Matches in Nanopublications for { ?s <http://purl.org/nanopub/x/asSentence> ?o ?g. }
- assertion asSentence Ribbon+formation+requires+the+Golgi+proteins+GM130+and+GRASP65. assertion.
- assertion asSentence Disruption+of+the+proteolytic+activity+of+TMPRSS3+is+tightly+correlated+with+the+pathogenesis+of+hearing+loss. assertion.
- assertion asSentence Overexpression+of+NUCKS+can+play+significant+role+in+breast+cancer+biology. assertion.
- assertion asSentence Ero1alpha+is+expressed+on+blood+platelets+in+association+with+protein-disulfide+isomerase+and+contributes+to+redox-controlled+remodeling+of+alphaIIbbeta3. assertion.
- assertion asSentence PDI+is+a+major+target+of+post-streptococcal+autoimmunity. assertion.
- assertion asSentence PDI+knockdown-induced+cell+death+is+cell-line-dependent+and+involves+apoptosis+in+MCF-7+cells. assertion.
- assertion asSentence Protein+disulfide+isomerase+blocks+CEBPA+translation+and+is+up-regulated+during+the+unfolded+protein+response+in+acute+myeloid+leukemia. assertion.
- assertion asSentence The+common+variable+number+of+tandem+repeats+polymorphism+in+SMYD3+is+a+susceptibility+factor+for+some+types+of+human+cancer. assertion.
- assertion asSentence Tensin3+mRNA+is+expressed+abundantly+in+all+twelve+functional+adenomas+at+almost+the+same+level+as+in+normal+thyroid+tissue. assertion.
- assertion asSentence Up-regulation+of+miR-143+expression+transcribed+by+NF-kappaB+in+hepatitis+B+virus-related+hepatocellular+carcinoma+promotes+cancer+cell+invasion%2Fmigration+and+tumor+metastasis+by+repression+of+FNDC3B+expression. assertion.
- assertion asSentence mTOR+generates+an+auto-amplification+loop+by+triggering+the+betaTrCP-+and+CK1alpha-dependent+degradation+of+DEPTOR. assertion.
- assertion asSentence Crystal+structure+of+human+nicotinamide+mononucleotide+adenylyltransferase+in+complex+with+NMN. assertion.
- assertion asSentence Mutations+in+NMNAT1+cause+Leber+congenital+amaurosis+with+early-onset+severe+macular+and+optic+atrophy. assertion.
- assertion asSentence NMNAT1+mutations+as+a+cause+of+Leber+congenital+amaurosis. assertion.
- assertion asSentence PI3-K+activation+is+signaled+by+rapid+feedback+amplification+that+involves+P2Y%2812%29+receptor-mediated+activation+of+Syk. assertion.
- assertion asSentence Functional+variability+of+platelet+response+to+clopidogrel+correlates+with+P2Y%2812%29+receptor+occupancy. assertion.
- assertion asSentence The+P2Y12+receptor+is+required+for+proinflammatory+actions+of+the+stable+abundant+mediator+LTE4. assertion.
- assertion asSentence In+diabetes+mellitus+patients+undergoing+percutaneous+coronary+intervention%2C+impaired+inhibition+of+P2Y12+by+clopidogrel+is+an+independent+predictor+of+cardiac+death. assertion.
- assertion asSentence Allergen+provocation+induces+functionally+relevant%2C+increased+expression+of+IL-25+and+its+receptor+in+the+asthmatic+bronchial+mucosa+and+dermis+of+sensitized+atopic+subjects. assertion.
- assertion asSentence Mutations+within+the+PORCN+gene+are+associated+with+Goltz-Gorlin+syndrome. assertion.
- assertion asSentence Axotrophin%2FMARCH-7+has+an+expression+profile+that+is+distinct+from+that+of+other+MARCH+family+members. assertion.
- assertion asSentence Signaling+pathway+by+which+G%28i%29-coupled+receptor+specifically+induces+Rac+and+Cdc42+activation+through+direct+interaction+of+Gbetagamma+with+FLJ00018. assertion.
- assertion asSentence SNM1B+%28Apollo%29+protein+exhibits+a+5%27-to-3%27+DNA+exonuclease+activity+and+functions+together+with+TRF2+to+protect+telomeres+from+damage+and+fusion. assertion.
- assertion asSentence SNM1B+%28Apollo%29+is+an+Artemis-like+nuclease+that+is+required+for+the+protection+of+telomeres+during+or+after+their+replication. assertion.
