Matches in Nanopublications for { ?s <http://purl.org/nanopub/x/asSentence> ?o ?g. }
- assertion asSentence DYNLL%2FLC8+protein+controls+signal+transduction+through+the+Nek9%2FNek6+signaling+module+by+regulating+Nek6+binding+to+Nek9. assertion.
- assertion asSentence MarvelD3+co-localises+with+occludin+at+tight+junctions+in+intestinal+and+corneal+epithelial+cells. assertion.
- assertion asSentence RFT1+deficiency+in+both+yeast+and+human+cells+leads+to+the+accumulation+of+incomplete+DolPP-GlcNAc%282%29Man%285%29+and+to+a+profound+glycosylation+disorder+in+humans. assertion.
- assertion asSentence Astrocyte+elevated+gene-1+activates+AMPK+in+response+to+cellular+metabolic+stress+and+promotes+protective+autophagy. assertion.
- assertion asSentence Implicate+cytoplasmic+MTDH+in+cell+survival+and+broad+drug+resistance+via+association+with+RNA+and+RNA-binding+proteins. assertion.
- assertion asSentence Tumour+AEG-1+overexpression+is+associated+with+poor+prognosis+and+cisplatin+resistance+in+advanced+serous+ovarian+cancer. assertion.
- assertion asSentence Biallelic+mutations+in+the+photoreceptor-specific+gene+PCDH21+cause+recessive+retinal+degeneration+in+humans. assertion.
- assertion asSentence ATP+and+MO25alpha+cooperate+to+maintain+STRADalpha+in+an+%22active%22+closed+conformation+required+for+LKB1+activation. assertion.
- assertion asSentence Defective+function+of+glucose-6-phosphatase%2C+catalytic+subunit+3%2C+underlies+a+severe+congenital+neutropenia+syndrome+associated+with+cardiac+and+urogenital+malformations. assertion.
- assertion asSentence The+far-UV+CD+spectra+of+Tim50%28IMS%29+in+native+and+denatured+states+revealed+that+the+protein+has+a+significantly+folded+secondary+structure+consisted+of+alpha-helixes+and+beta-sheets. assertion.
- assertion asSentence DUE-B%2C+a+c-myc+DNA-unwinding+element-binding+protein%2C+plays+an+important+role+in+replication+in+vivo. assertion.
- assertion asSentence B4GALT3%2C+DAP3%2C+RGS16%2C+TMEM183A+and+UCK2--were+significantly+overexpressed+in+dup%281q%29-positive+ALLs+compared+with+high+hyperdiploid+ALLs+without+dup%281q%29. assertion.
- assertion asSentence Dermokine+gene+is+expressed+in+epithelial+tissues+other+than+the+skin+and+this+expression+is+transcriptionally+and+posttranscriptionally+complex. assertion.
- assertion asSentence The+N-terminal+conserved+region+plays+a+multifaceted+role+in+Orai3+current+gating+with+distinct+structural+requirements+for+STIM1-+and+2-APB-stimulated+activation. assertion.
- assertion asSentence The+EWI-2%2Falpha-actinin+complex+is+involved+in+regulation+of+the+actin+cytoskeleton+at+T+cell+immune+and+virological+synapses%2C+providing+a+link+between+membrane+microdomains+and+the+formation+of+polarized+membrane+structures+involved+in+T+cell+recognition. assertion.
- assertion asSentence Forced+expression+of+the+myocardin+%28MyoC%29+gene+in+human+ventricular+scar+fibroblasts+leads+to+MyoC-dependent+activation+of+genes+that+encode+connexins%2C+strongly+enforcing+intercellular+electrical+coupling. assertion.
- assertion asSentence Epigenetic+inactivation+of+Myocardin+is+a+frequent+and+tumor-specific+event+in+nasopharyngeal+carcinoma. assertion.
- assertion asSentence Truncation+of+FOXP2+is+the+cause+of+developmental+speech+and+language+deficits. assertion.
