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- drugbank:DB01104 type drugbank_vocabulary:Drug assertion.
- drugbank:DB01104 label "Sertraline [drugbank:DB01104]" assertion.
- drugbank:DB01104 seeAlso sertral.htm assertion.
- drugbank:DB01104 seeAlso sertraline.html assertion.
- drugbank:DB01104 seeAlso DB01104 assertion.
- drugbank:DB01104 description "Sertraline hydrochloride belongs to a class of antidepressant agents known as selective serotonin-reuptake inhibitors (SSRIs). Despite distinct structural differences between compounds in this class, SSRIs possess similar pharmacological activity. As with other antidepressant agents, several weeks of therapy may be required before a clinical effect is seen. SSRIs are potent inhibitors of neuronal serotonin reuptake. They have little to no effect on norepinephrine or dopamine reuptake and do not antagonize α- or β-adrenergic, dopamine D<sub>2</sub> or histamine H<sub>1</sub> receptors. During acute use, SSRIs block serotonin reuptake and increase serotonin stimulation of somatodendritic 5-HT<sub>1A</sub> and terminal autoreceptors. Chronic use leads to desensitization of somatodendritic 5-HT<sub>1A</sub> and terminal autoreceptors. The overall clinical effect of increased mood and decreased anxiety is thought to be due to adaptive changes in neuronal function that leads to enhanced serotonergic neurotransmission. Side effects include dry mouth, nausea, dizziness, drowsiness, sexual dysfunction and headache (see Toxicity section below for a more detailed listing of side effects). Compared to other agents in this class, sertraline may cause greater diarrheal and male sexual dysfunction effects. Side effects generally occur within the first two weeks of therapy and are usually less severe and frequent than those observed with tricyclic antidepressants. Sertraline may be used to treat major depressive disorder, obsessive-compulsive disorder (OCD), panic disorder, post-traumatic stress disorder (PTSD), premenstrual dysphoric disorder (PMDD) and social anxiety disorder (social phobia)." assertion.
- drugbank:DB01104 identifier "drugbank:DB01104" assertion.
- drugbank:DB01104 title "Sertraline" assertion.
- drugbank:DB01104 drugbank_vocabulary:x-pubchemsubstance pubchem.substance:46505341 assertion.
- drugbank:DB01104 drugbank_vocabulary:x-pubchemcompound pubchem.compound:68617 assertion.
- drugbank:DB01104 drugbank_vocabulary:x-chemspider chemspider:61881 assertion.
- drugbank:DB01104 drugbank_vocabulary:x-cas cas:79617-96-2 assertion.
- drugbank:DB01104 drugbank_vocabulary:drugbank-id "APRD00175" assertion.
- drugbank:DB01104 drugbank_vocabulary:drugbank-id "DB01104" assertion.
- drugbank:DB01104 bio2rdf_vocabulary:x-identifiers.org DB01104 assertion.
- drugbank:DB01104 bio2rdf_vocabulary:uri "http://bio2rdf.org/drugbank:DB01104" assertion.
- drugbank:DB01104 bio2rdf_vocabulary:namespace "drugbank" assertion.
- drugbank:DB01104 bio2rdf_vocabulary:identifier "DB01104" assertion.
- drugbank:DB01104 drugbank_vocabulary:x-wikipedia wikipedia:Sertraline assertion.
- drugbank:DB01104 drugbank_vocabulary:x-pharmgkb pharmgkb:PA451333 assertion.
- drugbank:DB01104 drugbank_vocabulary:x-kegg kegg:D02360 assertion.
- drugbank:DB01104 drugbank_vocabulary:x-kegg kegg:C07246 assertion.
- drugbank:DB01104 drugbank_vocabulary:x-dpd dpd:2245749 assertion.
- drugbank:DB01104 drugbank_vocabulary:x-chebi chebi:9123 assertion.
- drugbank:DB01104 drugbank_vocabulary:x-atc atc:N06AB06 assertion.
- drugbank:DB01104 drugbank_vocabulary:x-ahfs ahfs:28:16.04.20 assertion.
- drugbank:DB01104 drugbank_vocabulary:x-ndc ndc:0049-4960-30 assertion.