Matches in Nanopublications for { ?s ?p ?o <http://bio2rdf.org/drugbank:DB00864_nanopub.RA2Be5UQtMrf-hQc5rjCt4RlkWUSKxU08t7Bs8QvI4vI8#assertion>. }
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- drugbank:DB00864 type drugbank_vocabulary:Drug assertion.
- drugbank:DB00864 label "Tacrolimus [drugbank:DB00864]" assertion.
- drugbank:DB00864 seeAlso tacrolimus.htm assertion.
- drugbank:DB00864 seeAlso tacrolimus.html assertion.
- drugbank:DB00864 seeAlso DB00864 assertion.
- drugbank:DB00864 description "Tacrolimus (also FK-506 or Fujimycin) is an immunosuppressive drug whose main use is after organ transplant to reduce the activity of the patient's immune system and so the risk of organ rejection. It is also used in a topical preparation in the treatment of severe atopic dermatitis, severe refractory uveitis after bone marrow transplants, and the skin condition vitiligo. It was discovered in 1984 from the fermentation broth of a Japanese soil sample that contained the bacteria Streptomyces tsukubaensis. Tacrolimus is chemically known as a macrolide. It reduces peptidyl-prolyl isomerase activity by binding to the immunophilin FKBP-12 (FK506 binding protein) creating a new complex. This FKBP12-FK506 complex interacts with and inhibits calcineurin thus inhibiting both T-lymphocyte signal transduction and IL-2 transcription." assertion.
- drugbank:DB00864 identifier "drugbank:DB00864" assertion.
- drugbank:DB00864 title "Tacrolimus" assertion.
- drugbank:DB00864 drugbank_vocabulary:x-pubchemsubstance pubchem.substance:46506004 assertion.
- drugbank:DB00864 drugbank_vocabulary:x-pubchemcompound pubchem.compound:445647 assertion.
- drugbank:DB00864 drugbank_vocabulary:x-pdb pdb:FK5 assertion.
- drugbank:DB00864 drugbank_vocabulary:x-cas cas:104987-11-3 assertion.
- drugbank:DB00864 drugbank_vocabulary:drugbank-id "APRD00276" assertion.
- drugbank:DB00864 drugbank_vocabulary:drugbank-id "DB00864" assertion.
- drugbank:DB00864 drugbank_vocabulary:drugbank-id "EXPT01437" assertion.
- drugbank:DB00864 bio2rdf_vocabulary:x-identifiers.org DB00864 assertion.
- drugbank:DB00864 bio2rdf_vocabulary:uri "http://bio2rdf.org/drugbank:DB00864" assertion.
- drugbank:DB00864 bio2rdf_vocabulary:namespace "drugbank" assertion.
- drugbank:DB00864 bio2rdf_vocabulary:identifier "DB00864" assertion.
- drugbank:DB00864 drugbank_vocabulary:x-wikipedia wikipedia:Tacrolimus assertion.
- drugbank:DB00864 drugbank_vocabulary:x-pharmgkb pharmgkb:PA451578 assertion.
- drugbank:DB00864 drugbank_vocabulary:x-kegg kegg:D00107 assertion.
- drugbank:DB00864 drugbank_vocabulary:x-kegg kegg:C01375 assertion.
- drugbank:DB00864 drugbank_vocabulary:x-dpd dpd:2243144 assertion.
- drugbank:DB00864 drugbank_vocabulary:x-chebi chebi:61049 assertion.
- drugbank:DB00864 drugbank_vocabulary:x-atc atc:D11AH01 assertion.
- drugbank:DB00864 drugbank_vocabulary:x-ahfs ahfs:84:92.00 assertion.
- drugbank:DB00864 drugbank_vocabulary:x-ndc ndc:0469-0607-73 assertion.