Matches in Nanopublications for { ?s <http://purl.org/nanopub/x/asSentence> ?o ?g. }
- assertion asSentence Enhanced+angiotensin+converting+enzyme+2+regulates+the+insulin%2FAkt+signalling+pathway+by+blockade+of+macrophage+migration+inhibitory+factor+expression. assertion.
- assertion asSentence The+spike+protein+of+SARS-CoV+%28SARS-S%29+induced+TNF-alpha-converting+enzyme+%28TACE%29-dependent+shedding+of+the+ACE2+ectodomain. assertion.
- assertion asSentence Genetic+variation+in+angiotensin-converting+enzyme+2+gene+is+associated+with+extent+of+left+ventricular+hypertrophy+in+hypertrophic+cardiomyopathy. assertion.
- assertion asSentence ACE2+is+shed+from+human+airway+epithelia%2C+a+site+of+severe+acute+respiratory+syndrome-coronaviruses+infection. assertion.
- assertion asSentence Elevated+plasma+ACE2+activity+is+associated+with+greater+severity+of+myocardial+dysfunction+and+is+an+independent+predictor+of+adverse+clinical+events. assertion.
- assertion asSentence Hypoxia+down-regulates+the+protein+and+gene+expression+of+ACE2+in+HUVECs. assertion.
- assertion asSentence Mutations+in+the+receptor-binding+domain+of+SARS-CoV+strengthen+favorable+interactions+with+two+virus-binding+hot+spots+on+ACE2. assertion.
- assertion asSentence Netrin-4%2C+at+physiologic+doses%2C+induces+proliferation%2C+migration%2C+adhesion%2C+tube+formation+and+survival+of+human+lymphatic+endothelial+cells. assertion.
- assertion asSentence Histamine+excites+human+enteric+neurones+and+this+effect+involves+histamine+H1-4+receptors. assertion.
- assertion asSentence Deletion+of+HRH4+gene+is+present+in+gastric+cancer+cases+and+is+closely+correlated+with+attenuated+gene+expression. assertion.
- assertion asSentence TRPV4+participates+in+hypotonic+reduction+of+AQP5. assertion.
- assertion asSentence There+is+TRPV4+functional+expression+in+human+corneal+epithelial+cells. assertion.
- assertion asSentence Plays+pivotal+roles+in+the+process+of+astrocytic+and+microglial+activation. assertion.
- assertion asSentence Astrocytes+contain+a+TRPV4%2FAQP4+complex+that+constitutes+a+key+element+in+the+brain%27s+volume+homeostasis+by+acting+as+an+osmosensor+that+couples+osmotic+stress+to+downstream+signaling+cascades. assertion.
- assertion asSentence The+SUMO-specific+isopeptidase+SENP2+associates+dynamically+with+nuclear+pore+complexes+through+interactions+with+karyopherins+and+the+Nup107-160+nucleoporin+subcomplex. assertion.
- assertion asSentence Lipoxygenase-3+%28ALOXE3%29+and+12%28R%29-lipoxygenase+%28ALOX12B%29+are+mutated+in+non-bullous+congenital+ichthyosiform+erythroderma+%28NCIE%29+linked+to+chromosome+17p13.1. assertion.
- assertion asSentence AFAP-110+is+required+for+actin+stress+fiber+formation+and+cell+adhesion+in+MDA-MB+231+breast+cancer+cells. assertion.
- assertion asSentence Expressed+prominently+in+the+vascular+endothelium%2C+particularly+capillaries%2C+also+in+islets+of+Langerhans. assertion.
- assertion asSentence BACH2+is+transcriptionally+regulated+by+the+BCR%2FABL+oncogene. assertion.
- assertion asSentence CHT1+variation+is+related+to+differences+in+a+distributed+corticolimbic+circuitry+mediating+behavioral+and+physiologic+arousal. assertion.
- assertion asSentence Polymorphic+variation+in+the+CHT1+gene+can+predict+early%2C+subclinical+measures+of+carotid+atherosclerosis. assertion.
- assertion asSentence Nedd4-2+mediated+ubiquitination+regulates+the+cell+surface+expression+of+CHT1+in+HEK293+cells. assertion.
- assertion asSentence Salvador+gene+is+not+frequently+mutated+in+human+carcinoma+tissues. assertion.
- assertion asSentence Isolation+of+a+human+gene+that+inhibits+HIV-1+infection+and+is+suppressed+by+the+viral+Vif+protein. assertion.