- assertion asSentence The+clustering+of+Gp140+and+signaling+components+in+membrane+microdomains+in+cell-cell+contacts+contributes+to+changes+in+cell+behavior. assertion.
- assertion asSentence Src-Trask+signaling+and+Src-focal+adhesion+signaling+inactivate+each+other%2C+constituting+two+opposing+modes+of+phosphotyrosine+signaling+that+define+a+switch+underlining+cell+anchorage+state. assertion.
- assertion asSentence Secreted+CDCP1+can+be+a+useful+genetic+marker+for+the+diagnosis+of+metastatic+prostate+cancer. assertion.
- assertion asSentence CTIP2+recruits+histone+deacetylase+%28HDAC%291+and+HDAC2+to+promote+local+histone+H3+deacetylation+at+the+HIV-1+promoter+region. assertion.
- assertion asSentence CTIP2+is+a+constitutive+p21+gene+suppressor+that+cooperates+with+SUV39H1+and+histone+methylation+to+silence+the+p21+gene+transcription. assertion.
- assertion asSentence Increased+expression+of+bcl11b+leads+to+chemoresistance+and+G1+arrest. assertion.
- assertion asSentence BCL11B+directly+interacts+with+P2+promoter+region+of+HDM2+and+inhibits+HDM2+promoter+activity+in+a+p53-dependent+manner. assertion.
- assertion asSentence Upregulation+of+CENP-H+in+tongue+cancer+is+associated+with+disease+progression. assertion.
- assertion asSentence CENP-H-containing+complex+facilitates+deposition+of+newly+synthesized+CENP-A+into+centromeric+chromatin+in+cooperation+with+FACT+and+CHD1. assertion.
- assertion asSentence MRPL36+contributes+to+the+regulation+of+mitochondrial+ATP+production+and+necrotic+cell+death. assertion.
- assertion asSentence Over+expression+of+NDRG4+inhibited+proliferation+of+GBM+cells. assertion.
- assertion asSentence The+subclinical+loss+of+striatal+dopamine+storage+capacity+found+in+PARK6+carriers+implies+that+the+unidentified+gene+on+the+short+arm+of+chromosome+1+exhibits+either+haploinsufficency+or+a+dominant+negative+effect. assertion.
- assertion asSentence Mutations+of+PINK1+gene+are+found+in+Chinese+families+with+autosomal+recessive+early-onset+Parkinsonism. assertion.
- assertion asSentence Its+missense+mutation+causes+autosomal+recessive+juvenile+parkinsonism. assertion.
- assertion asSentence PINK1-associated+Parkinson%27s+disease+is+caused+by+neuronal+vulnerability+to+calcium-induced+cell+death. assertion.
- assertion asSentence PINK1-specific+siRNA+remarkably+downregulated+Bcl-xL+and+TRAP1+proteins+and+upregulated+BAX+protein+expression. assertion.
- assertion asSentence RTP+and+REEP+gene+expression+in+human+circumvallate+papillae+and+testis%2C+both+of+which+are+sites+of+taste+receptor+gene+expression. assertion.
- assertion asSentence Increased+expression+of+TPP1+correlates+with+resistance+to+radiation+in+human+laryngeal+cancer+cell+lines. assertion.
- assertion asSentence TIN2-anchored+TPP1+plays+a+major+role+in+the+recruitment+of+telomerase+to+telomeres+in+human+cells. assertion.
- assertion asSentence Expression+of+the+genes+encoding+Nogo+and+its+receptor%2C+NgR%2C+between+weeks+eight+and+23+of+human+embryonic+development. assertion.
- assertion asSentence In+acute+slices+of+adult+mice%2C+transgenic+NGR+suppresses+long-term+potentiation+when+locally+applied+to+hippocampal+CA1+synapses. assertion.
- assertion asSentence A+multi-domain+fragment+of+Nogo-A+protein+is+a+potent+inhibitor+of+cortical+axon+regeneration+via+Nogo+receptor+1. assertion.
- assertion asSentence Gene+knockdown+in+prostate+cancer+cells+or+in+neurons+reveals+a+critical+role+for+MARCKSL1+in+migration+that+is+dependent+on+the+phosphorylation+state. assertion.
- assertion asSentence Three+mutations+lead+to+the+introduction+of+a+premature+termination+codon+and+subsequent+nonsense-mediated+mRNA+decay+of+mutant+UPF3B+mRNA. assertion.
