Matches in Nanopublications for { ?s <http://purl.org/nanopub/x/asSentence> ?o ?g. }
- assertion asSentence Significant+association+between+juvenile+myoclonic+epilepsy+and+a+Polymorphism%2C+Single+Nucleotide+within+exon+2+of+CX36. assertion.
- assertion asSentence Expression+of+activation-induced+cytidine+deaminase+is+confined+to+B-cell+non-Hodgkin%27s+lymphomas+of+germinal-center+phenotype. assertion.
- assertion asSentence The+distribution+of+nuclear+AID+is+consistent+with+the+topography+of+somatic+hypermutation+and+class+switch+recombination+in+activated+B+cells. assertion.
- assertion asSentence AID+acts+processively+in+naked+DNA+and+DNA+organized+within+transcribed+nucleosomes. assertion.
- assertion asSentence Aicda+is+regulated+by+the+balance+between+B+cell-specific+and+stimulation-responsive+elements+and+ubiquitous+silencers. assertion.
- assertion asSentence Altering+the+spectrum+of+immunoglobulin+V+gene+somatic+hypermutation+by+modifying+the+active+site+of+AID. assertion.
- assertion asSentence The+ectopic+expression+of+AICDA+in+rheumatoid+arthritis+fibroblast-like+synoviocytes+%28RA-FLS%29+causes+TP53+somatic+mutations+%26+dysfunction%2C+leading+to+acquisition+of+tumour-like+properties+by+RA-FLS. assertion.
- assertion asSentence Hsp90+inhibition+provides+the+first+pharmacological+means+to+down-regulate+AID+expression+and+activity. assertion.
- assertion asSentence Cdc2-like+kinases+and+DNA+topoisomerase+I+regulate+alternative+splicing+of+tissue+factor+in+human+endothelial+cells. assertion.
- assertion asSentence Overexpression+of+Nrdp1+promotes+ubiquitination+and+proteasomal+degradation+of+BRUCE. assertion.
- assertion asSentence AhRR+codon+185+polymorphism+is+associated+with+susceptibility+to+and+severity+of+endometriosis+in+Japanese+women. assertion.
- assertion asSentence Haploinsufficiency+of+ARID1B%2C+a+member+of+the+SWI%2FSNF-A+chromatin-remodeling+complex%2C+is+a+common+cause+of+ID. assertion.
- assertion asSentence Splice+variants+of+the+NLGN4+gene+are+associated+with+autism. assertion.
- assertion asSentence The+autism-associated+DeltaE4+mutation+in+NLGN4+compromises+the+ability+of+NLGN4+to+localize+correctly+to+the+cell+surface+when+overexpressed+and+to+induce+synaptic+differentiation. assertion.
- assertion asSentence IPS-1+is+an+essential+component+of+the+pathway+relevant+to+polyinosinic-polycytidylic+acid+signaling+of+type+I+interferon+in+intestinal+epithelial+cells. assertion.
- assertion asSentence Inactivation+of+Trif+and+Cardif+can+also+occur+through+cellular+caspases+activated+by+various+pro-apoptotic+signals. assertion.
- assertion asSentence C-Abl+modulates+innate+immune+response+through+MAVS. assertion.
- assertion asSentence Influenza+virus+A+PB2+protein+interacts+with+MAVS+and+inhibits+MAVS-mediated+beta+interferon+expression. assertion.
- assertion asSentence Human+respiratory+syncytial+virus+nucleoprotein+and+inclusion+bodies+antagonize+the+innate+immune+response+mediated+by+MDA5+and+MAVS. assertion.
- assertion asSentence Exp5+exports+eEF1A+via+tRNA+from+nuclei+and+synergizes+with+other+transport+pathways+to+confine+translation+to+the+cytoplasm. assertion.
- assertion asSentence Each+of+the+dsRBDs+in+ADAR1+interacts+with+the+export+factor+exportin-5. assertion.
- assertion asSentence Exportin-5+controls+Dicer1+expression+post-transcriptionally. assertion.
- assertion asSentence Specific+interaction+between+negatively+charged+phospholipid+PI%283%2C4%2C5%29P3+and+the+stretch+of+polybasic+residues+preceding+the+RhoGAP+domain+regulates+CdGAP+activity+in+vivo+and+is+required+for+its+cellular+functions. assertion.
- assertion asSentence Raptor+directly+binds+to+and+serves+as+a+scaffold+for+mTOR-mediated+phosphorylation+of+IRS-1+on+Ser636%2F639. assertion.