- assertion asSentence RNA+binding+by+APOBEC3G+is+key+for+initiation+of+APOBEC3G%3Anucleocapsid+complex+formation+in+vitro. assertion.
- assertion asSentence APOBEC3G+is+upregulated+in+the+PBMCs+of+chronic+hepatitis+B+patients. assertion.
- assertion asSentence T%28Q%2FD%2FE%29x%285%29ADx%282%29%28I%2FL%29+motif+of+HIV1+Vif+protein+is+a+critical+motif+for+interaction+with+APOBEC3G+and+APOBEC3F. assertion.
- assertion asSentence The+balance+between+the+jumping+and+sliding+of+Apo3G+is+needed+for+efficient+mutational+inactivation+of+HIV-1. assertion.
- assertion asSentence Phenotypic+expression+of+the+complete+type+of+X-linked+congenital+stationary+night+blindness+in+patients+with+different+mutations+in+the+NYX+gene. assertion.
- assertion asSentence Thr+allele+at+541+in+HPC2%2FELAC2+has+strong+significance+in+the+predisposition+of+sporadic+Pca+in+Japan. assertion.
- assertion asSentence ALX4+plays+a+critical+role+in+craniofacial+and+epidermal+development. assertion.
- assertion asSentence Loss-of-function+mutations+in+PROK2+and+PROKR2+underlie+both+Kallmann+syndrome+%28KS%29+and+normosmic+idiopathic+hypogonadotropic+hypogonadism+%28IHH%29. assertion.
- assertion asSentence Loss-of-function+mutations+in+the+genes+encoding+prokineticin-2+or+prokineticin+receptor-2+cause+autosomal+recessive+Kallmann+syndrome. assertion.
- assertion asSentence Male+patients+carrying+biallelic+mutations+in+PROK2+or+PROKR2+have+a+less+variable+and+on+average+a+more+severe+reproductive+phenotype+than+patients+carrying+monoallelic+mutations+in+these+genes. assertion.
- assertion asSentence Mutations+in+the+gene+encoding+the+RER+protein+FKBP65+cause+autosomal-recessive+osteogenesis+imperfecta. assertion.
- assertion asSentence Mutations+in+FKBP10+cause+both+Bruck+syndrome+and+isolated+osteogenesis+imperfecta+in+humans. assertion.
- assertion asSentence D-serine+is+synthesized+in+human+placenta+by+the+racemization+of+L-serine+by+serine+racemase. assertion.
- assertion asSentence Serine+racemase+and+D-serine+are+involved+in+both+pre-symptomatic+and+progressive+phases+of+amyotrophic+lateral+sclerosis%2C+demonstrating+a+link+between+mutant+superoxide+dismutase+%28SOD%291+and+a+glial-derived+toxic+mediator+in+transgenic+mice. assertion.
- assertion asSentence The+SCFbetaTrCP-dependent+degradation+of+claspin+is+necessary+for+the+efficient+and+timely+termination+of+the+DNA+replication+checkpoint. assertion.
- assertion asSentence The+degradation+of+Claspin+at+the+onset+of+mitosis+is+an+essential+step+for+the+recovery+of+a+cell+from+a+DNA-damage-induced+cell-cycle+arrest. assertion.
- assertion asSentence The+expression+of+Ki67+and+p53+in+various+forms+of+leukoplakia+point+to+the+increasing+instability+of+the+genome+in+parallel+with+the+severity+of+leukoplakia. assertion.
- assertion asSentence Apak+competes+with+p53+for+binding+to+inhibit+p53AIP1+expression. assertion.
- assertion asSentence Expression+of+Ngn2+during+the+differentiation+of+neuronl+human+embryo+stem+cells. assertion.
- assertion asSentence The+high+expression+of+PRDM14+in+non-small+cell+lung+cancer+is+associated+with+differentiation+and+histological+type. assertion.
- assertion asSentence Apoptosis+is+regulated+by+a+prostate-specific+and+prostate+cancer-associated+noncoding+gene%2C+PCGEM1. assertion.
- assertion asSentence Loss+of+NPAS3+is+associated+with+the+progression+of+Astrocytomas. assertion.
- assertion asSentence A+genetic+variant+in+SCL28A3+coding+for+the+concentrative+nucleoside+transporter+3+protects+patients+with+chronic+hepatitis+C+against+hemolytic+anemia+without+affecting+sustained+virological+response+in+hepatitis+C+virus+genotype+1. assertion.
- assertion asSentence CRLF2+overexpression+is+associated+with+acute+lymphoblastic+leukemia. assertion.
