Matches in Nanopublications for { ?s <http://purl.org/nanopub/x/asSentence> ?o ?g. }
- assertion asSentence ARFGAP2+and+ARFGAP3+are+essential+for+COPI+coat+assembly+on+the+Golgi+membrane+of+living+cells. assertion.
- assertion asSentence Hook3+is+recruited+to+pericentriolar+satellites+through+interaction+with+pericentriolar+material+1+protein+PCM1. assertion.
- assertion asSentence Loss+of+ECRG4+is+associated+with+glioma. assertion.
- assertion asSentence kDa+Ecrg4+localizes+to+the+cell+surface+of+prostate+%28PC3%29+or+kidney+%28HEK%29+epithelial+cells+after+transfection. assertion.
- assertion asSentence PROK1+and+PROKR1+expression+is+elevated+in+human+decidua+during+early+pregnancy+PROK1-PROKR1+interaction+regulates+expression+of+a+host+of+implantation-related+genes. assertion.
- assertion asSentence CARMA1+is+an+essential+signaling+component+that+mediates+TCR-induced+NF-kappa+B+activation. assertion.
- assertion asSentence SADB+kinase+activity+controls+centrosome+homeostasis+by+regulating+phosphorylation+of+gamma-tubulin. assertion.
- assertion asSentence Human+MEGF10+is+an+ortholog+of+Ced1. assertion.
- assertion asSentence Loss+of+NECC1+expression+is+involved+in+malignant+conversion+of+placental+trophoblasts. assertion.
- assertion asSentence The+10-amino-acid+cyclic+core+of+the+hMCH+neuropeptide+with+the+Arg+attached+to+the+N-terminus+of+the+disulfide+ring+is+sufficient+for+full+activation+of+melanin-concentrating+hormone+receptor+2. assertion.
- assertion asSentence MCHR2+positively+mediates+the+regulation+of+melanin-concentrating+hormone+during+preadipocyte+differentiation+and+is+involved+in+energy+balance+regulation+without+affecting+preadipocyte+proliferation. assertion.
- assertion asSentence The+presence+of+LC3+in+cytoplasmic+puncta+does+not+necessarily+reveal+their+participation+in+the+formation+of+phagophores+or+their+accumulation+on+the+membranes+from+autophagosomes. assertion.
- assertion asSentence PKC+regulates+autophagy+through+a+mechanism+independent+of+LC3+phosphorylation. assertion.
- assertion asSentence p62+can+be+efficiently+localized+to+autophagic+compartments+via+preferential+binding+with+LC3-II+form. assertion.
- assertion asSentence SHBs+%28HBV+small+surface+protein%29+partially+colocalized+and+interacted+with+autophagy+protein+LC3. assertion.
- assertion asSentence Expression+of+microtuble-associated+protein+1+light+chain+3+is+down-regulated+in+laryngeal+squamous+cell+carcinoma. assertion.
- assertion asSentence ECRG2+is+involved+in+the+regulation+of+cell+migration%2Finvasion+through+uPA%2FuPAR%2Fbeta1+integrin+pathway. assertion.
- assertion asSentence Proteases+contribute+indirectly+to+the+defense+function+of+the+stratum+corneum+by+releasing+the+RNase+inhibitor+mediated+inhibition+of+RNase+5+and+RNase+7. assertion.
- assertion asSentence The+DPY-30+C-terminal+domain+structure%2C+harboring+the+conserved+DPY-30+motif%2C+is+composed+of+two+alpha-helices+linked+by+a+sharp+loop+and+forms+a+typical+X-type+four-helix+bundle+required+for+dimer+formation. assertion.
- assertion asSentence BEX2+is+implicated+in+oligodendroglioma+biology. assertion.
- assertion asSentence BEX2+has+a+functional+interplay+with+c-Jun+and+p65%2FRelA+in+breast+cancer. assertion.
- assertion asSentence Both+BEX2+and+INI1%2FhSNF5+mainly+localized+in+cell+nucleus. assertion.
- assertion asSentence FAPP2+plays+a+specific+role+in+apical+transport+in+MDCK+cells. assertion.
- assertion asSentence hPc2+serves+as+a+SUMO+E3+ligase+for+cystathionine+beta-synthase%2C+increasing+the+efficiency+of+sumoylation. assertion.
- assertion asSentence Diabetic+patients+homozygous+for+CNDP1+are+protected+against+diabetic+nephropathy. assertion.
- assertion asSentence CTG+polymorphism+of+the+CNDP1+gene+does+not+affect+survival+of+Chinese+peritoneal+dialysis+subjects. assertion.
