Matches in Nanopublications for { ?s ?p ?o <http://bio2rdf.org/drugbank:DB00321_nanopub.RAjjfP7keVCQZEy6oVQhiCKcoOjDsaya9b8fkFuOgi0aE#assertion>. }
Showing items 1 to 28 of
28
with 100 items per page.
- drugbank:DB00321 type drugbank_vocabulary:Drug assertion.
- drugbank:DB00321 label "Amitriptyline [drugbank:DB00321]" assertion.
- drugbank:DB00321 seeAlso amitrip.htm assertion.
- drugbank:DB00321 seeAlso amitriptyline.html assertion.
- drugbank:DB00321 seeAlso DB00321 assertion.
- drugbank:DB00321 description "Amitriptyline hydrochloride is a dibenzocycloheptene-derivative tricyclic antidepressant (TCA). TCAs are structurally similar to phenothiazines. They contain a tricyclic ring system with an alkyl amine substituent on the central ring. In non-depressed individuals, amitriptyline does not affect mood or arousal, but may cause sedation. In depressed individuals, amitriptyline exerts a positive effect on mood. TCAs are potent inhibitors of serotonin and norepinephrine reuptake. Tertiary amine TCAs, such as amitriptyline, are more potent inhibitors of serotonin reuptake than secondary amine TCAs, such as nortriptyline. TCAs also down-regulate cerebral cortical β-adrenergic receptors and sensitize post-synaptic serotonergic receptors with chronic use. The antidepressant effects of TCAs are thought to be due to an overall increase in serotonergic neurotransmission. TCAs also block histamine-H<sub>1</sub> receptors, α<sub>1</sub>-adrenergic receptors and muscarinic receptors, which accounts for their sedative, hypotensive and anticholinergic effects (e.g. blurred vision, dry mouth, constipation, urinary retention), respectively. See toxicity section below for a complete listing of side effects. Amitriptyline may be used to treat depression, chronic pain (unlabeled use), irritable bowel syndrome (unlabeled use), diabetic neuropathy (unlabeled use), post-traumatic stress disorder (unlabeled use), and for migraine prophylaxis (unlabeled use)." assertion.
- drugbank:DB00321 identifier "drugbank:DB00321" assertion.
- drugbank:DB00321 title "Amitriptyline" assertion.
- drugbank:DB00321 drugbank_vocabulary:x-pubchemsubstance pubchem.substance:46508798 assertion.
- drugbank:DB00321 drugbank_vocabulary:x-pubchemcompound pubchem.compound:2160 assertion.
- drugbank:DB00321 drugbank_vocabulary:x-chemspider chemspider:2075 assertion.
- drugbank:DB00321 drugbank_vocabulary:x-cas cas:50-48-6 assertion.
- drugbank:DB00321 drugbank_vocabulary:drugbank-id "APRD00227" assertion.
- drugbank:DB00321 drugbank_vocabulary:drugbank-id "DB00321" assertion.
- drugbank:DB00321 bio2rdf_vocabulary:x-identifiers.org DB00321 assertion.
- drugbank:DB00321 bio2rdf_vocabulary:uri "http://bio2rdf.org/drugbank:DB00321" assertion.
- drugbank:DB00321 bio2rdf_vocabulary:namespace "drugbank" assertion.
- drugbank:DB00321 bio2rdf_vocabulary:identifier "DB00321" assertion.
- drugbank:DB00321 drugbank_vocabulary:x-wikipedia wikipedia:Amitriptyline assertion.
- drugbank:DB00321 drugbank_vocabulary:x-pharmgkb pharmgkb:PA448385 assertion.
- drugbank:DB00321 drugbank_vocabulary:x-kegg kegg:C06824 assertion.
- drugbank:DB00321 drugbank_vocabulary:x-dpd dpd:654515 assertion.
- drugbank:DB00321 drugbank_vocabulary:x-chebi chebi:2666 assertion.
- drugbank:DB00321 drugbank_vocabulary:x-atc atc:N06AA09 assertion.
- drugbank:DB00321 drugbank_vocabulary:x-ahfs ahfs:28:16.04.28 assertion.
- drugbank:DB00321 drugbank_vocabulary:x-ndc ndc:53489-104-07 assertion.
- drugbank:DB00321 drugbank_vocabulary:x-iuphar iuphar:200 assertion.
- drugbank:DB00321 drugbank_vocabulary:x-gtp gtp:200 assertion.