- assertion asSentence Disease-causing+mutations+in+FOXP2+map+either+to+the+DNA+binding+surface+or+the+domain-swapping+dimer+interface%2C+functionally+corroborating+the+crystal+structure. assertion.
- assertion asSentence MUC16-Mesothelin+binding+is+a+high+affinity%2C+N-glycan+dependent+interaction+that+facilitates+peritoneal+metastasis+of+ovarian+tumors. assertion.
- assertion asSentence MUC16+is+the+major+%5B%2835%29S%5Dsulphate-labelled+mucin+in+normal+human+bronchial+epithelial+cell+secretions. assertion.
- assertion asSentence Expression+and+distribution+of+MUC16+in+conjunctival+and+corneal+epithelial+cell+lines+is+monitored+by+RTPCR+and+immunocytochemistry. assertion.
- assertion asSentence Reflux+laryngitis+is+associated+with+down-regulation+of+mucin+gene+expression. assertion.
- assertion asSentence MUC16+expressing+ovarian+cancer+cells+are+protected+from+recognition+by+natural+killer+cells. assertion.
- assertion asSentence Ectopic+expression+of+the+MUC16CTD+enhances+SKOV3+tumor+cell+growth%2C+colony+formation+in+soft+agar+and+enhances+tumor+growth+and+metastases+in+SCID+mice. assertion.
- assertion asSentence p53+overexpression+strongly+downregulates+the+transcriptional+efficiency+driven+by+an+H+ferritin+promoter+construct+containing+only+the+NF-Y+recognition+sequence. assertion.
- assertion asSentence TP53INP1s+are+functionally+associated+with+p73+to+regulate+cell+cycle+progression+and+apoptosis. assertion.
- assertion asSentence TP53INP1+antisense+oligonucleotide+inhibits+proliferation+and+induces+apoptosis+in+castration-sensitive+LNCaP+tumor+cells. assertion.
- assertion asSentence Importance+of+PKC%2FCPI-17-mediated+pathway+in+histamine-triggered+cytoskeletal+rearrangements+leading+to+lung+microvascular+barrier+compromise. assertion.
- assertion asSentence The+FLCN-FNIP+complex+deregulated+in+Birt-Hogg-Dube+syndrome+is+absolutely+required+for+B-cell+differentiation. assertion.
- assertion asSentence The+protein+L-isoaspartyl+%28D-aspartyl%29+methyltransferase+%28PIMT%29+is+an+enzyme+that+recognizes+and+repairs+the+abnormal+L-isoaspartyl+residues+in+proteins. assertion.
- assertion asSentence PHD-dependent+oxygen-sensing+recruits+both+the+hypoxia-inducible+factor+%28HIF%29+and+ATF-4+systems. assertion.
- assertion asSentence Interferon-gamma+induces+prolyl+hydroxylase+%28PHD%293+through+a+STAT1-dependent+mechanism+in+human+endothelial+cells. assertion.
- assertion asSentence Human+SRBC+is+located+within+the+11p15.5-p15.4+tumor+suppressor+region+and+is+inactivated+in+breast+and+lung+cancers. assertion.
- assertion asSentence Human+IL-17F%2FIL-17A+heterodimer+can+bind+and+signal+through+the+same+receptor+complex+as+human+homodimeric+cytokines+IL-17F+and+IL-17A. assertion.
- assertion asSentence IL-17F+single+nucleotide+polymorphism+is+not+associated+with+psoriasis+vulgaris+or+atopic+dermatitis+in+the+Japanese+population. assertion.
- assertion asSentence cAMP-responsive+element+modulator+alpha+%28CREMalpha%29+suppresses+IL-17F+protein+expression+in+T+lymphocytes+from+patients+with+systemic+lupus+erythematosus+%28SLE%29. assertion.
- assertion asSentence C14ORF179+encoding+IFT43+is+mutated+in+Sensenbrenner+syndrome. assertion.