- assertion asSentence Single+nucleotide+polymorphisms+in+ZNF577+gene+is+associated+with+breast+cancer. assertion.
- assertion asSentence The+biologic+activity+of+IL-17+is+dependent+on+a+complex+composed+of+receptors+IL-17RA+and+IL-17RC. assertion.
- assertion asSentence The+human+DNA+replication+origin%2C+located+in+the+lamin+B2+gene%2C+interacts+with+the+DNA+topoisomerases+I+and+II+in+a+cell+cycle-modulated+manner. assertion.
- assertion asSentence The+concentration+of+FREB+FCRL+in+patients+with+rheumatoid+arthritis+is+three+times+higher+than+in+healthy+adults. assertion.
- assertion asSentence A+critical+role+of+DAPIT+in+maintaining+the+ATP+synthase+population+in+mitochondria+and+raise+an+intriguing+possibility+of+active+role+of+DAPIT+in+cellular+energy+metabolism. assertion.
- assertion asSentence The+single+nucleotide+polymorphism+of+the+Mina+gene+is+associated+with+the+development+of+asthma+in+Chinese+Han+children. assertion.
- assertion asSentence STEP%2861kDa%29+is+required+for+Abeta+transgene-mediated+internalization+of+GluA1%2FGluA2+glutamate+receptors+in+a+transgenic+mousemodel. assertion.
- assertion asSentence Tim-3+expression+on+peripheral+T+cell+subsets+correlates+with+disease+progression+in+hepatitis+B+infection. assertion.
- assertion asSentence TIM-3+and+its+interaction+with+Gal-9+are+closely+associated+with+rheumatoid+arthritis+activity. assertion.
- assertion asSentence Tim-3+is+constitutively+expressed+on+human+resting+CD14%28%2B%29+monocyte%2Fmacrophages+%28M%2FM%28O%29%29+and+functions+as+a+cap+to+block+IL-12. assertion.
- assertion asSentence CRACM1+multimers+form+the+ion-selective+pore+of+the+CRAC+channel. assertion.
- assertion asSentence Orai1-STIM1+protein+complex+is+one+of+the+molecular+components+involved+in+Pb2%2B+entry. assertion.
- assertion asSentence Increase+in+hydrophobicity+at+the+N+terminus%2Fmembrane+interface+represents+the+major+cause+for+yielding+non-functional+ORAI1+channels. assertion.
- assertion asSentence Heteromeric+Orai1%2F3+protein+assembly+provides+a+concept+for+less+Ca%282%2B%29-selective+store-operated+channels. assertion.
- assertion asSentence Calcium+entry+via+Orai1+is+the+predominant+SOCE+that+cooperates+with+cytoplasmic+calcium+store+release+in+coordinating+integrin-dependent+PMN+arrest+and+migration+in+the+acute+response+to+inflammation. assertion.
- assertion asSentence Orail1+is+the+generally+expressed+genes+in+normal+and+adenomatous+human+parathyroids. assertion.
- assertion asSentence Resting+state+Orai1+diffuses+as+homotetramer+in+the+plasma+membrane+of+live+mammalian+cells. assertion.
- assertion asSentence STIM1+translocation+can+consequently+occur+independently+of+Orai1+clustering+and+SOCE. assertion.
- assertion asSentence Hypertrophy+in+skeletal+myotubes+induced+by+junctophilin-2+mutant%2C+Y141H%2C+involves+an+increase+in+store-operated+Ca2%2B+entry+via+Orai1. assertion.
- assertion asSentence AMID+is+a+p53-downstream+gene+involved+in+tumorigenesis. assertion.
- assertion asSentence hFBH1+exhibited+DNA-dependent+ATPase+and+DNA+unwinding+activities+that+displace+duplex+DNA+in+the+3%27+to+5%27+direction. assertion.
- assertion asSentence Variant+in+the+sequence+of+the+LINGO1+gene+confers+risk+of+essential+tremor. assertion.
- assertion asSentence Single+nucleotide+polymorphism%28SNP%29s+of+LINGO1+play+a+role+in+the+development+of+Parkinson%27s+disease+in+the+Italian+population. assertion.
- assertion asSentence Cirhin+is+a+nucleolar+protein+and+the+R565W+mutation%2C+for+which+all+North+American+Indian+childhood+cirrhosis+patients+are+homozygous%2C+has+no+effect+on+subcellular+localization. assertion.
- assertion asSentence MASTL+enhances+cyclin+B1-Cdk1-dependent+mitotic+phosphorylation+events%2C+directing+mitotic+entry%2C+anaphase+and+cytokinesis+in+human+cells. assertion.