- assertion asSentence Inhibition+of+ubiquitin-mediated+degradation+of+MOAP1+by+apoptotic+stimuli+promotes+BAX+function+in+mitochondria. assertion.
- assertion asSentence The+association+of+RASSF1A+and+MOAP-1+with+death+receptors+involves+an+ordered+recruitment+to+receptor+complexes+to+promote+cell+death+and+inhibit+tumor+formation. assertion.
- assertion asSentence Involved+in+the+removal+of+fructosamine+residues+from+hemoglobin+in+erythrocytes. assertion.
- assertion asSentence Crohn%27s+disease+is+caused+by+mutations+in+the+bacterial+response+protein+NOD2. assertion.
- assertion asSentence Lack+of+common+NOD2+variants+in+Japanese+patients+with+Crohn%27s+disease. assertion.
- assertion asSentence There+is+not+a+strong+genetic+association+between+CARD15+gene+polymorphisms+and+psoriasis+in+the+Italian+population. assertion.
- assertion asSentence A+haplotype+in+yhis+gene+confers+a+risk+for+Crohn+disease+in+Ashkenazi+Jews. assertion.
- assertion asSentence The+insertion+3020insC+mutation+and+the+G2722C+missense+mutation+in+the+CARD15+gene+are+not+involved+in+susceptibility+to+ankylosing+spondylitis. assertion.
- assertion asSentence Single+nucleotide+polymorphisms+of+CARD15+do+not+cause+susceptibility+to+ulcerative+colitis. assertion.
- assertion asSentence CARD15+mutational+frequencies+are+not+increased+among+African+American+or+Hispanic+children+with+Crohn%27s+disease+compared+with+Whites. assertion.
- assertion asSentence A+mutation+in+CARD15+is+associated+with+sarcoidosis. assertion.
- assertion asSentence A+major+association+of+NOD2%2FCARD15+SNPs+with+the+occurrence+of+severe+graft-vs-host+disease. assertion.
- assertion asSentence Carriage+of+the+NOD2+gene+mutation+does+not+increase+susceptibility+for+Crohn%27s+disease+in+the+Hungarian+population. assertion.
- assertion asSentence Caspase-1-dependent+and+-independent+mechanisms+are+involved+in+the+synergy+between+NOD2+and+TLR. assertion.
- assertion asSentence Reduction+in+alpha-defensin+expression+is+independent+of+NOD2+status+and+is+due+to+loss+of+surface+epithelium+as+a+consequence+of+inflammatory+changes+rather+than+being+the+inciting+event+prior+to+inflammation+in+ileal+Crohn%27s+disease. assertion.
- assertion asSentence Blau+syndrome-related+CARD15%2FNOD2+mutations+are+not+linked+to+idiopathic+uveitis. assertion.
- assertion asSentence Mutations+in+NOD2+gene+is+associated+with+gastric+carcinogenesis. assertion.
- assertion asSentence In+short+gut+syndrome+in+children+NOD2+gene+polymorphism+associates+with+the+need+of+combined+liver+and+intestine+transplantation. assertion.
- assertion asSentence Common+variants+in+NOD2+and+IL23R+are+not+associated+with+inflammatory+bowel+disease+in+Indians. assertion.
- assertion asSentence In+the+Japanese+population%2C+unlike+the+Caucasian%2C+NOD2+is+not+a+major+contributor+to+susceptibility+to+severe+acute+GVHD. assertion.
- assertion asSentence Serum+ferritin+correlates+with+activity+of+anti-MDA5+antibody-associated+acute+interstitial+lung+disease+as+a+complication+of+dermatomyositis. assertion.
- assertion asSentence The+inflammatory+response+of+rhinovirus+infection+in+non-immune+cells+is+mediated+by+MDA-5. assertion.
- assertion asSentence In+patients+with+anti-double+stranded+DNA+antibodies%2C+an+IFIH1+risk+allele+increases+sensitivity+to+interferon-alpha+signaling. assertion.
- assertion asSentence TLR7%2F9+versus+TLR3%2FMDA5+signaling+during+virus+infections+and+diabetes. assertion.
- assertion asSentence HSV-1+US11+binds+to+RIG-I+and+MDA-5+and+inhibits+their+downstream+signaling+pathway. assertion.
- assertion asSentence The+common+ERAP2+single+nucleotide+polymorphism+rs2549782+that+codes+for+amino+acid+variation+Asp392Lys+leads+to+alterations+in+both+the+activity+and+the+specificity+of+the+enzyme. assertion.
