Matches in Nanopublications for { ?s ?p ?o <http://bio2rdf.org/drugbank:DB00744_nanopub.RAihxPrqkbk2ZwkuQfCAQkEjqp47blF7ZjtoaxrjCxjHY#assertion>. }
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- drugbank:DB00744 type drugbank_vocabulary:Drug assertion.
- drugbank:DB00744 label "Zileuton [drugbank:DB00744]" assertion.
- drugbank:DB00744 seeAlso zileuton.htm assertion.
- drugbank:DB00744 seeAlso zileuton.html assertion.
- drugbank:DB00744 seeAlso DB00744 assertion.
- drugbank:DB00744 description "Leukotrienes are substances that induce numerous biological effects including augmentation of neutrophil and eosinophil migration, neutrophil and monocyte aggregation, leukocyte adhesion, increased capillary permeability, and smooth muscle contraction. These effects contribute to inflammation, edema, mucus secretion, and bronchoconstriction in the airways of asthmatic patients. Zileuton relieves such symptoms through its selective inhibition of 5-lipoxygenase, the enzyme that catalyzes the formation of leukotrienes from arachidonic acid. Specifically, it inhibits leukotriene LTB4, LTC4, LTD4, and LTE4 formation. Both the R(+) and S(-) enantiomers are pharmacologically active as 5-lipoxygenase inhibitors in in vitro systems. The immediate release tablet of Zileuton has been withdrawn from the US market." assertion.
- drugbank:DB00744 identifier "drugbank:DB00744" assertion.
- drugbank:DB00744 title "Zileuton" assertion.
- drugbank:DB00744 drugbank_vocabulary:x-pubchemsubstance pubchem.substance:46506394 assertion.
- drugbank:DB00744 drugbank_vocabulary:x-pubchemcompound pubchem.compound:60490 assertion.
- drugbank:DB00744 drugbank_vocabulary:x-chemspider chemspider:54531 assertion.
- drugbank:DB00744 drugbank_vocabulary:x-cas cas:111406-87-2 assertion.
- drugbank:DB00744 drugbank_vocabulary:drugbank-id "APRD00265" assertion.
- drugbank:DB00744 drugbank_vocabulary:drugbank-id "DB00744" assertion.
- drugbank:DB00744 bio2rdf_vocabulary:x-identifiers.org DB00744 assertion.
- drugbank:DB00744 bio2rdf_vocabulary:uri "http://bio2rdf.org/drugbank:DB00744" assertion.
- drugbank:DB00744 bio2rdf_vocabulary:namespace "drugbank" assertion.
- drugbank:DB00744 bio2rdf_vocabulary:identifier "DB00744" assertion.
- drugbank:DB00744 drugbank_vocabulary:x-wikipedia wikipedia:Zileuton assertion.
- drugbank:DB00744 drugbank_vocabulary:x-pharmgkb pharmgkb:PA451955 assertion.
- drugbank:DB00744 drugbank_vocabulary:x-kegg kegg:D00414 assertion.
- drugbank:DB00744 drugbank_vocabulary:x-chebi chebi:10112 assertion.
- drugbank:DB00744 drugbank_vocabulary:x-ndc ndc:68734-700-10 assertion.