- assertion asSentence NAC-1+expression+is+higher+in+ovarian+carcinoma+cells+in+effusions+compared+with+their+solid+tumor+counterparts. assertion.
- assertion asSentence Mutations+of+riboflavin+transporter-2+gene+is+associated+with+Brown-Vialetto-Van+Laere+syndrome. assertion.
- assertion asSentence DTX2+is+a+gene+encoding+a+WWE-RING-finger+protein+and+involved+in+regulating+heart+development+and+heart+functions. assertion.
- assertion asSentence Ucn+3+plays+some+physiological+or+pathological+roles+in+the+modulation+of+gastrointestinal+functions+during+stressful+conditions. assertion.
- assertion asSentence Ucn3+is+produced+in+the+normal+adrenal+gland+and+in+adrenal+tumors+%28both+adrenocortical+tumors+and+pheochromocytomas%29+and+acts+as+an+autocrine+or+paracrine+regulator+in+both+the+normal+and+cancerous+adrenal+gland+tissue. assertion.
- assertion asSentence The+juvenile+myoclonic+epilepsy-related+protein+EFHC1+interacts+with+the+redox-sensitive+TRPM2+channel+linked+to+cell+death. assertion.
- assertion asSentence Chronic+infantile+neurological+cutaneous+and+articular+syndrome+is+caused+by+mutations+in+CIAS1%2C+a+gene+highly+expressed+in+polymorphonuclear+cells+and+chondrocytes. assertion.
- assertion asSentence Missense+mutations+of+CIAS1%2FPYPAF1%2FNALP3+gene+occurred+in+7+unrelated+Spanish+families+with+recurrent+autoinflammatory+diseases. assertion.
- assertion asSentence Common+variants+in+NLRP2+and+NLRP3+genes+are+strong+prognostic+factors+for+the+outcome+of+HLA-identical+sibling+allogeneic+stem+cell+transplantation. assertion.
- assertion asSentence NALP3+gene+polymorphism+is+an+important+factor+of+developing+Croh+disease+in+men. assertion.
- assertion asSentence Activation+of+NLRP3-mediated+inflammatory+response+pathways+is+an+important+venue+associated+with+host+response+and+pathogenesis+of+N.+gonorrhoeae. assertion.
- assertion asSentence The+mutant+NLRP3+A+allele+is+a+risk+factor+for+the+development+of+symptoms%2C+specifically+lower+abdominal+pain%2C+after+a+C.+trachomatis+infection+in+women+attending+an+STD+clinic. assertion.
- assertion asSentence Synergism+of+NOD2+and+NLRP3+activators+promotes+a+unique+transcriptional+profile+in+murine+dendritic+cells. assertion.
- assertion asSentence Adenovirus+type+5+%28Ad5%29+cell+membrane+penetrations+activates+the+NLRP3+Inflammasome. assertion.
- assertion asSentence Crystal+structure+of+NALP3+protein+pyrin+domain+%28PYD%29+and+its+implications+in+inflammasome+assembly. assertion.
- assertion asSentence C.+pneumoniae+infection+of+mononuclear+cells+stimulates+IL-1beta+production+dependent+on+a+NLRP3+inflammasome-mediated+processing+of+proIL-1beta+which+is+controlled+by+Rac1. assertion.
- assertion asSentence A.+actinomycetemcomitans+enhances+NLRP3+and+reduces+NLRP6+inflammasome+expression. assertion.
- assertion asSentence The+Q705K+polymorphism+in+NLRP3+is+a+gain-of-function+alteration+leading+to+an+overactive+NLRP3+inflammasome. assertion.
- assertion asSentence After+differentiation%2C+murine+oligodendrocyte+precursor+and+human+oligodendroglioma+derived+cell+lines+up-regulate+the+expression+of+MAL2+and+accumulate+it+in+an+intracellular+compartment%2C+exhibiting+a+peri-centrosomal+localization. assertion.
- assertion asSentence Mal+S180L+variant+attenuated+TLR2+signal+transduction+and+confers+a+protective+effect+against+infectious+diseases. assertion.
