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- drugbank:DB01175 type drugbank_vocabulary:Drug assertion.
- drugbank:DB01175 label "Escitalopram [drugbank:DB01175]" assertion.
- drugbank:DB01175 seeAlso lexapro.htm assertion.
- drugbank:DB01175 seeAlso lex1642.shtml assertion.
- drugbank:DB01175 seeAlso escitalopram.html assertion.
- drugbank:DB01175 seeAlso DB01175 assertion.
- drugbank:DB01175 description "Escitalopram, the <i>S</i>-enantiomer of citalopram, belongs to a class of antidepressant agents known as selective serotonin-reuptake inhibitors (SSRIs). Despite distinct structural differences between compounds in this class, SSRIs possess similar pharmacological activity. As with other antidepressant agents, several weeks of therapy may be required before a clinical effect is seen. SSRIs are potent inhibitors of neuronal serotonin reuptake. They have little to no effect on norepinephrine or dopamine reuptake and do not antagonize α- or β-adrenergic, dopamine D<sub>2</sub> or histamine H<sub>1</sub> receptors. During acute use, SSRIs block serotonin reuptake and increase serotonin stimulation of somatodendritic 5-HT<sub>1A</sub> and terminal autoreceptors. Chronic use leads to desensitization of somatodendritic 5-HT<sub>1A</sub> and terminal autoreceptors. The overall clinical effect of increased mood and decreased anxiety is thought to be due to adaptive changes in neuronal function that leads to enhanced serotonergic neurotransmission. Side effects include dry mouth, nausea, dizziness, drowsiness, sexual dysfunction and headache. Side effects generally occur within the first two weeks of therapy and are usually less severe and frequent than those observed with tricyclic antidepressants. Escitalopram may be used to treat major depressive disorder (MDD) and generalized anxiety disorder (GAD)." assertion.
- drugbank:DB01175 identifier "drugbank:DB01175" assertion.
- drugbank:DB01175 title "Escitalopram" assertion.
- drugbank:DB01175 drugbank_vocabulary:x-pubchemsubstance pubchem.substance:46507040 assertion.
- drugbank:DB01175 drugbank_vocabulary:x-pubchemcompound pubchem.compound:146570 assertion.
- drugbank:DB01175 drugbank_vocabulary:x-chemspider chemspider:129277 assertion.
- drugbank:DB01175 drugbank_vocabulary:x-cas cas:128196-01-0 assertion.
- drugbank:DB01175 drugbank_vocabulary:drugbank-id "APRD00683" assertion.
- drugbank:DB01175 drugbank_vocabulary:drugbank-id "DB01175" assertion.
- drugbank:DB01175 bio2rdf_vocabulary:x-identifiers.org DB01175 assertion.
- drugbank:DB01175 bio2rdf_vocabulary:uri "http://bio2rdf.org/drugbank:DB01175" assertion.
- drugbank:DB01175 bio2rdf_vocabulary:namespace "drugbank" assertion.
- drugbank:DB01175 bio2rdf_vocabulary:identifier "DB01175" assertion.
- drugbank:DB01175 drugbank_vocabulary:x-wikipedia wikipedia:Escitalopram assertion.
- drugbank:DB01175 drugbank_vocabulary:x-pharmgkb pharmgkb:PA10074 assertion.
- drugbank:DB01175 drugbank_vocabulary:x-dpd dpd:2263238 assertion.
- drugbank:DB01175 drugbank_vocabulary:x-chebi chebi:36791 assertion.
- drugbank:DB01175 drugbank_vocabulary:x-ahfs ahfs:28:16.04.20 assertion.
- drugbank:DB01175 drugbank_vocabulary:x-ndc ndc:0456-2005-01 assertion.