- assertion asSentence Proarteriosclerotic+effects+of+interferon+gamma+are+associated+with+mammalian+target+of+rapamycin+raptor+complex+%28mTORC1%29+and+PI-3+kinase+activiation. assertion.
- assertion asSentence RSK-mediated+phosphorylation+of+Raptor+regulates+mTORC1+activity. assertion.
- assertion asSentence Complex+raptor+phosphorylation+functions+as+a+biochemical+rheostat+that+modulates+mTORC1+signaling+in+accordance+with+environmental+cues. assertion.
- assertion asSentence HACE1+is+a+candidate+chromosome+6q21+tumor-suppressor+gene+involved+in+multiple+cancers. assertion.
- assertion asSentence Catalytic+subunit+of+PDP2+crystals+belonged+to+space+group+P2%281%292%281%292%281%29%2C+with+unit-cell+parameters+a+%3D+53.6%2C+b+%3D+69.1%2C+c+%3D+109.7+A. assertion.
- assertion asSentence KIAA1363%2C+an+uncharacterized+enzyme+highly+elevated+in+aggressive+cancer+cells%2C+serves+as+a+central+node+in+an+ether+lipid+signaling+network+that+bridges+platelet-activating+factor+and+lysophosphatidic+acid. assertion.
- assertion asSentence Ritonavir+%28at+100+mg+once+daily+and+100+mg+twice+daily+significantly+down-regulated+neutral+cholesterol+ester+hydrolase+1+in+20+healthy+individuals. assertion.
- assertion asSentence The+role+of+OL-protocadherin-dependent+striatal+axon+growth+in+neural+circuit+formation. assertion.
- assertion asSentence Sp1%2FSp3+and+CBF%2FNF-Y+transcription+factors+play+a+crucial+role+in+the+basal+expression+of+the+human+PCDH10+gene. assertion.
- assertion asSentence PCDH10+gene+is+a+target+for+epigenetic+silencing+in+multiple+myeloma+and+provides+a+link+between+the+dysregulation+of+angiogenesis+and+DNA+methylation. assertion.
- assertion asSentence S1P%281%29+signaling+linked+to+cell+migration+is+facilitated+by+a+functional+interaction+with+P-Rex1+via+a+mechanism+that+involves+the+maintenance+of+S1P%281%29+receptors+at+the+cell+membrane. assertion.
- assertion asSentence The+P-Rex1+is+highly+overexpressed+in+human+breast+cancers+and+their+derived+cell+lines%2C+particularly+those+with+high+ErbB2+and+ER+expression. assertion.
- assertion asSentence Single+nucleotide+polymorphism+in+the+megakaryoblastic+leukemia+factor-1+gene+is+associated+with+coronary+artery+disease. assertion.
- assertion asSentence Myocardin-related+transcription+factor+A+mediates+OxLDL-induced+endothelial+injury. assertion.
- assertion asSentence USP1+and+UAF1+form+a+complex+in+the+cytoplasm+that+subsequently+translocates+to+the+nucleus+through+import+mediated+by+USP1+nuclear+localization+signals. assertion.
- assertion asSentence DUB-1+is+present+ubuquitously+within+cells+and+has+deubiitinating+enzyme+activity+in+vivo+and+in+vitro. assertion.
- assertion asSentence This+KRAB-zinc+finger+protein+serves+as+a+moderate+transcriptional+factor+for+Rpe65+gene+upregulation. assertion.
- assertion asSentence Mutations+in+TSHZ2+and+TSHZ3+are+not+a+major+cause+of+pelvi-ureteric+junction+obstruction%2C+at+least+in+Albanian+and+Macedonian+populations. assertion.
- assertion asSentence STIM2+is+a+necessary+partner+of+STIM1+for+excitation-contraction+coupling. assertion.
- assertion asSentence CIP2A+is+associated+with+clinical+aggressivity+in+human+breast+cancer+and+promotes+the+malignant+growth+of+breast+cancer+cells. assertion.
- assertion asSentence Overexpression+of+CIP2A+is+associated+with+non-small+cell+lung+cancer. assertion.
- assertion asSentence Expression+of+the+CIP2A+protein+is+increased+in+prostate+cancer+specimens+and+its+expression+is+associated+with+poorly+differentiated+and+high-risk+tumors. assertion.
- assertion asSentence Bortezomib+sensitized+solid+tumor+cells+to+radiation-induced+apoptosis+through+the+inhibition+of+CIP2A. assertion.
- assertion asSentence Mutations+in+UVSSA+cause+UV-sensitive+syndrome+and+recruits+USP7+to+regulate+transcription-coupled+repair. assertion.