- assertion asSentence The+Upf+complex+communicates+with+the+exon-junction+complex+and+triggers+nonsense-mediated+decay+in+the+cytoplasm. assertion.
- assertion asSentence Protein+kinase+B+mediates+the+phosphorylation+of+WNK1+at+Thr-60. assertion.
- assertion asSentence Both+mouse+and+human+protocadherin+15+genes+have+complex+genomic+structures+and+transcription+control+mechanisms. assertion.
- assertion asSentence Alberta+Hutterites+with+Usher+syndrome+type+I+do+not+carry+the+exon+10+mutation+in+the+PCDH15+gene. assertion.
- assertion asSentence Single-nucleotide+polymorphims+of+WNK4+in+whites+and+African+Americans+with+hypertension. assertion.
- assertion asSentence WNK2+is+involved+in+the+modulation+of+growth+factor-induced+cancer+cell+proliferation+through+the+MEK1%2FERK1%2F2+pathway. assertion.
- assertion asSentence WNK2+controls+a+RhoA-mediated+cross-talk+mechanism+that+regulates+the+efficiency+with+which+MEK1+can+activate+ERK1%2F2+upon+growth+factor+stimulation. assertion.
- assertion asSentence Epigenetic+silencing+of+the+kinase+tumor+suppressor+WNK2+is+tumor-type+and+tumor-grade+specific. assertion.
- assertion asSentence Up-regulated+in+psoriasis+vulgaris. assertion.
- assertion asSentence Association+of+single-nucleotide+polymorphisms+in+MTMR9+gene+with+obesity. assertion.
- assertion asSentence Mutations+in+BOULE+can+be+eliminated+as+a+major+cause+of+impaired+spermatogenesis. assertion.
- assertion asSentence Warfarin+dose+requirements+in+Asian+patients+homozygous+for+VKORC1+H1+haplotype+are+significantly+lower+compared+with+patients+homozygous+for+the+H7+haplotype. assertion.
- assertion asSentence VKORC1+polymorphisms+are+associated+with+warfarin+dose+requirements+in+Turkish+patients. assertion.
- assertion asSentence VKORC1+polymorphisms+are+associated+with+differences+in+the+initial+response+to+warfarin+when+given+at+fixed+doses%2C+without+affecting%2C+as+expected%2C+its+plasma+concentration. assertion.
- assertion asSentence VKORC1+genotype+and+CYP2C9+polymorphism+affect+daily+dose+requirements+and+time+to+therapeutic+INR+in+Turkish+patients+receiving+warfarin+for+anticoagulation. assertion.
- assertion asSentence Polymorphisms+in+VKORC1+is+not+associated+with+dosing+of+vitamin+K+antagonists+in+thrombosis. assertion.
- assertion asSentence VKORC1+and+CYP2C9+polymorphisms+are+associated+with+variability+in+warfarin+dose+requirement. assertion.
- assertion asSentence VKORC1+polymorphisms+are+associated+with+variability+in+warfarin+dose+requirement. assertion.
- assertion asSentence TRIM32+is+a+widely+expressed+ubiquitin+ligase+and+binds+and+ubiquitinates+dysbindin. assertion.
- assertion asSentence PANE1+localizes+to+the+centromere+throughout+the+cell+cycle+and+its+localization+is+dependent+on+the+centromere+specific+histone+variant+CENP-A. assertion.
- assertion asSentence INTS3+controls+the+SSB1-mediated+DNA+damage+response. assertion.
- assertion asSentence Selenocysteine+insertion+sequence+%28SECIS%29-binding+protein+2+alters+conformational+dynamics+of+residues+involved+in+tRNA+accommodation+in+80+S+ribosomes. assertion.
- assertion asSentence ALG8+splice+site+mutations+and+missense+mutations+causing+ALG8+deficiency+in+patients+with+congenital+disorders+of+glycosylation+type+Ih. assertion.
- assertion asSentence Icilin+specifically+inhibits+TRPM8+independently+of+its+interaction+site+within+the+S2-S3+linker+through+a+process+distinct+from+desensitization. assertion.
- assertion asSentence mRNA+for+TRPA1+and+TRPM8+are+strongly+upregulated+in+differentiating+IMR-32+cells. assertion.
- assertion asSentence Increased+BMI+in+morbid+obesity+is+associated+with+a+combination+of+FTO+and+INSIG2+SNPs. assertion.