- assertion asSentence Loss+of+RERG+expression+is+associated+with+breast+cancer+and+distant+metastasis. assertion.
- assertion asSentence LMPB1+is+indeed+an+integral+membrane+protein+that+targets+to+lysosomal+structures. assertion.
- assertion asSentence Fibronectin+adhesive+capacity+and+integrin+expression+of+monocytes+of+type+1+and+type+2+diabetic+patients+is+related+to+the+subjects%27+serum+levels+of+MRP-8. assertion.
- assertion asSentence Phosphorylation+inhibits+tubulin+polymerization+in+microtubules. assertion.
- assertion asSentence Cytoplasmic+body+component+TRIM5%7Balpha%7D+requires+lipid-enriched+microdomains+for+efficient+HIV-1+restriction. assertion.
- assertion asSentence The+ALG2+binding+site+is+necessary+for+the+punctate+distribution+of+the+carboxyl-terminal+proline-rich+region+of+Alix+in+HeLa+cells. assertion.
- assertion asSentence MYLK+gene+is+a+risk+factor+for+the+development+of+acute+lung+injuries. assertion.
- assertion asSentence MTHDIX+%28KIAA1735%29+protein+consists+of+Myosine-tail+homologous+%28MTH%29+domain+and+C-terminal+DIX+domain. assertion.
- assertion asSentence Ccd1+inhibits+Axin-mediated+JNK+activation+by+simultaneously+adopting+two+distinct+mechanisms%2C+one+through+conformational+changes+that+disallow+MEKK1+binding+and+the+other+via+direct+sequestration+of+MEKK4. assertion.
- assertion asSentence OX40+ligand+%28OX40L%29+is+a+critical+in+vivo+mediator+of+TSLP-mediated+Th2+responses. assertion.
- assertion asSentence A+genetic+variant+in+the+region+of+the+thymic+stromal+lymphopoietin+gene+is+associated+with+the+phenotypes+of+asthma+and+airway+hyperresponsiveness. assertion.
- assertion asSentence TSLP+expression+is+induced+in+airway+epithelial+cells+by+exposure+to+allergen-derived+proteases+and+PAR-2+is+involved+in+the+process. assertion.
- assertion asSentence Roles+of+Thymic+stromal+lymphopoietin+in+immunity. assertion.
- assertion asSentence TSLP+is+present+in+human+breast+milk+with+Levels+significantly+higher+%28p%3C0.001%29+at+3-5+days+than+at+11-26+days+postpartum. assertion.
- assertion asSentence First+description+of+PSKH2%2C+predicted+as+a+catalytically-active+protein+kinase+homolog+of+PSKH1. assertion.
- assertion asSentence An+important+role+for+hPNPase%28old-35%29in+growth+control+associated+with+terminal+differentiation+and+cellular+senescence. assertion.
- assertion asSentence Inhibition+of+PNPase+by+shRNA+or+stable+overexpression+of+miR-221+protected+melanoma+cells+from+IFN-beta-mediated+growth+inhibition%2C+accentuating+the+importance+of+PNPase+induction+and+miR-221+down-regulation+in+mediating+IFN-beta+action. assertion.
- assertion asSentence Radial+spoke+protein+44+denotes+the+restricted+localization+of+the+protein+to+the+radial+spokes+of+the+axonemes+of+both+sperm+and+cilia. assertion.
- assertion asSentence ILK+activity+can+modulate+acute+Wnt3a+mediated+beta-catenin+phosphorylation%2C+stabilization+and+nuclear+activation+in+a+PI3K-independent+manner. assertion.
- assertion asSentence Both+Wnt5a+and+Wnt3a+bound+Ror2%2C+only+Wnt5a+induced+Ror2+homo-dimerization+and+tyrosine+phosphorylation+in+U2OS+human+osteoblastic+cells. assertion.
- assertion asSentence Loss+of+CYLD+instigates+tumor+growth+in+human+cylindromatosis+through+a+mechanism+in+which+hyperubiquitination+of+polymerized+Dvl+drives+enhancement+of+Wnt3%2Fbeta-catenin+responses. assertion.
- assertion asSentence Up-regulation+of+DPAGT1+transcripts+by+Wnt3a+led+to+altered+N-glycosylation+of+E-cadherin. assertion.
- assertion asSentence Forced+expression+of+C4ST-1+in+L-Wnt-3a+cells+inhibited+diffusion+of+Wnt-3a+due+to+structural+alterations+in+CS+chains+mediated+by+C4ST-1. assertion.
- assertion asSentence Growth+inhibition+of+magnolol+against+human+colon+cancer+cells+can+be+partly+attributed+to+the+regulation+of+the+Wnt3a%2Fbeta-catenin+signaling+pathway. assertion.
