Matches in Nanopublications for { ?s <http://purl.org/nanopub/x/asSentence> ?o ?g. }
- assertion asSentence Over+expression+of+pancreatic+lipase-related+protein+3+is+associated+with+hepatocellular+carcinoma. assertion.
- assertion asSentence The+structure+reveals+the+secosteroid+binding+mode+in+an+extended+active+site+and+allows+rationalization+of+the+molecular+basis+of+the+inherited+rickets+associated+with+CYP2R1. assertion.
- assertion asSentence Dbx1-derived+neurons+are+essential+for+the+transgenic+expression+and+generation+of+respiratory+behavior+both+in+vitro+and+in+vivo. assertion.
- assertion asSentence LRRK2+gene+heterozygous+mutation+%28Gly2019+ser%29+CAUSE+dominantly+inherited+Parkinson%27s+disease. assertion.
- assertion asSentence LRRK2+G2019S+is+the+single+most+common+pathogenic+mutation+linked+to+neurodegenerative+disease+to+date. assertion.
- assertion asSentence LRRK2+mutations+are+present+in+patients+with+autosomal+dominant+Parkinson%27s+disease+%28AdPD%29and+sporadic+PD+patients+of+Greek+origin. assertion.
- assertion asSentence Lrrk2+is+linked+to+frontotemporal+atrophy+of+PPND+type+caused+by+N279K+tau+mutation. assertion.
- assertion asSentence Mutations+in+LRRK2+as+a+cause+of+Parkinson%27s+disease. assertion.
- assertion asSentence LRRK2+p.2385G%3ER+substitution+contributes+to+the+development+of+PD+in+ethnic+Han-Chinese+population. assertion.
- assertion asSentence Overexpression+of+human+LRRK2+strongly+protects+Caenorhabditis+elegans+against+cellular+responses+to+the+mitochondrial+toxin+rotenone. assertion.
- assertion asSentence Age+of+onset+and+clinical+features+in+Lrrk2+Arg1441Cys+patients+are+similar+to+idiopathic+and+Lrrk2+Gly2019Ser+parkinsonism. assertion.
- assertion asSentence LRRK2+P755L+is+a+non-disease-associated+polymorphism+in+sporadic+Parkinson%27s+disease. assertion.
- assertion asSentence LRRK2+normally+localizes+to+the+endosomal-lysosomal+compartment+within+morphologically+altered+neurons+in+neurodegenerative+diseases%2C+particularly+in+the+brains+of+patients+with+Lewy+body+diseases. assertion.
- assertion asSentence Ubiquitous+expression+of+hLRRK2+increased+lifespan+and+fertility+of+the+flies. assertion.
- assertion asSentence LRRK2+p.G2019S+mutation+is+not+common+among+Alzheimer%27s+disease+patients. assertion.
- assertion asSentence The+frequency+of+LRRK2+G2019S+is+30-41%25+in+familial+PD+and+30-39%25+in+apparently+sporadic+Parkinson+disease+in+North+Africa. assertion.
- assertion asSentence The+localization+of+LRRK2+protein+in+the+core+of+a+subset+of+Lewy+bodies+%28LB%29+demonstrates+the+contribution+of+LRRK2+to+LB+formation+and+Parkinson+disease+pathogenesis. assertion.
- assertion asSentence Leucine-rich+repeat+kinase+2+%28LRRK2+S1647T%29+genetic+variant+is+associated+with+increased+risk+of+Parkinson%27s+disease+in+a+Taiwanese+population. assertion.
- assertion asSentence Mutant+human+LRRK2+is+highly+expressed+in+the+hippocampus+in+the+dorsal+root+ganglia+and+subventricular+zone+of+adult+transgenic+mice. assertion.
- assertion asSentence LRRK2+Gly2019Ser+mutation+among+Parkinson%27s+disease+patients+in+Cantabria+%28Spain%29+is+high-frequency+and+reduced-penetrance. assertion.
- assertion asSentence LRRK2+plays+an+important+role+as+a+physiological+regulator+for+phosphorylation-mediated+dissociation+of+tau+from+microtubules. assertion.
- assertion asSentence Endogenous+or+human+LRRK2+and+A53T+alpha-synuclein+do+not+interact+together+to+influence+the+number+of+nigrostriatal+dopaminergic+neurons. assertion.
- assertion asSentence LRRK2+has+minimal+role+as+a+candidate+and+susceptibility+gene+in+Parkinson%27s+disease+pathogenesis+among+East+Indians. assertion.
- assertion asSentence Claudin-7+can+be+used+as+a+useful+diagnostic+marker+in+diagnosing+chromophobe+RCC+and+oncocytoma. assertion.
- assertion asSentence RHEBL1+is+a+positive+regulator+of+NF-kappa+B-mediated+gene+transcription. assertion.