- assertion asSentence The+single+nucleotide+polymorphisms+most+strongly+associated+with+ankylosing+spondylitis+are+those+most+associated+with+CARD9+expression. assertion.
- assertion asSentence High+caspase-9+activity+is+associated+with+cervical+malignancy. assertion.
- assertion asSentence Frequent+silencing+of+POPDC3+is+associated+with+promoter+hypermethylation+in+gastric+cancer. assertion.
- assertion asSentence Variation+is+not+a+highly+penetrant+autosomal+dominant+susceptibility+locus+for+mood+disorder+in+families. assertion.
- assertion asSentence Promoter-independent+DNA+conformation-dependent+transcription+required+TFB2M. assertion.
- assertion asSentence In+fibroboasts%2C+STRA6+transports+retinol+bidirectionally+in+an+RBP4+dependent+manner. assertion.
- assertion asSentence ABCGG5+and+ABCG8+are+required+to+modulate+biliary+cholesterol+secretion+in+response+to+cholate+and+diosgenin. assertion.
- assertion asSentence Polymorphisms+at+the+half-transporter+ABCG5+and+ABCG8+genes+affect+blood+cholesterol+concentrations+in+prepubertal+children+by+influencing+dietary+responsiveness. assertion.
- assertion asSentence The+associations+of+four+ABCG5%2FG8+single+nucleotide+polymorphisms+and+serum+lipid+levels+are+different+between+the+Mulao+and+Han+populations+in+China%2C+or+between+males+and+females. assertion.
- assertion asSentence SOX17%28%2B%29-human+embryonic+stem+cell+progeny+expressed+endodermal+markers. assertion.
- assertion asSentence Screening+for+NSD1+mutations+and+deletions+in+patients+with+autism+and+macrocephaly+is+not+warranted+in+the+absence+of+other+features+of+Sotos+syndrome. assertion.
- assertion asSentence The+structure+of+NSD1+reveals+an+autoregulatory+mechanism+underlying+histone+H3K36+methylation. assertion.
- assertion asSentence Increased+COP1+is+associated+with+hepatocellular+carcinoma. assertion.
- assertion asSentence MAIL+is+a+key+regulator+of+IL-6+production+in+human+monocytes+and+plays+an+important+role+in+both+TLR+and+NOD-like+receptor+ligand+induced+inflammation. assertion.
- assertion asSentence HS1PB3+protein+is+mutated+in+essential+tremor+combined+with+Parkinson+disease. assertion.
- assertion asSentence The+spatiotemporal+mobilization+of+TICAM-1+in+response+to+dsRNA+and+the+formation+of+the+TICAM-1+speckles+containing+RIP1+and+NAP1+are+important+for+the+activation+of+the+TLR3-TICAM-1+pathway. assertion.
- assertion asSentence The+expression+of+HIF-3alpha4+suppresses+the+growth+of+tumor+xenografts+in+SCID+mice. assertion.
- assertion asSentence The+very+C-terminal+residues+of+SIL1+play+a+role+in+its+structural+integrity+rather+than+its+localization. assertion.
- assertion asSentence Mouse+GMCL1+interacts+with+the+DP+component+of+the+E2F+transcription+factor. assertion.
- assertion asSentence The+cell+polarity+protein+PALS1+is+expressed+in+T+lymphocytes+and+participates+to+the+optimal+activation+of+NF-kappaB+following+TCR+stimulation. assertion.
- assertion asSentence Artemis+efficiently+trims+long+3%27-phosphoglycate-terminated+overhangs+induced+in+DNA+by+radiation+and+other+radical-based+toxins. assertion.
- assertion asSentence The+Artemis+C+terminus+is+essential+for+V%28D%29J+recombination+at+the+normal+Artemis+expression+level. assertion.
- assertion asSentence Artemis+and+DNA-PKcs+participate+in+a+new%2C+signaling+pathway+to+modulate+p53+function+in+response+to+oxidative+stress+produced+by+mitochondrial+respiration. assertion.
- assertion asSentence The+loss+of+function+CPEB1+protein+would+enhance+tumorigenesis+by+promoting+the+survival+of+rapidly+dividing+and+hypermetabolic+tumor+cells+as+levels+of+available+nutrients+decline. assertion.
- assertion asSentence CD37+is+important+for+dectin-1+stabilization+in+APC+membranes+and+controls+dectin-1-mediated+IL-6+production. assertion.
- assertion asSentence hDectin-1+is+involved+in+the+uptake+and+cross-presentation+of+cellular+antigens. assertion.