- assertion asSentence NAV3+has+a+role+in+linking+tissue+inflammation+to+cancer+development+in+the+colon. assertion.
- assertion asSentence Male+infertility-linked+point+mutation+disrupts+the+Ca2%2B+oscillation-inducing+and+PIP%282%29+hydrolysis+activity+of+sperm+PLC+gamma. assertion.
- assertion asSentence Phospholipase+C-zeta-induced+Ca2%2B+oscillations+cause+coincident+cytoplasmic+movements+in+human+oocytes+that+failed+to+fertilize+after+intracytoplasmic+sperm+injection. assertion.
- assertion asSentence LHX4+mutations+are+a+relatively+rare+cause+of+combined+pituitary+hormone+deficiency. assertion.
- assertion asSentence HS6ST2+knockdown+disrupts+epithelial-mesenchymal+transition+and+suggesets+that+HS6ST2+potentiates+Notch+signaling+in+pancreatic+cancer+cells. assertion.
- assertion asSentence LRSAM1+as+a+component+of+the+antibacterial+autophagic+response. assertion.
- assertion asSentence LRSAM1+is+a+strong+candidate+for+the+causal+gene+for+the+Charcot-Marie-Tooth+disease. assertion.
- assertion asSentence IL33+is+constitutively+expressed+in+the+nucleus+of+endothelial+cells+and+epithelial+cells+in+vivo. assertion.
- assertion asSentence IL-33+is+strongly+associated+with+fibrosis+in+chronic+liver+injury+and+activated+hepatic+stellate+cells+are+a+source+of+IL-33. assertion.
- assertion asSentence IL-33%2C+acting+specifically+through+ST2%2C+regulates+the+formation+of+osteoclasts+from+human+peripheral+blood+CD14%2B+monocytes+and+bone+resorption. assertion.
- assertion asSentence Genetic+variants+of+IL-33+affect+susceptibility+to+late+onset+Alzheimer+disease+in+Han+Chinese. assertion.
- assertion asSentence The+dual+function+cytokine+IL-33+interacts+with+the+transcription+factor+NF-kappaB+to+dampen+NF-kappaB-stimulated+gene+transcription. assertion.
- assertion asSentence Rapid+amplification+of+cDNA+ends+revealed+exon+6+of+the+cAMP-responsive+element+binding+protein+3-like+1+gene+%28CREB3L1%29+fused+in-frame+to+the+EWSR1+exon+11. assertion.
- assertion asSentence Overexpression+of+CerS5+increased+apoptosis+in+HeLa+cells. assertion.
- assertion asSentence The+Meckel-Gruber+Syndrome+proteins+MKS1+and+meckelin+interact+and+are+required+for+primary+cilium+formation. assertion.
- assertion asSentence Missense+mutations+within+the+MKS3+gene+are+associated+with+nephronophthisis+with+liver+fibrosis. assertion.
- assertion asSentence DNA+damage+recognition+and+remodeling+activities+of+FANCM+and+FAAP24+cooperate+to+promote+efficient+activation+of+DNA+damage+checkpoints+in+Fanconi+anemia. assertion.
- assertion asSentence Overexpression+of+farnesyl+diphosphate+synthase+reverses+viperin-mediated+inhibition+of+virus+production+and+restores+normal+membrane+fluidity. assertion.
- assertion asSentence Viperin+inhibits+hepatitis+C+virus+replication+by+interfering+with+binding+of+NS5A+to+host+protein+VAP-33. assertion.
- assertion asSentence Viperin+is+an+alpha-beta+protein+containing+iron-sulfur+cluster+at+the+center+pocket. assertion.
- assertion asSentence Cdo+and+Boc+bind+Shh+through+a+high-affinity+interaction+with+a+specific+fibronectin+repeat+that+is+essential+for+activity. assertion.
- assertion asSentence Boc+receptor+is+required+for+segregation+of+ipsilateral+axons+at+the+optic+chiasm+and%2C+conversely%2C+Boc+expression+in+contralateral+retinal+ganglion+cells+prevents+their+axons+from+crossing+the+optic+chiasm. assertion.
- assertion asSentence ATP+binding+by+NLRP12+is+critical+for+its+inhibitory+function. assertion.
- assertion asSentence C14ORF43+%28MIDEAS%29+is+part+of+a+mitotic+deacetylase+complex+%28MIDAC%29+formed+in+cell+division+with+HDAC1%2FHDAC2+and+DNTTIP1. assertion.
- assertion asSentence ZNF804A+is+predicted+to+have+a+role+in+phenotypes+reflecting+altered+neural+connectivity. assertion.