- assertion asSentence The+NH%282%29-terminal+regulatory+domain+is+the+source+of+hTPH2+instability+and+reduced+solubility. assertion.
- assertion asSentence Both+the+5%27-UTR+and+common+polymorphisms+%28especially+the+90A%2FG%29+in+the+5%27+regulatory+region+of+human+TPH2+have+a+significant+impact+on+gene+expression. assertion.
- assertion asSentence TPH2+gene+is+involved+in+affective+disorders+in+children. assertion.
- assertion asSentence TPH2+gene+polymorhism+is+involved+in+coronary+artery+lesions+in+Korean+children+with+Kawasaki+disease. assertion.
- assertion asSentence BTG2+contributes+to+retinoic+acid+activity+by+favoring+differentiation+through+a+gene-specific+modification+of+histone+H4+arginine+methylation+and+acetylation+levels. assertion.
- assertion asSentence High+expression+of+acetylated+H4+is+more+common+in+aggressive+than+indolent+cutaneous+T-cell+lymphoma. assertion.
- assertion asSentence Downregulated+by+zinc+and+upregulated+by+docosahexaenoate+in+a+neuroblastoma+cell+line. assertion.
- assertion asSentence In+neuron+reduced+levels+of+ACSL4+led+to+a+significant+reduction+in+dendritic+spine+density+and+an+alteration+in+spine%2Ffilopodia+distribution. assertion.
- assertion asSentence LGR8.1+spliced+isoform+is+expressed+at+the+cell+surface%2C+unable+to+stimulate+cAMP+production. assertion.
- assertion asSentence Proteasome+beta5t+is+expressed+in+most+type+B+and+in+some+type+AB+thymomas+and+is+a+marker+useful+in+differentiating+type+B3+thymomas+from+thymic+carcinomas+when+used+in+combination+with+other+diagnostic+markers. assertion.
- assertion asSentence Genome-wide+and+gene-based+association+implicates+FRMD6+in+Alzheimer+disease. assertion.
- assertion asSentence IRF4+and+SLC24A4+loci+are+associated+with+human+hair+color+and+skin+pigmentation. assertion.
- assertion asSentence The+human+and+mouse+SLC25A29+mitochondrial+ornithine+transporters+%28designated+as+ORNT3%29+rescue+the+deficient+ornithine+metabolism+in+fibroblasts+of+patients+with+the+hyperornithinemia-hyperammonemia-homocitrullinuria+%28HHH%29+syndrome. assertion.
- assertion asSentence Interaction+of+solute+transporter+beta+with+human+organic+solute+transporter+alpha. assertion.
- assertion asSentence The+hereditary+spastic+paraplegia+proteins+NIPA1%2C+spastin+and+spartin+inhibit+BMP+signalling+by+promoting+BMP+receptors+degradation. assertion.
- assertion asSentence CMTM3+inhibits+prostate-specific+antigen+expression+at+both+mRNA+and+protein+levels+with+no+obvious+influence+on+androgen+receptor+expression. assertion.
- assertion asSentence Serves+as+a+sorting+molecule+that+cycles+P-selectin+ligand+protein+into+endosomes+with+no+impact+on+leukocyte+recruitment. assertion.
- assertion asSentence A+role+of+the+SANS-myomegalin+complex+in+microtubule-dependent+inner+segment+cargo+transport+towards+the+ciliary+base+of+photoreceptor+cells. assertion.
- assertion asSentence Utilization+of+HEXIM1+or+HEXIM2+to+bind+and+inhibit+P-TEFb+can+be+differentially+regulated+in+vivo. assertion.
- assertion asSentence Positive+transcription+elongation+factor+b+regulates+eukaryotic+gene+expression+at+the+level+of+elongation+and+is+controlled+by+the+reversible+association+with+HEXIM2. assertion.
- assertion asSentence Because+the+DNA+substrate-binding+site+in+APOBEC3C+differs+from+the+region+for+7SK+binding%2C+7SK+does+not+act+as+a+substrate+competitor+in+inhibiting+APOBEC3C. assertion.
- assertion asSentence Tat+efficiently+replaces+HEXIM1+on+the+7SK+snRNA+in+vivo+and+it+promotes+the+disassembly+of+the+7SK%2FHEXIM%2FP-TEFb+negative+transcriptional+regulatory+snRNP+to+augment+the+nuclear+level+of+active+P-TEFb. assertion.
- assertion asSentence The+7SK+snRNP+complex+acts+as+a+reservoir+where+active+transcription+elongation+factor+P-TEFb+can+be+withdrawn+by+Tat+to+stimulate+HIV-1+transcription. assertion.
- assertion asSentence Smith-Magenis+syndrome+is+caused+by+a+de+novo+deletion+on+chromosome+17. assertion.
