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- drugbank:DB01065 type drugbank_vocabulary:Drug assertion.
- drugbank:DB01065 label "Melatonin [drugbank:DB01065]" assertion.
- drugbank:DB01065 seeAlso mel_0286.shtml assertion.
- drugbank:DB01065 seeAlso melatonin.html assertion.
- drugbank:DB01065 seeAlso DB01065 assertion.
- drugbank:DB01065 description "Melatonin is a biogenic amine that is found in animals, plants and microbes. Aaron B. Lerner of Yale University is credited for naming the hormone and for defining its chemical structure in 1958. In mammals, melatonin is produced by the pineal gland. The pineal gland is small endocrine gland, about the size of a rice grain and shaped like a pine cone (hence the name), that is located in the center of the brain (rostro-dorsal to the superior colliculus) but outside the blood-brain barrier. The secretion of melatonin increases in darkness and decreases during exposure to light, thereby regulating the circadian rhythms of several biological functions, including the sleep-wake cycle. In particular, melatonin regulates the sleep-wake cycle by chemically causing drowsiness and lowering the body temperature. Melatonin is also implicated in the regulation of mood, learning and memory, immune activity, dreaming, fertility and reproduction. Melatonin is also an effective antioxidant. Most of the actions of melatonin are mediated through the binding and activation of melatonin receptors. Individuals with autism spectrum disorders (ASD) may have lower than normal levels of melatonin. A 2008 study found that unaffected parents of individuals with ASD also have lower melatonin levels, and that the deficits were associated with low activity of the ASMT gene, which encodes the last enzyme of melatonin synthesis. Reduced melatonin production has also been proposed as a likely factor in the significantly higher cancer rates in night workers." assertion.
- drugbank:DB01065 identifier "drugbank:DB01065" assertion.
- drugbank:DB01065 title "Melatonin" assertion.
- drugbank:DB01065 drugbank_vocabulary:x-pubchemsubstance pubchem.substance:46509101 assertion.
- drugbank:DB01065 drugbank_vocabulary:x-pubchemcompound pubchem.compound:896 assertion.
- drugbank:DB01065 drugbank_vocabulary:x-pdb pdb:ML1 assertion.
- drugbank:DB01065 drugbank_vocabulary:x-chemspider chemspider:872 assertion.
- drugbank:DB01065 drugbank_vocabulary:x-cas cas:73-31-4 assertion.
- drugbank:DB01065 drugbank_vocabulary:drugbank-id "APRD00742" assertion.
- drugbank:DB01065 drugbank_vocabulary:drugbank-id "DB01065" assertion.
- drugbank:DB01065 drugbank_vocabulary:drugbank-id "DB08189" assertion.
- drugbank:DB01065 bio2rdf_vocabulary:x-identifiers.org DB01065 assertion.
- drugbank:DB01065 bio2rdf_vocabulary:uri "http://bio2rdf.org/drugbank:DB01065" assertion.
- drugbank:DB01065 bio2rdf_vocabulary:namespace "drugbank" assertion.
- drugbank:DB01065 bio2rdf_vocabulary:identifier "DB01065" assertion.
- drugbank:DB01065 drugbank_vocabulary:x-wikipedia wikipedia:Melatonin assertion.
- drugbank:DB01065 drugbank_vocabulary:x-pharmgkb pharmgkb:PA164752558 assertion.
- drugbank:DB01065 drugbank_vocabulary:x-kegg kegg:C01598 assertion.
- drugbank:DB01065 drugbank_vocabulary:x-dpd dpd:793167 assertion.
- drugbank:DB01065 drugbank_vocabulary:x-chebi chebi:16796 assertion.
- drugbank:DB01065 drugbank_vocabulary:x-atc atc:N05CH01 assertion.
- drugbank:DB01065 drugbank_vocabulary:x-bindingdb bindingdb:9019 assertion.
- drugbank:DB01065 drugbank_vocabulary:x-iuphar iuphar:1357 assertion.
- drugbank:DB01065 drugbank_vocabulary:x-gtp gtp:1357 assertion.