- assertion asSentence An+Asp96Asn+single+nucleotide+polymorphism+prevents+Mal+from+recruiting+its+signaling+partner+MyD88+to+the+plasma+membrane+and+fails+to+induce+NF-kappa+B+signaling+in+human+tumor+line+Huh-7+hepatocytes. assertion.
- assertion asSentence A+molecular+and+structural+basis+for+the+role+of+MAL+in+TLR+signaling+and+disease+protection. assertion.
- assertion asSentence The+human+ermap+gene+plays+an+important+role+in+differentiation+and+development+of+erythroid+cells. assertion.
- assertion asSentence CSMD2+protein+domain+structure+and+the+sequence+of+the+cytoplasmic+tail+are+highly+conserved+between+mammals+and+fish. assertion.
- assertion asSentence CSMD3+protein+domain+structure+and+the+sequence+of+the+cytoplasmic+tail+are+highly+conserved+between+mammals+and+fish. assertion.
- assertion asSentence Testosterone+represses+MAFbx+expression+via+interactions+of+the+AR+with+Oct-1. assertion.
- assertion asSentence Atrophic+AKT-FOXO+signaling+play+major+roles+in+eliciting+pathological+changes+associated+with+diaphragm+disuse. assertion.
- assertion asSentence OMA1+controls+OPA1+cleavage+and+function. assertion.
- assertion asSentence Susceptibility+to+type+1+autoimmune+hepatitis+in+Japanese+patients+is+not+influenced+by+FcgammaRIIA%2C+FcgammaRIIB%2C+or+FCRL3+polymorphisms. assertion.
- assertion asSentence FcRL3+gene+promoter+variant+is+associated+with+peripheral+arthritis+in+Crohn%27s+disease. assertion.
- assertion asSentence Augmented+inhibition+of+BCR-mediated+signaling+by+FCRL3+with+the+disease-risk+genotype+alter+the+activation+threshold+and+promote+tolerance+breakdown+in+B+cells. assertion.
- assertion asSentence A+significant+association+of+fcrl3_3+with+primary+biliary+cirrhosis+only+in+Japanese. assertion.
- assertion asSentence NIRF+is+a+ubiquitin+ligase+that+is+capable+of+ubiquitinating+PCNP+%28PEST-containing+nuclear+protein%29. assertion.
- assertion asSentence TCGAP+interacts+with+Fyn+and+is+phosphorylated+by+Fyn%2C+with+tyrosine-406+in+the+GTPase-activating+protein+%28GAP%29+domain+as+a+major+Fyn-mediated+phosphorylation+site. assertion.
- assertion asSentence A+genetic+variant+of+ARLTS1+predisposes+patients+to+familial+cancer. assertion.
- assertion asSentence Cysteine148Arginine+variant+is+associated+with+a+moderately+increased+risk+of+colorectal+cancer%2C+both+in+sporadic+and+familial+cases. assertion.
- assertion asSentence CHX10+regulates+RdCVF+promoter+activity+in+the+inner+retina. assertion.
- assertion asSentence PDZK1+plays+a+role+in+regulating+the+functional+activity+of+URAT1-mediated+urate+transport+in+the+apical+membrane+of+renal+proximal+tubules. assertion.
- assertion asSentence Functioning+as+an+antiporter%2C+hURAT1+mediates+the+uptake+of+urate+from+the+lumen+into+proximal+tubule+cells+in+exchange+for+organic+and+inorganic+anions. assertion.
- assertion asSentence The+G774A+mutation+in+the+SLC22A12+gene+encoding+URAT1+%28+urate+anion+exchanger+1+%29+predominates+in+Japanese+renal+hypouricemia. assertion.
- assertion asSentence Significant+lower+protein+and+mRNA+levels+of+the+N-methyl-D-aspartate+receptors%2C+NR-1+and+hr-3a+in+frontal+corte+in+bipolar+disorder. assertion.