- assertion asSentence Infantile-onset+ascending+hereditary+spastic+paralysis+is+associated+with+mutations+in+the+alsin+gene. assertion.
- assertion asSentence A+peptide+derived+from+the+ALS2+protein+is+selectively+localized+to+the+somatodendritic+compartment+of+motor+neurons+in+human+spinal+cord. assertion.
- assertion asSentence Colocalization+of+Alsin+with+the+centrosomal+markers+gamma-tubulin+and+A+kinase+anchoring+protein. assertion.
- assertion asSentence CHD8+interacts+with+elongating+RNA+polymerase+II+and+controls+expression+of+CCNE2+and+TYMS+genes. assertion.
- assertion asSentence FANCM+is+hyperphosphorylated+and+degraded+during+mitosis+and+beta-transducin+repeat-containing+protein+and+Polo-like+kinase+1+are+the+key+regulators+of+FANCM+degradation. assertion.
- assertion asSentence FANCM+%28mutated+in+the+human+cancer+predisposition+syndrome%2C+Fanconi%27s+anaemia+%28FA%29%29+co-ordinately+regulates+checkpoint+signalling+and+replication+fork+progression. assertion.
- assertion asSentence MHF1+and+MHF2+form+a+compact+tetramer+to+which+FANCM-F+binds+through+a+%27dual-V%27+shaped+structure. assertion.
- assertion asSentence In+cultured+cells%2C+overexpression+of+TRB3+completely+inhibits+insulin-stimulated+hepatic+p70+S6+kinase+activation+by+mammalian+target+of+rapamycin. assertion.
- assertion asSentence TRB3+is+a+critical+molecule+in+the+homocysteine-mediated+cell-cycle+arrest+in+endothelial+cells. assertion.
- assertion asSentence RBaK+interacts+with+the+androgen+receptor+and+increases+its+transcriptional+activity. assertion.
- assertion asSentence DBC-1+functions+to+modulate+ER+alpha+expression+and+hormone-independent+breast+cancer+cell+survival. assertion.
- assertion asSentence IL-6+mediates+anemia+of+inflammation+by+inducing+the+synthesis+of+HEPC. assertion.
- assertion asSentence Hepcidin+gene+which+plays+a+critical+role+in+regulating+systemic+iron+homeostasis. assertion.
- assertion asSentence Il-6+through+the+Jak%2FSTAT-3+signaling+pathway+is+involved+in+the+regulation+of+hepcidin+expression+providing+a+link+between+inflammation+and+iron+metabolism. assertion.
- assertion asSentence A+redundant+system+of+proprotein+convertases+cleaves+prohepcidin+at+the+predicted+site+releasing+active+hepcidin-25+from+the+proprotein. assertion.
- assertion asSentence Association+of+hepcidin+promoter+c.-582+A%3EG+variant+and+iron+overload+in+thalassemia+major. assertion.
- assertion asSentence HAMP+promoter+mutation+is+associated+with+homozygous+patients+with+iron+overload. assertion.
- assertion asSentence Testosterone+administration+is+associated+with+suppression+of+serum+hepcidin. assertion.
- assertion asSentence Bone+morphogenetic+protein+2+is+a+major+mediator+of+the+hepcidin+stimulatory+activity+of+multiple+myeloma+sera. assertion.
- assertion asSentence Hepcidin+mRNA+expression+of+Hep-3b+cells+can+be+increased+by+untreated+multiple+myeloma+patient+serum. assertion.
- assertion asSentence Airway+epithelial+cells+express+hepcidin+in+the+lung+in+response+to+IFN-gamma. assertion.
- assertion asSentence Elevated+urinary+hepcidin-25+1+day+after+cardiopulmonary+bypass+is+a+strong+predictor+of+avoidance+of+acute+kidney+injury+beyond+postoperative+day+1. assertion.
- assertion asSentence NS5A+inhibits+the+transcription+of+hepcidin+mRNA+and+expression+of+hepcidin+protein%2C+inducing+hepatic+intracellular+iron+storage. assertion.
- assertion asSentence Variations+and+single-nucleotide+polymorphisms+are+associated+in+variations+in+fasting+plasma+glucose+and+an+increased+risk+of+type+2+diabetes. assertion.
- assertion asSentence The+effects+of+hyperglycemia+on+insulin+secretion+override+the+more+subtle+effects+of+genetic+variation+in+the+G6PC2+locus+on+insulin+secretion. assertion.
- assertion asSentence HEI10+defines+a+divergent+class+of+E3+ubiquitin+ligase%2C+functioning+in+progression+through+G%282%29%2FM. assertion.
