Matches in Nanopublications for { ?s ?p ?o <http://bio2rdf.org/drugbank:DB00344_nanopub.RAeIBLZ6YBRe_K_BloLkJmCbs4-HTYqKRG1u64id6DZT0#assertion>. }
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- drugbank:DB00344 type drugbank_vocabulary:Drug assertion.
- drugbank:DB00344 label "Protriptyline [drugbank:DB00344]" assertion.
- drugbank:DB00344 seeAlso viv1617.shtml assertion.
- drugbank:DB00344 seeAlso protriptyline.html assertion.
- drugbank:DB00344 seeAlso DB00344 assertion.
- drugbank:DB00344 description "Protriptyline hydrochloride is a dibenzocycloheptene-derivative tricyclic antidepressant (TCA). TCAs are structurally similar to phenothiazines. They contain a tricyclic ring system with an alkyl amine substituent on the central ring. In non-depressed individuals, protriptyline does not affect mood or arousal, but may cause sedation. In depressed individuals, protriptyline exerts a positive effect on mood. TCAs are potent inhibitors of serotonin and norepinephrine reuptake. In addition, TCAs down-regulate cerebral cortical β-adrenergic receptors and sensitize post-synaptic serotonergic receptors with chronic use. The antidepressant effects of TCAs are thought to be due to an overall increase in serotonergic neurotransmission. TCAs also block histamine H<sub>1</sub> receptors, α<sub>1</sub>-adrenergic receptors and muscarinic receptors, which accounts for their sedative, hypotensive and anticholinergic effects (e.g. blurred vision, dry mouth, constipation, urinary retention), respectively. See toxicity section below for a complete listing of side effects. Protriptyline may be used for the treatment of depression." assertion.
- drugbank:DB00344 identifier "drugbank:DB00344" assertion.
- drugbank:DB00344 title "Protriptyline" assertion.
- drugbank:DB00344 drugbank_vocabulary:x-pubchemsubstance pubchem.substance:46505128 assertion.
- drugbank:DB00344 drugbank_vocabulary:x-pubchemcompound pubchem.compound:4976 assertion.
- drugbank:DB00344 drugbank_vocabulary:x-chemspider chemspider:4805 assertion.
- drugbank:DB00344 drugbank_vocabulary:x-cas cas:438-60-8 assertion.
- drugbank:DB00344 drugbank_vocabulary:drugbank-id "APRD00441" assertion.
- drugbank:DB00344 drugbank_vocabulary:drugbank-id "DB00344" assertion.
- drugbank:DB00344 bio2rdf_vocabulary:x-identifiers.org DB00344 assertion.
- drugbank:DB00344 bio2rdf_vocabulary:uri "http://bio2rdf.org/drugbank:DB00344" assertion.
- drugbank:DB00344 bio2rdf_vocabulary:namespace "drugbank" assertion.
- drugbank:DB00344 bio2rdf_vocabulary:identifier "DB00344" assertion.
- drugbank:DB00344 drugbank_vocabulary:x-wikipedia wikipedia:Protriptyline assertion.
- drugbank:DB00344 drugbank_vocabulary:x-pharmgkb pharmgkb:PA451168 assertion.
- drugbank:DB00344 drugbank_vocabulary:x-kegg kegg:C07408 assertion.
- drugbank:DB00344 drugbank_vocabulary:x-dpd dpd:322741 assertion.
- drugbank:DB00344 drugbank_vocabulary:x-chebi chebi:8597 assertion.
- drugbank:DB00344 drugbank_vocabulary:x-atc atc:N06AA11 assertion.
- drugbank:DB00344 drugbank_vocabulary:x-ndc ndc:0555-0595-02 assertion.