Matches in Nanopublications for { ?s ?p ?o <http://bio2rdf.org/drugbank:DB00630_nanopub.RAdgX8ny_LXA66rW-nVZy8OUMOXaRlAt1RIc5H6PoZRg8#assertion>. }
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- drugbank:DB00630 type drugbank_vocabulary:Drug assertion.
- drugbank:DB00630 label "Alendronate [drugbank:DB00630]" assertion.
- drugbank:DB00630 seeAlso alendron.htm assertion.
- drugbank:DB00630 seeAlso alendronate.html assertion.
- drugbank:DB00630 seeAlso DB00630 assertion.
- drugbank:DB00630 description "Alendronate is a nitrogen-containing, second generation bisphosphonate. Bisphosphonates were first used to treat Pagetâs disease in 1971. This class of medications is comprised of inorganic pyrophosphate analogues that contain non-hydrolyzable P-C-P bonds. Similar to other bisphosphonates, alendronate has a high affinity for bone mineral and is taken up during osteoclast resorption. Alendronate inhibits farnesyl pyrophosphate synthetase, one of the enzymes in the mevalonic acid pathway involved in producing isoprenoid compounds that are essential for post-translational modification of small guanosine triphosphate (GTP)-binding proteins, such as Rho, Ras and Rab. Inhibition of this process interferes with osteoclast function and survival. Alendronate is used for the treatment of osteoporosis and Pagetâs disease." assertion.
- drugbank:DB00630 identifier "drugbank:DB00630" assertion.
- drugbank:DB00630 title "Alendronate" assertion.
- drugbank:DB00630 drugbank_vocabulary:x-pubchemsubstance pubchem.substance:46507199 assertion.
- drugbank:DB00630 drugbank_vocabulary:x-pubchemcompound pubchem.compound:2088 assertion.
- drugbank:DB00630 drugbank_vocabulary:x-pdb pdb:AHD assertion.
- drugbank:DB00630 drugbank_vocabulary:x-chemspider chemspider:2004 assertion.
- drugbank:DB00630 drugbank_vocabulary:x-cas cas:66376-36-1 assertion.
- drugbank:DB00630 drugbank_vocabulary:drugbank-id "APRD00561" assertion.
- drugbank:DB00630 drugbank_vocabulary:drugbank-id "DB00630" assertion.
- drugbank:DB00630 bio2rdf_vocabulary:x-identifiers.org DB00630 assertion.
- drugbank:DB00630 bio2rdf_vocabulary:uri "http://bio2rdf.org/drugbank:DB00630" assertion.
- drugbank:DB00630 bio2rdf_vocabulary:namespace "drugbank" assertion.
- drugbank:DB00630 bio2rdf_vocabulary:identifier "DB00630" assertion.
- drugbank:DB00630 drugbank_vocabulary:x-wikipedia wikipedia:Alendronate assertion.
- drugbank:DB00630 drugbank_vocabulary:x-pharmgkb pharmgkb:PA448082 assertion.
- drugbank:DB00630 drugbank_vocabulary:x-kegg kegg:C07752 assertion.
- drugbank:DB00630 drugbank_vocabulary:x-dpd dpd:2261715 assertion.
- drugbank:DB00630 drugbank_vocabulary:x-chebi chebi:2567 assertion.
- drugbank:DB00630 drugbank_vocabulary:x-atc atc:M05BA04 assertion.
- drugbank:DB00630 drugbank_vocabulary:x-ahfs ahfs:92:00.00 assertion.
- drugbank:DB00630 drugbank_vocabulary:x-bindingdb bindingdb:25313 assertion.
- drugbank:DB00630 drugbank_vocabulary:x-ndc ndc:0006-0925-31 assertion.