- assertion asSentence Altered+expression+of+splice+variants+of+CS1+and+2B4+that+mediate+differential+signalling+in+PBMC+from+patients+with+SLE. assertion.
- assertion asSentence Expression+of+entry+receptors+nectin-1+and+HVEM+prevent+entry+of+HSV-1+into+human+conjunctival+epithelium. assertion.
- assertion asSentence Prolonged+high-glucose+exposure+down-regulates+PTB+levels+and+insulin+biosynthesis+rates+in+human+islets+by+increasing+miR-133a+levels. assertion.
- assertion asSentence Sites+of+interaction+between+Ngb+and+Galpha%28i%29. assertion.
- assertion asSentence Cimeric+Myoglobin+has+a+cell-membrane-penetrating+activity+similar+to+zebrafish+Ngb. assertion.
- assertion asSentence CXCL16+plays+important+roles+in+human+extravillous+cytotrophoblast+invasion+and+placentation. assertion.
- assertion asSentence Plasma+level+of+CXCL16+is+an+independent+predictor+of+the+prognosis+of+the+patients+with+intermediate+coronary+lesions. assertion.
- assertion asSentence An+increase+in+plasma+CXCL16+during+the+first+days+after+the+initial+event+is+associated+with+an+adverse+outcome+in+patients+with+acute+ischemic+stroke. assertion.
- assertion asSentence hNAIP+and+hIpaf+mediate+innate+intracellular+defense+against+flagellated+Legionella+in+human+cells. assertion.
- assertion asSentence ZF+binds+ATF4%2FCREB2+and+enhances+its+response+to+MEK1+activation. assertion.
- assertion asSentence Examine+JAM-2+expression+in+normal%2Finflammed+lymphatic+endothelium. assertion.
- assertion asSentence Increased+amplification+of+PRUNE+is+associated+with+T4+breast+carcinoma. assertion.
- assertion asSentence Dominant-negative+effect+of+NMMHC-IIA+is+involved+in+the+formation+of+inclusion+bodies+in+Fechtner+syndrome. assertion.
- assertion asSentence Human+IL-21+and+IL-4+bind+to+partially+overlapping+epitopes+of+common+gamma-chain. assertion.
- assertion asSentence IL-21+prevents+down-modulation+of+CD28+and+enhances+interferon-gamma+production+in+naive+CD8%2B+T+cells+that+undergo+IL-15-+mediated+homeostatic+proliferation. assertion.
- assertion asSentence Genetic+variation+in+a+linkage+disequilibrium+block+encompassing+the+KIAA1109-TENR-IL2-IL21+genes+predisposes+to+celiac+disease. assertion.
- assertion asSentence IL-21+induced+apoptosis+in+follicular+lymphoma+cells+expressing+high+levels+of+IL-21+receptor. assertion.
- assertion asSentence Serum+levels+of+IL-21+are+significantly+reduced+in+AIDS+patients+and+correlate+significantly+with+their+CD4%28%2B%29+T-cell+counts. assertion.
- assertion asSentence IL-21+is+a+strong+inducer+of+IgE+production+in+human+beings+concomitantly+with+AID+expression+and+the+differentiation+into+plasma+cells. assertion.
- assertion asSentence Genetic+treatment+with+pIL-15+and+pIL-21+in+the+presence+or+absence+of+cognate+antigen+can+contribute+to+immune-enhancement+against+HSV. assertion.
- assertion asSentence Tax1+transactivates+the+interleukin-21+%28IL-21%29+and+its+receptor+%28IL-21R%29+genes+in+human+T-cells. assertion.
- assertion asSentence The+KIAA1109-TENR-IL2-IL21+gene+cluster%2C+that+encodes+an+interleukin+%28IL-21%29+that+plays+an+important+role+in+Th17+cell+biology%2C+is+the+20th+locus+for+which+there+is+a+genome-wide+level+of+support+for+association+with+rheumatoid+arthritis. assertion.
- assertion asSentence Increase+in+serum+IL-6+and+IL-21+levels+is+associated+with+markers+of+B+cell+activation+in+patients+with+rheumatoid+arthritis. assertion.
- assertion asSentence Overexpression+of+KRC+in+transformed+and+primary+T+cells+leads+to+increased+IL-2+production. assertion.
- assertion asSentence Single+nucleotide+polymorphisms+strongly+support+HIVEP3+as+a+candidate+for+PARK10+in+Parkinson+disease. assertion.
- assertion asSentence An+interaction+between+ZAS3+and+Smad+proteins+enhances+transforming+growth+factor+beta+signaling. assertion.