amino-Nogo+%28nucleotide+fragment+540-2592%29+contributes+to+the+failure+of+central+nervous+system+axon+regeneration. assertion.
- assertion asSentence Epithelial+reticulon+4B+%28Nogo-B%29+is+an+endogenous+regulator+of+Th2-driven+lung+inflammation. assertion.
- assertion asSentence Nucleocytoplasmic+shuttling+of+PAK7+regulates+its+antiapoptotic+properties. assertion.
- assertion asSentence ARS+Component+B+and+its+protein+product+SLURP1+are+implicated+in+maintaining+the+physiological+and+structural+integrity+of+the+keratinocyte+layers+of+the+skin. assertion.
- assertion asSentence Mutations+in+JPH2-encoded+junctophilin-2+associated+with+hypertrophic+cardiomyopathy. assertion.
- assertion asSentence Pellino+2+plays+a+critical+role+for+TLR%2FIL-1R-mediated+post-transcriptional+control. assertion.
- assertion asSentence Smad6+bound+to+Pellino-1+promoted+TGF-beta-mediated+anti-inflammatory+effects. assertion.
- assertion asSentence GJA12+mutations+are+the+initiaial+genetic+test+in+patients+with+consanguineous+parents+with+Pelizaeus-Merzbacher-like+disease. assertion.
- assertion asSentence BMI1+is+a+target+gene+for+SALL4+in+leukemic+cells. assertion.
- assertion asSentence SALL4+and+BMI-1+expressions+are+up-regulated+significantly+in+acute+leukemia. assertion.
- assertion asSentence SALL4+is+a+sensitive+marker+for+AFP-producing+gastric+carcinoma+and+is+especially+useful+to+distinguish+hepatoid+gastric+carcinoma+from+hepatocellular+carcinoma. assertion.
- assertion asSentence High+SALL4+expression+is+associated+with+Wilms+tumors. assertion.
- assertion asSentence SelN+plays+a+key+role+in+redox+homeostasis+and+human+cell+protection+against+oxidative+stress. assertion.
- assertion asSentence ALG-2+acts+as+a+Ca%282%2B%29+sensor+that+modulates+the+function+of+MCOLN1+along+the+late+endosomal-lysosomal+pathway. assertion.
- assertion asSentence KIAA1199+is+upregulated+in+gastric+adenocarcinoma+and+is+associated+with+tumor+progression. assertion.
- assertion asSentence KIAA1199+is+differentially+expressed+in+neoplastic+tissues+and+KIAA1199+transcripts+are+more+abundant+in+the+plasma+of+patients+with+either+cancer+or+adenoma+compared+to+controls. assertion.
- assertion asSentence Van+Gogh-Like+2+regulates+tumor+cell+migration+and+matrix+metalloproteinase-dependent+invasion. assertion.
- assertion asSentence The+planar+cell+polarity+genes+Celsr1+and+Vangl2+are+required+for+normal+lung+branching+morphogenesis. assertion.
- assertion asSentence JPH3+mutations+should+be+considered+in+the+differential+diagnosis+of+early-onset+dementia+and+hypokinetic-rigid+syndromes+in+individuals+of+African+descent. assertion.