- assertion asSentence In+a+human+embryonic+brain+cDNA+library+mTOR-activating+GTPase+Rheb+is+screened+as+an+interacting+protein+of+the+NMDAR+subunit+NR3A. assertion.
- assertion asSentence APOA5+gene+expression+is+regulated+by+the+LXR+ligand+T0901317+in+a+negative+manner+through+SREBP-1c. assertion.
- assertion asSentence The+strong+association+between+triglyceride+level+in+diabetic+nephropathy+is+not+affected+by+apoA5+polymorphism. assertion.
- assertion asSentence DNA+polymorphisms+within+APOA5+are+associated+with+hypertriglyceridemia. assertion.
- assertion asSentence APOA5+genetic+variants+are+markers+for+classic+hyperlipoproteinemia+phenotypes+and+hypertriglyceridemia. assertion.
- assertion asSentence Effects+of+established+gene+variation+on+lipid+and+glucose+traits+do+not+tend+to+alter+with+age+during+adulthood+or+over+time. assertion.
- assertion asSentence SNPs+in+GCKR+and+APOA5+have+an+additive+effect+on+both+fasting+and+postprandial+triacylglycerol+and+contribute+to+the+interindividual+variability+in+response+to+fenofibrate+treatment. assertion.
- assertion asSentence The+development+of+atherosclerosis+in+patients+with+Type+III+HLP+is+modulated+by+variation+in+the+APOA5+gene. assertion.
- assertion asSentence In+a+population+with+atherogenic+dyslipidemia%2C+common+SNPs+and+haplotypes+within+the+APOA5-ZNF259+region+are+highly+associated+with+HDL-C+and+ApoA-I+response+to+combination+therapy+with+statins+and+fenofibric+acid. assertion.
- assertion asSentence ARAP2+is+an+Arf6GAP+that+functions+downstream+of+RhoA+to+regulate+focal+adhesion+dynamics. assertion.
- assertion asSentence ARAP1+acts+primarily+on+Arf6+in+vivo. assertion.
- assertion asSentence Akt-phosphorylated+PIKE-A+inhibits+UNC5B-induced+apoptosis+in+cancer+cell+lines+in+a+p53-dependent+manner. assertion.
- assertion asSentence PIKE+is+a+critical+factor+in+controlling+synaptic+AMPA+receptor+insertion. assertion.
- assertion asSentence By+in+situ+hybridization%2C+UGRP1+is+found+to+be+expressed+by+lung+Clara-like+cells+in+the+bronchial+epithelium+and+up-regulated+in+lung+epithelium+of+a+patient+with+cystic+fibrosis. assertion.
- assertion asSentence Pleiotrophin+%28PTN%29+and+syndecan-2+and+-3+as+direct+binding+partners+of+Y-P30. assertion.
- assertion asSentence Nuclear+protein+SS2IP+interacts+with+cancer-related+protein+SSX2+and+the+human+homologue+of+a+Ras-like+GTPase+interactor%2C+RABIN3. assertion.
- assertion asSentence Divalent+metal+ion+coordination+by+residue+T118+of+anthrax+toxin+receptor+2+is+not+essential+for+protective+antigen+binding. assertion.
- assertion asSentence ANTXR2+and+IL-1R2+polymorphisms+are+not+associated+with+ankylosing+spondylitis+in+Chinese+Han+population. assertion.
- assertion asSentence VAP-A+is+an+important+regulator+both+of+the+subcellular+localization+of+protrudin+and+of+its+ability+to+stimulate+neurite+outgrowth. assertion.
- assertion asSentence A+nonsynchronous+polymorphism+in+the+MMP-21+promoter+does+not+significantly+confer+susceptibility+to+hepatocellular+carcinoma+in+a+southern+Chinese+population. assertion.
- assertion asSentence The+predicted+protein+encoded+by+MSAG+contains+110+amino+acids+and+has+a+theoretical+molecular+weight+of+11667.04+and+an+isoelectric+point+of+4.91+%28MSAG%29. assertion.