- assertion asSentence The+14-3-3+zeta+mutation+mimicking+phosphorylation+of+Ser184+does+not+markedly+affect+interaction+with+tau+protein+and+improves+the+interaction+of+14-3-3+zeta+with+HspB6. assertion.
- assertion asSentence Nevertheless%2C+in+solution%2C+both+alpha-crystallin+domain+proteins+form+stable+dimers+via+the+symmetric+antiparallel+interaction+of+beta7+strands. assertion.
- assertion asSentence The+acetylation+of+lysine%2856%29+residue+of+Histone+H3+is+critical+for+genomic+stability+and+DNA+damage+response. assertion.
- assertion asSentence UHRF1+PHD+finger+%28including+the+preceding+zinc-Cys4+knuckle%29+acts+together+with+the+adjacent+double+Tudor+domain+to+specifically+recognize+the+H3K9me3+mark. assertion.
- assertion asSentence A+recombinant+fragment+from+the+luminal+domain+of+the+human+receptor+protein+syt+II+can+bind+specifically+to+botulinum+neurotoxin+B+and+its+Hc+domain. assertion.
- assertion asSentence Paracrine+role+for+the+PKs+and+their+receptors+in+endometrial+vascular+function. assertion.
- assertion asSentence OSR1+is+expressed+in+human+mesenchymal+stem+cells%2C+the+blastemal+component+of+Wilms+tumors+and+CD24%2B%2FCD133%2B+progenitor+cells+isolated+from+the+mature+kidney. assertion.
- assertion asSentence An+AIP-1+human+homologue%2C+ZFAND2B%2C+has+a+similar+protective+effect+against+Abeta+toxicity. assertion.
- assertion asSentence In+human+tonsils%2C+CD200R+is+differentially+expressed+on+B+cells%2C+with+high+expression+on+memory+cells+and+plasmablasts. assertion.
- assertion asSentence Dok1+negatively+regulates+Dok2-mediated+CD200R+signaling+through+the+recruitment+of+CrkL. assertion.
- assertion asSentence hNUDT16+can+also+actively+cleave+the+mGDP+cap+from+mRNAs+in+the+presence+of+Mg%282%29%28%2B%29+or+Mn%282%29%28%2B%29. assertion.
- assertion asSentence IL-17RE+as+a+receptor+of+IL-17C+that+regulates+early+innate+immunity+to+intestinal+pathogens. assertion.
- assertion asSentence MAPCs+express+the+OCT4+and+REX1+transcription+factors%2C+two+specific+markers+of+undifferentiated+embryonic+stem+%28ES%29+cells. assertion.
- assertion asSentence PGC-1beta+is+a+substrate+for+general+control+of+amino-acid+synthesis+%28GCN5%29+and+is+acetylated+on+at+least+10+lysine+residues+that+are+distributed+along+multiple+domains+of+the+protein. assertion.
- assertion asSentence AFAP1L1+has+a+role+in+the+progression+of+spindle+cell+sarcomas+and+is+a+prognostic+biomarker. assertion.
- assertion asSentence Expression+of+neuronal+trace+amine-associated+receptor+%28Taar%29+mRNAs+in+leukocytes. assertion.
- assertion asSentence Suspected+association+of+SNP%27s+with+leprosy+is+not+borne+out+in+Indian+population. assertion.
- assertion asSentence Human+GlcAT-S+gene-located+on+human+chromosome+6+encodes+a+protein+involved+in+biosynthesis+of+HNK-1+carbohydrate+epitope+on+glycoproteins. assertion.
- assertion asSentence CD109+plays+a+unique+role+in+the+regulation+of+isoform-specific+TGF-beta+signaling+in+keratinocytes. assertion.
- assertion asSentence CD109+regulates+TGF-beta+receptor+endocytosis+and+degradation+to+inhibit+TGF-beta+signaling. assertion.
- assertion asSentence Mutations+of+the+homeobox+region+of+the+NOBOX+gene+are+uncommon+in+Japanese+patients+with+premature+ovarian+failure. assertion.
- assertion asSentence Variants+in+ASB10+are+associated+with+open-angle+glaucoma. assertion.
- assertion asSentence Functional+inactivation+of+the+WTX+gene+is+not+a+frequent+event+in+Wilms%27+tumors. assertion.
- assertion asSentence Reflux+laryngitis+is+associated+with+down-regulation+of+mucin+gene+expression. assertion.
- assertion asSentence A+role+for+Nek7+in+regulating+proper+spindle+assembly+and+mitotic+progression. assertion.
- assertion asSentence Frequent+silencing+of+GATA-4+and+GATA-5+in+human+esophageal+neoplasia+is+associated+with+gene+promoter+hypermethylation. assertion.