- assertion asSentence Lack+of+association+of+FTO+SNPs+with+insulin+sensitivity+is+consistent+with+the+lack+of+association+with+visceral+adipose+tissue. assertion.
- assertion asSentence Variants+within+the+FTO+gene+influence+hyperandrogenemia+and+anthropometric+parameters+in+women+with+PCOS. assertion.
- assertion asSentence Fine+mapping+of+the+association+with+obesity+at+the+FTO+locus+in+African+derived+populations. assertion.
- assertion asSentence The+FTO+rs9939609+variant+is+strongly+associated+with+body+mass+index+and+the+risk+of+obesity+in+a+population+of+children+and+adolescents+in+Beijing%2C+China. assertion.
- assertion asSentence FTO+SNPs+in+intron+1+are+significantly+associated+with+breast+cancer+risk. assertion.
- assertion asSentence FTO+gene+polymorphism+is+associated+with+end-stage+renal+disease. assertion.
- assertion asSentence The+rs9939609+polymorphism+in+the+FTO+gene+is+related+to+abnormal+glucose+levels+and+higher+lipid+accumulation+product%2C+a+surrogate+marker+of+diabetes+and+cardiovascular+risk+in+postmenopause. assertion.
- assertion asSentence The+human+Sin1+proteins+form+a+complex+with+Jun+N-terminal+kinase. assertion.
- assertion asSentence LGP2+competes+with+the+kinase+IKKi+for+a+common+interaction+site+on+IPS-1%2C+as+an+element+of+negative-feedback+regulation+of+intracellular+antiviral+signaling. assertion.
- assertion asSentence The+pool+of+active+Derlin-1+in+the+ER+membrane+can+be+modulated+in+response+to+ER+stress. assertion.
- assertion asSentence LENG4+is+located+in+the+leukocyte+receptor+cluster+on+chromosome+19. assertion.
- assertion asSentence Co-injection+of+fish+or+human+FKRP+mRNA+along+with+the+morpholino+restored+normal+development+and+alpha-dystroglycan+glycosylation. assertion.
- assertion asSentence FKRP+co-localises+with+the+middle-to-trans-Golgi+marker+MG160%2C+between+the+myofibrils+in+human+rectus+femoris+muscle+fibres. assertion.
- assertion asSentence Epilysin+%28MMP-28%29+expression+is+associated+with+cell+proliferation+during+epithelial+repair. assertion.
- assertion asSentence Epilysin+%28MMP-28%29+is+deposited+to+the+basolateral+extracellular+matrix+of+epithelial+cells. assertion.
- assertion asSentence Gene+expression+of+MMP28+in+the+intervertebral+disk+is+not+regulated+by+inflammatory+mechanisms%2C+is+donor-dependent+and+cannot+be+positively+or+negatively+linked+to+the+grade+of+degeneration+and+only+weakly+to+the+occurrence+of+trauma. assertion.
- assertion asSentence ABIN-2+exerts+unexpected+function+in+mediating+transcriptional+coactivation. assertion.
- assertion asSentence Role+for+an+ABIN-sensitive+non-classical+NF-kappaB+signalling+pathway+in+the+proliferation+of+EGFR-overexpressing+tumour+cells. assertion.
- assertion asSentence Mutations+within+the+GNPTAB+gene+are+associated+with+Mucolipidoses. assertion.
- assertion asSentence Role+of+ZXD+proteins+in+regulating+MHC+II+transcription. assertion.
- assertion asSentence Role+of+the+BHLHB3+protein+as+a+tumor+suppressor+for+lung+cancer. assertion.
- assertion asSentence DEC2+has+anti-apoptotic+effects+on+the+paclitaxel-induced+apoptosis+in+human+breast+cancer+MCF-7+cells. assertion.
- assertion asSentence JAB1+is+involved+in+the+regulation+of+mitochondrial+apoptotic+pathway+through+specific+interaction+with+BclGs. assertion.
- assertion asSentence NO-mediated+down-regulation+by+shear+stress+preferentially+affects+the+gp91%28phox%29%2Fp47%28phox%29-containing+NAD%28P%29H+oxidase+complex. assertion.
- assertion asSentence Acid-induced+NOX5-S+expression+is+mediated+by+platelet+activating+factor+and+STAT5+in+esophageal+adenocarcinoma+cells. assertion.
- assertion asSentence Shingosylphosphorylcholine+down-regulates+FLG+gene+transcription+through+NOX5-based+NADPH+oxidase+and+COX-2+in+human+keratinocytes. assertion.