- assertion asSentence Subjects+with+schizophrenia+exhibited+expression+deficits+in+GABA+transpter+1. assertion.
- assertion asSentence BORIS+acts+as+a+platform+upon+which+BAT3+and+SET1A+assemble+and+exert+effects+upon+chromatin+structure+and+gene+expression. assertion.
- assertion asSentence Up-regulation+of+TRPM6+transcriptional+activity+by+AP-1+in+renal+epithelial+cells. assertion.
- assertion asSentence Relationship+between+ATM+kinase+and+extracellular+signal-regulated+kinase+1%2F2+%28ERK1%2F2%29%2C+a+key+mitogenic+stimulator. assertion.
- assertion asSentence A+specific+functional+role+for+SIRPalpha+in+chondrocyte+mechano-transduction. assertion.
- assertion asSentence CD47%2FSIRP-alpha+interactions+are+implicated+in+the+pathogenesis+of+DC-driven+allergic+airway+inflammation. assertion.
- assertion asSentence Insulin-like+growth+factor-I-stimulated+insulin+receptor+substrate-1+negatively+regulates+Src+homology+2+domain-containing+protein-tyrosine+phosphatase+substrate-1+function+in+vascular+smooth+muscle+cells. assertion.
- assertion asSentence Poor+prognosis+of+breast+cancer+patients+with+high+expression+of+CD47+is+due+to+an+active+CD47%2FSIRPA+signaling+pathway+in+circulating+cells. assertion.
- assertion asSentence Single+Nucleotide+Polymorphisms+in+PTPNS1+is+associated+with+inflammatory+bowel+disease. assertion.
- assertion asSentence hSIRPa-transgenic+Rag2%28-%2F-%29gamma%28c%29%28-%2F-%29+mice+represent+a+unique+mouse+strain+supporting+high+levels+of+human+cell+engraftment. assertion.
- assertion asSentence MPP7+is+a+PDZ+protein+that+interacts+with+human+papillomavirus-16+E6+and+forms+a+tripartite+complex+with+LIN7A+or+LIN7C+and+DLG1%2C+regulating+the+stability+and+localization+of+DLG1+to+cell+junctions. assertion.
- assertion asSentence This+article+provides+an+overview+of+some+of+the+components+in+the+human+20+S+proteasome. assertion.
- assertion asSentence Molecular+cloning+and+gene+expression+patterns+of+XRRA1. assertion.
- assertion asSentence Alternative+splice+variants%2C+K80+and+K80.1+distribute+differently+in+epithelia+of+hair+and+skin. assertion.
- assertion asSentence Low+vaspin+serum+concentrations+correlate+with+recently+experienced+ischemic+events+in+patients+with+carotid+stenosis+despite+the+lack+of+an+association+between+circulating+vaspin+and+parameters+of+atherosclerosis+severity. assertion.
- assertion asSentence Besides+targeting+cyclooxygenase%2C+indomethacin+inhibits+PTGR2+with+a+binding+mode+similar+to+that+of+15-keto-PGE%282%29. assertion.
- assertion asSentence Large+deletions+in+OTOA+gene+is+associated+with+hearing+loss. assertion.
- assertion asSentence Intracellular+CMTM2+can+negatively+regulate+HIV-1+transcription%2C+at+least+in+part%2C+by+targeting+the+AP-1+and+CREB+pathways. assertion.
- assertion asSentence The+different+spatiotemporal+expression+of+IL-34+and+CSF-1+allows+for+complementary+activation+of+the+CSF-1R+in+developing+and+adult+tissues. assertion.
- assertion asSentence hMATE1+and+hMATE2-K+function+together+as+a+detoxication+system%2C+by+mediating+the+tubular+secretion+of+intracellular+ionic+compounds+across+the+brush-border+membranes+of+the+kidney. assertion.
- assertion asSentence GPCR+activation+of+Ras+and+PI3Kc+in+neutrophils+depends+on+PLCb2%2Fb3+and+the+RasGEF+RasGRP4. assertion.
- assertion asSentence The+human+desmoglein+4+gene+%28DSG4%29+demonstrates+that+it+is+composed+of+16+exons+spanning+approximately+37+kb+of+18q12+and+is+situated+between+DSG1+and+DSG3. assertion.
- assertion asSentence Apak+%28ZNF420+or+FLJ32191%29+is+a+negative+regulator+of+p53-mediated+apoptosis. assertion.
- assertion asSentence Dysregulation+of+TLR4-triggered+MyD88-+and+TRIF-dependent+signaling+pathways+and+increased+expression+of+negative+regulators+of+TLR+signaling+in+endotoxin-tolerant+human+monocytes. assertion.
- assertion asSentence Nixin%2FZNRF4+to+be+central+for+the+regulation+of+calnexin+turnover. assertion.